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Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction
Open accessAbstract
Both oxytocin (OT) and vasopressin (AVP) are known to modulate social behavior, and dysfunction in both systems has been postulated as a potential cause of certain psychiatric disorders that involve social behavioral deficits. In particular, there is growing interest in intranasal OT as a potential treatment for certain psychiatric disorders, and preliminary pre-clinical and clinical studies suggest efficacy in alleviating some of the associated symptoms. However, the vast majority of research participants in these studies have been male, and there is evidence for sexually differentiated effects of nonapeptides in both humans and non-human animals. To date, no study has investigated the effect of intranasal OT on brain function in human males and females within the same paradigm. Previously, in a randomized, placebo-controlled, double-blind fMRI study, we reported effects of intranasal OT and AVP on behavior and brain activity of human males as they played an interactive social game known as the Prisoner's Dilemma Game. Here, we present findings from an identical study in human females, and compare these with our findings from males. Overall, we find that both behavioral and neural responses to intranasal OT and AVP are highly sexually differentiated. In women, AVP increased conciliatory behavior, and both OT and AVP caused women to treat computer partners more like humans. In men, AVP increased reciprocation of cooperation from both human and computer partners. However, no specific drug effects on behavior were shared between men and women. During cooperative interactions, both OT and AVP increased brain activity in men within areas rich in OT and AVP receptors and in areas playing a key role in reward, social bonding, arousal and memory (e.g., the striatum, basal forebrain, insula, amygdala and hippocampus), whereas OT and AVP either had no effect or in some cases actually decreased brain activity in these regions in women. OT treatment rendered neural responses of males more similar to responses of females in the placebo group and vice versa, raising the prospect of an inverted u-shaped dose response to central OT levels. These findings emphasize the need to fully characterize the effects of intranasal OT and AVP in both males and females and at multiple doses before widespread clinical application will be warranted.
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“Sex differences were also found for the effect of OT on brain activation during reciprocated cooperation.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Rilling et al., 2014
In the citing paper
“This bias can be observed in much of the prior work on oxytocin in humans as well, with some neuroimaging studies indicating potential differences in the oxytocin system between sexes.13, 14, 47, 48, 49”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [48]
In the citing paper
“This bias can be observed in much of the prior work on oxytocin in humans as well, with some neuroimaging studies indicating potential differences in the oxytocin system between sexes.13, 14, 47, 48, 49”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [48]
In the citing paper
“These data have, however, found OT and AVP can have differential effects on neural activity (i.e., BOLD fMRI responses) and cognition, at least in some cases although the effects of OT are more robust [84; 86; 87; 88; 89; 90].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [88]
In the citing paper
“The few studies that have compared the effects of intranasally administered OT and AVP in humans have reported that these peptides do not have opposing roles.”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [88]
In the citing paper
“In humans, intranasal VP had sex-specific effects during social communication and cooperation interactions”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Rilling et al., 2014
In the citing paper
“Intranasal OT increased the caudate/putamen response in males, whereas it decreased this response in females (Rilling et al., 2014).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Rilling et al., 2014
In the citing paper
“previous research has shown that oxytocin effects can vary as a function of emotion regulation skills (Quirin et al., 2011), social context history of childhood maltreatment (Ebert et al., 2013; Flanagan et al., 2015), and sex (Ditzen et al., 2012; Rilling et al., 2014).”
From Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial (2018) · cites this paper as Rilling et al., 2014
In the citing paper
“In healthy individuals, OT effects seem to follow an inverted u-shape (Rilling et al, 2014), with doses ~24 IU, resulting in more anxiolytic effects than higher doses of OT (Cardoso et al, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Rilling et al, 2014
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BackgroundThe Social Salience Hypothesis of Oxytocin
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BackgroundInfluentialThe placebo effect: From concepts to genes
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BackgroundKinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity
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“, 2014) and humans (Rilling et al., 2014).”
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Galea, L. A. M., Frick, K. M., Hampson, E., Sohrabji, F., & Choleris, E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.024 · Cited by 195
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InfluentialOxytocin, testosterone, and human social cognition
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“Such sex differences, including many effects that are opposite between males and females, are commonly observed (e.g. Rilling et al., 2014), although they have yet to be systematically addressed from perspectives based on adaptive significance.”
BackgroundVascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
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Sex and gender differences in the development of empathy
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InfluentialHormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face
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“For example, previous research has shown that oxytocin effects can vary as a function of emotion regulation skills (Quirin et al., 2011), social context history of childhood maltreatment (Ebert et al., 2013; Flanagan et al., 2015), and sex (Ditzen et al., 2012; Rilling et al., 2014).”
Oxytocin facilitates social approach behavior in women
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ResultVasopressin Boosts Placebo Analgesic Effects in Women: A Randomized Trial
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BackgroundIntranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women
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“…on STG activity might be independent of the valence of the processes, as we found that IN-OT increased STG activity was contributed by studies examining positive (Voorthuis et al., 2014; Rilling et al., 2014) or negative processes (Domes et al., 2010; Riem et al., 2011; Lischke et al., 2012).”
BackgroundInfluentialLinks between the neurobiology of oxytocin and human musicality
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Oxytocin’s effect on resting-state functional connectivity varies by age and sex
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“In clinical studies, OXT treatment for patients with ASD is mostly concentrated during adolescence or adulthood, with a demonstrable therapeutic effect (Hollander et al., 2003; Hollander et al., 2007; Andari et al., 2010; Guastella et al., 2010; Hall et al., 2012; Rilling et al., 2014).”
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“We have also previously reported OT and AVP modulation of the BOLD fMRI response to positive social interactions (reciprocated cooperation in the PD game), using a sub-set of the sample reported here (Rilling et al. 2014).”
Self-citationOxytocin facilitates reciprocity in social communication
Spengler, F. B., Scheele, D., Marsh, N., Kofferath, C., Flach, A., Schwarz, S., Stoffel-Wagner, B., Maier, W., & Hurlemann, R. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx061 · Cited by 83
“As a substantial body of evidence now points to sexual-dimorphic effects of OXT (Preckel et al., 2014; Rilling et al., 2014; Scheele et al., 2014), we cannot extrapolate our findings to women.”
BackgroundEbner, N. C., Lin, T., Muradoglu, M., Weir, D. H., Plasencia, G. M., Lillard, T. S., Pournajafi-Nazarloo, H., Cohen, R. A., Sue Carter, C., & Connelly, J. J. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.01.008 · Cited by 79
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“Specifically, intranasal OXT enhanced striatal responses to reciprocated cooperation in a Prisoner’s Dilemma Game in men, but not in women [Rilling et al., 2014].”
BackgroundSex-Related Differences in Plasma Oxytocin Levels in Humans
Marazziti, D., Baroni, S., Mucci, F., Piccinni, A., Moroni, I., Giannaccini, G., Carmassi, C., Massimetti, E., & Dell’Osso, L. (2019) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901915010058 · Cited by 80
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Oxytocin makes females, but not males, less forgiving following betrayal of trust
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“, 2010) and during social cooperation interactions (Rilling et al., 2014).”
BackgroundIntranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw123 · Cited by 72
“Taken together, our and previous findings fit with the notion that neural effects of oxytocin administration depend on individual factors such as patient status, sex or other individual characteristics, but only if these factors are related to differences in baseline functioning (Labuschagne et al., 2010; Bartz et al.…”
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“…of intranasal OT (Bartz et al., 2011; Macdonald, 2012), as well as associations between variation in oxytocin receptor gene polymorphisms (Tabak, 2013), the effects of AVP also appear to be moderated by similar factors (Rilling et al., 2012, 2014; Shalev et al., 2011; Thompson et al., 2006).”
BackgroundMethodResultInfluentialLinking Social Cognition to Learning and Memory
Leblanc, H., & Ramirez, S. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1280-20.2020 · Cited by 69
“, the amygdala) are ripe for future investigation (Markham and Juraska, 2002; Lebron-Milad et al., 2012; Rilling et al., 2014; Dumais and Veenema, 2016; Allsop et al., 2018).”
BackgroundThe endocrinology of human caregiving and its intergenerational transmission
Bos, P. A. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000973 · Cited by 71
“…increases sensitivity to social stress (Ebstein et al., 2009) and aggressive facial responses to others (Thompson, George, Walton, Orr, & Benson, 2006), but also increased social cooperation (Brunnlieb et al., 2016; Rilling et al., 2014) and empathic concern for others (Tabak et al., 2015).”
BackgroundResultOxytocin reduces amygdala responses during threat approach
Radke, S., Volman, I., Kokal, I., Roelofs, K., de Bruijn, E. R. A., & Toni, I. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.028 · Cited by 67
“…after oxytocin administration, ales’ neural responses appear to become more similar to those f females receiving placebo and vice-versa (Rilling et al., 2014), hich might provide an explanatory framework for opposing mygdala responses between males and females in the placebo roups of…”
BackgroundSex- and context-dependent effects of oxytocin on social sharing
Ma, X., Zhao, W., Luo, R., Zhou, F., Geng, Y., Xu, L., Gao, Z., Zheng, X., Becker, B., & Kendrick, K. M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.004 · Cited by 68
Oxytocin and sex differences in behavior
Caldwell, H. K. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.02.002 · Cited by 68
Oxytocin improves emotion recognition for older males
Campbell, A., Ruffman, T., Murray, J. E., & Glue, P. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.04.021 · Cited by 63
“Second, oxytocin increases functional connectivity in men but not women (Rilling et al., 2014).”
BackgroundRigney, N., Whylings, J., Mieda, M., de Vries, G. J., & Petrulis, A. (2019) · eNeuro · doi:10.1523/eneuro.0415-18.2019 · Cited by 63
Lukas, M., & Neumann, I. D. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.013 · Cited by 65
Improving the precision of intranasal oxytocin research
Winterton, A., Westlye, L. T., Steen, N. E., Andreassen, O. A., & Quintana, D. S. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-00996-4 · Cited by 65
Sparapani, S., Millet-Boureima, C., Oliver, J., Mu, K., Hadavi, P., Kalostian, T., Ali, N., Avelar, C. M., Bardies, M., Barrow, B., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9010089 · Cited by 64
“Brain fMRI during a Prisoner’s Dilemma Game revealed that, upon intranasal administration of 20 international units (IU) of AVP and compared to placebo, AVP increased BNST activity and reciprocated cooperation in men [255,299].”
BackgroundFrijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.278 · Cited by 60
Ebert, A., & Brüne, M. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_21 · Cited by 66
Oxytocin and love: myths, metaphors and mysteries.
Carter, C. S. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100107 · Cited by 57
Nawijn, L., van Zuiden, M., Koch, S. B. J., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.020 · Cited by 60
Kraaijenvanger, E. J., He, Y., Spencer, H., Smith, A. K., Bos, P. A., & Boks, M. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.016 · Cited by 63
Laursen, H. R., Siebner, H. R., Haren, T., Madsen, K., Grønlund, R., Hulme, O., & Henningsson, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00423 · Cited by 56
Opposing Oxytocin Effects on Intergroup Cooperative Behavior in Intuitive and Reflective Minds
Ma, Y., Liu, Y., Rand, D. G., Heatherton, T. F., & Han, S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.87 · Cited by 55
Swaab, D. F., & Bao, A. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00023-0 · Cited by 57
Daniëls, N., Moerkerke, M., Steyaert, J. G., Bamps, A., Debbaut, E., Prinsen, J., Tang, T., der Donck, S. V., Boets, B., & Alaerts, K. (2023) · Molecular Autism · doi:10.1186/s13229-023-00546-5 · Cited by 59
“Second, considering prior evidence of differential effects of oxytocin administration in men and women [21], we investigated treatment effect moderation depending on the biological sex of the participant.”
BackgroundSzymanska, M., Schneider, M., Chateau‐Smith, C., Nezelof, S., & Vulliez‐Coady, L. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12544 · Cited by 54
“In males, OT increased the activity of the caudate nucleus and left amygdala in response to reciprocated cooperation, and led to more rewarding cooperative interactions; whereas in women, OT either had no effect or decreased brain activity in those regions.(97) The administration of OT rendered male brain activity sim…”
BackgroundResultOxytocin Selectively Improves Empathic Accuracy: A Replication in Men and Novel Insights in Women
Bartz, J. A., Nitschke, J. P., Krol, S. A., & Tellier, P. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.01.014 · Cited by 64
Endogenous oxytocin, cortisol, and testosterone in response to group singing
Bowling, D. L., Gahr, J., Ancochea, P. G., Hoeschele, M., Canoine, V., Fusani, L., & Fitch, W. T. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.105105 · Cited by 51
“…differences remain “ very difficult ” to state (Caldwell, 2018), and evidence that oxytocin responses and reactions can be more pronounced in males is not unusual (Dumais et al., 2016; Feldman et al., 2010; Herzmann et al., 2013; Lynn et al., 2014; Rilling et al., 2014; Theodoridou et al., 2013).”
Schenk, L. A., Krimmel, S. R., & Colloca, L. (2017) · Pain · doi:10.1097/j.pain.0000000000000943 · Cited by 51
Rilling, J. K., Li, T., Chen, X., Gautam, P., Haroon, E., & Thompson, R. R. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00200 · Cited by 52
“Most studies have been done in men, where intranasal AVP has been found to facilitate cooperation (18, 19), enhance recognition of sexual cues (20), and enhance encoding of happy and angry faces (21).”
BackgroundSelf-citationFlattery, C. N. R., Ross, A. P., Sahu, S. P., Siegel, E. R., Dooyema, J. M., Cree, M. A., Stopa, E. G., Young, L. J., Rilling, J. K., Albers, H. E., et al. (2018) · American Journal of Primatology · doi:10.1002/ajp.22875 · Cited by 53
“AVP effects are also contextdependent, as it can promote pair-bonding behavior and cooperation (Brunnlieb et al., 2016; Rilling et al., 2014), but can also increase reactivity to threat and enhance anxiety (Morales-Medina, Witchey & Caldwell, 2016).”
BackgroundSelf-citationRole of oxytocin in the ventral tegmental area in social reinforcement
Borland, J. M., Grantham, K. N., Aiani, L. M., Frantz, K. J., & Albers, H. E. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.028 · Cited by 62
“Studies in humans also support a role for OT in regulating social behavior (Groppe et al., 2013; Rilling et al., 2014), and OT has been proposed as a potential treatment for a range of psychiatric disorders including autism spectrum disorder (Dichter et al.”
BackgroundWorsley, R., Santoro, N. F., Miller, K. K., Parish, S. J., & Davis, S. R. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2015.12.014 · Cited by 50
Rigney, N., Beaumont, R., & Petrulis, A. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104715 · Cited by 49
“AVP, working through the vasopressin V1a receptor (V1aR), has been repeatedly implicated in modulation of social behaviors across vertebrate species, including humans, and often in a sex-different way (Choleris et al. 2009; Donaldson and Young 2008; Insel 2010; Duque-Wilckens et al. 2016; Guastella et al., 2010; Rilli…”
BackgroundResultNishina, K., Takagishi, H., Inoue‐Murayama, M., Takahashi, H., & Yamagishi, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137089 · Cited by 50
“[37] provide an alternative account of sex differences; they reported sex differences in neural activity following intranasal administration of oxytocin, and further stated that Table 1.”
BackgroundResultInfluentialSocial status strategy in early adolescent girls: Testosterone and value-based decision making
Cardoos, S. L., Suleiman, A. B., Johnson, M. M., van den Bos, W., Hinshaw, S. P., & Dahl, R. E. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.03.013 · Cited by 50
Oxytocin reduces neural activation in response to infant faces in nulliparous young women
Bos, P. A., Spencer, H., & Montoya, E. R. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy080 · Cited by 47
Nishina, K., Takagishi, H., Takahashi, H., Sakagami, M., & Inoue‐Murayama, M. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00230 · Cited by 49
Shou, X., Xu, X., Zeng, X., Liu, Y., Yuan, H., Xing, Y., Jia, M., Wei, Q.-Y., Han, S., Zhang, R., et al. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0109-2 · Cited by 45
A neuroendocrine account of facial mimicry and its dynamic modulation
Kraaijenvanger, E. J., Hofman, D., & Bos, P. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.006 · Cited by 50
Neuropeptide Regulation of Social Attachment: The Prairie Vole Model
Tabbaa, M., Paedae, B., Liu, Y., & Wang, Z. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150055 · Cited by 54
Seeley, S. H., Chou, Y., & O'Connor, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.011 · Cited by 43
“Conversely, for female participants, IN-OT either had no significant effect or in fact decreased activation in those same regions (Rilling et al., 2014).”
Aita, C., Mizoguchi, Y., Yamamoto, M., SeguchI, Y., Yatsuga, C., Nishimura, T., Sugimoto, Y., Takahashi, D., Nishihara, R., Ueno, T., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.139 · Cited by 53
Flanagan, J. C., Hand, A., Jarnecke, A. M., Maria, M. M. M., Brady, K. T., & Joseph, J. E. (2018) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000197 · Cited by 47
“…small sample size prevented us from explicitly examining sex differences in oxytocin response (Ditzen et al., 2013; Hoge et al., 2014; Lynn, Hoge, Fischer, Barrett, & Simon, 2014; Rilling et al., 2014), although the similar distribution by sex within groups partially mitigates this concern.”
Ma, X., Luo, L., Geng, Y., Zhao, W., Zhang, Q., & Kendrick, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00266 · Cited by 44
Rigney, N., Whylings, J., de Vries, G. J., & Petrulis, A. (2021) · Neuroendocrinology · doi:10.1159/000509421 · Cited by 42
The Effect of Oxytocin on Third-Party Altruistic Decisions in Unfair Situations: An fMRI Study
Hu, Y., Scheele, D., Becker, B., Voos, G., David, B., Hurlemann, R., & Weber, B. (2016) · Scientific Reports · doi:10.1038/srep20236 · Cited by 44
Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
Naja, W., & Aoun, M. P. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0819-1 · Cited by 42
Flanagan, J. C., Allan, N. P., Calhoun, C. D., Badour, C. L., Maria, M. M. M., Brady, K. T., & Back, S. E. (2018) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000232 · Cited by 43
“Emerging literature indicates important sex differences in both neurobioloical and behavioral oxytocin outcomes (Ditzen et al., 2013; Flanagan et al., 2018; Hoge et al., 2014; MacDonald, 2015; Rilling et al., 2014; Yao et al., 2014).”
Skyt, I., Lunde, S. J., Baastrup, C., Svensson, P. J., Jensen, T. S., & Vase, L. (2019) · Pain · doi:10.1097/j.pain.0000000000001682 · Cited by 43
Intrinsic, dynamic and effective connectivity among large-scale brain networks modulated by oxytocin
Jiang, X., Ma, X., Geng, Y., Zhao, Z., Zhou, F., Zhao, W., Yao, S., Yang, S., Zhao, Z., Becker, B., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117668 · Cited by 39
Zhao, X., Mohammed, R., Tran, H., Erickson, M., & Kentner, A. C. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.018 · Cited by 44
A human tendency to anthropomorphize is enhanced by oxytocin
Scheele, D., Schwering, C., Elison, J. T., Spunt, R., Maier, W., & Hurlemann, R. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.05.009 · Cited by 41
Positive reinforcing effect of oxytocin microinjection in the rat central nucleus of amygdala
László, K., Kovács, A., Zagorácz, O., Ollmann, T., Péczely, L., Kertes, E., Lacy, D. G., & Lénárd, L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.09.021 · Cited by 43
An integrated framework for the role of oxytocin in multistage social decision‐making
Piva, M., & Chang, S. W. C. (2018) · American Journal of Primatology · doi:10.1002/ajp.22735 · Cited by 38
“…as a line of research ultimately including a sample size of over 300 participants determined that OT increases activation in the ventral striatum inmen but decreases activation in the same region in women during the canonical prisoner's dilemma game (Feng et al., 2015; Rilling et al., 2012, 2014).”
BackgroundA precision medicine approach to oxytocin trials
Andari, E., Hurlemann, R., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_29 · Cited by 40
Metadata
- Authors
- Rilling, J. K., DeMarco, A. C., Hackett, P. D., Chen, X., Gautam, P., Stair, S., Haroon, E., Thompson, R., Ditzen, B., Patel, R., & Pagnoni, G.
- Affiliations
- Emory University (US)
- University of Kansas (US)
- Bowdoin College (US)
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Rilling, James K.
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 39
- Pages
- 237-248
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC3842401
- OpenAlex
- W2129575907
- Cited by
- 343
- References
- 54
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 13 · 2023: 16 · 2022: 19 · 2021: 38 · 2020: 35 · 2019: 50 · 2018: 35 · 2017: 35 · 2016: 32 · 2015: 28 · 2014: 17
- FWCI
- 38.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Funders
- National Institute of Mental Health (R01 MH084068-01A1)
- National Center for Research Resources
- Yerkes Regional Primate Research Center (2P51RR000165-51)
- National Institutes of Health
- Presbyterian Historical Society (UL1 RR025008)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, vasopressin, sex differences, intranasal administration, social interaction, prisoner's dilemma game, cooperation, conciliation, social bonding, reward processing, brain activity, nonapeptide, mental illness
- MeSH terms
- Administration, Intranasal, Adolescent, Arginine Vasopressin, Brain, Cooperative Behavior, Double-Blind Method, Female, Game Theory, Humans, Image Processing, Computer-Assisted, Interpersonal Relations, Magnetic Resonance Imaging, Male, Oxytocin, Sex Characteristics, Social Behavior, Young Adult, Functional Neuroimaging
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