Acute NK₁ receptor antagonist administration affects reward incentive anticipation processing in healthy volunteers
Open accessAbstract
The primary brain structures of reward processing are mainly situated in the mid-brain dopamine system. The nucleus accumbens (NAc) receives dopaminergic projections from the ventral tegmental area and works as a key brain region for the positive incentive value of rewards. Because neurokinin-1 (NK₁) receptor, the cognate receptor for substance P (SP), is highly expressed in the NAc, we hypothesized that the SP/NK₁ receptor system might play a role in positive reward processing in the NAc in humans. Therefore, we conducted a functional MRI (fMRI) study to assess the effects of an NK₁ receptor antagonist on human reward processing through a monetary incentive delay task that is known to elicit robust activation in the NAc especially during gain anticipation. Eighteen healthy adults participated in two series of an fMRI study, taking either a placebo or the NK₁ receptor antagonist aprepitant. Behavioural measurements revealed that there was no significant difference in reaction time, hit rate, or self-reported effort for incentive cues between the placebo and aprepitant treatments. fMRI showed significant decrease in blood oxygenation-level-dependent signals in the NAc during gain anticipation with the aprepitant treatment compared to the placebo treatment. These results suggest that SP/NK₁ receptor system is involved in processing of positive incentive anticipation and plays a role in accentuating positive valence in association with the primary dopaminergic pathways in the reward circuit.
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Several fMRI studies using the monetary incentive delay task find ventral striatal activation changes without reaction-time changes, which suggests reaction time may be an insensitive reward-processing marker.
“It should be noted that in various studies utilizing fMRI and the monetary incentive delay task, changes in ventral striatal activation are often found in the absence of changes in reaction time (Jansma et al., 2013; Saji et al., 2013; Smoski et al., 2011), suggesting that reaction time may lack sensitivity as a marker for reward processing.”
From The effects of early life stress on reward processing (2018) · cites this paper as Saji et al., 2013
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The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“It should be noted that in various studies utilizing fMRI and the monetary incentive delay task, changes in ventral striatal activation are often found in the absence of changes in reaction time (Jansma et al., 2013; Saji et al., 2013; Smoski et al., 2011), suggesting that reaction time may lack sensitivity as a marke…”
Background
- Authors
- Saji, K., Ikeda, Y., Kim, W., Shingai, Y., Tateno, A., Takahashi, H., Okubo, Y., Fukayama, H., & Suzuki, H.
- Affiliations
- Anesthesiology and Clinical Physiology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
- Nippon Medical School (JP)
- Kyoto University (JP)
- Tokyo Medical and Dental University (JP)
- Corresponding author
- Suzuki, Hidenori
- Venue
- International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-08-01
- Volume
- 16
- Issue
- 7
- Pages
- 1461-1471
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2123549359
- Cited by
- 19
- References
- 57
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 4 · 2019: 3 · 2018: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 2
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (S0801035)
- Dainippon Sumitomo Pharma
- Soochow University
- Japan Society for the Promotion of Science (24791237, 24243061, 22659212)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- NK1 receptor antagonists, aprepitant, substance P, nucleus accumbens, reward processing, monetary incentive delay task, dopaminergic system, positive valence, human brain imaging
- MeSH terms
- Aprepitant, Adult, Brain, Female, Games, Experimental, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Morpholines, Motivation, Oxygen, Psychological Tests, Reaction Time, Reward, Single-Blind Method, Cross-Over Studies, Young Adult, Neurokinin-1 Receptor Antagonists
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