The DOI matches its Crossref record; 154 of the 156 references it cites were found in a registry or an index.
Neural mechanisms of mother–infant bonding and pair bonding: Similarities, differences, and broader implications
Open accessAbstract
This article is part of a Special Issue "Parental Care". Mother-infant bonding is a characteristic of virtually all mammals. The maternal neural system may have provided the scaffold upon which other types of social bonds in mammals have been built. For example, most mammals exhibit a polygamous mating system, but monogamy and pair bonding between mating partners occur in ~5% of mammalian species. In mammals, it is plausible that the neural mechanisms that promote mother-infant bonding have been modified by natural selection to establish the capacity to develop a selective bond with a mate during the evolution of monogamous mating strategies. Here we compare the details of the neural mechanisms that promote mother-infant bonding in rats and other mammals with those that underpin pair bond formation in the monogamous prairie vole. Although details remain to be resolved, remarkable similarities and a few differences between the mechanisms underlying these two types of bond formation are revealed. For example, amygdala and nucleus accumbens-ventral pallidum (NA-VP) circuits are involved in both types of bond formation, and dopamine and oxytocin actions within NA appear to promote the synaptic plasticity that allows either infant or mating partner stimuli to persistently activate NA-VP attraction circuits, leading to an enduring social attraction and bonding. Further, although the medial preoptic area is essential for maternal behavior, its role in pair bonding remains to be determined. Our review concludes by examining the broader implications of this comparative analysis, and evidence is provided that the maternal care system may have also provided the basic neural foundation for other types of strong social relationships, beyond pair bonding, in mammals, including humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Oxytocin is also released somatodendritically to act within the SON and PVN to facilitate synchronous firing and pulsatile release during parturition and nursing”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Numan & Young 2016
Experimental — accuracy not yet measuredIn the citing paper
“Animal24 and human studies25 indicate that similar neural systems and behavioral patterns underpin the parent-infant and pair bonds and demonstrate that both forms of human attachment are characterized by behavioral synchrony26–28.”
From Brain-to-Brain Synchrony during Naturalistic Social Interactions (2017) · cites this paper as [24]
In the citing paper
“Work in rats has demonstrated that central OT signalling is crucial for the onset of maternal nurturing behaviour (1,2).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [2]
In the citing paper
“In monogamous prairie voles (Microtus ochrogaster), OT and AVP interact with the dopamine system to facilitate the formation of pair bonds between mates (2,6).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [2]
In the citing paper
“OXTR affects a range of social behaviors in animals including maternal nurturing and bonding (1, 2), social reward and gregariousness (3, 4), social recognition (5), and pair bonding in monogamous species (6–8).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [2]
In the citing paper
“The mother–infant bond is thought to be the evolutionary and neurobiological origin for the capacity to form adult social bonds in species that form bonds between mates, like humans.”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Numan and Young 2016
In the citing paper
“Although it remains unclear whether learning in human infants is the same as the rodent, NE plays a critical role in bond formation in numerous species (Nelson and Panksepp, 1998, Numan and Young, 2016), suggesting it is a phylogenetically conserved system.”
From Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior (2017) · cites this paper as Numan and Young, 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,876
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 2×
“As an example, the anterior insular cortex (AI) is a prominent part of the neural circuitry underlying empathic feeling states in humans (Craig, 2009; Engen and Singer, 2013), and AI has direct and indirect neural connections with the amygdala, PFC, NA, and hypothalamus.”
BackgroundMothers and others: the evolutionary origins of mutual understanding
(2010) · Choice Reviews Online · doi:10.5860/choice.47-3250 · Cited by 1,735
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · cited 7×
“While the roles of OT, vasopressin, and DA in the NAs and VP in regulating pair bonding have been well documented (Young et al., 2011; Young and Wang, 2004), the precise neural mechanisms by which these molecules lead to the formation of a selective social preference for the partner has yet to be determined, and is th…”
BackgroundResultInfluentialSelf-citationKleiman, D. G. (1977) · The Quarterly Review of Biology · doi:10.1086/409721 · Cited by 1,436
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Self-citationSocial reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C. (2013) · Nature · doi:10.1038/nature12518 · Cited by 1,161
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043
Self-citationA role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 5×
“Early research in male prairie voles suggested that arginine vasopressin (AVP, which is structurally similar to OT), but not OT, regulated the development of partner preferences following mating (Winslow et al., 1993).”
BackgroundResultInfluential
Flagged first, then by citations
2 of the 156 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Mogenson, 1987, Limbic-motor integration, Prog. Psychobiol. Physiol. Psychol., 12, 117
- Numan, 2006, Maternal behavior, vol. 2, 1921
Cited by
Sorted by citations
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
The Neurobiology of Human Attachments
Feldman, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.11.007 · Cited by 839
Oxytocin-dependent consolation behavior in rodents
Burkett, J. P., Andari, E., Johnson, Z. V., Curry, D. C., de Waal, F. B. M., & Young, L. J. (2016) · Science · doi:10.1126/science.aac4785 · Cited by 692
Self-citationOxytocin, Neural Plasticity, and Social Behavior
Froemke, R. C., & Young, L. J. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102320-102847 · Cited by 480
“Oxytocin is also released somatodendritically to act within the SON and PVN to facilitate synchronous firing and pulsatile release during parturition and nursing (Burbach et al. 2006, Leng et al. 2008, Numan & Young 2016, Jurek & Neumann 2018, Valtcheva & Froemke 2019).”
BackgroundSelf-citationBrain-to-Brain Synchrony during Naturalistic Social Interactions
Kinreich, S., Djalovski, A., Kraus, L., Louzoun, Y., & Feldman, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-17339-5 · Cited by 402
The neural mechanisms and circuitry of the pair bond
Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353
Self-citationWhat is resilience: an affiliative neuroscience approach
Feldman, R. (2020) · World Psychiatry · doi:10.1002/wps.20729 · Cited by 324
Ko, J. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00041 · Cited by 229
Freeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196
“Work in rats has demonstrated that central OT signalling is crucial for the onset of maternal nurturing behaviour (1,2).”
BackgroundSelf-citationSexually Dimorphic Control of Parenting Behavior by the Medial Amygdala
Chen, P. B., Hu, R. K., Wu, Y. E., Pan, L., Huang, S., Micevych, P. E., & Hong, W. (2019) · Cell · doi:10.1016/j.cell.2019.01.024 · Cited by 209
Oxytocin and early parent-infant interactions: A systematic review
Scatliffe, N., Casavant, S. G., Vittner, D. J., & Cong, X. S. (2019) · International Journal of Nursing Sciences · doi:10.1016/j.ijnss.2019.09.009 · Cited by 202
King, L. B., Walum, H., Inoue, K., Eyrich, N. W., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.008 · Cited by 191
“The OXTR affects a range of social behaviors in animals, including maternal nurturing and bonding (1,2), social reward and gregariousness (3,4), social recognition (5), and pair bonding in monogamous species (6–8).”
Self-citationJohnson, Z. V., Walum, H., Jamal, Y. A., Xiao, Y., Keebaugh, A. C., Inoue, K., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.11.011 · Cited by 190
Self-citationDopamine in the medial amygdala network mediates human bonding
Atzil, S., Touroutoglou, A., Rudy, T., Salcedo, S., Feldman, R., Hooker, J. M., Dickerson, B. C., Catana, C., & Barrett, L. F. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612233114 · Cited by 182
The Use of Oxytocin to Improve Feeding and Social Skills in Infants With Prader–Willi Syndrome
Tauber, M., Boulanouar, K., Diene, G., Çabal-Berthoumieu, S., Ehlinger, V., Fichaux-Bourin, P., Molinas, C., Faye, S., Valette, M., Pourrinet, J., et al. (2017) · PEDIATRICS · doi:10.1542/peds.2016-2976 · Cited by 189
The neural mechanisms and consequences of paternal caregiving
Feldman, R., Braun, K., & Champagne, F. A. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0124-6 · Cited by 181
Walter, M. H., Abele, H., & Plappert, C. F. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.742236 · Cited by 216
Oxytocin and Social Relationships: From Attachment to Bond Disruption
Bosch, O. J., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_10 · Cited by 162
Self-citationPet Face: Mechanisms Underlying Human-Animal Relationships
Borgi, M., & Cirulli, F. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00298 · Cited by 129
Lonstein, J. S., Lévy, F., & Fleming, A. S. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.011 · Cited by 158
The neurobiology of parenting: A neural circuit perspective
Kohl, J., Autry, A. E., & Dulac, C. G. (2016) · BioEssays · doi:10.1002/bies.201600159 · Cited by 143
Perry, R. E., Blair, C., & Sullivan, R. M. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.04.022 · Cited by 133
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121
Coates, D., & Foureur, M. J. (2019) · Health & Social Care in the Community · doi:10.1111/hsc.12740 · Cited by 131
Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face
Scheele, D., Plota, J., Stoffel-Wagner, B., Maier, W., & Hurlemann, R. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv157 · Cited by 116
“Thus, our observation that OXT contributes to pair-bonding behavior in both men and women lends support to the notion that human pair-bonding behavior may have evolved from the evolutionarily older mother-infant bonding (Numan and Young, 2015).”
BackgroundOxytocin receptors modulate a social salience neural network in male prairie voles
Johnson, Z. V., Walum, H., Xiao, Y., Riefkohl, P. C., & Young, L. J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.10.009 · Cited by 113
Self-citationHormone-mediated neural remodeling orchestrates parenting onset during pregnancy
Ammari, R., Monaca, F., Cao, M., Nassar, E., Wai, P. T., Grosso, N. A. D., Lee, M., Borak, N., Schneider-Luftman, D., & Kohl, J. (2023) · Science · doi:10.1126/science.adi0576 · Cited by 118
Perception of social synchrony induces mother–child gamma coupling in the social brain
Levy, J., Goldstein, A., & Feldman, R. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx032 · Cited by 109
Song, Z., Borland, J. M., Larkin, T. E., O’Malley, M., & Albers, H. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.001 · Cited by 101
Hrdy, S. B. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.10.016 · Cited by 101
Proximate and Ultimate Perspectives on Romantic Love
Bode, A., & Kushnick, G. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.573123 · Cited by 114
Role of oxytocin in the control of stress and food intake
Onaka, T., & Takayanagi, Y. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12700 · Cited by 102
Oxytocin and Parental Behaviors
Yoshihara, C., Numan, M., & Kuroda, K. O. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_11 · Cited by 104
Self-citationOpendak, M., Gould, E., & Sullivan, R. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.02.002 · Cited by 94
Abraham, E., Hendler, T., Zagoory‐Sharon, O., & Feldman, R. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw090 · Cited by 91
How the brain codes intimacy: The neurobiological substrates of romantic touch
Kreuder, A.-K., Scheele, D., Wassermann, L., Wollseifer, M., Stoffel-Wagner, B., Lee, M. R., Hennig, J., Maier, W., & Hurlemann, R. (2017) · Human Brain Mapping · doi:10.1002/hbm.23679 · Cited by 89
Do Pregnancy-Induced Brain Changes Reverse? The Brain of a Mother Six Years after Parturition
Martínez‐Garcia, M., Paternina-Die, M., Barba‐Müller, E., de Blas, D. M., Beumala, L., Cortizo, R., Pozzobon, C., Vidal, L. M., Fernández‐Pena, A., Picado, M., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11020168 · Cited by 86
Synchronous caregiving from birth to adulthood tunes humans’ social brain
Ulmer-Yaniv, A., Salomon, R., Waidergoren, S., Shimon-Raz, O., Djalovski, A., & Feldman, R. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012900118 · Cited by 86
Pohl, T. T., Young, L. J., & Bosch, O. J. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.12.011 · Cited by 83
Self-citationSpecific maternal brain responses to their own child’s face: An fMRI meta-analysis
Rigo, P., Kim, P., Esposito, G., Putnick, D. L., Venuti, P., & Bornstein, M. H. (2018) · Developmental Review · doi:10.1016/j.dr.2018.12.001 · Cited by 74
Testosterone, oxytocin, and the development of human parental care
Gordon, I., Pratt, M., Bergunde, K., Zagoory‐Sharon, O., & Feldman, R. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.05.016 · Cited by 77
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 106
Self-citationUlmer-Yaniv, A., Avitsur, R., Kanat-Maymon, Y., Schneiderman, I., Zagoory-Sharon, O., & Feldman, R. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.02.017 · Cited by 68
Thalamic integration of social stimuli regulating parental behavior and the oxytocin system
Dobolyi, A., Cservenák, M., & Young, L. J. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.05.002 · Cited by 64
Self-citationThe Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication
Maejima, Y., Yokota, S., Nishimori, K., & Shimomura, K. (2018) · Neuroendocrinology · doi:10.1159/000489263 · Cited by 68
Sexually dimorphic role of oxytocin in medaka mate choice
Yokoi, S., Naruse, K., Kamei, Y., Ansai, S., Kinoshita, M., Mito, M., Iwasaki, S., Inoue, S., Okuyama, T., Nakagawa, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921446117 · Cited by 62
Self-citationTiti Monkeys as a Novel Non-Human Primate Model for the Neurobiology of Pair Bonding .
Bales, K. L., Razo, R. A., Conklin, Q. A., Hartman, S., Mayer, H. S., Rogers, F. D., Simmons, T. C., Smith, L. K., Williams, A. V., Williams, D. R., et al. (2017) · Europe PMC (PubMed Central) · Cited by 62
Sexually dimorphic oxytocin receptor-expressing neurons in the preoptic area of the mouse brain
Sharma, K., LeBlanc, R. M., Haque, M., Nishimori, K., Reid, M. M., & Teruyama, R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219784 · Cited by 67
Maternal behaviour in domestic dogs
Lezama-García, K., Mariti, C., Mota‐Rojas, D., Martı́nez-Burnes, J., Barrios-García, H., & Gazzano, A. (2019) · International Journal of Veterinary Science and Medicine · doi:10.1080/23144599.2019.1641899 · Cited by 61
Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59
Minimal influence of estrous cycle on studies of female mouse behaviors
Zeng, P.-Y., Tsai, Y.-H., Lee, C.-L., Ma, Y.-K., & Kuo, T.-H. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1146109 · Cited by 66
Early Parenting Intervention Effects on Brain Responses to Maternal Cues Among High-Risk Children
Valadez, E. A., Tottenham, N., Tabachnick, A. R., & Dozier, M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20010011 · Cited by 65
Neuromodulation of maternal circuits by oxytocin
Valtcheva, S., & Froemke, R. C. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-2883-1 · Cited by 54
Zhao, Z., Ma, X., Geng, Y., Zhao, W., Zhou, F., Wang, J., Markett, S. A., Biswal, B. B., Ma, Y., Kendrick, K. M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.09.067 · Cited by 56
Neuroendocrine control in social relationships in non-human primates: Field based evidence
Ziegler, T. E., & Crockford, C. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.03.004 · Cited by 58
Pratt, M., Zeev‐Wolf, M., Goldstein, A., & Feldman, R. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.03.005 · Cited by 54
Zilkha, N., Sofer, Y., Beny, Y., & Kimchi, T. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.014 · Cited by 52
Duclot, F., Wang, H., Youssef, C., Liu, Y., Wang, Z., & Kabbaj, M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.04.001 · Cited by 52
The Neuroscience of Resilience
Hunter, R. G., Gray, J. D., & McEwen, B. S. (2018) · Journal of the Society for Social Work and Research · doi:10.1086/697956 · Cited by 60
Imaging, Behavior and Endocrine Analysis of “Jealousy” in a Monogamous Primate
Maninger, N., Mendoza, S. P., Williams, D. R., Mason, W. A., Cherry, S. R., Rowland, D. J., Schaefer, T., & Bales, K. L. (2017) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2017.00119 · Cited by 51
Maternal brain in the process of maternal-infant bonding: Review of the literature
Gholampour, F., Riem, M. M. E., & van den Heuvel, M. I. (2020) · Social Neuroscience · doi:10.1080/17470919.2020.1764093 · Cited by 48
Slattery, D. A., & Hillerer, K. M. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.01.004 · Cited by 49
Evolution of affiliation: patterns of convergence from genomes to behaviour
Fischer, E. K., Nowicki, J. P., & O’Connell, L. A. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0242 · Cited by 46
Horie, K., Inoue, K., Nishimori, K., & Young, L. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.08.023 · Cited by 46
“The BLA has been proposed as a key brain region regulating pair bonding as well (Numan and Young, 2016; Walum and Young, 2018).”
BackgroundSelf-citationRole of oxytocin in parental behaviour
Olazábal, D. E. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12594 · Cited by 49
Higashida, H., Furuhara, K., Yamauchi, A.-M., Deguchi, K., Harashima, A., Munesue, S., Lopatina, O. L., Gerasimenko, M., Salmina, A. B., Zhang, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07949-4 · Cited by 46
Levy, J., Lankinen, K., Hakonen, M., & Feldman, R. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa061 · Cited by 46
Neuropeptide Regulation of Social Attachment: The Prairie Vole Model
Tabbaa, M., Paedae, B., Liu, Y., & Wang, Z. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150055 · Cited by 53
Paraventricular nucleus oxytocin subsystems promote active paternal behaviors in mandarin voles
He, Z., Zhang, L., Hou, W., Zhang, X., Young, L. J., Li, L., Liu, L., Ma, H., Xun, Y., Lv, Z., et al. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2864-20.2021 · Cited by 45
Self-citationInoue, K., Ford, C. L., Horie, K., & Young, L. J. (2022) · Journal of Comparative Neurology · doi:10.1002/cne.25382 · Cited by 45
Self-citationThe neurobiology of safety and threat learning in infancy
Dębiec, J., & Sullivan, R. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.10.015 · Cited by 49
Hinde, K., Muth, C., Maninger, N., Ragen, B., Larke, R. H., Jarcho, M. R., Mendoza, S. P., Mason, W. A., Ferrer, E. E., Cherry, S. R., et al. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00221 · Cited by 46
Rogers, F. D., Freeman, S. M., Anderson, M., Palumbo, M. C., & Bales, K. L. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13001 · Cited by 44
Zhong, J., Amina, S., Liang, M., Akther, S., Yuhi, T., Nishimura, T., Tsuji, C., Tsuji, T., Liu, H.-X., Hashii, M., et al. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00304 · Cited by 42
Grundwald, N. J., Benítez, D. P., & Brunton, P. J. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12343 · Cited by 46
Ishimoto, H., & Kamikouchi, A. (2020) · Current Biology · doi:10.1016/j.cub.2019.11.065 · Cited by 46
Valera-Marín, G., Young, L. J., Camacho, F., Paredes, R. G., Rodríguez, V. M., Díaz, N. F., & Portillo, W. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113264 · Cited by 43
Self-citationBienboire‐Frosini, C., Chabaud, C., Cozzi, A., Codecasa, E., & Pageat, P. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00524 · Cited by 44
A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior
Carollo, A., Balagtas, J. P. M., Neoh, M. J. Y., & Esposito, G. (2021) · Brain Sciences · doi:10.3390/brainsci11030393 · Cited by 41
Abraham, E., Hendler, T., Zagoory-Sharon, O., & Feldman, R. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.02.001 · Cited by 38
Jiménez, A., Young, L. J., Río, R. T.-D., LaPrairie, J. L., & González‐Mariscal, G. (2015) · Brain Research · doi:10.1016/j.brainres.2015.10.043 · Cited by 41
Self-citationIntranasal oxytocin modulates neural functional connectivity during human social interaction
Rilling, J. K., Chen, X., Chen, X., & Haroon, E. (2018) · American Journal of Primatology · doi:10.1002/ajp.22740 · Cited by 40
Child brain exhibits a multi-rhythmic response to attachment cues
Pratt, M., Goldstein, A., & Feldman, R. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy062 · Cited by 44
Understanding the Oxytocin System and Its Relevance to Psychiatry
Shamay‐Tsoory, S., & Young, L. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.014 · Cited by 39
Self-citationProunis, G. S., Thomas, K., & Ophir, A. G. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24450 · Cited by 38
Bio-behavioral synchrony is a potential mechanism for mate selection in humans
Zeevi, L., Selle, N. K., Kellmann, E. L., Boiman, G., Hart, Y., & Atzil, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-08582-6 · Cited by 40
Guoynes, C. D., Simmons, T. C., Downing, G., Jacob, S., Solomon, M., & Bales, K. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.037 · Cited by 38
Effects of opioids on the parental brain in health and disease
Swain, J. E., Ho, S.-H. S., Fox, H. C., Garry, D. J., & Brummelte, S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100766 · Cited by 38
Social behavior, hormones and adult neurogenesis
Opendak, M. M., Briones, B. A., & Gould, E. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.02.002 · Cited by 38
Oxytocin increases eye-gaze towards novel social and non-social stimuli
Eckstein, M., Bamert, V., Stephens, S. B. Z., Wallen, K., Young, L. J., Ehlert, U., & Ditzen, B. (2018) · Social Neuroscience · doi:10.1080/17470919.2018.1542341 · Cited by 36
Self-citationNavarro-Moreno, C., Barneo‐Muñoz, M., Ibáñez, M. V., Lanuza, E., Agustín‐Pavón, C., Sánchez-Catalán, M. J., & Martínez‐Garciá, F. (2022) · iScience · doi:10.1016/j.isci.2022.104525 · Cited by 34
Brieger, S. A., Sonbol, D., & Clercq, D. D. (2023) · Journal of Small Business Management · doi:10.1080/00472778.2023.2235755 · Cited by 39
Oxytocin and vulnerable romantic relationships
Grebe, N. M., Kristoffersen, A. A., Grøntvedt, T. V., Emery Thompson, M., Kennair, L. E. O., & Gangestad, S. W. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.02.009 · Cited by 34
The role of dopamine signaling in prairie vole peer relationships
Lee, N. S., & Beery, A. K. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104876 · Cited by 34
A unified circuit for social behavior
Modi, M. E., & Şahin, M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.08.010 · Cited by 36
Shih, H.-C., Kuo, M.-E., Wu, C., Chao, Y.-P., Huang, H.-W., & Huang, C.-M. (2022) · Brain Sciences · doi:10.3390/brainsci12070830 · Cited by 32
Beyond romance: Neural and genetic correlates of altruism in pair-bonds.
Acevedo, B. P., Poulin, M. J., & Brown, L. L. (2019) · Behavioral Neuroscience · doi:10.1037/bne0000293 · Cited by 35
Iwasa, T., Matsuzaki, T., Mayila, Y., Yanagihara, R., Yamamoto, Y., Kawakita, T., Kuwahara, A., & Irahara, M. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.03.002 · Cited by 33
A comparative perspective on the evolution of mammalian reactions to dead conspecifics
Bercovitch, F. B. (2019) · Primates · doi:10.1007/s10329-019-00722-3 · Cited by 32
Romantic love evolved by co-opting mother-infant bonding
Bode, A. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1176067 · Cited by 32
Metadata
- Authors
- Numan, M., & Young, L. J.
- Affiliations
- Emory University (US)
- Corresponding author
- Numan, Michael
- ORCID
- Young, Larry J.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 77
- Pages
- 98-112
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC4671834
- OpenAlex
- W625443388
- Cited by
- 355
- References
- 156
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 31 · 2023: 28 · 2022: 29 · 2021: 39 · 2020: 50 · 2019: 26 · 2018: 30 · 2017: 38 · 2016: 33
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01MH096983, 1P50MH100023, OD P51OD11132)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- mother-infant bonding, pair bonding, monogamy, Microtus ochrogaster, rats, amygdala, dopamine, oxytocin, synaptic plasticity, medial preoptic area, maternal behavior
- MeSH terms
- Animals, Dopamine, Female, Mammals, Maternal Behavior, Mothers, Object Attachment, Oxytocin, Pair Bond, Cerebrum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
