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Cited by 295

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

Open access
Fieblinger, Tim, Graves, Steven M., Sebel, Luke E., Alcacer, Cristina, Plotkin, Joshua L., Gertler, Tracy S., Chan, C. Savio, Heiman, Myriam, Greengard, Paul, Cenci, M. Angela, Surmeier, D. James·2014·Nature Communications
DOI 10.1038/ncomms6316
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Abstract

The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of striatal direct pathway spiny projection neurons (dSPNs) and indirect pathway spiny projection neurons (iSPNs) is disrupted, leading to aberrant action selection. However, it is unclear whether countervailing mechanisms are engaged in these states. Here we report that iSPN intrinsic excitability and excitatory corticostriatal synaptic connectivity were lower in PD models than normal; L-DOPA treatment restored these properties. Conversely, dSPN intrinsic excitability was elevated in tissue from PD models and suppressed in LID models. Although the synaptic connectivity of dSPNs did not change in PD models, it fell with L-DOPA treatment. In neither case, however, was the strength of corticostriatal connections globally scaled. Thus, SPNs manifested homeostatic adaptations in intrinsic excitability and in the number but not strength of excitatory corticostriatal synapses. Parkinson’s disease and L-DOPA-induced dyskinesia are both associated with imbalances in activity between populations of spiny projection neurons. Fieblinger et al.show that homeostatic adaptations in excitability are engaged by these disease states, but synaptic strengths are not scaled accordingly.

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Metadata

Authors
Fieblinger, T., Graves, S. M., Sebel, L. E., Alcacer, C., Plotkin, J. L., Gertler, T. S., Chan, C. S., Heiman, M., Greengard, P., Cenci, M. A., & Surmeier, D. J.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2014-10-31
Volume
5
Issue
1
Pages
5316-5316
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms6316
OpenAlex
W2025783008
Cited by
295
References
67
FWCI
15.91
Type
journal article
Language
en
Open access
bronze

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