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Cited by 494Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stress

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Mitochondrial Oxygen Radical Generation and Leak: Sites of Production in States 4 and 3, Organ Specificity, and Relation to Aging and Longevity

Barja, Gustavo·1999·Journal of Bioenergetics and Biomembranes
DOI 10.1023/a:1005427919188
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Abstract

Studies in heart and nonsynaptic brain mitochondria from two mammals and three birds show that complex I generates oxygen radicals in heart and nonsynaptic brain mitochondria in States 4 and 3, whereas complex III does it only in heart mitochondria and only in State 4. The increase in oxygen consumption during the State 4 to 3 transition is not accompanied by a proportional increase in oxygen radical generation. This will protect mitochondria and tissues during bursts of activity. Comparisons between young and old rodents do not show a consistent pattern of variation in mitochondrial oxygen radical production during aging. However, all the interspecies comparisons performed to date between different mammals, and between mammals and birds, agree that animals with high maximum longevities have low rates of mitochondrial oxygen radical production, irrespective of the value of their basal specific metabolic rate. The sites and mechanisms allowing this, the recently described low degree of membrane fatty acid unsaturation of longevous animals, and their relation to longevity and aging are discussed.

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Crossref · 10.1023/a:1005427919188

Cites

107 of 107 references verified0 citation errors · 0 not checkable

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  • The mitochondrial respiratory chain produces partially reduced dioxygen species such as hydrogen peroxide and superoxide at considerable rates (ca 1-4% of O2 reduced) even under normal conditions and during ischaemia.

    “Even under 'normal' conditions, as well as during ischaemia when tissue oxygenation levels are low, the redox poise of the mitochondrial respiratory chain is such that the normally complete four-electron reduction of dioxygen to water is also accompanied by the production, at considerable rates (ca 1–4% of O2 reduced), of partially reduced forms of dioxygen such as hydrogen peroxide and superoxide”

    From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [29]

Citations

Cites

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Research works printed but not linked: 16

  1. Barja, G. (1999). In Methods in Aging Research (Yu, B. P. ed.), CRC Press, Boca Raton, Florida, pp. 533-548.
  2. Barja, G., Cadenas, S., Rojas, C., López-Torres, M., and Pérez-Campo, R. (1994a). Comp. Biochem. Physiol. 108B, 501-512.
  3. Chance, B., and Williams, G. R. (1956). Advan. Enzymol. Related Subjects Biochem. 17, 65-134.
  4. Floyd, R. A., Zaleska, M. M., and Harmon, H. J. (1984). In Free Radicals in Molecular Biology, Aging and Disease (Aarmstrong, D., ed.), Raven Press, New York, pp. 143-161.
  5. Gaziano, J. M., and Hennekens, C. H. (1995). Cont. Internal Med. 7, 9-14.
  6. Grigorieff, N. (1998). J. Mol. Evol. 277, 1033-1046.
  7. Hiraku, Y. and Kawanishi, S. (1996). Cancer Res. 56, 5172-5178.
  8. Lee, I. M., Sieh, C. C. H., and Paffenbarger, R. S. (1995). J. Amer. Med. Assoc. 273, 1179-1184. · DOI
  9. Nohl, H. (1986) In Modern Aging Research. Free Radicals, Aging and Degenerative Diseases (Johnson, J. E., Walford, R., and Harman, D. eds.), Vol. 8. Alan Liss, New York, pp.77-97.
  10. Reznick, A., and Gershon, D. (1999). In Methods in Aging Research (Yu, B. P. ed.), CRC Press, Boca Raton, Florida, pp. 167-190.
  11. Richter, C. (1995). Current Topics Bioenerg. 17, 1-19.
  12. Saul, R. L., Gee, P., and Ames, B. N. (1987). In Modern Biological Theories of Aging (Warner, H. R. ed.), Raven Press, New York, pp. 113-129.
  13. Sherratt, H. S. A., Watmough, N. J., Johnson, M. A., and Turnbull, D. M. (1988). Methods Biochem. Anal. 33, 304-305.
  14. Souza-Pinto, N. C., Croteau, D. L., Hudson, E. K., Hansford, E. K., and Bohr, R. G. (1998). Revista de Farmacia e Bioquímica da Universidade de Sao Paulo, vol. 34, Presented at the 16-04 Symposium of the IX Biennial Meeting of the International Society for Free Radical Research, Sao Paulo, 7–11 September, 1998, pp. 73.
  15. Tyler, D. D. (1992). The Mitochondria in Health and Disease, VCH, New York, pp. 90, 172–188, 253, and 305–310.
  16. Tzagoloff, A. (1982). Mitochondria, Plenum Press, New York, pp. 136-137, 140–141.

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Metadata

Authors
Barja, G.
Affiliations
Universidad Complutense de Madrid (ES)
Corresponding author
Barja, Gustavo
ORCID
Barja, Gustavo
Venue
Journal of Bioenergetics and Biomembranes
Publisher
Springer Science and Business Media LLC
Published
1999-08
Volume
31
Issue
4
Pages
347-366
ISSN
  • 0145-479X (ISSN-L)
  • 1573-6881
DOI
10.1023/a:1005427919188
OpenAlex
W1565127991
Cited by
494
References
107
Citations by year
2026: 4 · 2025: 1 · 2024: 5 · 2023: 14 · 2022: 19 · 2021: 15 · 2020: 15 · 2019: 12 · 2018: 17 · 2017: 17 · 2016: 15 · 2015: 13 · 2014: 26 · 2013: 32 · 2012: 26
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Bioenergetics and Biomembranes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
complex I, cytochrome bc1 complex, mitochondrial oxygen consumption, aging, longevity, organ specificity, heart mitochondria, cross-species comparison, specific metabolic rate
MeSH terms
Aging, Animals, Humans, Longevity, Mitochondria, Organ Specificity, Reactive Oxygen Species

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