Cited by 70Neural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on Behavior

Depression and anxious apprehension distinguish frontocingulate cortical activity during top-down attentional control.

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Silton, Rebecca Levin, Heller, Wendy, Engels, Anna S., Towers, David N., Spielberg, Jeffrey M., Edgar, J. Christopher, Sass, Sarah M., Stewart, Jennifer L. +3 more·2011·Journal of Abnormal Psychology

Abstract

A network consisting of left dorsolateral prefrontal cortex (LDLPFC) and dorsal anterior cingulate cortex (dACC) has been implicated in top-down attentional control. Few studies have systematically investigated how this network is altered in psychopathology, despite evidence that depression and anxiety are associated with attentional control impairments. Functional MRI and dense-array event-related brain potential (ERP) data were collected in separate sessions from 100 participants during a color-word Stroop task. Functional MRI results guided ERP source modeling to characterize the time course of activity in LDLPFC (300-440 ms) and dACC (520-680 ms). At low levels of depression, LDLPFC activity was indirectly related to Stroop interference and only via dACC activity. In contrast, at high levels of depression, dACC did not play an intervening role, and increased LDLPFC activity was directly related to decreased Stroop interference. Specific to high levels of anxious apprehension, higher dACC activity was related to more Stroop interference. Results indicate that depression and anxious apprehension modulate temporally and functionally distinct aspects of the frontocingulate network involved in top-down attention control.

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  1. Bredemeier K Spielberg JM Silton RL Berenbaum H Heller W Miller GA Screening for clinical depression using the MASQ anhedonic depression scale: A receiver-operator characteristic analysis Psychological Assessment In press PMC2992834 20822283
  2. Edgar JC Stewart JL Miller GA Handy TC Digital filtering in EEG/ERP research Event-related potentials: A handbook 2005 85 113 MIT Press Cambridge, MA
  3. First MB Spitzer RL Gibbon M Williams JBW Structured clinical interview for DSM-IV axis I disorders – non-patient edition (SCID-I/NP, version 2.0 – 4/97 revision) 1997 Biometrics Research Department New York
  4. Luck SJ An Introduction to the Event-Related Potential Technique 2005 The MIT Press London
  5. Miller GA Lutzenberger W Elbert T The linked-reference issue in EEG and ERP recording Journal of Psychophysiology 1991 5 273 276

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Authors
Silton, R. L., Heller, W., Engels, A. S., Towers, D. N., Spielberg, J. M., Edgar, J. C., Sass, S. M., Stewart, J. L., Sutton, B. P., Banich, M. T., & Miller, G. A.
Affiliations
  • University of Illinois Urbana-Champaign (US)
  • University of Colorado Boulder (US)
Venue
Journal of Abnormal Psychology
Published
2011-05
Volume
120
Issue
2
Pages
272-285
ISSN
  • 0021-843X (ISSN-L)
  • 1939-1846
OpenAlex
W2141791757
Cited by
70
References
97
Citations by year
2025: 4 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 1 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 1
FWCI
2.60
Type
journal article
Language
en
Open access
Locations
  • Journal of Abnormal Psychology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (P50 MH079485; R01 MH61358; T32 MH19554)
  • National Institute on Drug Abuse (R21 DA14111)
  • University of Illinois
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
depression, anxious apprehension, top-down attentional control, dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, Stroop interference, psychopathology
MeSH terms
Adolescent, Adult, Anxiety, Attention, Brain Mapping, Depression, Evoked Potentials, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Reaction Time, Stroop Test

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