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XRCC1 and DNA strand break repair

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Caldecott, Keith W.·2003·DNA Repair
DOI 10.1016/s1568-7864(03)00118-6
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Abstract

DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base excision repair, or directly from damage to deoxyribose. Because single-strand breaks are induced by endogenous reactive molecules such as reactive oxygen species, these lesions pose a continuous threat to genetic integrity. XRCC1 protein plays a major role in facilitating the repair of single-strand breaks in mammalian cells, via an ability to interact with multiple enzymatic components of repair reactions. Here, the protein-protein interactions facilitated by XRCC1, and the repair processes in which these interactions operate, are reviewed. Models for the repair of single-strand breaks during base excision repair and at direct breaks are presented.

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Research works printed but not linked: 110

  1. Thompson, 1982, A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange, Mutat. Res., 95, 427, 10.1016/0027-5107(82)90276-7 · DOI · Paper page
  2. Zdzienicka, 1992, A Chinese hamster ovary cell mutant (Em-c-11) with sensitivity to simple alkylating-agents and a very high-level of sister chromatid exchanges, Mutagenesis, 7, 265, 10.1093/mutage/7.4.265 · DOI
  3. Caldecott, 1995, Characterization of the XRCC1–DNA ligase III complex in vitro and its absence from mutant hamster cells, Nucleic Acids Res., 23, 4836, 10.1093/nar/23.23.4836 · DOI · Paper page
  4. Shen, 1998, Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair, Nucleic Acids Res., 26, 1032, 10.1093/nar/26.4.1032 · DOI
  5. Cantoni, 1987, Induction and repair of DNA single-strand breaks in EM9 mutant CHO cells treated with hydrogen-peroxide, Chem.-Biol. Interact., 63, 29, 10.1016/0009-2797(87)90102-5 · DOI
  6. Christie, 1984, Use of mammalian DNA repair-deficient mutants to assess the effects of toxic metal compounds on DNA, Biochem. Pharmacol., 33, 1661, 10.1016/0006-2952(84)90289-2 · DOI
  7. Churchill, 1991, Correlation between cell-survival and dna single-strand break repair proficiency in the Chinese hamster ovary cell-lines aa8 and EM9 irradiated with 365-nm ultraviolet—a radiation, Photochem. Photobiol., 53, 229, 10.1111/j.1751-1097.1991.tb03927.x · DOI
  8. Churchill, 1991, Repair of near-visible-light-induced and blue-light-induced DNA single-strand breaks by the CHO cell-lines aa8 and EM9, Photochem. Photobiol., 54, 639, 10.1111/j.1751-1097.1991.tb02068.x · doi:10.1111/j.1751-1097.1991.tb02068.x
  9. Thompson, 2000, XRCC1 keeps DNA from getting stranded, Mutat. Res., 459, 1, 10.1016/S0921-8777(99)00058-0 · DOI · Paper page
  10. Dillehay, 1984, DNA-strand breaks associated with halogenated pyrimidine incorporation, Mutat. Res., 131, 129
  11. Schwartz, 1987, Recovery from sublethal and potentially lethal damage in an X-ray-sensitive CHO cell, Radiat. Res., 111, 58, 10.2307/3577021 · DOI
  12. vanAnkeren, 1988, Induction and rejoining of gamma-ray-induced DNA single- and double-strand breaks in Chinese hamster AA8 cells and in two radiosensitive clones, Radiat. Res., 116, 511, 10.2307/3577393 · DOI
  13. Nocentini, 1999, Rejoining kinetics of DNA single- and double-strand breaks in normal and DNA ligase-deficient cells after exposure to ultraviolet C and gamma radiation: An evaluation of ligating activities involved in different DNA repair processes, Radiat. Res., 151, 423, 10.2307/3579829 · DOI
  14. Ikejima, 1990, The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA, J. Biol. Chem., 265, 21907, 10.1016/S0021-9258(18)45824-3 · DOI · Paper page
  15. Henrie, 2003, Lethality in PARP-1/Ku80 double mutant mice reveals physiological synergy during early embryogenesis, DNA Repair (Amsterdam), 2, 151, 10.1016/S1568-7864(02)00199-4 · DOI
  16. Dillehay, 1983, The relationship between sister-chromatid exchange and perturbations in DNA replication in mutant EM9 and normal CHO cells, Mutat. Res., 109, 283, 10.1016/0027-5107(83)90053-2 · DOI
  17. Carrano, 1986, Incorporated bromodeoxyuridine enhances the sister-chromatid exchange and chromosomal aberration frequencies in an EMS-sensitive Chinese hamster cell line, Mutat. Res., 162, 233, 10.1016/0027-5107(86)90090-4 · DOI
  18. Kuzminov, 2001, Single-strand interruptions in replicating chromosomes cause double-strand breaks, Proc. Natl. Acad. Sci. U.S.A., 98, 8241, 10.1073/pnas.131009198 · DOI · Paper page
  19. Kuzminov, 2001, DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination, Proc. Natl. Acad. Sci. U.S.A., 98, 8461, 10.1073/pnas.151260698 · DOI · Paper page
  20. Dominguez, 1998, A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9, Mutat. Res., 398, 67, 10.1016/S0027-5107(97)00241-8 · DOI
  21. Op, 1994, Molecular analysis of ethyl methanesulfonate-induced mutations at the hprt gene in the ethyl methanesulfonate-sensitive Chinese hamster cell line EM-C11 and its parental line CHO9, Cancer Res., 54, 3001
  22. Op, 1998, Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its XRCC1-deficient derivative EM-C11, Mutat. Res., 398, 83, 10.1016/S0027-5107(97)00243-1 · DOI
  23. Kubota, 2003, Independent roles of XRCC1’s two BRCT motifs in recovery from methylation damage, DNA Repair (Amsterdam), 2, 407, 10.1016/S1568-7864(02)00242-2 · DOI
  24. Burkle, 2001, Physiology and pathophysiology of poly(ADP-ribosyl)ation, Bioessays, 23, 795, 10.1002/bies.1115 · DOI · Paper page
  25. De Murcia, 1994, Poly(ADP-ribose) polymerase: a molecular nick-sensor, Trends Biochem. Sci., 19, 172, 10.1016/0968-0004(94)90280-1 · DOI · Paper page
  26. Herceg, 2001, Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair genomic integrity and cell death, Mutat. Res., 477, 97, 10.1016/S0027-5107(01)00111-7 · DOI · Paper page
  27. Shall, 2000, Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?, Mutat. Res., 460, 1, 10.1016/S0921-8777(00)00016-1 · DOI · Paper page
  28. Masutani, 2000, The response of Parp knockout mice against DNA damaging agents, Mutat. Res., 462, 159, 10.1016/S1383-5742(00)00033-8 · DOI
  29. Tulin, 2003, Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci, Science, 299, 560, 10.1126/science.1078764 · DOI · Paper page
  30. Simbulan-Rosenthal, 2000, Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase, Proc. Natl. Acad. Sci. U.S.A., 97, 11274, 10.1073/pnas.200285797 · DOI
  31. Ha, 2002, Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia, Proc. Natl. Acad. Sci. U.S.A., 99, 3270, 10.1073/pnas.052712399 · DOI · Paper page
  32. Meisterernst, 1997, Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro, Proc. Natl. Acad. Sci. U.S.A., 94, 2261, 10.1073/pnas.94.6.2261 · DOI
  33. Ullrich, 2001, Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1, Nat. Cell Biol., 3, 1035, 10.1038/ncb1201-1035 · DOI · Paper page
  34. Vispe, 2000, A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage, Proc. Natl. Acad. Sci. U.S.A., 97, 9886, 10.1073/pnas.170280397 · DOI
  35. Chiarugi, 2002, Cell biology. PARP-1—a perpetrator of apoptotic cell death?, Science, 297, 200, 10.1126/science.1074592 · DOI
  36. Schreiber, 2002, Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1, J. Biol. Chem., 277, 23028, 10.1074/jbc.M202390200 · DOI · Paper page
  37. Le Cam, 1994, Conformational analysis of a 139 base-pair DNA fragment containing a single-stranded break and its interaction with human poly(ADP-ribose) polymerase, J. Mol. Biol., 235, 1062, 10.1006/jmbi.1994.1057 · doi:10.1006/jmbi.1994.1057
  38. Mol, 2000, DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination (corrected), Nature, 403, 451, 10.1038/35000249 · DOI · Paper page
  39. Wilson, 2000, Passing the baton in base excision repair, Nat. Struct. Biol., 7, 176, 10.1038/82818 · DOI
  40. Ferro, 1982, Poly(ADP-ribosylation) in vitro. Reaction parameters and enzyme mechanism, J. Biol. Chem., 257, 7808, 10.1016/S0021-9258(18)34453-3 · DOI
  41. Zahradka, 1982, A shuttle mechanism for DNA–protein interactions. The regulation of poly(ADP-ribose) polymerase, Eur. J. Biochem., 127, 579, 10.1111/j.1432-1033.1982.tb06912.x · DOI · Paper page
  42. Lindahl, 1995, Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks, Trends Biochem. Sci., 20, 405, 10.1016/S0968-0004(00)89089-1 · DOI · Paper page
  43. Sanderson, 2002, Down-regulation of DNA repair synthesis at DNA single-strand interruptions in poly(ADP-ribose) polymerase-1 deficient murine cell extracts, DNA Repair (Amsterdam), 1, 547, 10.1016/S1568-7864(02)00054-X · DOI
  44. Satoh, 1992, Role of poly(ADP-ribose) formation in DNA repair, Nature, 356, 356, 10.1038/356356a0 · DOI · Paper page
  45. Vodenicharov, 2000, Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1, Nucleic Acids Res., 28, 3887, 10.1093/nar/28.20.3887 · DOI
  46. Caldecott, 1996, XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly(ADP-ribose) polymerase, and DNA ligase III is a novel molecular ‘nick-sensor’ in vitro, Nucleic Acids Res., 24, 4387, 10.1093/nar/24.22.4387 · DOI · Paper page
  47. Masson, 1998, XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage, Mol. Cell. Biol., 18, 3563, 10.1128/MCB.18.6.3563 · DOI · Paper page
  48. Dantzer, 2000, Base excision repair is impaired in mammalian cells lacking poly(ADP-ribose) polymerase-1, Biochemistry, 39, 7559, 10.1021/bi0003442 · DOI · Paper page
  49. Pleschke, 2000, Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins, J. Biol. Chem., 275, 40974, 10.1074/jbc.M006520200 · DOI · Paper page
  50. Satoh, 1993, NAD(+)-dependent repair of damaged DNA by human cell extracts, J. Biol. Chem., 268, 5480, 10.1016/S0021-9258(18)53346-9 · DOI · Paper page
  51. Satoh, 1994, Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage, Biochemistry, 33, 7099, 10.1021/bi00189a012 · DOI · Paper page
  52. S. Okano, L. Li, K.W. Caldecott, T. Mori, A. Yasui, Spatial and temporal cellular responses to single-strand breaks in human cells, Mol. Cell. Biol. 23 (11) 2003 (ref. type: generic). · DOI · Paper page
  53. Caldecott, 2001, Mammalian DNA single-strand break repair: an X-ra(y)ted affair, Bioessays, 23, 447, 10.1002/bies.1063 · DOI · Paper page
  54. Whitehouse, 2001, XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair, Cell, 104, 1, 10.1016/S0092-8674(01)00195-7 · DOI · Paper page
  55. Bennett, 1997, Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway, Proc. Natl. Acad. Sci. U.S.A., 94, 7166, 10.1073/pnas.94.14.7166 · DOI · Paper page
  56. Caldecott, 2003, DNA single-strand break repair and spinocerebellar ataxia, Cell, 112, 7, 10.1016/S0092-8674(02)01247-3 · DOI
  57. Trucco, 1998, DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines, Nucleic Acids Res., 26, 2644, 10.1093/nar/26.11.2644 · DOI · Paper page
  58. F. Le Page, V. Schreiber, C. Dherin, G. De Murcia, S. Boiteux, Poly(ADP-ribose) polymerase-1 (PARP-1) is required in murine cell lines for base excision repair of oxidative DNA damage in absence of DNA polymerase beta, J. Biol. Chem., 2003. · DOI
  59. Prasad, 2001, DNA polymerase beta-mediated long patch base excision repair, poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis, J. Biol. Chem., 276, 32411, 10.1074/jbc.C100292200 · DOI · Paper page
  60. Mol, 2000, Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3′ ends justify the means, Mutat. Res., 460, 211, 10.1016/S0921-8777(00)00028-8 · DOI · Paper page
  61. Nakamura, 2000, 5′-Nicked apurinic/apyrimidinic sites are resistant to beta-elimination by beta-polymerase and are persistent in human cultured cells after oxidative stress, J. Biol. Chem., 275, 5323, 10.1074/jbc.275.8.5323 · DOI
  62. Xu, 1998, Excision of C-4′-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase beta, J. Biol. Chem., 273, 28837, 10.1074/jbc.273.44.28837 · DOI
  63. Chen, 1991, Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA, Nucleic Acids Res., 19, 5907, 10.1093/nar/19.21.5907 · DOI · Paper page
  64. Izumi, 2000, Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species, Carcinogenesis, 21, 1329, 10.1093/carcin/21.7.1329 · DOI
  65. Winters, 1994, Removal of 3′-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1, Nucleic Acids Res., 22, 1866, 10.1093/nar/22.10.1866 · DOI
  66. Demple, 1994, Repair of oxidative damage to DNA: enzymology and biology, Annu. Rev. Biochem., 63, 915, 10.1146/annurev.bi.63.070194.004411 · DOI · Paper page
  67. Dianova, 2001, Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair, Biochemistry, 40, 12639, 10.1021/bi011117i · DOI
  68. Ranalli, 2002, AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair, J. Biol. Chem., 277, 41715, 10.1074/jbc.M207207200 · DOI
  69. Tom, 2001, Regulatory roles of p21 and apurinic/apyrimidinic endonuclease 1 in base excision repair, J. Biol. Chem., 276, 48781, 10.1074/jbc.M109626200 · DOI
  70. Vidal, 2001, XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions, EMBO J., 20, 6530, 10.1093/emboj/20.22.6530 · DOI · Paper page
  71. Jilani, 2002, Purification and partial characterization of a DNA 3′-phosphatase from Schizosaccharomyces pombe, Biochemistry, 41, 7688, 10.1021/bi012213m · DOI
  72. Karimi-Busheri, 1998, Repair of DNA strand gaps and nicks containing 3′-phosphate and 5′-hydroxyl termini by purified mammalian enzymes, Nucleic Acids Res., 26, 4395, 10.1093/nar/26.19.4395 · DOI
  73. Karimi-Busheri, 1997, Purification and substrate specificity of polydeoxyribonucleotide kinases isolated from calf thymus and rat liver, J. Cell Biochem., 64, 258, 10.1002/(SICI)1097-4644(199702)64:2<258::AID-JCB9>3.0.CO;2-W · DOI
  74. Inamdar, 2002, Conversion of phosphoglycolate to phosphate termini on 3’ overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1, J. Biol. Chem., 277, 27162, 10.1074/jbc.M204688200 · DOI · Paper page
  75. Whitehouse, 2001, XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair, Cell, 104, 107, 10.1016/S0092-8674(01)00195-7 · DOI · Paper page
  76. Meijer, 2002, Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe, J. Biol. Chem., 277, 4050, 10.1074/jbc.M109383200 · DOI
  77. Beard, 2000, Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta, Mutat. Res., 460, 231, 10.1016/S0921-8777(00)00029-X · DOI
  78. Wilson, 1998, Mammalian base excision repair and DNA polymerase beta, Mutat. Res., 407, 203, 10.1016/S0921-8777(98)00002-0 · DOI · Paper page
  79. DiGiuseppe, 1989, Bleomycin-induced DNA repair synthesis in permeable human fibroblasts: mediation of long-patch and short-patch repair by distinct DNA polymerases, Biochemistry, 28, 9515, 10.1021/bi00450a040 · DOI
  80. Miller, 1982, The roles of DNA polymerases alpha, beta, and gamma in DNA repair synthesis induced in hamster and human cells by different DNA damaging agents, J. Biol. Chem., 257, 10204, 10.1016/S0021-9258(18)34005-5 · DOI
  81. Miller, 1982, Evidence that DNA polymerases alpha and beta participate differentially in DNA repair synthesis induced by different agents, J. Biol. Chem., 257, 46, 10.1016/S0021-9258(19)68323-7 · doi:10.1016/s0021-9258(19)68323-7
  82. Winters, 1999, Determination of human DNA polymerase utilization for the repair of a model ionizing radiation-induced DNA strand break lesion in a defined vector substrate, Nucleic Acids Res., 27, 2423, 10.1093/nar/27.11.2423 · DOI
  83. Frosina, 1994, Repair of abasic sites by mammalian cell extracts, Biochem. J., 304, 699, 10.1042/bj3040699 · DOI
  84. Frosina, 1996, Two pathways for base excision repair in mammalian cells, J. Biol. Chem., 271, 9573, 10.1074/jbc.271.16.9573 · DOI · Paper page
  85. Matsumoto, 1999, Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins, J. Biol. Chem., 274, 33703, 10.1074/jbc.274.47.33703 · DOI · Paper page
  86. Pascucci, 1999, Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon, J. Biol. Chem., 274, 33696, 10.1074/jbc.274.47.33696 · DOI · Paper page
  87. Klungland, 1997, Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1), EMBO J., 16, 3341, 10.1093/emboj/16.11.3341 · DOI · Paper page
  88. Matsumoto, 1994, Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair, Mol. Cell. Biol., 14, 6187, 10.1128/MCB.14.9.6187 · DOI · Paper page
  89. Prasad, 2000, FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair, J. Biol. Chem., 275, 4460, 10.1074/jbc.275.6.4460 · DOI · Paper page
  90. Cappelli, 1997, Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair, J. Biol. Chem., 272, 23970, 10.1074/jbc.272.38.23970 · DOI · Paper page
  91. Levin, 2000, Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair, Curr. Biol., 10, 919, 10.1016/S0960-9822(00)00619-9 · DOI · Paper page
  92. Kubota, 1996, Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein, EMBO J., 15, 6662, 10.1002/j.1460-2075.1996.tb01056.x · DOI · Paper page
  93. Marintchev, 1999, Solution structure of the single-strand break repair protein XRCC1 N-terminal domain, Nat. Struct. Biol., 6, 884, 10.1038/12347 · DOI
  94. Marintchev, 2000, Domain specific interaction in the XRCC1–DNA polymerase beta complex, Nucleic Acids Res., 28, 2049, 10.1093/nar/28.10.2049 · DOI
  95. Marintchev, 2003, Site-directed mutagenesis analysis of the structural interaction of the single-strand-break repair protein X-ray cross-complementing group 1, with DNA polymerase beta, Nucleic Acids Res., 31, 580, 10.1093/nar/gkg159 · DOI
  96. Rice, 1999, Holding damaged DNA together, Nat. Struct. Biol., 6, 805, 10.1038/12257 · DOI
  97. Caldecott, 1994, An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III, Mol. Cell. Biol., 14, 68, 10.1128/MCB.14.1.68 · DOI · Paper page
  98. Chen, 1995, Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination, Mol. Cell. Biol., 15, 5412, 10.1128/MCB.15.10.5412 · DOI
  99. Mackey, 1997, An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination, Mol. Cell. Biol., 17, 989, 10.1128/MCB.17.2.989 · DOI
  100. Wei, 1995, Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III an enzyme active in DNA repair and recombination, Mol. Cell. Biol., 15, 3206, 10.1128/MCB.15.6.3206 · DOI · Paper page
  101. Nash, 1997, XRCC1 protein interacts with one of two distinct forms of DNA ligase III, Biochemistry, 36, 5207, 10.1021/bi962281m · DOI · Paper page
  102. Zhang, 1998, Structure of an XRCC1 BRCT domain: a new protein–protein interaction module, EMBO J., 17, 6404, 10.1093/emboj/17.21.6404 · DOI · Paper page
  103. Ljungquist, 1994, Altered DNA ligase III activity in the CHO EM9 mutant, Mutat. Res., 314, 177, 10.1016/0921-8777(94)90081-7 · doi:10.1016/0921-8777(94)90081-7
  104. Moore, 2000, Mutation of a BRCT domain selectively disrupts DNA single-strand break repair in non-cycling Chinese hamster ovary cells, Proc. Natl. Acad. Sci. U.S.A., 97, 13649, 10.1073/pnas.250477597 · DOI
  105. Cappelli, 1997, Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair, J. Biol. Chem., 272, 23970, 10.1074/jbc.272.38.23970 · DOI · Paper page
  106. Taylor, 2000, A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair, Mol. Cell. Biol., 20, 735, 10.1128/MCB.20.2.735-740.2000 · DOI
  107. Taylor, 1998, Role of the DNA ligase III zinc finger in polynucleotide binding and ligation, Nucleic Acids Res., 26, 4804, 10.1093/nar/26.21.4804 · DOI
  108. Taylor, 2000, The DNA ligase III zinc finger stimulates binding to DNA secondary structure and promotes end joining (in process citation), Nucleic Acids Res., 28, 3558, 10.1093/nar/28.18.3558 · DOI
  109. Mackey, 1999, DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase—identification of two functionally distinct DNA binding regions within DNA ligase III, J. Biol. Chem., 274, 21679, 10.1074/jbc.274.31.21679 · DOI
  110. Taylor, 2002, Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair, Mol. Cell. Biol., 22, 2556, 10.1128/MCB.22.8.2556-2563.2002 · DOI · Paper page

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Metadata

Authors
Caldecott, K. W.
Venue
DNA Repair
Publisher
Elsevier BV
Published
2003-09
Volume
2
Issue
9
Pages
955-969
ISSN
  • 1568-7856 (ISSN-L)
  • 1568-7864
DOI
10.1016/s1568-7864(03)00118-6
OpenAlex
W2028392042
Cited by
598
References
7
FWCI
10.19
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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