The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Superoxide Production by the Mitochondrial Respiratory Chain
Abstract
This mini-review describes the role of different mitochondrial components in the formation of reactive oxygen species under normal and pathological conditions and the effect of inhibitors and uncouplers on superoxide formation.
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The generation of reactive species by leakage of electrons from the electron transport chain is highly dependent on maintenance of the electrochemical gradient across the inner mitochondrial membrane.
“The generation of RS by leakage of electrons from the electron transport chain is highly dependent on maintenance of the electrochemical gradient across the IMM (Turrens, 1997).”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Turrens, 1997
Under basal conditions, human cells produce about 2 trillion O2•− and H2O2 per cell per day, the major source of which is the mitochondria.
“Under basal conditions, human cells produce about 2 trillion O2•− and H2O2 per cell per day, the major source of which is the mitochondria [23].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [23]
Citations
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Metadata
- Authors
- Turrens, J. F.
- Affiliations
- University of South Alabama (US)
- Corresponding author
- Turrens, Julio F.
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 1997-02-01
- Volume
- 17
- Issue
- 1
- Pages
- 3-8
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- OpenAlex
- W1911339081
- Cited by
- 903
- References
- 32
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 10 · 2023: 10 · 2022: 14 · 2021: 25 · 2020: 25 · 2019: 23 · 2018: 27 · 2017: 32 · 2016: 45 · 2015: 39 · 2014: 43 · 2013: 51 · 2012: 48
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- superoxide production, mitochondrial respiratory chain, reactive oxygen species, mitochondrial electron transport chain, respiratory chain inhibitors, uncouplers of oxidative phosphorylation, oxidative stress
- MeSH terms
- Animals, Electron Transport, Humans, Mitochondria, Models, Chemical, Oxygen Consumption, Superoxides, Uncoupling Agents, Reactive Oxygen Species, Oxidative Stress
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