Cited by 839T-cell and B-cell ImmunologySignaling Pathways in DiseaseTGF-β signaling in diseases

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Tone, Yukiko, Furuuchi, Keiji, Kojima, Yoshitsugu, Tykocinski, Mark L, Greene, Mark I, Tone, Masahide·2008·Nature Immunology

DOI 10.1038/ni1549

Open this paper in CoChat — free account

Abstract

The transcription factor Foxp3 is involved in the differentiation, function and survival of CD4+CD25+ regulatory T (T(reg)) cells. Details of the mechanism underlying the induction of Foxp3 expression remain unknown, because studies of the transcriptional regulation of the Foxp3 gene are limited by the small number of T(reg) cells in mononuclear cell populations. Here we have generated a model system for analyzing Foxp3 induction and, by using this system with primary T cells, we have identified an enhancer element in this gene. The transcription factors Smad3 and NFAT are required for activity of this Foxp3 enhancer, and both factors are essential for histone acetylation in the enhancer region and induction of Foxp3. These biochemical properties that define Foxp3 expression explain many of the effects of transforming growth factor-beta on the function of Foxp3+ T(reg) cells.

Integrity signals

Registry

Crossref · 10.1038/ni1549

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.
Frohman, M. A., Dush, M. K., & Martin, G. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8998 · Cited by 4,554
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576
N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses
Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,315
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628
Smad transcription factorsPreprint
Massagué, J., Seoane, J., & Wotton, D. (2005) · Genes & Development · doi:10.1101/gad.1350705 · Cited by 2,519
Regulatory T cells, tumour immunity and immunotherapy
Zou, W. (2006) · Nature reviews. Immunology · doi:10.1038/nri1806 · Cited by 2,135

Show all 31 references

Sorted by citations

Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366
CD4 T cells: fates, functions, and faults
Zhu, J., & Paul, W. E. (2008) · Blood · doi:10.1182/blood-2008-05-078154 · Cited by 1,915
CD4 + T Cells: Differentiation and Functions
Luckheeram, R. V., Zhou, R., Verma, A. D., & Xia, B. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/925135 · Cited by 1,381
mTOR differentially regulates effector and regulatory T cell lineage commitment
Delgoffe, G. M., Kole, T., Zheng, Y., Zarek, P. E., Matthews, K., Xiao, B., Worley, P., Kozma, S., & Powell, J. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.014 · Cited by 1,293
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
Zheng, Y., Josefowicz, S. Z., Chaudhry, A., Peng, X. P., Forbush, K. A., & Rudensky, A. Y. (2010) · Nature · doi:10.1038/nature08750 · Cited by 1,170
Th17 and regulatory T cells in mediating and restraining inflammation
Littman, D. R., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.02.021 · Cited by 1,039
Signaling cross-talk between TGF-β/BMP and other pathways
Guo, X., & Wang, X. (2008) · Cell Research · doi:10.1038/cr.2008.302 · Cited by 1,077
TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944
The roles of TGFβ in the tumour microenvironment
Pickup, M. W., Novitskiy, S. V., & Moses, H. L. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3603 · Cited by 936
TGF-β: A Master of All T Cell Trades
Li, M. O., & Flavell, R. A. (2008) · Cell · doi:10.1016/j.cell.2008.07.025 · Cited by 916
TGF-β signaling in health and disease
Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
Sauer, S., Bruno, L., Hertweck, A., Finlay, D. K., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D. A., O’Connor, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800928105 · Cited by 888
TGF-β Activation and Function in Immunity
Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856
Contextual determinants of TGFβ action in development, immunity and cancer
David, C. J., & Massagué, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0007-0 · Cited by 851
Immunoregulatory functions of mTOR inhibition
Thomson, A. W., Turnquist, H. R., & Raimondi, G. (2009) · Nature reviews. Immunology · doi:10.1038/nri2546 · Cited by 873
Regulatory T cells and Foxp3
Rudensky, A. Y. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01018.x · Cited by 839
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
Josefowicz, S. Z., Niec, R. E., Kim, H. Y., Treuting, P. M., Chinen, T., Zheng, Y., Umetsu, D. T., & Rudensky, A. Y. (2012) · Nature · doi:10.1038/nature10772 · Cited by 862
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
Apetoh, L., Quintana, F. J., Pot, C., Joller, N., Xiao, S., Kumar, D., Burns, E. J., Sherr, D. H., Weiner, H. L., & Kuchroo, V. K. (2010) · Nature Immunology · doi:10.1038/ni.1912 · Cited by 725
Development and Maintenance of Regulatory T cells
Ohkura, N., Kitagawa, Y., & Sakaguchi, S. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.002 · Cited by 742
Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and InfectionPreprint
Sanjabi, S., Oh, S. A., & Li, M. O. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022236 · Cited by 664
Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict
Samstein, R. M., Josefowicz, S. Z., Arvey, A. J., Treuting, P. M., & Rudensky, A. Y. (2012) · Cell · doi:10.1016/j.cell.2012.05.031 · Cited by 650
Peripheral CD4+ T‐cell differentiation regulated by networks of cytokines and transcription factors
Zhu, J., & Paul, W. E. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00951.x · Cited by 624
NFAT, immunity and cancer: a transcription factor comes of age
Müller, M., & Rao, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2818 · Cited by 611
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance
Oh‐hora, M., Yamashita, M., Hogan, P. G., Sharma, S., Lamperti, E., Chung, W. Y., Prakriya, M., Feske, S., & Rao, A. (2008) · Nature Immunology · doi:10.1038/ni1574 · Cited by 597
Control of Regulatory T Cell Lineage Commitment and Maintenance
Josefowicz, S. Z., & Rudensky, A. Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.009 · Cited by 584
Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation
Lal, G., Zhang, N., van der Touw, W., Ding, Y., Ju, W., Böttinger, E. P., Reid, S. P., Levy, D. E., & Bromberg, J. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.259 · Cited by 564
The Role of Retinoic Acid in Tolerance and Immunity
Hall, J. A., Grainger, J. R., Spencer, S. P., & Belkaid, Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.07.002 · Cited by 559
Development and maintenance of intestinal regulatory T cells
Tanoue, T., Atarashi, K., & Honda, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.36 · Cited by 553
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
Huehn, J., Polansky, J. K., & Hamann, A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2474 · Cited by 524
T cell receptor signalling in the control of regulatory T cell differentiation and function
Li, M. O., & Rudensky, A. Y. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.26 · Cited by 493
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells
Gandhi, R., Kumar, D., Burns, E. J., Nadeau, M., Dake, B., Laroni, A., Kozoriz, D., Weiner, H. L., & Quintana, F. J. (2010) · Nature Immunology · doi:10.1038/ni.1915 · Cited by 497
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
Ouyang, W., Beckett, O. R., Ma, Q., Paik, J.-H., DePinho, R. A., & Li, M. O. (2010) · Nature Immunology · doi:10.1038/ni.1884 · Cited by 467
1,25-Dihydroxyvitamin D 3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A
Joshi, S., Pantalena, L. C., Liu, X. K., Gaffen, S. L., Liu, H., Rohowsky‐Kochan, C., Ichiyama, K., Yoshimura, A., Steinman, L., Christakos, S., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05020-11 · Cited by 478
Induced Regulatory T Cells: Their Development, Stability, and Applications
Kanamori, M., Nakatsukasa, H., Okada, M., Lu, Q., & Yoshimura, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.08.012 · Cited by 465
Ion channels and transporters in lymphocyte function and immunity
Feske, S., Skolnik, E. Y., & Prakriya, M. (2012) · Nature Reviews Immunology · doi:10.1038/nri3233 · Cited by 441
Foxo Transcription Factors Control Regulatory T Cell Development and Function
Kerdiles, Y. M., Stone, E. L., Beisner, D. R., McGargill, M. A., Ch’en, I. L., Stockmann, C., Katayama, C. D., & Hedrick, S. Μ. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.002 · Cited by 438
Calcium signaling in lymphocytes
Oh‐hora, M., & Rao, A. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.04.004 · Cited by 426
Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease
Kaye, D. M., Shihata, W., Jama, H. A., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Vijay, A., Giam, B., Vinh, A., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.043081 · Cited by 428
NF‐κB: roles and regulation in different CD 4+ T‐cell subsets
Oh, H., & Ghosh, S. (2013) · Immunological Reviews · doi:10.1111/imr.12033 · Cited by 408
“Three highly conserved non-coding sequences have been identified in the FoxP3 locus (27, 28): CNS1, CNS2, and CNS3.”
Background
Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor
Long, M., Park, S., Strickland, I., Hayden, M. S., & Ghosh, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.022 · Cited by 392
Cellular and molecular basis for the regulation of inflammation by TGF-
Yoshimura, A., Wakabayashi, Y., & Mori, T. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq043 · Cited by 405
Overcoming TGFβ-mediated immune evasion in cancer
Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00413-6 · Cited by 377
Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome
Ruan, Q., Kameswaran, V., Tone, Y., Li, L., Liou, H., Greene, M. I., Tone, M., & Chen, Y. H. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.006 · Cited by 397
Self-citation
Regulatory T cells in allergic diseases
Rivas, M. N., & Chatila, T. A. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.003 · Cited by 387
Epigenetic mechanisms of regulation of Foxp3 expression
Lal, G., & Bromberg, J. S. (2009) · Blood · doi:10.1182/blood-2009-05-219584 · Cited by 382
Intricacies of TGF-β signaling in Treg and Th17 cell biology
Wang, J., Zhao, X., & Wan, Y. Y. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01036-7 · Cited by 404
Control of Foxp3 stability through modulation of TET activity
Yue, X., Trifari, S., Äijö, T., Tsagaratou, A., Pastor, W. A., Zepeda-Martínez, J. A., Lio, C.-W. J., Li, X., Huang, Y., Vijayanand, P., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151438 · Cited by 355
Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases
Ohkura, N., & Sakaguchi, S. (2020) · Cell Research · doi:10.1038/s41422-020-0324-7 · Cited by 374
Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells
Wu, C., Thalhamer, T., França, R. F. D. O., Xiao, S., Wang, C., Hotta, C., Zhu, C. Y., Hirashima, M., Anderson, A. C., & Kuchroo, V. K. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.011 · Cited by 358
Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance
Soroosh, P., Doherty, T. A., Duan, W., Mehta, A. K., Choi, H., Adams, Y. F., Mikulski, Z., Khorram, N., Rosenthal, P., Broide, D. H., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121849 · Cited by 340
Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development
Takimoto, T., Wakabayashi, Y., Sekiya, T., Inoue, N., Morita, R., Ichiyama, K., Takahashi, R., Asakawa, M., Muto, G., Mori, T., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904100 · Cited by 357
From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation
Bacchetta, R., Barzaghi, F., & Roncarolo, M. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13011 · Cited by 346
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
Ravi, R., Noonan, K. A., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., V. Artemov, A., Wysocki, P. T., Mehra, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02696-6 · Cited by 325
The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells
Liu, G., Yang, K., Burns, S., Shrestha, S., & Chi, H. (2010) · Nature Immunology · doi:10.1038/ni.1939 · Cited by 331
Hair follicle immune privilege and its collapse in alopecia areata
Bertolini, M., McElwee, K. J., Gilhar, A., Bulfone‐Paus, S., & Paus, R. (2020) · Experimental Dermatology · doi:10.1111/exd.14155 · Cited by 348
TGF-β: Guardian of T Cell Function
Oh, S. A., & Li, M. O. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301843 · Cited by 322
HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
Satou, Y., Yasunaga, J.-I., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001274 · Cited by 319
Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity
van Loosdregt, J., Fleskens, V., Fu, J. L., Brenkman, A. B., Bekker, C. P. J., Pals, C. E. G. M., Meerding, J., Berkers, C. R., Barbi, J. J., Gröne, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.018 · Cited by 321
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
Sekiya, T., Kashiwagi, I., Yoshida, R., Fukaya, T., Morita, R., Kimura, A., Ichinose, H., METZGER, D., Chambon, P., & Yoshimura, A. (2013) · Nature Immunology · doi:10.1038/ni.2520 · Cited by 314
Zinc signals and immunity
Maywald, M., Wessels, I., & Rink, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102222 · Cited by 309
ORAI1 and STIM1 deficiency in human and mice: roles of store‐operated Ca 2+ entry in the immune system and beyond
Feske, S. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00818.x · Cited by 306
Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation
Jiang, S., Li, C., Olive, V., Lykken, E. A., Feng, F., Sevilla, J., Wan, Y., He, L., & Li, Q.-J. (2011) · Blood · doi:10.1182/blood-2011-05-355644 · Cited by 303
Bridging intestinal immunity and gut microbiota by metabolites
Wang, G., Huang, S., Wang, Y., Cai, S., Yu, H., Liu, H., Zeng, X., Zhang, G., & Qiao, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03190-6 · Cited by 305
Metalloimmunology: The metal ion-controlled immunity
Wang, C., Zhang, R., Wei, X., Lv, M., & Jiang, Z. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.11.007 · Cited by 302
TGF-β Regulation of T Cells
Chen, W. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-045939 · Cited by 299
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
Harada, Y., Harada, Y., Elly, C., Ge, Y., Paik, J.-H., DePinho, R. A., & Liu, Y. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100004 · Cited by 281
Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity
Yadav, M., Stephan, S. R., & Bluestone, J. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00232 · Cited by 286
Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity
Li, X., Liang, Y., Leblanc, M., Benner, C. W., & Zheng, Y. (2014) · Cell · doi:10.1016/j.cell.2014.07.030 · Cited by 277
TGF-β: the sword, the wand, and the shield of FOXP3+ regulatory T cells
Tran, D. Q. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjr033 · Cited by 272
A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells
Getnet, D., Grosso, J. F., Goldberg, M. V., Harris, T., Yen, H., Bruno, T. C., Durham, N. M., Hipkiss, E. L., Pyle, K. J., & Wada, S. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.02.001 · Cited by 248
Once a Treg, always a Treg?
Sawant, D. V., & Vignali, D. A. A. (2014) · Immunological Reviews · doi:10.1111/imr.12173 · Cited by 255
Function and Role of Regulatory T Cells in Rheumatoid Arthritis
Jiang, Q., Yang, G., Liu, Q., Wang, S., & Cui, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.626193 · Cited by 254
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function
Kurniawan, H., Franchina, D. G., Guerra, L., Bonetti, L., Soriano‐Baguet, L., Grusdat, M., Schlicker, L., Hunewald, O. E., Dostert, C., Merz, M. P., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.004 · Cited by 249
Transforming growth factor–β1 in regulatory T cell biology
Moreau, J. M., Velegraki, M., Bolyard, C. M., Rosenblum, M. D., & Li, Z. (2022) · Science Immunology · doi:10.1126/sciimmunol.abi4613 · Cited by 260
D-mannose induces regulatory T cells and suppresses immunopathology
Zhang, D., Chia, C., Jiao, X., Jin, W., Kasagi, S., Wu, R., Konkel, J. E., Nakatsukasa, H., Zanvit, P., Goldberg, N., et al. (2017) · Nature Medicine · doi:10.1038/nm.4375 · Cited by 243
Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development
Ouyang, W., Beckett, O. R., Ma, Q., & Li, M. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.012 · Cited by 256
Indispensable Role of the Runx1-Cbfβ Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T Cells
Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T., Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi, Y., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.003 · Cited by 239
The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1
Yi, M., Zhang, J., Li, A., Niu, M., Yan, Y., Jiao, Y., Luo, S., Zhou, P., & Wu, K. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01045-x · Cited by 233
Generation and Function of Induced Regulatory T Cells
Schmitt, E. G., & Williams, C. B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00152 · Cited by 239
Calcium signaling and cell proliferation
Pinto, M. C. X., Kihara, A. H., Goulart, V. A. M., Tonelli, F. M. P., Gomes, K. N., Ulrich, H., & Resende, R. R. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.08.006 · Cited by 239
FOXP3 and scurfy: how it all began
Ramsdell, F., & Ziegler, S. F. (2014) · Nature reviews. Immunology · doi:10.1038/nri3650 · Cited by 225
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells
Bour‐Jordan, H., & Bluestone, J. A. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00775.x · Cited by 229
NFAT pulls the strings during CD4+ T helper cell effector functions
Hermann-Kleiter, N., & Baier, G. (2010) · Blood · doi:10.1182/blood-2009-10-233585 · Cited by 218
Treg cells in autoimmunity: from identification to Treg-based therapies
Göschl, L., Scheinecker, C., & Bonelli, M. M. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00741-8 · Cited by 222
STAT3 in CD4+ T helper cell differentiation and inflammatory diseases
Egwuagu, C. E. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.003 · Cited by 219
TGF-β in T Cell Biology: Implications for Cancer Immunotherapy
Dahmani, A., & Delisle, J. (2018) · Cancers · doi:10.3390/cancers10060194 · Cited by 222
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
Sekiya, T., Kashiwagi, I., Inoue, N., Morita, R., Hori, S., Waldmann, H., Rudensky, A. Y., Ichinose, H., METZGER, D., Chambon, P., et al. (2011) · Nature Communications · doi:10.1038/ncomms1272 · Cited by 215
Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
Polansky, J. K., Schreiber, L., Thelemann, C., Ludwig, L. S., Krüger, M., Baumgrass, R., Cording, S., Floess, S., Hamann, A., & Huehn, J. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0642-1 · Cited by 213
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
Sumida, T. S., Cheru, N. T., & Hafler, D. A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00994-x · Cited by 229
Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts
Ammirante, M., Shalapour, S., Kang, Y., Jamieson, C., & Karin, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416498111 · Cited by 209
1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region
Kang, S. W., Kim, S., Lee, N., Lee, W., Hwang, K., Shin, M. S., Lee, S., Kim, W., & Kang, I. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101211 · Cited by 198
Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
Rudra, D., Egawa, T., Chong, M. M. W., Treuting, P. M., Littman, D. R., & Rudensky, A. Y. (2009) · Nature Immunology · doi:10.1038/ni.1795 · Cited by 202
Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity
Liu, Y., Wang, L., Predina, J. D., Han, R., Beier, U. H., Wang, L. S., Kapoor, V., Bhatti, T. R., Akimova, T., Singhal, S. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3286 · Cited by 207
TGF-β Function in Immune Suppression
Yoshimura, A., & Muto, G. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_87 · Cited by 210
Combined CDK4/6 and PI3Kα Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer
Teo, Z. L., Versaci, S., Dushyanthen, S., Caramia, F., Savas, P., Mintoff, C. P., Zethoven, M., Virassamy, B., Luen, S. J., McArthur, G. A., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-2210 · Cited by 196
Tregs: Where We Are and What Comes Next?
Hai, Z., Liao, X., & Kang, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01578 · Cited by 200
Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
Klunker, S., Chong, M. M. W., Mantel, P., Palomares, Ó., Bassin, C., Ziegler, M., Rückert, B., Meiler, F., Akdiş, M., Littman, D. R., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090596 · Cited by 198
TGF-β Signaling and Resistance to Cancer Therapy
Zhang, M., Zhang, Y. Y., Chen, Y., Wang, J., Wang, Q., & Lu, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.786728 · Cited by 204

Authors: Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M. L., Greene, M. I., & Tone, M.
Affiliations: University of Pennsylvania (US)
Corresponding author: Tone, Masahide
ORCID: Furuuchi, Keiji
Kojima, Yoshitsugu
Tykocinski, Mark L
Greene, Mark I
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2007-12-23
Volume: 9
Issue: 2
Pages: 194-202
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni1549
OpenAlex: W2019077533
Cited by: 807
References: 31
Citations by year: 2026: 16 · 2025: 17 · 2024: 32 · 2023: 34 · 2022: 35 · 2021: 41 · 2020: 45 · 2019: 49 · 2018: 44 · 2017: 45 · 2016: 47 · 2015: 54 · 2014: 45 · 2013: 64 · 2012: 37
FWCI: 17.12
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: Foxp3, regulatory T cells, Smad3, NFAT, transcriptional regulation, histone acetylation, TGF-beta, CD4+CD25+ T cells, transcription factor cooperation
MeSH terms: Animals, Base Sequence, Enhancer Elements, Genetic, Gene Expression Regulation, Molecular Sequence Data, Cell Line, Tumor, T-Lymphocytes, Regulatory, NFATC Transcription Factors, Mice, Forkhead Transcription Factors, Smad3 Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks