Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, David E., Strong, Randy, Sharp, Zelton Dave, Nelson, James F., Astle, Clinton M., Flurkey, Kevin, Nadon, Nancy L., Wilkinson, J. Erby, Frenkel, Krystyna, Carter, Christy S., Pahor, Marco, Javors, Martin A., Fernandez, Elizabeth, Miller, Richard A.·2009·Nature
Cited by (3,881)
Items 101–200 of 3,881
- Stem cell metabolism in tissue development and agingNg Shyh‐Chang, George Q. Daley, Lewis C. Cantley · 2013 · Development
- mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-ReviewWeichhart, Thomas · 2018 · Gerontology
- Replicative and chronological aging in Saccharomyces cerevisiaeLongo, Valter D., Shadel, Gerald S., Kaeberlein, Matt, Kennedy, Brian · 2012 · Cell Metabolism
- Interventions to slow aging in humans: are we ready?Longo, Valter D., Antebi, Adam, Bartke, Andrzej, Barzilai, Nir, Brown‐Borg, Holly M., Caruso, Calogero, Curiel, Tyler J., Cabo, Rafael, Franceschi, Claudio, Gems, David et al. · 2015 · Aging Cell
- Small molecule SIRT1 activators for the treatment of aging and age-related diseasesBasil P. Hubbard, David A. Sinclair · 2014 · Trends in Pharmacological Sciences
- The GH/IGF-1 axis in ageing and longevityJunnila, Riia K., List, Edward O., Berryman, Darlene E., Murrey, John W., Kopchick, John J. · 2013 · Nature Reviews Endocrinology
- Measuring biological age using omics dataRutledge, Jarod, Oh, Hamilton, Wyss-Coray, Tony · 2022 · Nature Reviews Genetics
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- The mechanistic target of rapamycin: the grand conducTOR of metabolism and agingKennedy, Brian K., Lamming, Dudley W. · 2016 · Cell Metabolism
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- Aging as an event of proteostasis collapseTaylor, R. C., Dillin, A. · 2011 · Cold Spring Harbor Perspectives in Biology
- Cellular and molecular biology of aging endothelial cellsDonato, Anthony J., Morgan, R. Garrett, Walker, Ashley E., Lesniewski, Lisa A. · 2015 · Journal of Molecular and Cellular Cardiology
- The Keap1-Nrf2 System: A Mediator between Oxidative Stress and AgingYu, Chao, Xiao, Jian-Hui · 2021 · Oxidative Medicine and Cellular Longevity
- Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)Ristow, Michael, Schmeisser, Kathrin · 2014 · Dose-Response
- Fighting neurodegeneration with rapamycin: mechanistic insightsJordi Bové, Marta Martínez‐Vicente, Miquel Vila · 2011 · Nature reviews. Neuroscience
- Rapalogs and mTOR inhibitors as anti-aging therapeuticsLamming, Dudley W., Ye, Lan, Sabatini, David M., Baur, Joseph A. · 2013 · Journal of Clinical Investigation
- Molecular and physiological manifestations and measurement of aging in humansKhan, Sadiya S., Singer, Benjamin D., Vaughan, Douglas E. · 2017 · Aging Cell
- The metabolic footprint of aging in miceHoutkooper, Riekelt H., Argmann, Carmen, Houten, Sander M., Cantó, Carles, Jeninga, Ellen H., Andreux, Pénélope A., Thomas, Charles, Doenlen, Raphaël, Schoonjans, Kristina, Auwerx, Johan · 2011 · Scientific Reports
- Polyamines in aging and diseaseNadège Minois, Didac Carmona‐Gutiérrez, Frank Madeo · 2011 · Aging
- The role of cellular senescence in ageing and endocrine diseaseKhosla, Sundeep, Farr, Joshua N., Tchkonia, Tamara, Kirkland, James L. · 2020 · Nature Reviews Endocrinology
- mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh SyndromeJohnson, Simon C., Yanos, Melana E., Kayser, Ernst-Bernhard, Quintana, Albert, Sangesland, Maya, Castanza, Anthony, Uhde, Lauren, Hui, Jessica, Wall, Valerie Z., Gagnidze, Arni et al. · 2013 · Science
- Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging ClockRando, Thomas A., Chang, Howard Y. · 2012 · Cell
- Immunosenescence: a key player in cancer developmentLian, Jingyao, Yue, Ying, Yu, Weina, Zhang, Yi · 2020 · Journal of Hematology & Oncology
- Hallmarks of HealthLópez-Otín, Carlos, Kroemer, Guido · 2021 · Cell
- Genetics of longevity in model organisms: debates and paradigm shiftsGems, David, Partridge, Linda · 2013 · Annual Review of Physiology
- New Insights Into the Role of mTOR Signaling in the Cardiovascular SystemSebastiano Sciarretta, Maurizio Forte, Giacomo Frati, Junichi Sadoshima · 2018 · Circulation Research
- Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging MiceNewman, John C., Covarrubias, Anthony J., Zhao, Minghao, Yu, Xinxing, Gut, Philipp, Ng, Che-Ping, Huang, Yu, Haldar, Saptarsi, Verdin, Eric · 2017 · Cell Metabolism
- mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagyJinghui Zhao, Bo Zhai, Steven P. Gygi, Alfred Lewis Goldberg · 2015 · Proceedings of the National Academy of Sciences
- Endothelial dysfunction and angiogenesis impairment in the ageing vasculatureZoltan I. Ungvari, Stefano Tarantini, Tamás Kiss, Jonathan D. Wren, Cory B. Giles, Courtney T. Griffin, Walter Lee Murfee, Pál Pacher, Anna Csiszár · 2018 · Nature Reviews Cardiology
- The aging stress responseHaigis, Marcia C., Yankner, Bruce A. · 2010 · Molecular Cell
- Autophagy: for better or for worseEllen Wirawan, Tom Vanden Berghe, Saskia Lippens, Patrizia Agostinis, Peter Vandenabeele · 2011 · Cell Research
- AMPK at the Nexus of Energetics and AgingBurkewitz, Kristopher, Zhang, Yue, Mair, William B. · 2014 · Cell Metabolism
- The Role of Autophagy in Parkinson's DiseaseMelinda A. Lynch-Day, K. Mao, K. Wang, M. Zhao, Daniel J. Klionsky · 2012 · Cold Spring Harbor Perspectives in Medicine
- Control of satellite cell function in muscle regeneration and its disruption in ageingSousa-Victor, Pedro, García-Prat, Laura, Muñoz-Cánoves, Pura · 2022 · Nature Reviews Molecular Cell Biology
- Protein Homeostasis and Aging: the importance of exquisite quality controlKoga, Hiroshi, Kaushik, Susmita, Cuervo, Ana Maria · 2011 · Ageing research reviews
- Transient rapamycin treatment can increase lifespan and healthspan in middle-aged miceBitto, Alessandro, Ito, Takashi K, Pineda, Victor V, LeTexier, Nicolas J, Huang, Heather Z, Sutlief, Elissa, Tung, Herman, Vizzini, Nicholas, Chen, Belle, Smith, Kaleb et al. · 2016 · eLife
- The quest to slow ageing through drug discoveryPartridge, Linda, Fuentealba, Matias, Kennedy, Brian K. · 2020 · Nature Reviews Drug Discovery
- Autophagy activation by rapamycin reduces severity of experimental osteoarthritisBeatriz Caramés, Akihiko Hasegawa, Noboru Taniguchi, Shigeru Miyaki, Francisco Javier Blanco, Martin Lotz · 2011 · Annals of the Rheumatic Diseases
- Essential role for autophagy in life span extensionMadeo, Frank, Zimmermann, Andreas, Maiuri, Maria Chiara, Kroemer, Guido · 2015 · Journal of Clinical Investigation
- NF-κB inhibition delays DNA damage–induced senescence and aging in miceTilstra, Jeremy S., Robinson, Andria R., Wang, Jin, Gregg, Siobhán Q., Clauson, Cheryl L., Reay, Daniel P., Nasto, Luigi A., St Croix, Claudette M., Usas, Arvydas, Vo, Nam et al. · 2012 · Journal of Clinical Investigation
- mTOR Signaling in DiseaseDazert, Eva, Hall, Michael N · 2011 · Current Opinion in Cell Biology
- The p53 network: cellular and systemic DNA damage responses in aging and CancerReinhardt, H. Christian, Schumacher, Björn · 2012 · Trends in Genetics
- Mammalian Target of Rapamycin Signaling in Cardiac Physiology and DiseaseSebastiano Sciarretta, Massimo Volpe, Junichi Sadoshima · 2014 · Circulation Research
- mTOR in aging, metabolism, and cancerMarion Cornu, Verena Albert, Michael N. Hall · 2013 · Current Opinion in Genetics & Development
- Inflammaging: disturbed interplay between autophagy and inflammasomesSalminen, Antero, Kaarniranta, Kai, Kauppinen, Anu · 2012 · Aging
- Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosisMasaldan, Shashank, Clatworthy, Sharnel A.S., Gamell, Cristina, Meggyesy, Peter M., Rigopoulos, Antonia-Tonia, Haupt, Sue, Haupt, Ygal, Denoyer, Delphine, Adlard, Paul A., Bush, Ashley I. et al. · 2018 · Redox Biology
- Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in MiceMitchell, Sarah J., Madrigal-Matute, Julio, Scheibye-Knudsen, Morten, Fang, Evandro, Aon, Miguel, González-Reyes, José A., Cortassa, Sonia, Kaushik, Susmita, Gonzalez-Freire, Marta, Patel, Bindi et al. · 2016 · Cell Metabolism
- Aging and Autophagy in the HeartAkihiro Shirakabe, Yoshiyuki Ikeda, Sebastiano Sciarretta, Daniela Zablocki, Junichi Sadoshima · 2016 · Circulation Research
- Autophagy and cellular immune responsesMa, Yuting, Galluzzi, Lorenzo, Zitvogel, Laurence, Kroemer, Guido · 2013 · Immunity
- Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in malesHarrison, David E., Strong, Randy, Allison, David B., Ames, Bruce N., Astle, Clinton M., Atamna, Hani, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin A., Nadon, Nancy L. et al. · 2014 · Aging Cell
- Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle WastingLionel A. J. Tintignac, Hans-Rudolf Brenner, Markus A. Rüegg · 2015 · Physiological Reviews
- mTOR as a central regulator of lifespan and agingDavid J. Papadopoli, Karine Boulay, Lawrence Kazak, Michaël Pollak, Frédérick A. Mallette, Ivan Topisirović, Laura Hulea · 2019 · F1000Research
- Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic ImplicationsUddin, Md. Sahab, Stachowiak, Anna, Mamun, Abdullah Al, Tzvetkov, Nikolay T., Takeda, Shinya, Atanasov, Atanas G., Bergantin, Leandro B., Abdel-Daim, Mohamed M., Stankiewicz, Adrian M. · 2018 · Frontiers in Aging Neuroscience
- From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular SenescenceWiley, Christopher D., Campisi, Judith · 2016 · Cell Metabolism
- Can autophagy promote longevity?Frank Madeo, Nektarios Tavernarakis, Guido Kroemer · 2010 · Nature Cell Biology
- Amino acids and mTORC1: from lysosomes to diseaseEfeyan, Alejo, Zoncu, Roberto, Sabatini, David M. · 2012 · Trends in Molecular Medicine
- Lessons on longevity from budding yeastMatt R. Kaeberlein · 2010 · Nature
- Autophagy and the cell biology of age-related diseaseLeidal, Andrew M., Levine, Beth, Debnath, Jayanta · 2018 · Nature Cell Biology
- Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging MiceAzar Asadi Shahmirzadi, Daniel Edgar, Chen‐Yu Liao, Yueh-Mei Hsu, Mark Lucanic, Arash Asadi Shahmirzadi, Christopher D. Wiley, Garbo Gan, Dong Eun Kim, Herbert G. Kasler et al. · 2020 · Cell Metabolism
- Autophagy in metabolic disease and ageingMunehiro Kitada, Daisuke Koya · 2021 · Nature Reviews Endocrinology
- mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and RapamycinSeong A. Kang, Michael E. Pacold, Christopher Cervantes, Daniel Lim, Hua Jane Lou, Kathleen A. Ottina, Nathanael S. Gray, Benjamin E. Turk, Michael B. Yaffe, David M. Sabatini · 2013 · Science
- Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritisY. Zhang, Faezeh Vasheghani, Yinghua Li, Meryem Blati, Kayla Simeone, Hassan Fahmi, Bertrand Lussier, Peter J. Roughley, David Lagares, Jean‐Pierre Pelletier et al. · 2014 · Annals of the Rheumatic Diseases
- Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive DeficitsMajumder, Smita, Richardson, Arlan, Strong, Randy, Oddo, Salvatore · 2011 · PLoS ONE
- The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard DietSarah Jayne Mitchell, Alejandro Martín‐Montalvo, Evi M. Mercken, Hector H. Palacios, Theresa M. Ward, Gelareh A. Abulwerdi, Robin K. Minor, George P. Vlasuk, James L. Ellis, David A. Sinclair et al. · 2014 · Cell Reports
- The benefits and limitations of animal models for translational research in neurodegenerative diseasesJucker, Mathias · 2010 · Nature Medicine
- SIRT1 Negatively Regulates the Mammalian Target of RapamycinGhosh, Hiyaa Singhee, McBurney, Michael, Robbins, Paul D. · 2010 · PLoS ONE
- The role of DNA methylation in epigenetics of agingArchana Unnikrishnan, Willard M. Freeman, Jordan A. Jackson, Jonathan D. Wren, Hunter L. Porter, Arlan G Richardson · 2018 · Pharmacology & Therapeutics
- Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during agingJuan Ignacio Jiménez‐Loygorri, Beatriz Villarejo‐Zori, Álvaro Viedma-Poyatos, Juan Zapata‐Muñoz, Rocío Benítez‐Fernández, María Dolores Frutos-Lisón, Francisco Abraham Tomás-Barberán, Juan Carlos Espı́n, Estela Área-Gómez, Aurora Gómez-Durán et al. · 2024 · Nature Communications
- Biomarkers of agingHainan Bao, Jiani Cao, Mengting Chen, Chen Min, Wei Chen, Xiao Chen, Yanhao Chen, Yu Chen, Yutian Chen, Zhiyang Chen et al. · 2023 · Science China Life Sciences
- The role of DNA damage and repair in aging through the prism of Koch-like criteriaMoskalev, Alexey A., Shaposhnikov, Mikhail V., Plyusnina, Ekaterina N., Zhavoronkov, Alex, Budovsky, Arie, Yanai, Hagai, Fraifeld, Vadim E. · 2013 · Ageing Research Reviews
- The genetics of human ageingDavid R. Melzer, Luke C. Pilling, Luigi Ferrucci · 2019 · Nature Reviews Genetics
- Progeria syndromes and ageing: what is the connection?Burtner, Christopher R., Kennedy, Brian K. · 2010 · Nature Reviews Molecular Cell Biology
- Metabolites as signalling moleculesSteven Andrew Baker, Jared P. Rutter · 2023 · Nature Reviews Molecular Cell Biology
- Pharmacological approaches to restore mitochondrial functionAndreux, Pénélope A., Houtkooper, Riekelt H., Auwerx, Johan · 2013 · Nature Reviews Drug Discovery
- Protein homeostasis and aging in neurodegenerationPeter M. Douglas, Andrew G. Dillin · 2010 · The Journal of Cell Biology
- mTOR in Brain Physiology and PathologiesJoël Bockaert, Philippe Marin · 2015 · Physiological Reviews
- The Role of Curcumin in Aging and Senescence: Molecular MechanismsZia, Aliabbas, Farkhondeh, Tahereh, Pourbagher-Shahri, Ali Mohammad, Samarghandian, Saeed · 2021 · Biomedicine & Pharmacotherapy
- Rapamycin extends murine lifespan but has limited effects on agingNeff, Frauke, Flores-Dominguez, Diana, Ryan, Devon P., Horsch, Marion, Schröder, Susanne, Adler, Thure, Afonso, Luciana Caminha, Aguilar-Pimentel, Juan Antonio, Becker, Lore, Garrett, Lillian et al. · 2013 · Journal of Clinical Investigation
- Mitochondrial function in hypoxic ischemic injury and influence of agingPhillip Benson Ham, Raghavan Pillai Raju · 2016 · Progress in Neurobiology
- Targeting the biology of aging with mTOR inhibitorsMannick, Joan B., Lamming, Dudley W. · 2023 · Nature Aging
- Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutantsBansal, Ankita, Zhu, Lihua J., Yen, Kelvin, Tissenbaum, Heidi A. · 2015 · Proceedings of the National Academy of Sciences
- How ageing processes influence cancerde Magalhães, João Pedro · 2013 · Nature Reviews Cancer
- Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-InducerStrong, Randy, Miller, Richard A., Antebi, Adam, Astle, Clinton M., Bogue, Molly, Denzel, Martin S., Fernandez, Elizabeth, Flurkey, Kevin, Hamilton, Karyn L., Lamming, Dudley W. et al. · 2016 · Aging Cell
- mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathiesCaccamo, Antonella, Magrì, Andrea, Medina, David X., Wisely, Elena V., López‐Aranda, Manuel F., Silva, Alcino J., Oddo, Salvatore · 2013 · Aging Cell
- SARS-CoV-2, COVID-19 and the aging immune systemBartleson, Juliet M., Radenkovic, Dina, Covarrubias, Anthony J., Furman, David, Winer, Daniel A., Verdin, Eric · 2021 · Nature Aging
- Spermidine induces autophagy by inhibiting the acetyltransferase EP300Pietrocola, F, Lachkar, S, Enot, D P, Niso-Santano, M, Bravo-San Pedro, J M, Sica, V, Izzo, V, Maiuri, M C, Madeo, F, Mariño, G et al. · 2015 · Cell Death & Differentiation
- Chemical modulators of autophagy as biological probes and potential therapeuticsAngeleen Fleming, Takeshi Noda, Tamotsu Yoshimori, David Chaim Rubinsztein · 2010 · Nature Chemical Biology
- Microbial Genetic Composition Tunes Host LongevityBing Han, Priya Sivaramakrishnan, Chih-Chun Lin, Isaiah A.A. Neve, Jingquan He, Li Wei Rachel Tay, Jessica N. Sowa, Antons Sizovs, Guangwei Du, Jin Wang et al. · 2017 · Cell
- Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female miceVladimir Nikolaevich Anisimov, Mark A. Zabezhinski, Irina G. Popovich, Tatiana S. Piskunova, Anna V. Semenchenko, Маргарита Леонидовна Тындык, M. N. Yurova, Svetlana V. Rosenfeld, Mikhail V. Blagosklonny · 2011 · Cell Cycle
- Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cellsCao, Kan, Graziotto, John J., Blair, Cecilia D., Mazzulli, Joseph R., Erdos, Michael R., Krainc, Dimitri, Collins, Francis S. · 2011 · Science Translational Medicine
- Functions and regulation of the 70 kDa ribosomal S6 kinasesTim R. Fenton, Ivan T. Gout · 2010 · The International Journal of Biochemistry & Cell Biology
- Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends SurvivalRamos, Fresnida J., Chen, Steven C., Garelick, Michael G., Dai, Dao-Fu, Liao, Chen-Yu, Schreiber, Katherine H., MacKay, Vivian L., An, Elroy H., Strong, Randy, Ladiges, Warren C. et al. · 2012 · Science Translational Medicine
- Autophagy controls mesenchymal stem cell properties and senescence during bone agingYang Ma, Meng Qi, Ying An, Liqiang Zhang, Rui Yang, Daniel H. Doro, Wenjia Liu, Yan J. Jin · 2017 · Aging Cell
- Senescence mechanisms and targets in the heartMaggie S Chen, Richard Theodore Lee, Jessica C. Garbern · 2021 · Cardiovascular Research