Congenital leptin deficiency is associated with severe early-onset obesity in humans

Montague, Carl T., Farooqi, I. Sadaf, Whitehead, Jonathan P., Soos, Maria A., Rau, Harald, Wareham, Nicholas J., Sewter, Ciaran P., Digby, Janet E., Mohammed, Shehla N., Hurst, Jane A., Cheetham#, Christopher H., Earley#, Alison R., Barnett, Anthony H., Prins, Johannes B., O'Rahilly, Stephen·1997·Nature
DOI 10.1038/43185

Cited by (139)

Items 101–139 of 139

  1. Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats
    Morton, Gregory J., Niswender, Kevin D., Rhodes, Christopher J., Myers, Martin G., Blevins, James E., Baskin, Denis G., Schwartz, Michael W. · 2003 · Endocrinology
  2. Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity
    Bouret, Sebastien, Levin, Barry E., Ozanne, Susan E. · 2015 · Physiological Reviews
  3. Genetic approaches to stature, pubertal timing, and other complex traits
    Palmert, Mark R, Hirschhorn, Joel N · 2003 · Molecular Genetics and Metabolism
  4. Latest approaches for the treatment of obesity
    Jackson, V Margaret, Breen, Danna M, Fortin, Jean-Philippe, Liou, Alice, Kuzmiski, J Brent, Loomis, A Katrina, Rives, Marie-Laure, Shah, Bhavik, Carpino, Philip A · 2015 · Expert Opinion on Drug Discovery
  5. Effect of Leptin Replacement on Pituitary Hormone Regulation in Patients with Severe Lipodystrophy
    Oral, Elif Arioglu, Ruiz, Elaine, Andewelt, Alexa, Sebring, Nancy, Wagner, Anthony J., Depaoli, Alex M., Gorden, Phillip · 2002 · The Journal of Clinical Endocrinology & Metabolism
  6. Leptin and the Hypothalamic-Pituitary Regulation of the Gonadotropin-Gonadal Axis
    Chan, Jean L., Mantzoros, Christos S. · 2001 · Pituitary
  7. Changes in rat olfactory detection performance induced by orexin and leptin mimicking fasting and satiation
    JULLIARD, A, CHAPUT, M, APELBAUM, A, AIME, P, MAHFOUZ, M, DUCHAMPVIRET, P · 2007 · Behavioural Brain Research
  8. Abnormal regulation of the leptin gene in the pathogenesis of obesity.
    Ioffe, Ella, Moon, Byoung, Connolly, Eileen, Friedman, Jeffrey M. · 1998 · Proceedings of the National Academy of Sciences
  9. Central Nervous System Regulation of Energy Metabolism: Ghrelin versus Leptin
    Nogueiras, Ruben, Tschöp, Matthias H., Zigman, Jeffrey M. · 2008 · Annals of the New York Academy of Sciences
  10. Sleep duration and circulating adipokine levels
    Hayes, Amanda L., Xu, Fang, Babineau, Denise, Patel, Sanjay R. · 2011 · Sleep
  11. The Genetics of Obesity Lessons for Polycystic Ovary Syndrome
    LEGRO, RICHARD S. · 2000 · Annals of the New York Academy of Sciences
  12. CD36-Facilitated Fatty Acid Uptake Inhibits Leptin Production and Signaling in Adipose Tissue
    Hajri, Tahar, Hall, Angela M., Jensen, Dalan R., Pietka, Terri A., Drover, Victor A., Tao, Huan, Eckel, Robert, Abumrad, Nada A. · 2007 · Diabetes
  13. Adipose tissue as an endocrine organ
    Prins, Johannes B. · 2002 · Best Practice & Research Clinical Endocrinology & Metabolism
  14. The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits
    Hinney, Anke, Körner, Antje, Fischer-Posovszky, Pamela · 2022 · Nature Reviews Endocrinology
  15. Effect of Leptin on CYP17 Enzymatic Activities in Human Adrenal Cells: New Insight in the Onset of Adrenarche 1
    Biason-Lauber, Anna, Zachmann, Milo, Schoenle, Eugen J. · 2000 · Endocrinology
  16. Adiposity Signaling and Biological Defense Against Weight Gain: Absence of Protection or Central Hormone Resistance?
    Schwartz, Michael W., Niswender, Kevin D. · 2004 · The Journal of Clinical Endocrinology & Metabolism
  17. Chronic Sleep Fragmentation During the Sleep Period Induces Hypothalamic Endoplasmic Reticulum Stress and PTP1b-Mediated Leptin Resistance in Male Mice
    Hakim, Fahed, Wang, Yang, Carreras, Alba, Hirotsu, Camila, Zhang, Jing, Peris, Eduard, Gozal, David · 2015 · Sleep
  18. Leptin and diabetes in lipoatrophic mice
    Gavrilova, Oksana, Marcus-Samuels, Bernice, Leon, Lisa R., Vinson, Charles, Reitman, Marc L. · 2000 · Nature
  19. 20 YEARS OF LEPTIN: Leptin in common obesity and associated disorders of metabolism
    DePaoli, Alex M · 2014 · Journal of Endocrinology
  20. Obesity–a genetic disease of adipose tissue?
    Arner, Peter · 2000 · British Journal Of Nutrition
  21. Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
    Shi, Haifei, Strader, April D., Sorrell, Joyce E., Chambers, James B., Woods, Stephen C., Seeley, Randy J. · 2008 · American Journal of Physiology-Endocrinology and Metabolism
  22. Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation
    Belfort-DeAguiar, Renata, Seo, Dongju · 2018 · Current Obesity Reports
  23. Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength
    Bassett, J. H. Duncan, Gogakos, Apostolos, White, Jacqueline K., Evans, Holly, Jacques, Richard M., van der Spek, Anne H., Sanger Mouse Genetics Project, Ramirez-Solis, Ramiro, Ryder, Edward, Sunter, David et al. · 2012 · PLoS Genetics
  24. Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level
    Perello, Mario, Çakir, Isin, Cyr, Nicole E., Romero, Amparo, Stuart, Ronald C., Chiappini, Franck, Hollenberg, Anthony N., Nillni, Eduardo A. · 2010 · American Journal of Physiology-Endocrinology and Metabolism
  25. Insulin and NPY pathways and the control of GnRH function and puberty onset
    Pralong, François P. · 2010 · Molecular and Cellular Endocrinology
  26. The Effects of Leptin Administration in Non‐obese Human Subjects
    Mackintosh, Ronald M., Hirsch, Jules · 2001 · Obesity Research
  27. The genetics of obesity
    Damcott, Coleen M, Sack, Paul, Shuldiner, Alan R · 2003 · Endocrinology and Metabolism Clinics of North America
  28. Thermogenic and metabolic antiobesity drugs: rationale and opportunities
    Clapham, J. C., Arch, J. R. S. · 2007 · Diabetes, Obesity and Metabolism
  29. Leptin repletion restores depressed β‐adrenergic contractility in ob/ob mice independently of cardiac hypertrophy
    Minhas, Khalid M., Khan, Shakil A., Raju, Shubha V. Y., Phan, Alexander C., Gonzalez, Daniel R., Skaf, Mike W., Lee, Kwangho, Tejani, Ankit D., Saliaris, Anastasies P., Barouch, Lili A. et al. · 2005 · The Journal of Physiology
  30. LRb signals act within a distributed network of leptin‐responsive neurones to mediate leptin action
    Leinninger, G. M., Myers, M. G. · 2008 · Acta Physiologica
  31. Insights into the constellating drivers of satiety impacting dietary patterns and lifestyle
    Rakha, Allah, Mehak, Fakiha, Shabbir, Muhammad Asim, Arslan, Muhammad, Ranjha, Muhammad Modassar Ali Nawaz, Ahmed, Waqar, Socol, Claudia Terezia, Rusu, Alexandru Vasile, Hassoun, Abdo, Aadil, Rana Muhammad · 2022 · Frontiers in Nutrition
  32. Central and peripheral neuroendocrine peptides and signalling in appetite regulation: considerations for obesity pharmacotherapy
    Atkinson, T. J. · 2008 · Obesity Reviews
  33. Effects of nutrition on neuro-endocrine stress responses
    Rohleder, Nicolas, Kirschbaum, Clemens · 2007 · Current Opinion in Clinical Nutrition and Metabolic Care
  34. Adipokines in healthy skeletal muscle and metabolic disease
    Coles, C. A. · 2016 · Advances in experimental medicine and biology
  35. Loss of Leptin Actions in Obesity: Two Concepts with Cardiovascular Implications
    Mark, Allyn L., Correia, Marcelo L. G., Rahmouni, Kamal, Haynes, William G. · 2004 · Clinical and Experimental Hypertension
  36. Insufficiency of Janus Kinase 2–Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions
    Robertson, Scott, Ishida-Takahashi, Ryoko, Tawara, Isao, Hu, Jiang, Patterson, Christa M., Jones, Justin C., Kulkarni, Rohit N., Myers, Martin G. · 2010 · Diabetes
  37. Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight.
    Licinio, Julio, Milane, Michael, Thakur, Sarika, Whelan, Fiona, Yildiz, Bulent O., Delibasi, Tuncay, de Miranda, Patricia B., Ozata, Metin, Bolu, Erol, DePaoli, Alex et al. · 2007 · Appetite
  38. Differential Involvement of Dopamine D1And D2Receptors and Inhibition by Dopamine of Hypothalamic VMN Neurons in Early Postnatally Overfed Juvenile Rats
    Davidowa, Helga, Heidel, Einar, Plagemann, Andreas · 2002 · Nutritional Neuroscience
  39. Biology or Behavior: Which Is the Strongest Contributor to Weight Gain?
    Byrne, Nuala M., Hills, Andrew P. · 2013 · Current Obesity Reports