The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Coordination of circadian timing in mammals
Abstract
Time in the biological sense is measured by cycles that range from milliseconds to years. Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most ubiquitous and well-studied timing systems. At the core of this timing mechanism is an intricate molecular mechanism that ticks away in many different tissues throughout the body. However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
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In the citing paper
“The 24-h rhythm of cortisol expressed in humans is driven by the central circadian pacemaker located in the suprachiasmatic nucleus [56, 57], which entrains all other peripheral clocks throughout the body to coordinate bodily processes with the environment [58, 59].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [58]
In the citing paper
“In normal physiology, the central circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), synchronizes the timing of peripheral clocks in the liver, gut, pancreas, and adipose tissue via multiple neural and hormonal pathways (1).”
From Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism (2018) · cites this paper as [1]
In the citing paper
“Circadian rhythms are near-24-hour oscillations found in essentially every physiological process in the human brain and body1.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [1]
In the citing paper
“In individual cells, molecular rhythms are generated by a transcriptional–translational feedback loop involving core transcriptional activators — circadian locomotor output cycles kaput (CLOCK), the closely related neuronal PAS domain protein 2 (NPAS2) and brain and muscle ARNT-like protein 1 (BMAL1) — that regulate the expression of many genes, including those encoding period (PER) and cryptochr”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [1]
In the citing paper
“The circadian rhythm of the HPA axis is orchestrated by the suprachiasmatic nucleus (SCN) of the hypothalamus (9) and the oscillating release of GCs is believed to optimize stress responses.”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [9]
Citations
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Metadata
- Authors
- Reppert, S. M., & Weaver, D. R.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Reppert, Steven M.
- Venue
- Nature
- Published
- 2002-08
- Volume
- 418
- Issue
- 6901
- Pages
- 935-941
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2003302378
- Cited by
- 4,379
- References
- 83
- Citations by year
- 2026: 139 · 2025: 152 · 2024: 162 · 2023: 193 · 2022: 198 · 2021: 182 · 2020: 197 · 2019: 162 · 2018: 172 · 2017: 210 · 2016: 196 · 2015: 204 · 2014: 216 · 2013: 212 · 2012: 218
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Advanced Frequency and Time Standards
- Keywords
- circadian rhythm, circadian clock, circadian pacemaker, suprachiasmatic nucleus, light input, molecular clock mechanisms, biological timing, mammals
- MeSH terms
- Animals, Circadian Rhythm, Gene Expression Regulation, Light, Mammals, Models, Biological, Phosphorylation, Suprachiasmatic Nucleus, Visual Pathways, Photoreceptor Cells, Vertebrate, Active Transport, Cell Nucleus, Feedback, Physiological
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