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β-globin Gene Switching and DNase I Sensitivity of the Endogenous β-globin Locus in Mice Do Not Require the Locus Control Region
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We have generated mice with a targeted deletion of the beta-globin locus control region (LCR). Mice homozygous for the deletion die early in embryogenesis but can be rescued with a YAC containing the human beta-globin locus. After germline passage, deletion of the LCR leads to a severe reduction in expression of all mouse beta-like globin genes, but no alteration in the developmental specificity of expression. Furthermore, a DNase I-sensitive "open" chromatin conformation of the locus is established and maintained. Thus, the dominant role of the LCR in the native locus is to confer high-level transcription, and elements elsewhere in the locus are sufficient to establish and maintain an open conformation and to confer developmentally regulated globin gene expression.
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“previous studies deleting the entire β-globin SE showed that the β-globin genes remain accessible and marked by histone acetylation;55–57”
From Super-enhancers include classical enhancers and facilitators to fully activate gene expression (2023) · cites this paper as [55]
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“These models were initially applied to the mammalian β-globin locus, in which the developmental β-globin genes are regulated by a powerful tissue-specific enhancer known as a locus control region (LCR) [254–257].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [256]
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Cites
Position-independent, high-level expression of the human β-globin gene in transgenic mice
Grosveld, F. G., van Assendelft, G. B., Greaves, D. R., & Kollias, G. A. (1987) · Cell · doi:10.1016/0092-8674(87)90584-8 · Cited by 1,908
The Molecular Basis of Blood Diseases.
(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-6-950_3 · Cited by 640
The "beta-like-globin" gene domain in human erythroid cells.
Tuan, D., Solomon, W., Li, Q., & London, I. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.19.6384 · Cited by 601
Looping versus linking: toward a model for long-distance gene activationPreprint
Bulger, M., & Groudine, M. T. (1999) · Genes & Development · doi:10.1101/gad.13.19.2465 · Cited by 483
Self-citationTransgenic Knockout Mice with Exclusively Human Sickle Hemoglobin and Sickle Cell Disease
Pászty, C., Brion, C. M., Manci, E., Witkowska, H. E., Stevens, M. E., Mohandas, N., & Rubin, E. M. (1997) · Science · doi:10.1126/science.278.5339.876 · Cited by 467
Forrester, W. C., Epner, E. M., Driscoll, M. C., Enver, T., Brice, M. C., Papayannopoulou, T., & Groudine, M. T. (1990) · Genes & Development · doi:10.1101/gad.4.10.1637 · Cited by 464
Self-citationA developmentally stable chromatin structure in the human beta-globin gene cluster.
Forrester, W. C., Thompson, C. B., Elder, J. T., & Groudine, M. T. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.5.1359 · Cited by 376
Self-citationThe Molecular Basis of Blood Diseases
Baron, J. M. (1994) · JAMA · doi:10.1001/jama.1994.03520170097047 · Cited by 370
Fiering, S., Epner, E. M., Robinson, K. M., Zhuang, Y., Telling, A., Hu, M., Martin, D. I. K., Enver, T., Ley, T. J., & Groudine, M. T. (1995) · Genes & Development · doi:10.1101/gad.9.18.2203 · Cited by 334
Self-citationArmstrong, J. A., Bieker, J. J., & Emerson, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81785-7 · Cited by 303
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Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Canver, M. C., Smith, E. C., Sher, F., Pinello, L., Sanjana, N. E., Shalem, O., Chen, D. D., Schupp, P. G., Vinjamur, D. S., Garcia, S. P., et al. (2015) · Nature · doi:10.1038/nature15521 · Cited by 886
Functional and Mechanistic Diversity of Distal Transcription Enhancers
Bulger, M., & Groudine, M. (2011) · Cell · doi:10.1016/j.cell.2011.01.024 · Cited by 803
Self-citationDeng, W., Lee, J., Wang, H., Miller, J., Reik, A., Gregory, P. D., Dean, A., & Blobel, G. A. (2012) · Cell · doi:10.1016/j.cell.2012.03.051 · Cited by 734
“The strong induction of b-globin transcription by ZF-Ldb1 or ZFSA implicates an involvement of the LCR and, hence, chromatin looping, because in the absence of the LCR, b-globin transcription is very low (Bender et al., 2000).”
InfluentialLong-range chromatin regulatory interactions in vivo
Carter, D., Chakalova, L., Osborne, C. S., Dai, Y.-F., & Fraser, P. (2002) · Nature Genetics · doi:10.1038/ng1051 · Cited by 663
Correction of sickle cell disease in transgenic mouse models by gene therapy
Pawliuk, R., Westerman, K. A., Fabry, M. E., Payen, E., Tighe, R., Bouhassira, E. E., Acharya, S. A., Ellis, J., London, I. M., Eaves, C. J., et al. (2001) · Science · doi:10.1126/science.1065806 · Cited by 579
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Vakoc, C. R., Letting, D. L., Gheldof, N., Sawado, T., Bender, M. A., Groudine, M., Weiss, M. J., Dekker, J., & Blobel, G. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.028 · Cited by 490
Self-citationLi, Q., Peterson, K. R., Fang, X., & Stamatoyannopoulos, G. (2002) · Blood · doi:10.1182/blood-2002-04-1104 · Cited by 456
Reactivation of developmentally silenced globin genes by forced chromatin looping
Deng, W., Rupon, J. W., Krivega, I., Breda, L., Motta, I., Jahn, K. S., Reik, A., Gregory, P. D., Rivella, S., Dean, A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.050 · Cited by 443
Control of globin gene expression during development and erythroid differentiation
Stamatoyannopoulos, G. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2004.11.007 · Cited by 393
Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W., & Orkin, S. H. (2010) · Genes & Development · doi:10.1101/gad.1897310 · Cited by 361
The active spatial organization of the β-globin locus requires the transcription factor EKLF
Drissen, R., Palstra, R.-J., Gillemans, N., Splinter, E., Grosveld, F., Philipsen, S., & de Laat, W. (2004) · Genes & Development · doi:10.1101/gad.317004 · Cited by 352
Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping
Bartman, C. R., Hsu, S. C., Hsiung, C. C.-S., Raj, A., & Blobel, G. A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.007 · Cited by 345
Ragoczy, T., Bender, M. A., Telling, A., Byron, R., & Groudine, M. T. (2006) · Genes & Development · doi:10.1101/gad.1419506 · Cited by 326
Self-citationSize Matters: Use of YACs, BACs and PACs in Transgenic Animals
Giraldo, P., & Montoliu, L. (2001) · Transgenic Research · doi:10.1023/a:1008918913249 · Cited by 314
Schübeler, D., Francastel, C., Cimbora, D. M., Reik, A., Martin, D. I. K., & Groudine, M. T. (2000) · Genes & Development · doi:10.1101/gad.14.8.940 · Cited by 314
Self-citationRemote control of gene transcription
West, A. G., & Fraser, P. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi104 · Cited by 302
Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs
Hirota, K., Miyoshi, T., Kugou, K., Hoffman, C. S., Shibata, T., & Ohta, K. (2008) · Nature · doi:10.1038/nature07348 · Cited by 275
RNA polymerase II elongation through chromatin
Orphanides, G., & Reinberg, D. (2000) · Nature · doi:10.1038/35035000 · Cited by 244
Transcription factories are nuclear subcompartments that remain in the absence of transcriptionPreprint
Mitchell, J. A., & Fraser, P. (2008) · Genes & Development · doi:10.1101/gad.454008 · Cited by 225
Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain
Forsberg, E. C., Downs, K. M., Christensen, H. M., Im, H., Nuzzi, P. A., & Bresnick, E. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14494 · Cited by 226
Enhancer hubs and loop collisions identified from single-allele topologies
Allahyar, A., Vermeulen, C., Bouwman, B. A. M., Krijger, P. H. L., Verstegen, M. J. A. M., Geeven, G., van Kranenburg, M., Pieterse, M., Straver, R., Haarhuis, J. H. I., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0161-5 · Cited by 227
Evolution of Hemoglobin and Its Genes
Hardison, R. C. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011627 · Cited by 217
Pinaud, E., Khamlichi, A. A., Morvan, C. L., Drouet, M., Nalesso, V., Bert, M. L., & Cogné, M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00181-9 · Cited by 218
Advances in the understanding of haemoglobin switching
Sankaran, V. G., Xu, J., & Orkin, S. H. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08105.x · Cited by 225
Brand, M., Ranish, J. A., Kummer, N. T., Hamilton, J., Igarashi, K., Francastel, C., Chi, T. H., Crabtree, G. R., Aebersold, R. H., & Groudine, M. T. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsmb713 · Cited by 210
Self-citationKleinjan, D. A. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.19.2049 · Cited by 209
Super-enhancers include classical enhancers and facilitators to fully activate gene expression
Blayney, J. W., Francis, H., Rampasekova, A., Camellato, B., Mitchell, L., Stolper, R., Cornell, L., Babbs, C., Boeke, J. D., Higgs, D. R., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.030 · Cited by 196
Enhancers: The abundance and function of regulatory sequences beyond promoters
Bulger, M., & Groudine, M. T. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.11.035 · Cited by 192
Self-citationConserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci
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Engel, J. D., & Tanimoto, K. (2000) · Cell · doi:10.1016/s0092-8674(00)80686-8 · Cited by 180
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Johnson, K. D., Christensen, H. M., Zhao, B. M., & Bresnick, E. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00309-4 · Cited by 168
On a chromosome far, far away: LCRs and gene expression
Dean, A. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.11.001 · Cited by 168
“Maturational” globin switching in primary primitive erythroid cells
Kingsley, P. D., Malik, J. T., Emerson, R. L., Bushnell, T. P., McGrath, K. E., Bloedorn, L. A., Bulger, M., & Palis, J. (2005) · Blood · doi:10.1182/blood-2005-08-3097 · Cited by 165
Self-citationSawado, T., Halow, J. M., Bender, M. A., & Groudine, M. T. (2003) · Genes & Development · doi:10.1101/gad.1072303 · Cited by 163
Self-citationLee, G. R., Spilianakis, C. G., & Flavell, R. A. (2004) · Nature Immunology · doi:10.1038/ni1148 · Cited by 158
Bulger, M., Schübeler, D., Bender, M. A., Hamilton, J., Farrell, C. M., Hardison, R. C., & Groudine, M. T. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5234-5244.2003 · Cited by 157
Self-citationHistone acetylation beyond promoters: long‐range acetylation patterns in the chromatin world*
Forsberg, E. C., & Bresnick, E. H. (2001) · BioEssays · doi:10.1002/bies.1117 · Cited by 153
Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells
Brown, K. E., Amoils, S., Horn, J. M., Buckle, V. J., Higgs, D. R., Merkenschlager, M., & Fisher, A. G. (2001) · Nature Cell Biology · doi:10.1038/35078577 · Cited by 146
The human β‐globin locus control region: A center of attraction
Levings, P. P., & Bungert, J. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2002.02797.x · Cited by 144
Antoniou, M. N., Harland, L., Mustoe, T., Williams, S., Holdstock, J., Yagüe, E., Mulcahy, T., Griffiths, M. N. D., Edwards, S., Ioannou, P. A., et al. (2003) · Genomics · doi:10.1016/s0888-7543(03)00107-1 · Cited by 145
Letting, D. L., Rakowski, C., Weiss, M. J., & Blobel, G. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1334-1340.2003 · Cited by 137
Chapter 4 β‐Globin Regulation and Long‐Range Interactions
Palstra, R., de Laat, W., & Grosveld, F. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00004-1 · Cited by 131
Sawado, T., Igarashi, K., & Groudine, M. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181344198 · Cited by 129
Self-citationTahara, T., Sun, J., Nakanishi, K., Yamamoto, M., Mori, H., Saito, T., Fujita, H., Igarashi, K., & Taketani, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m302733200 · Cited by 126
A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements
Ragoczy, T., Telling, A., Sawado, T., Groudine, M. T., & Kosak, S. T. (2003) · Chromosome Research · doi:10.1023/a:1024939130361 · Cited by 123
Self-citationGriffin, C. T., Brennan, J. A., & Magnuson, T. (2007) · Development · doi:10.1242/dev.010090 · Cited by 122
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Hsiung, C. C. ‐., Bartman, C., Huang, P., Ginart, P., Stonestrom, A. J., Keller, C. A., Face, C. J., Jahn, K. S., Evans, P., Sankaranarayanan, L., et al. (2016) · Genes & Development · doi:10.1101/gad.280859.116 · Cited by 105
Cimbora, D. M., Schübeler, D., Reik, A., Hamilton, J., Francastel, C., Epner, E. M., & Groudine, M. T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5581-5591.2000 · Cited by 115
Self-citationJohnson, K. D., Grass, J. A., Boyer, M. E., Kiekhaefer, C. M., Blobel, G. A., Weiss, M. J., & Bresnick, E. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192285999 · Cited by 113
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Wendt, K. S., & Peters, J. (2009) · Chromosome Research · doi:10.1007/s10577-008-9017-7 · Cited by 111
Spicuglia, S., Kumar, S., Yeh, J.-H., Vachez, E., Chasson, L., Gorbatch, S., Cautres, J., & Ferrier, P. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00791-8 · Cited by 95
Chaturvedi, C.-P., Hosey, A. M., Palii, C. G., Perez‐Iratxeta, C., Nakatani, Y., Ranish, J. A., Dilworth, F. J., & Brand, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906769106 · Cited by 95
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Kontaraki, J. E., Chen, H.-H., Riggs, A. D., & Bonifer, C. (2000) · Genes & Development · doi:10.1101/gad.14.16.2106 · Cited by 90
Wen, J., Huang, S., Rogers, H. M., Dickinson, L. A., Kohwi-shigematsu, T., & Noguchi, C. T. (2004) · Blood · doi:10.1182/blood-2004-08-2988 · Cited by 89
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Self-citationBulger, M., Bender, M. A., van Doorninck, J. H., Wertman, B., Farrell, C. M., Felsenfeld, G., Groudine, M. T., & Hardison, R. C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14560 · Cited by 85
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Johnson, K. D., Grass, J. A., Park, C., Im, H., Choi, K., & Bresnick, E. H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6484-6493.2003 · Cited by 76
Kooren, J. A., Palstra, R.-J. T. S., Klous, P., Splinter, E., Lindern, M. V., Grosveld, F. G., & de Laat, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701159200 · Cited by 72
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Developmental stage differences in chromatin subdomains of the β-globin locus
Kim, A., & Dean, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307985101 · Cited by 66
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Self-citationRegulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster
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Dissecting Molecular Steps in Chromatin Domain Activation during Hematopoietic Differentiation
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Ellmeier, W., Sunshine, M. J., Maschek, R., & Littman, D. R. (2002) · Immunity · doi:10.1016/s1074-7613(02)00309-6 · Cited by 63
Bottardi, S., Aumont, A., Grosveld, F. G., & Milot, É. (2003) · Blood · doi:10.1182/blood-2003-05-1540 · Cited by 63
Chakraborty, T., Perlot, T., Subrahmanyam, R., Jani, A. R., Goff, P. H., Zhang, Y., Иванова, И., Alt, F. W., & Sen, R. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081621 · Cited by 60
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Cai, W., Huang, J., Zhu, Q., Li, B. E., Seruggia, D., Zhou, P., Nguyen, M., Fujiwara, Y., Xie, H., Yang, Z., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008672117 · Cited by 56
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Leach, K. M., Nightingale, K. P., Igarashi, K., Levings, P. P., Engel, J. D., Becker, P. B., & Bungert, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2629-2640.2001 · Cited by 52
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Molete, J. M., Petrykowska, H. M., Bouhassira, E. E., Feng, Y., Miller, W., & Hardison, R. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.2969-2980.2001 · Cited by 49
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Metadata
- Authors
- Bender, M. A., Bulger, M., Close, J., & Groudine, M.
- Affiliations
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Groudine, Mark
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 5
- Issue
- 2
- Pages
- 387-393
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1982328581
- Cited by
- 224
- References
- 46
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 7 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P30 HD28834, DK54071, DK44746)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- beta-globin locus control region, DNase I sensitivity, open chromatin, globin gene expression, embryonic lethality, developmental gene expression, chromatin conformation
- MeSH terms
- Animals, Chromatin, Deoxyribonuclease I, Globins, Heterozygote, Humans, Mice, Mutant Strains, Thalassemia, Gene Rearrangement, Sequence Deletion, Chromosomes, Artificial, Yeast, Gene Expression Regulation, Developmental, DNA Footprinting, Locus Control Region, Mice
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