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The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia

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Cohen, Samuel M., Tsien, Richard W., Goff, Donald C., Halassa, Michael M.·2015·Schizophrenia Research
DOI 10.1016/j.schres.2014.12.026
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Abstract

While the dopamine hypothesis has dominated schizophrenia research for several decades, more recent studies have highlighted the role of fast synaptic transmitters and their receptors in schizophrenia etiology. Here we review evidence that schizophrenia is associated with a reduction in N-methyl-D-aspartate receptor (NMDAR) function. By highlighting post mortem, neuroimaging and electrophysiological studies, we provide evidence for preferential disruption of GABAergic circuits in the context of NMDAR hypo-activity states. The functional relationship between NMDARs and GABAergic neurons is realized at the molecular, cellular, microcircuit and systems levels. A synthesis of findings across these levels explains how NMDA-mediated inhibitory dysfunction may lead to aberrant interactions among brain regions, accounting for key clinical features of schizophrenia. This synthesis of schizophrenia unifies observations from diverse fields and may help chart pathways for developing novel diagnostics and therapeutics.

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Cited by

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Metadata

Authors
Cohen, S. M., Tsien, R. W., Goff, D. C., & Halassa, M. M.
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2015-09
Volume
167
Issue
1-3
Pages
98-107
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2014.12.026
OpenAlex
W2006955019
Cited by
232
References
60
FWCI
18.33
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia. https://app.cochat.ai/papers/10.1016/j.schres.2014.12.026
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Cohen, S. M., Tsien, R. W., Goff, D. C., & Halassa, M. M. (2015). The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia. Schizophrenia Research. https://doi.org/10.1016/j.schres.2014.12.026

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