Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies
Open accessAbstract
The hypothalamic peptide oxytocin (OT) is crucial in social adaptation and used to treat emotional and social deficits. Here, we conducted a systematic, quantitative meta-analysis of functional-MRI studies intranasally administering OT (IN-OT) to uncover neural substrates underlying the IN-OT effects and to elucidate differential IN-OT effects between healthy and clinical populations. Meta-analyses were conducted on 66 IN-OT fMRI studies, stratified by psychopathology, valence and sex. IN-OT increased bilateral amygdala, caudate head, and superior temporal activity in healthy individuals and increased dorsal anterior cingulate activity in patients. Moreover, IN-OT decreased amygdala activity in both patients and healthy individuals but did so to a greater degree in patients than healthy individuals. The OT-increased amygdala activity was only found on the negative social and affective processes, whereas the OT-decreased amygdala activity was mainly contributed by contrasts on negative-valenced processes. IN-OT increased parahippocampal activity and decreased amygdala activity during negative socio-affective processing. During positive socio-affective processes, IN-OT increased caudate head activity. This study indicates convergent neural substrates and the underlying neuropsychological mechanisms for IN-OT effects on social and affective processes. The common and different effects of IN-OT on patients and healthy individuals and the modulation of OT effects by valence have critical implications.
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The anatomical contradiction is at odds with numerous in vivo fMRI studies in humans that report changes in cortical BOLD signal after IN-OXT treatment.
“This anatomical contradiction is also at odds with the numerous in vivo fMRI studies in humans that report changes in cortical BOLD signal after IN-OXT treatment (see the sixty-six publications using fMRI and IN-OXT that were included in this meta-analysis62).”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [62]
A 24 IU dosage is the most commonly used dosage in oxytocin literature.
“A 24 IU dosage is the most commonly used dosage in oxytocin literature (Wang et al., 2017)”
From Oxytocin promotes coordinated out-group attack during intergroup conflict in humans (2019) · cites this paper as Wang et al., 2017
Intranasal oxytocin modulates neural responses in brain regions involved in threat detection and reward processing.
“intranasal administration of oxytocin has been shown to modulate neural responses in brain regions involved in threat detection and reward processing (Ma et al., 2016b; Paloyelis et al., 2016; Wang et al., 2017; Liu et al., 2019).”
From Oxytocin promotes coordinated out-group attack during intergroup conflict in humans (2019) · cites this paper as Wang et al., 2017
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Oxytocin modulates social value representations in the amygdala
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Neural effects of oxytocin and mimicry in frontotemporal dementia: A randomized crossover study
Oliver, L. D., Stewart, C., Coleman, K., Kryklywy, J. H., Bartha, R., Mitchell, D. G. V., & Finger, E. C. (2020) · Neurology · doi:10.1212/wnl.0000000000010933 · Cited by 26 · see citing works
- Authors
- Wang, D., Yan, X., Li, M., & Ma, Y.
- Affiliations
- Beijing Normal University (CN)
- Kunming Institute of Zoology (CN)
- Corresponding author
- Ma, Yina
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-06-27
- Volume
- 12
- Issue
- 10
- Pages
- 1565-1573
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC5647800
- OpenAlex
- W2665141230
- Cited by
- 86
- References
- 83
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 11 · 2021: 7 · 2020: 16 · 2019: 10 · 2018: 16 · 2017: 2
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (91632118)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, intranasal administration, neural correlates, amygdala, caudate nucleus, dorsal anterior cingulate cortex, parahippocampal cortex, valence, sex differences, psychopathology, social behavior, emotional processing
- MeSH terms
- Affect, Mental Disorders, Brain, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Oxytocin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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