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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
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“In the absence of either IL-25 or IL-33, resistance to helminth infection is severely impaired.40”
From Global issues in allergy and immunology: Parasitic infections and allergy (2017) · cites this paper as [40]
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- Maizels, R. M., Pearce, E. J., Artis, D., Yazdanbakhsh, M. & Wynn, T. A. Regulation of pathogenesis and immunity in helminth infections. J. Exp. Med. 206, 2059–2066 (2009) · DOI
- Perrigoue, J. G., Marshall, F. A. & Artis, D. On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites. Cell. Microbiol. 10, 1757–1764 (2008) · DOI
- Holgate, S. T. & Polosa, R. Treatment strategies for allergy and asthma. Nature Rev. Immunol. 8, 218–230 (2008) · DOI
- Larché, M., Robinson, D. S. & Kay, A. B. The role of T lymphocytes in the pathogenesis of asthma. J. Allergy Clin. Immunol. 111, 450–463 (2003) · DOI
- Fallon, P. G. et al. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17, 7–17 (2002) · DOI
- Grünig, G. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282, 2261–2263 (1998) · DOI
- Urban, J. F. J. et al. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis . Immunity 8, 255–264 (1998) · DOI
- Min, B. et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med. 200, 507–517 (2004) · DOI
- Ohnmacht, C. & Voehringer, D. Basophil effector function and homeostasis during helminth infection. Blood 113, 2816–2825 (2009) · DOI
- Perrigoue, J. G. et al. MHC class II-dependent basophil-CD4+ T cell interactions promote TH2 cytokine-dependent immunity. Nature Immunol. 10, 697–705 (2009) · DOI
- Voehringer, D. The role of basophils in helminth infection. Trends Parasitol. 25, 551–556 (2009) · DOI
- Yoshimoto, T. et al. Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nature Immunol. 10, 706–712 (2009) · DOI
- McKenzie, G. J., Bancroft, A., Grencis, R. K. & McKenzie, A. N. A distinct role for interleukin-13 in Th2-cell-mediated immune responses. Curr. Biol. 8, 339–342 (1998) · DOI
- Walter, D. M. et al. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J. Immunol. 167, 4668–4675 (2001) · DOI
- Voehringer, D., Reese, T. A., Huang, X., Shinkai, K. & Locksley, R. M. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J. Exp. Med. 203, 1435–1446 (2006) · DOI
- Arinobu, Y. et al. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc. Natl Acad. Sci. USA 102, 18105–18110 (2005) · DOI · Paper page
- Haig, D. M. et al. Effects of stem cell factor (kit-ligand) and interleukin-3 on the growth and serine proteinase expression of rat bone-marrow-derived or serosal mast cells. Blood 83, 72–83 (1994) · DOI
- McKenzie, G. J., Fallon, P. G., Emson, C. L., Grencis, R. K. & McKenzie, A. N. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J. Exp. Med. 189, 1565–1572 (1999) · DOI
- Fallon, P. G. et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J. Exp. Med. 203, 1105–1116 (2006) · DOI
- Shinkai, Y. et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855–867 (1992) · DOI · Paper page
- Cui, J. et al. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science 278, 1623–1626 (1997) · DOI
- Tono, T. et al. c-kit gene was not transcribed in cultured mast cells of mast cell-deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region. Blood 80, 1448–1453 (1992) · DOI
- Liu, P., Jenkins, N. A. & Copeland, N. G. A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res. 13, 476–484 (2003) · DOI
- Warming, S., Costantino, N., Court, D. L., Jenkins, N. A. & Copeland, N. G. Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res. 33, e36 (2005) · DOI
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Metadata
- Authors
- Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M., Langford, T. K. A., Bucks, C., Kane, C. M., Fallon, P. G., Pannell, R., Jolin, H. E., & McKenzie, A. N. J.
- Venue
- Nature
- Published
- 2010-04
- Volume
- 464
- Issue
- 7293
- Pages
- 1367-1370
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC2862165
- Cited by
- 1,938
- References
- 0
- Language
- en
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