Vasopressin, but not oxytocin, increases empathic concern among individuals who received higher levels of paternal warmth: a randomized controlled trial
Open accessAbstract
Background Empathy improves our ability to communicate in social interactions and motivates prosocial behavior. The neuropeptides arginine vasopressin and oxytocin play key roles in socioemotional processes such as pair bonding and parental care, which suggests that they may be involved in empathic processing.Methods We investigated how vasopressin and oxytocin affect empathic responding in a randomized, double-blind, placebo controlled, between-subjects study design. We also examined the moderating role of parental warmth, as reported in the early family environment, on empathic responding following vasopressin, oxytocin, or placebo administration.Results Among participants who reported higher levels of paternal warmth (but not maternal warmth), vasopressin (vs. placebo and oxytocin) increased ratings of empathic concern after viewing distressing and uplifting videos. No main or interaction effects were found for individuals who received oxytocin.Conclusions Vasopressin has a role in enhancing empathy among individuals who received higher levels of paternal warmth.Trial registration NCT01680718.
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Intranasal VP altered empathic concern similarly in men and women.
“intranasal VP altered empathic concern similarly in men and women (Tabak et al., 2015)”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Tabak et al., 2015
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“On the other hand, a recent study which did include both men and women found that VP influenced empathic concern in men and women with no effect of sex (Tabak et al., 2015).”
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- Authors
- Tabak, B. A., Meyer, M. L., Castle, E., Dutcher, J. M., Irwin, M. R., Han, J. H., Lieberman, M. D., & Eisenberger, N. I.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Tabak, Benjamin A.
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 51
- Pages
- 253-261
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC4268337
- OpenAlex
- W1987742093
- Cited by
- 67
- References
- 55
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 11 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 1
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nd)
- Funders
- National Institute of Mental Health (T32MH015750)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Keywords
- vasopressin, oxytocin, empathic concern, empathy, paternal warmth, maternal warmth, parental care, neuropeptides, prosocial behavior, moderating effect
- MeSH terms
- Adolescent, Adult, Double-Blind Method, Empathy, Father-Child Relations, Female, Humans, Male, Oxytocin, Social Behavior, Vasopressins, Young Adult
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