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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
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Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409
Self-citationSOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation
Kinjyo, I., Hanada, T., Inagaki-Ohara, K., Mori, H., Aki, D., Ohishi, M., Yoshida, H., Kubo, M., & Yoshimura, A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00446-6 · Cited by 630
Krikos, A., Laherty, C. D., & Dixit, V. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37138-8 · Cited by 444
Song, H. Y., Rothe, M., & Goeddel, D. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6721 · Cited by 414
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
Chuang, T.-H., & Ulevitch, R. J. (2004) · Nature Immunology · doi:10.1038/ni1066 · Cited by 374
A20 Blocks Endothelial Cell Activation through a NF-κB-dependent Mechanism
Cooper, J. T., Stroka, D. M., Brostjan, C., Palmetshofer, A., Bach, F. H., & Ferran, C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18068 · Cited by 247
Heyninck, K., & Beyaert, R. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01645-7 · Cited by 169
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Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
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Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301
The gut flora as a forgotten organ
O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
O'Neill, L. A. J., & Bowie, A. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2079 · Cited by 2,667
Breaking the chains: structure and function of the deubiquitinases
Komander, D., Clague, M. J., & Urbé, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2731 · Cited by 1,969
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
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Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509
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Chen, Z. J. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-758 · Cited by 1,184
Beutler, B. A. (2009) · Blood · doi:10.1182/blood-2008-07-019307 · Cited by 840
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Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791
Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
Cario, E., Gerken, G., & Podolsky, D. K. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.056 · Cited by 697
Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells
Schuijs, M. J., Willart, M. A., Vergote, K., Gras, D., Deswarte, K., Ege, M. J., Madeira, F. B., Beyaert, R., van Loo, G., Bracher, F., et al. (2015) · Science · doi:10.1126/science.aac6623 · Cited by 576
Detecting shared pathogenesis from the shared genetics of immune-related diseases
Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551
Staudt, L. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000109 · Cited by 485
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Nahid, M. A., Pauley, K. M., Satoh, M., & Chan, E. K. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056317 · Cited by 423
ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB
Liu, M.-J., Bao, S., Gálvez-Peralta, M., Pyle, C. J., Rudawsky, A. C., Pavlovicz, R. E., Killilea, D. W., Li, C., Nebert, D. W., Wewers, M. D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.009 · Cited by 367
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Wang, C., Chen, T., Zhang, J., Yang, M., Li, N., Xu, X., & Cao, X. (2009) · Nature Immunology · doi:10.1038/ni.1742 · Cited by 317
Maywald, M., Wessels, I., & Rink, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102222 · Cited by 309
de Bie, P., & Ciechanover, A. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.16 · Cited by 296
Onizawa, M., Oshima, S., Schulze-Topphoff, U., Oses-Prieto, J. A., Lu, T., Tavares, R., Prodhomme, T., Duong, B., Whang, M. I., Advincula, R., et al. (2015) · Nature Immunology · doi:10.1038/ni.3172 · Cited by 284
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Adrianto, I., Wen, F., Templeton, A., Wiley, G., King, J. B., Lessard, C. J., Bates, J. S., Hu, Y., Kelly, J. A., Kaufman, K. M., et al. (2011) · Nature Genetics · doi:10.1038/ng.766 · Cited by 279
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Zinngrebe, J., Montinaro, A., Peltzer, N., & Walczak, H. (2014) · The EMBO Reports · doi:10.1002/embr.201338025 · Cited by 227
Zhong, B., Liu, X., Wang, X., Chang, S. H., Liu, X., Wang, A., Reynolds, J. M., & Dong, C. (2012) · Nature Immunology · doi:10.1038/ni.2427 · Cited by 206
ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling
Verstrepen, L., Carpentier, I., Verhelst, K., & Beyaert, R. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.02.009 · Cited by 180
Li, Y., Zhang, P., Wang, C., Han, C., Meng, J., Liu, X., Xu, S., Li, N., Wang, Q., Shi, X., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.454538 · Cited by 177
A20 and cell death-driven inflammation
Priem, D., van Loo, G., & Bertrand, M. J. M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.03.001 · Cited by 139
MicroRNA-125b regulates microglia activation and motor neuron death in ALS
Parisi, C., Napoli, G., Amadio, S., Spalloni, A., Apolloni, S., Longone, P., & Volonté, C. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.153 · Cited by 139
Lampropoulou, V., Calderon‐Gomez, E., Roch, T., Neves, P., Shen, P., Stervbo, U., Boudinot, P., Anderton, S. M., & Fillatreau, S. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00855.x · Cited by 130
The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling
Garg, A. V., Ahmed, M., Vallejo, A. N., Ma, A., & Gaffen, S. L. (2013) · Science Signaling · doi:10.1126/scisignal.2003699 · Cited by 128
Self-citationA pervasive role of ubiquitin conjugation in activation and termination of IκB kinase pathways
Krappmann, D., & Scheidereit, C. (2005) · The EMBO Reports · doi:10.1038/sj.embor.7400380 · Cited by 128
Liu, J., Han, C., Xie, B., Wu, Y., Liu, S., Chen, K., Xia, M., Zhang, Y., Song, L., Li, Z., et al. (2014) · Nature Immunology · doi:10.1038/ni.2898 · Cited by 128
Toll-like receptors in skin infections and inflammatory diseases
Lai, Y., & Gallo, R. (2008) · Infectious Disorders - Drug Targets · doi:10.2174/1871526510808030144 · Cited by 119
Kanayama, M., Inoue, M., Danzaki, K., Hammer, G., He, Y.-W., & Shinohara, M. L. (2015) · Nature Communications · doi:10.1038/ncomms6779 · Cited by 114
Bellail, A. C., Olson, J. J., Yang, X., Chen, Z. J., & Hao, C. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0172 · Cited by 113
Wang, S., Wen, F., Wiley, G. B., Kinter, M. T., & Gaffney, P. M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003750 · Cited by 98
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Sanada, T., Takaesu, G., Mashima, R., Yoshida, R., Kobayashi, T., & Yoshimura, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806923200 · Cited by 66
Kim, E., Beon, J., Lee, S., Park, S. J., Ahn, H., Kim, M. G., Park, J. E., Kim, W., Yuk, J.-M., Kang, S.-J., et al. (2017) · Science Advances · doi:10.1126/sciadv.1602296 · Cited by 50
Metadata
- Authors
- Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R.-C., Wheeler, M. T., Tsui, C., Hurley, P., Chien, M., Chai, S., Hitotsumatsu, O., McNally, E., Pickart, C., & Ma, A.
- Venue
- Nature Immunology
- Published
- 2004-08-29
- Volume
- 5
- Issue
- 10
- Pages
- 1052-1060
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2043801813
- Cited by
- 1,090
- References
- 10
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.