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Coordination of circadian timing in mammals

Reppert, Steven M., Weaver, David R.·2002·Nature

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Abstract

Time in the biological sense is measured by cycles that range from milliseconds to years. Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most ubiquitous and well-studied timing systems. At the core of this timing mechanism is an intricate molecular mechanism that ticks away in many different tissues throughout the body. However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.

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Authors: Reppert, S. M., & Weaver, D. R.
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: Reppert, Steven M.
ORCID: Reppert, Steven M.
Weaver, David R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-08
Volume: 418
Issue: 6901
Pages: 935-941
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature00965
OpenAlex: W2003302378
Cited by: 4,379
References: 83
Citations by year: 2026: 139 · 2025: 152 · 2024: 162 · 2023: 193 · 2022: 198 · 2021: 182 · 2020: 197 · 2019: 162 · 2018: 172 · 2017: 210 · 2016: 196 · 2015: 204 · 2014: 216 · 2013: 212 · 2012: 218
FWCI: 14.96
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
eScholarship@UMassChan (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Advanced Frequency and Time Standards
Keywords: circadian rhythm, circadian clock, circadian pacemaker, suprachiasmatic nucleus, light input, molecular clock mechanisms, biological timing, mammals
MeSH terms: Animals, Circadian Rhythm, Gene Expression Regulation, Light, Mammals, Models, Biological, Phosphorylation, Suprachiasmatic Nucleus, Visual Pathways, Photoreceptor Cells, Vertebrate, Active Transport, Cell Nucleus, Feedback, Physiological

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Coordination of circadian timing in mammals

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