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Cited by 2,076

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

Open access
Kawai, Taro, Adachi, Osamu, Ogawa, Tomohiko, Takeda, Kiyoshi, Akira, Shizuo·1999·Immunity
DOI 10.1016/s1074-7613(00)80086-2
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Abstract

MyD88 is a general adaptor protein that plays an important role in the Toll/IL-1 receptor family signalings. Recently, Toll-like receptors 2 and 4 (TLR2 and TLR4) have been suggested to be the signaling receptors for lipopolysaccharide (LPS). In this study, we demonstrate that MyD88 knockout mice lack the ability to respond to LPS as measured by shock response, B cell proliferative response, and secretion of cytokines by macrophages and embryonic fibroblasts. However, activation of neither NF-kappaB nor the mitogen-activated protein (MAP) kinase family is abolished in MyD88 knockout mice. These findings demonstrate that signaling via MyD88 is essential for LPS response, but the inability of MyD88 knockout mice to induce LPS-dependent gene expression cannot simply be attributed to lack of the activation of MAP kinases and NF-kappaB.

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Metadata

Authors
Kawai, T., Adachi, O., Ogawa, T., Takeda, K., & Akira, S.
Venue
Immunity
Publisher
Elsevier BV
Published
1999-07
Volume
11
Issue
1
Pages
115-122
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/s1074-7613(00)80086-2
OpenAlex
W1996120614
Cited by
2,076
References
4
FWCI
26.60
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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