Cited by 163Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

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Preliminary evidence that plasma oxytocin levels are elevated in major depression

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Parker, Karen J., Kenna, Heather A., Zeitzer, Jamie M., Keller, Jennifer, Blasey, Christine M., Amico, Janet A., Schatzberg, Alan F.·2010·Psychiatry Research

DOI 10.1016/j.psychres.2009.09.017PMC PMC2902664

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Abstract

It is well established that the neuropeptide oxytocin (OT) is involved in regulating social behavior, anxiety, and hypothalamic-pituitary-adrenal (HPA) axis physiology in mammals. Because individuals with major depression often exhibit functional irregularities in these measures, we test in this pilot study whether depressed subjects (n=11) exhibit dysregulated OT biology compared to healthy control subjects (n=19). Subjects were hospitalized overnight and blood samples were collected hourly between 1800 and 0900h. Plasma levels of OT, the closely related neuropeptide argine-vasopressin (AVP), and cortisol were quantified. Results indicated that depressed subjects exhibit increased OT levels compared to healthy control subjects, and this difference is most apparent during the nocturnal peak. No depression-related differences in AVP or cortisol levels were discerned. This depression-related elevation in plasma OT levels is consistent with reports of increased hypothalamic OT-expressing neurons and OT mRNA in depressed patients. This present finding is likewise consistent with the hypothesis that dysregulated OT biology may be a biomarker of the emotional distress and impaired social relationships which characterize major depression. Additional research is required to elucidate the role of OT in the pathophysiology of this psychiatric disorder.

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Authors: Parker, K. J., Kenna, H. A., Zeitzer, J. M., Keller, J., Blasey, C. M., Amico, J. A., & Schatzberg, A. F.
Affiliations: Stanford Medicine (US)
VA Palo Alto Health Care System (US)
University of Pittsburgh (US)
Corresponding author: Parker, Karen J.
ORCID: Parker, Karen J.
Zeitzer, Jamie M.
Keller, Jennifer
Schatzberg, Alan F.
Venue: Psychiatry Research
Publisher: Elsevier BV
Published: 2010-07
Volume: 178
Issue: 2
Pages: 359-362
ISSN: 0165-1781 (ISSN-L)
DOI: 10.1016/j.psychres.2009.09.017
PMC: PMC2902664
OpenAlex: W2146551770
Cited by: 163
References: 30
Citations by year: 2026: 2 · 2025: 8 · 2024: 3 · 2023: 2 · 2022: 14 · 2021: 14 · 2020: 7 · 2019: 9 · 2018: 11 · 2017: 11 · 2016: 10 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 11
FWCI: 19.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (MH50604, MH66537, RR-00070)
The Pritzker Foundation
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, major depressive disorder, plasma oxytocin, vasopressin, cortisol, hypothalamic-pituitary-adrenal axis, depression biomarkers, social behavior, anxiety
MeSH terms: Adult, Major Depressive Disorder, Female, Humans, Hydrocortisone, Male, Middle Aged, Oxytocin, Psychiatric Status Rating Scales, Regression Analysis, Vasopressins

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Preliminary evidence that plasma oxytocin levels are elevated in major depression

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