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Cited by 836

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice

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Wang, Jingjing, Tang, Huang, Zhang, Chenhong, Zhao, Yufeng, Derrien, Muriel, Rocher, Emilie, van-Hylckama Vlieg, Johan E T, Strissel, Katherine, Zhao, Liping, Obin, Martin, Shen, Jian·2015·The ISME Journal
DOI 10.1038/ismej.2014.99
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Abstract

Structural disruption of gut microbiota and associated inflammation are considered important etiological factors in high fat diet (HFD)-induced metabolic syndrome (MS). Three candidate probiotic strains, Lactobacillus paracasei CNCM I-4270 (LC), L. rhamnosus I-3690 (LR) and Bifidobacterium animalis subsp. lactis I-2494 (BA), were individually administered to HFD-fed mice (108 cells day−1) for 12 weeks. Each strain attenuated weight gain and macrophage infiltration into epididymal adipose tissue and markedly improved glucose–insulin homeostasis and hepatic steatosis. Weighted UniFrac principal coordinate analysis based on 454 pyrosequencing of fecal bacterial 16S rRNA genes showed that the probiotic strains shifted the overall structure of the HFD-disrupted gut microbiota toward that of lean mice fed a normal (chow) diet. Redundancy analysis revealed that abundances of 83 operational taxonomic units (OTUs) were altered by probiotics. Forty-nine altered OTUs were significantly correlated with one or more host MS parameters and were designated ‘functionally relevant phylotypes’. Thirteen of the 15 functionally relevant OTUs that were negatively correlated with MS phenotypes were promoted, and 26 of the 34 functionally relevant OTUs that were positively correlated with MS were reduced by at least one of the probiotics, but each strain changed a distinct set of functionally relevant OTUs. LC and LR increased cecal acetate but did not affect circulating lipopolysaccharide-binding protein; in contrast, BA did not increase acetate but significantly decreased adipose and hepatic tumor necrosis factor-α gene expression. These results suggest that Lactobacillus and Bifidobacterium differentially attenuate obesity comorbidities in part through strain-specific impacts on MS-associated phylotypes of gut microbiota in mice.

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Cited by

Metadata

Authors
Wang, J., Tang, H., Zhang, C., Zhao, Y., Derrien, M., Rocher, E., van-Hylckama Vlieg, J. E. T., Strissel, K., Zhao, L., Obin, M., & Shen, J.
Venue
The ISME Journal
Publisher
Oxford University Press (OUP)
Published
2014-06-17
Volume
9
Issue
1
Pages
1-15
ISSN
  • 1751-7362 (ISSN-L)
  • 1751-7370
DOI
10.1038/ismej.2014.99
OpenAlex
W2037648723
Cited by
836
References
19
FWCI
27.50
Type
journal article
Language
en
Open access
hybrid
Licence

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