Depression and anxious apprehension distinguish frontocingulate cortical activity during top-down attentional control.
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A network consisting of left dorsolateral prefrontal cortex (LDLPFC) and dorsal anterior cingulate cortex (dACC) has been implicated in top-down attentional control. Few studies have systematically investigated how this network is altered in psychopathology, despite evidence that depression and anxiety are associated with attentional control impairments. Functional MRI and dense-array event-related brain potential (ERP) data were collected in separate sessions from 100 participants during a color-word Stroop task. Functional MRI results guided ERP source modeling to characterize the time course of activity in LDLPFC (300-440 ms) and dACC (520-680 ms). At low levels of depression, LDLPFC activity was indirectly related to Stroop interference and only via dACC activity. In contrast, at high levels of depression, dACC did not play an intervening role, and increased LDLPFC activity was directly related to decreased Stroop interference. Specific to high levels of anxious apprehension, higher dACC activity was related to more Stroop interference. Results indicate that depression and anxious apprehension modulate temporally and functionally distinct aspects of the frontocingulate network involved in top-down attention control.
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Higher dorsal anterior cingulate cortex activity has been associated with greater levels of anxious apprehension.
“Moreover, higher dACC activity has been associated with greater levels of anxious apprehension (Silton et al., 2011).”
From Extension of the Transdiagnostic Model to Focus on Intolerance of Uncertainty: A Review of the Literature and Implications for Treatment (2014) · cites this paper as Silton et al., 2011
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- First MB Spitzer RL Gibbon M Williams JBW Structured clinical interview for DSM-IV axis I disorders – non-patient edition (SCID-I/NP, version 2.0 – 4/97 revision) 1997 Biometrics Research Department New York
- Luck SJ An Introduction to the Event-Related Potential Technique 2005 The MIT Press London
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Award for distinguished contributions to psychophysiology: Gregory A. Miller
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Self-citation
- Authors
- Silton, R. L., Heller, W., Engels, A. S., Towers, D. N., Spielberg, J. M., Edgar, J. C., Sass, S. M., Stewart, J. L., Sutton, B. P., Banich, M. T., & Miller, G. A.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- University of Colorado Boulder (US)
- ORCID
- Venue
- Journal of Abnormal Psychology
- Published
- 2011-05
- Volume
- 120
- Issue
- 2
- Pages
- 272-285
- ISSN
- 0021-843X (ISSN-L)
- 1939-1846
- PMC
- PMC4406398
- OpenAlex
- W2141791757
- Cited by
- 70
- References
- 97
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 1 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Abnormal Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50 MH079485; R01 MH61358; T32 MH19554)
- National Institute on Drug Abuse (R21 DA14111)
- University of Illinois
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- depression, anxious apprehension, top-down attentional control, dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, Stroop interference, psychopathology
- MeSH terms
- Adolescent, Adult, Anxiety, Attention, Brain Mapping, Depression, Evoked Potentials, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Reaction Time, Stroop Test
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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