The influence of motherhood on neural systems for reward processing in low income, minority, young women
Open accessAbstract
Objective Given the association between maternal caregiving behavior and heightened neural reward activity in experimental animal studies, the present study examined whether motherhood in humans positively modulates reward-processing neural circuits, even among mothers exposed to various life stressors and depression.Methods Subjects were 77 first-time mothers and 126 nulliparous young women from the Pittsburgh Girls Study, a longitudinal study beginning in childhood. Subjects underwent a monetary reward task during functional magnetic resonance imaging in addition to assessment of current depressive symptoms. Life stress was measured by averaging data collected between ages 8-15 years. Using a region-of-interest approach, we conducted hierarchical regression to examine the relationship of psychosocial factors (life stress and current depression) and motherhood with extracted ventral striatal (VST) response to reward anticipation. Whole-brain regression analyses were performed post-hoc to explore non-striatal regions associated with reward anticipation in mothers vs nulliparous women.Results Anticipation of monetary reward was associated with increased neural activity in expected regions including caudate, orbitofrontal, occipital, superior and middle frontal cortices. There was no main effect of motherhood nor motherhood-by-psychosocial factor interaction effect on VST response during reward anticipation. Depressive symptoms were associated with increased VST activity across the entire sample. In exploratory whole brain analysis, motherhood was associated with increased somatosensory cortex activity to reward (FWE cluster forming threshold p<0.001).Conclusions These findings indicate that motherhood is not associated with reward anticipation-related VST activity nor does motherhood modulate the impact of depression or life stress on VST activity. Future studies are needed to evaluate whether earlier postpartum assessment of reward function, inclusion of mothers with more severe depressive symptoms, and use of reward tasks specific for social reward might reveal an impact of motherhood on reward system activity.
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Moses-Kolko and colleagues tested, but were unable to find, that motherhood affected ventral striatal response in expectation of a financial reward.
“Moses-Kolko and colleagues tested, but were unable to find, that motherhood affected ventral striatal response in expectation of a financial reward”
From Becoming a sexual being: The “elephant in the room” of adolescent brain development (2017) · cites this paper as Moses-Kolko et al., 2016
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- Authors
- Moses-Kolko, E. L., Forbes, E. E., Stepp, S., Fraser, D., Keenan, K. E., Guyer, A. E., Chase, H. W., Phillips, M. L., Zevallos, C. R., Guo, C., & Hipwell, A. E.
- Affiliations
- University of Pittsburgh (US)
- Chatham University (US)
- University of Chicago (US)
- University of California, Davis (US)
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 66
- Pages
- 130-137
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC4788565
- OpenAlex
- W2237571919
- Cited by
- 6
- References
- 42
- Citations by year
- 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Pennsylvania Department of Health
- National Institutes of Health
- National Institute of Mental Health (MH093605, R01MH093605, MH056630, R01MH056630)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD067185, R01HD067185)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- motherhood, reward processing, ventral striatum, reward anticipation, maternal care, life events, depressive symptoms, primiparous women, low-income minority women, somatosensory cortex, Pittsburgh Girls Study
- MeSH terms
- Adolescent, Adult, Child, Child, Preschool, Depression, Female, Humans, Longitudinal Studies, Minority Groups, Mothers, Motivation, Neural Pathways, Poverty, Reward, Stress, Psychological, Parenting, Young Adult
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