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A role for central vasopressin in pair bonding in monogamous prairie voles
Abstract
Monogamous social organization is characterized by selective affiliation with a partner, high levels of paternal behaviour and, in many species, intense aggression towards strangers for defence of territory, nest and mate. Although much has been written about the evolutionary causes of monogamy, little is known about the proximate mechanisms for pair bonding in monogamous mammals. The prairie vole, Microtus ochrogaster, is a monogamous, biparental rodent which exhibits long-term pair bonds characterized by selective affiliation (partner preference) and aggression. Here we describe the rapid development of both selective aggression and partner preferences following mating in the male of this species. We hypothesized that either arginine-vasopressin (AVP) or oxytocin (OT), two nine-amino-acid neuropeptides with diverse forebrain projections, could mediate the development of selective aggression and affiliation. This hypothesis was based on the following observations: (1) monogamous and polygamous voles differ specifically in the distribution of forebrain AVP and OT receptors; (2) AVP innervation in the prairie vole brain is sexually dimorphic and important for paternal behaviour; (3) central AVP pathways have been previously implicated in territorial displays and social memory; and (4) central OT pathways have been previously implicated in affiliative behaviours. We now demonstrate that central AVP is both necessary and sufficient for selective aggression and partner preference formation, two critical features of pair bonding in the monogamous prairie vole.
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In the citing paper
“Although not shown in a photomicrograph, OT fibers in the NAcc have been mentioned previously in rats using immunohistochemisry [122] and radioimmunoassay [137].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [137]
In the citing paper
“Monogamous male prairie voles have elevated levels of the hormone vasopressin after mating, leading to territoriality and partner protection (Winslow, Hastings, Carter, Harbaugh, & Insel, 1993).”
From Birth of a Father: Fathering in the First 1,000 Days (2019) · cites this paper as Winslow et al., 1993
In the citing paper
“In support, ICV injections of OTR antagonist failed to inhibit partner preference in male prairie voles (Winslow et al., 1993), but injections into the lateral septum did (Liu et al., 2001).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Winslow et al., 1993
In the citing paper
“AVP expression within the bed nucleus of the striaterminalis (BST) and the centromedial amygdala (CMA) is known to be involved in a number of social behaviors, [18][19][20] including social play behavior.21”
From Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression (2012) · cites this paper as [18]
In the citing paper
“AVP also facilitates the expression of selective aggression, or mate guarding behaviour, in male prairie voles (7).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [7]
In the citing paper
“intracerebroventricular (ICV) V1aR antagonist impaired partner preference formation in males (Winslow et al., 1993), but there was no effect in females (Insel & Hulihan, 1995).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Winslow et al., 1993
In the citing paper
“In rodents, sex-specific regulation of partner preference in prairie voles, social recognition in rats, social play in rats, and aggression in hamsters has been found”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Winslow et al., 1993
In the citing paper
“ICV OT administration facilitated partner preference formation in female (Williams et al., 1994; Insel and Hulihan, 1995), but not in male (Winslow et al., 1993) prairie voles.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Winslow et al., 1993
In the citing paper
“OT plays a stronger role in partner preference in female prairie voles compared to males (Winslow et al., 1993; Williams et al., 1994; Insel and Hulihan, 1995; Liu et al., 2001).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Winslow et al., 1993
In the citing paper
“ICV V1aR antagonist administration impaired partner preference in male voles only (Winslow et al., 1993; Insel & Hulihan, 1995)”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Winslow et al., 1993
In the citing paper
“Pair bonding in prairie voles is operationally defined based on two observable behaviors: preference for the partner over the stranger in a choice test (or “partner preference”); and intense aggression toward prairie voles other than the mate (or “selective aggression”) (Williams et al 1992; Winslow et al 1993; Insel et al 1995; Wang et al 1997b; Ahern et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Winslow et al 1993
In the citing paper
“In male prairie voles, AVP plays a critical role in the regulation of partner preferences, although it is likely that OT also plays a role [18, 19].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [19]
In the citing paper
“Increased arginine-vasopressin (AVP) signaling, especially in the ventral pallidum (VP) and lateral septum (Liu et al. 2001), is a prerequisite for partner preference formation and expression in male prairie voles”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Winslow et al. 1993
In the citing paper
“a single seminal paper failed to show that OTR blockade inhibits mating induced partner preferences in males (Winslow and Insel, 1993).”
From Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles (2016) · cites this paper as Winslow and Insel, 1993
In the citing paper
“Previous work has suggested that the central OT system may modulate pair bonding in prairie voles in a sex-specific manner (Insel and Hulihan, 1995; Winslow and Insel, 1993), with central OTRs modulating pair bonding in females but not in males.”
From Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles (2016) · cites this paper as Winslow and Insel, 1993
In the citing paper
“A single pharmacological study, using a less selective OTA and relatively small sample sizes for experimental groups (n=6-8 per group), failed to demonstrate an effect of OTA on male pair bonding (Winslow and Insel, 1993)”
From Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles (2016) · cites this paper as Winslow and Insel, 1993
In the citing paper
“In addition to the critical role of AVP in partner-preference formation (Winslow et al., 1993), it is also highly involved in other male-typic behavior, including aggression and courtship (Goodson and Bass, 2001).”
From Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers (2014) · cites this paper as Winslow et al., 1993
In the citing paper
“First, oxytocin effects are moderated by robust, hard-wired neurobiological mechanisms; thus, centrally administered oxytocin increases aggression to same-sex intruders after mating in monogamous Prairie voles, but not in non-monogamous Montane voles (Winslow et al., 1993).”
From Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers (2014) · cites this paper as Winslow et al., 1993
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“In adults, OT and AVP have been implicated in social behaviors, including pair-bonding (Winslow et al., 1993; Williams et al., 1994; Cho et al., 1999; Lim”
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“…1992; DeVries et al. 1995, 1996) or pharmacologically induced in a shorter period of time by treating animals prior to pairing with vasopressin (Winslow et al., 1993; Cho et al., 1999), oxytocin (Williams et al., 1994; Cho et al., 1999; Cushing and Carter, 2000; Insel and Hulihan, 1995),…”
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“This “partner preference” is associated with positive social interactions (Williams et al., 1992; Winslow et al., 1993) that are regulated by reward circuitry (Aragona and Wang, 2009).”
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“Furthermore, AVP has been implicated in mediating aggression in several rodent species (Bester-Meredith et al., 1999; Goodson, 1998; Stribley and Carter, 1999; Winslow et al., 1993).”
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“In prairie voles, the AVP system is suggested to be involved in mate-guarding, because AVP system mediates mate-induced selective aggression in a dyadic situation [20, 21].”
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“AVT or AVP administration also enhances scent-marking behaviors in newts, hamsters, squirrel monkeys, and musk shrews [3,46,92,115], and enhances pair-bonding behaviors in male voles [116].”
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“…5 April 2002, revised 17 May 2002, accepted 21 May 2002 doi:10.1046/j.1460-9568.2002.02083.x social attachment in the monogamous prairie voles (Winslow et al., 1993; Wang et al., 1994; Cho et al., 1999; Young et al., 1999; Liu et al., 2001), yet does not have similar affects in montane voles…”
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“We saw no differences in aromatase activity within the MA or VMH. The apparent change in aromatase activity in the BNST could be associated with changes in aggression. Male prairie voles became more aggressive after pair bonding [”
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“In this context, the evo–devo paradigm does hold as the same genes (underlying neurotransmitter function and nerve cell growth) are reused to create novel nervous system modules (Winslow et al. 1993; Insel et al. 1994; Carter et al. 1995; Fitzpatrick et al. 2005; Turner et al. 2010).”
BackgroundBielsky, I. F., Hu, S.-B., & Young, L. J. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.005 · Cited by 91
Neuropeptides and social behavior: animal models relevant to autism
Young, L. J., Pitkow, L. J., & Ferguson, J. N. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001175 · Cited by 91
Antiaggressive activity of central oxytocin in male rats
Calcagnoli, F., de Boer, S. F., Althaus, M., den Boer, J. A., & Koolhaas, J. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3124-7 · Cited by 90
Why Women Have Orgasms: An Evolutionary Analysis
Puts, D. A., Dawood, K., & Welling, L. L. M. (2012) · Archives of Sexual Behavior · doi:10.1007/s10508-012-9967-x · Cited by 91
Amygdala Kisspeptin Neurons: Putative Mediators of Olfactory Control of the Gonadotropic Axis
Pineda, R., Plaisier, F., Millar, R. P., & Ludwig, M. (2016) · Neuroendocrinology · doi:10.1159/000445895 · Cited by 90
Fuxe, K., Borroto-Escuela, D. O., Romero-Fernandez, W., Ciruela, F., Manger, P., Leo, G., Díaz-Cabiale, Z., & Agnati, L. F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.062 · Cited by 81
“There exists a marked increase in the density of the vasopressin receptor V1a in the ventral pallidum of the monogamous male prairie vole vs the polygamous montane vole which appears to play a key role for monogamy in the male prairie vole (Winslow et al., 1993; Young et al., 1999, 2001).”
BackgroundSex differences in the regulation of offensive aggression and dominance by arginine-vasopressin
Terranova, J. I., Ferris, C. F., & Albers, H. E. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00308 · Cited by 85
“It has been suggested that AVP is necessary for the transition to increased aggressiveness following pair bonding but not for the expression of aggressive behavior (34).”
BackgroundSerotonin and neuropeptides in affiliative behaviors
Insel, T. R., & Winslow, J. T. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00094-8 · Cited by 105
Self-citationEstrogen receptors in the medial amygdala inhibit the expression of male prosocial behavior
Cushing, B. S., Perry, A., Musatov, S., Ogawa, S., & Papademetriou, E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1928-08.2008 · Cited by 95
de Souza, M. A., Centenaro, L. A., Menegotto, P. R., Henriques, T. P., Bonini, J. S., Achaval, M., & Lucion, A. B. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1049-5 · Cited by 86
Kessler, M. S., Bosch, O. J., Bunck, M., Landgraf, R., & Neumann, I. D. (2010) · Social Neuroscience · doi:10.1080/17470919.2010.495567 · Cited by 87
Familiarity and gender influence social preferences in prairie voles (Microtus ochrogaster)
DeVries, A. C., Johnson, C. L., & Carter, C. S. (1997) · Canadian Journal of Zoology · doi:10.1139/z97-037 · Cited by 84
Self-citationParker, K. J., Kinney, L. F., Phillips, K. M., & Lee, T. M. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.6.1341 · Cited by 82
The Role of Vasopressin in the Genetic and Neural Regulation of Monogamy
Lim, M. M., Hammock, E. A. D., & Young, L. J. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01162.x · Cited by 84
Some Thoughts on the Neurobiology of Stalking
Meloy, J. R., & Fisher, H. E. (2005) · Journal of Forensic Sciences · doi:10.1520/jfs2004508 · Cited by 81
The Monogamy Paradox: What Do Love and Sex Have to Do With It?
Carter, C. S., & Perkeybile, A. M. (2018) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2018.00202 · Cited by 87
Self-citationDoom, J. R., Doyle, C., & Gunnar, M. R. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1149095 · Cited by 92
Editorial comment: Oxytocin, vasopressin and social behavior
Young, L. J., & Flanagan-Cato, L. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.019 · Cited by 81
Involvement of vasopressin in affective disorders
Surget, A., & Belzung, C. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.065 · Cited by 84
Neuroendocrinology of social behavior
Adkins-Regan, E. (2009) · ILAR Journal · doi:10.1093/ilar.50.1.5 · Cited by 81
“Infusion of these peptides into the brain greatly shortens the cohabitation time necessary for selective affi liation to form, and, conversely, infusion of receptor antagonists prevents selective affi liation even after more extended periods of cohabitation (Insel and Hulihan 1995; Liu et al. 2001; Williams et al. 199…”
BackgroundInfluentialEvaluation of two automated metrics for analyzing partner preference tests
Ahern, T. H., Modi, M. E., Burkett, J. P., & Young, L. J. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.06.010 · Cited by 82
“, 2004), and social attachment (Williams et al., 1992; Winslow et al., 1993; Carter et al., 1995; Insel and Hulihan, 1995; Young and Wang, 2004).”
Hopkins, W. D., Donaldson, Z. R., & Young, L. J. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00799.x · Cited by 78
“Furthermore, central administration of vasopressin in male prairie voles selectively increases aggression and territoriality (Winslow et al., 1993), traits that seems to overlap with the items loading on the dominance factor in chimpanzees (see Tables 1 & 2).”
BackgroundLateral septal vasopressin in rats: role in social and object recognition?
Everts, H. G. J., & Koolhaas, J. M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00269-2 · Cited by 98
Young, L. J., Wang, Z., Cooper, T. T., & Albers, H. E. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00573.x · Cited by 88
Vleet, M. V., & Feeney, B. C. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615596789 · Cited by 88
Vasopressin selectively impairs emotion recognition in men
Uzefovsky, F., Shalev, I., Israel, S., Knafo‐Noam, A., & Ebstein, R. P. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.018 · Cited by 79
“…injected centrally inhibit creation of mate preference and aggressive behaviors towards intruders, while infusion of AVP induces partner preference behavior even without mating (Winslow et al., 1993) and induces long lasting tendencies towards male-to-male aggression (Stribley and Carter, 1999).”
BackgroundNeuroendocrinology and sexual differentiation in eusocial mammals
Holmes, M. M., Goldman, B. D., Goldman, S. L., Seney, M. L., & Forger, N. G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.010 · Cited by 80
“these peptides enhance pair-bond formation even in the absence of mating and antagonists prevent pair-bonding [25,130].”
Social bonding: regulation by neuropeptides
Lieberwirth, C., & Wang, Z. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00171 · Cited by 86
“…OT seems to be gender-specific as OT administration does not result in partner preference formation and selective OTR antagonist administration does not block partner preference formation in males (Williams et al., 1992a; Winslow et al., 1993; Insel and Hulihan, 1995; but see Cho et al., 1999).”
BackgroundCushing, B. S., Razzoli, M., Murphy, A. Z., Epperson, P. M., Le, W.-W., & Hoffman, G. E. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.010 · Cited by 77
Curtis, J. T., Liu, Y., & Wang, Z. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02343-5 · Cited by 78
Ventral tegmental area involvement in pair bonding in male prairie voles
CURTIS, J., & WANG, Z. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.022 · Cited by 74
“Second, mating activates the VTA in both sexes [3,24,25] and is known to facilitate the formation of pair bonds in voles [48,49].”
Wang, Z., Toloczko, D., Young, L. J., Moody, K., Newman, J. D., & Insel, T. R. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00636-7 · Cited by 75
Self-citationHo, J. M., Murray, J. H., Demas, G. E., & Goodson, J. L. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.021 · Cited by 76
“The neuropeptide arginine vasopressin (AVP) and its avian homolog arginine vasotocin (AVT) influence a variety of social behaviors, including pair bonding in voles (Winslow et al., 1993; Insel and Hulihan, 1995; Lim et al., 2004); social recognition in male mice and rats (Engelmann et al.”
Perkeybile, A. M., Delaney-Busch, N., Hartman, S., Grimm, K. J., & Bales, K. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00191 · Cited by 76
“…social behaviors are modulated differently between sexes, including alloparental behavior (Bales et al., 2004; Olazábal and Young, 2006a,b; Kenkel et al., 2012), pair bonding (Winslow et al., 1993; Williams et al., 1994), and parental behavior (Insel and Shapiro, 1992b; Bamshad et al., 1993, 1994).”
BackgroundEngelmann, M., Ludwig, M., & Landgraf, R. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00598.x · Cited by 76
“Taken together with other findings (14, 33-35), the results of the present paper provide evidence for an extensive participa-”
ResultCurtis, J. T., Liu, Y., Aragona, B. J., & Wang, Z. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.126 · Cited by 74
“Pair bonded prairie voles of both sexes display a robust selective aggression toward unfamiliar conspecifics of either sex, behavior not seen in sexually naive, unpaired voles (Aragona et al., 2006; Thomas and Wolff, 2004; Wang et al., 1997a;Winslow et al., 1993).”
BackgroundInfluentialCognitive Enhancement, Virtue Ethics and the Good Life
Fröding, B. E. E. (2010) · Neuroethics · doi:10.1007/s12152-010-9092-2 · Cited by 75
“Williams et al. [53]; Winslow et al. [ 54 ] Cognitive Enhancement, Virtue Ethics and the Good Life”
BackgroundSocial Monogamy in Nonhuman Primates: Phylogeny, Phenotype, and Physiology
French, J. A., Cavanaugh, J., Mustoe, A. C., Carp, S. B., & Womack, S. L. (2017) · The Journal of Sex Research · doi:10.1080/00224499.2017.1339774 · Cited by 76
Loth, M. K., & Donaldson, Z. R. (2020) · Endocrinology · doi:10.1210/endocr/bqaa223 · Cited by 78
“Specifically, injections of AVP facilitate partner preference, whereas V1aR antagonists block partner preference formation (25-27).”
BackgroundPrairie voles as a novel model of socially facilitated excessive drinking
Anacker, A. M. J., Loftis, J. M., Kaur, S., & Ryabinin, A. E. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00234.x · Cited by 75
Paternal Behavior and Aggression: Endocrine Mechanisms and Nongenomic Transmission of Behavior
Marler, C. A., Bester‐Meredith, J. K., & Trainor, B. C. (2003) · Advances in the study of behavior · doi:10.1016/s0065-3454(03)01006-4 · Cited by 74
Northcutt, K. V., & Lonstein, J. S. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.018 · Cited by 74
“Because mating greatly facilitates partner preference formation in male prairie voles (Insel et al., 1995, Winslow et al., 1993), these four neural sites may be particularly influential in the formation of social bonds with mates.”
BackgroundMethodInfluentialArginine vasotocin regulates social ascent in the African cichlid fish Astatotilapia burtoni
Huffman, L. S., Hinz, F. I., Wojcik, S., Aubin‐Horth, N., & Hofmann, H. A. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.03.004 · Cited by 75
“…in the regulation of a variety of social behaviors in all vertebrate species studied thus far (reproduction, Salek et al., 2002; pair-bonding, Winslow et al., 1993; Oldfield and Hofmann, 2011; parental care, Wang et al., 1994; Kleszczyńska et al., 2012; affiliation, Landgraf et al., 2003;…”
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Castration Does Not Inhibit Aggressive Behavior in Adult Male Prairie Voles (Microtus ochrogaster)
Demas, G. E., Moffatt, C. A., Drazen, D. L., & Nelson, R. J. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00268-6 · Cited by 74
“Recent evidence suggests that the neuropeptides arginine-vasopressin and oxytocin are involved in the mediation of male–male aggression in prairie voles (6,29).”
BackgroundSong, Z., Tai, F., Yu, C., Wu, R., Zhang, X., Broders, H. G., He, F., & Guo, R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.045 · Cited by 73
Social Circuits: Peptidergic Regulation of Mammalian Social Behavior
Storm, E. E., & Tecott, L. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.004 · Cited by 73
“Conversely, V1aR antagonists block the formation of partner preference (Winslow et al., 1993).”
Background
Metadata
- Authors
- Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R.
- Affiliations
- National Institute of Mental Health (US)
- University of Maryland, College Park (US)
- Venue
- Nature
- Published
- 1993-10
- Volume
- 365
- Issue
- 6446
- Pages
- 545-548
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2043050293
- Cited by
- 948
- References
- 24
- Citations by year
- 2026: 20 · 2025: 19 · 2024: 20 · 2023: 22 · 2022: 30 · 2021: 29 · 2020: 35 · 2019: 26 · 2018: 34 · 2017: 38 · 2016: 32 · 2015: 38 · 2014: 38 · 2013: 49 · 2012: 55
- FWCI
- 25.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- vasopressin, pair bonding, monogamy, Microtus ochrogaster, mate preferences, oxytocin, neuropeptides, social behavior, sexual dimorphism
- MeSH terms
- Aggression, Animals, Arginine Vasopressin, Central Nervous System, Arvicolinae, Female, Male, Oxytocin, Sexual Behavior, Animal, Receptors, Oxytocin, Antidiuretic Hormone Receptor Antagonists
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