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Dicer is essential for mouse development

Bernstein, Emily, Kim, Sang Yong, Carmell, Michelle A, Murchison, Elizabeth P, Alcorn, Heather, Li, Mamie Z, Mills, Alea A, Elledge, Stephen J, Anderson, Kathryn V, Hannon, Gregory J·2003·Nature Genetics
DOI 10.1038/ng1253
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Abstract

To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.

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Research works printed but not linked: 15

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Metadata

Authors
Bernstein, E., Kim, S. Y., Carmell, M. A., Murchison, E. P., Alcorn, H., Li, M. Z., Mills, A. A., Elledge, S. J., Anderson, K. V., & Hannon, G. J.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2003-10-05
Volume
35
Issue
3
Pages
215-217
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/ng1253
Cited by
1,627
References
0
Language
en
Update notices
erratum (2003-11-01)
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