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Cited by 840

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo

Open access
Huang, Keyang, Ma, Huili, Liu, Juan, Huo, Shuaidong, Kumar, Anil, Wei, Tuo, Zhang, Xu, Jin, Shubin, Gan, Yaling, Wang, Paul C., He, Shengtai, Zhang, Xiaoning, Liang, Xing-Jie·2012·ACS Nano
DOI 10.1021/nn301282m
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Abstract

This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display unique advantages over nanoparticles larger than 10 nm in terms of localization to, and penetration of, breast cancer cells, multicellular tumor spheroids, and tumors in mice. Au@tiopronin nanoparticles that have tunable sizes from 2 to 15 nm with identical surface coatings of tiopronin and charge were successfully prepared. For monolayer cells, the smaller the Au@tiopronin NPs, the more AuNPs found in each cell. In addition, the accumulation of Au NPs in the ex vivo tumor model was size-dependent: smaller AuNPs were able to penetrate deeply into tumor spheroids, whereas 15 nm nanoparticles were not. Owing to their ultrasmall nanostructure, 2 and 6 nm nanoparticles showed high levels of accumulation in tumor tissue in mice after a single intravenous injection. Surprisingly, both 2 and 6 nm Au@tiopronin nanoparticles were distributed throughout the cytoplasm and nucleus of cancer cells in vitro and in vivo, whereas 15 nm Au@tiopronin nanoparticles were found only in the cytoplasm, where they formed aggregates. The ex vivo multicellular spheroid proved to be a good model to simulate in vivo tumor tissue and evaluate nanoparticle penetration behavior. This work gives important insights into the design and functionalization of nanoparticles to achieve high levels of accumulation in tumors.

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Metadata

Authors
Huang, K., Ma, H., Liu, J., Huo, S., Kumar, A., Wei, T., Zhang, X., Jin, S., Gan, Y., Wang, P. C., He, S., Zhang, X., & Liang, X.-J.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2012-05-04
Volume
6
Issue
5
Pages
4483-4493
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
DOI
10.1021/nn301282m
OpenAlex
W2122751535
Cited by
840
References
7
FWCI
18.64
Type
journal article
Language
en
Open access
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