Cited by 7,745T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisSignaling Pathways in Disease

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, Jason D., Gavin, Marc A., Rudensky, Alexander Y.·2003·Nature Immunology

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Abstract

CD4+CD25+ regulatory T cells are essential for the active suppression of autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T cells and is required for their development. The lethal autoimmune syndrome observed in Foxp3-mutant scurfy mice and Foxp3-null mice results from a CD4+CD25+ regulatory T cell deficiency and not from a cell-intrinsic defect of CD4+CD25- T cells. CD4+CD25+ regulatory T cells rescue disease development and preferentially expand when transferred into neonatal Foxp3-deficient mice. Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function.

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Authors: Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Rudensky, Alexander Y.
ORCID: Fontenot, Jason D.
Gavin, Marc A.
Rudensky, Alexander Y.
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2003-03-03
Volume: 4
Issue: 4
Pages: 330-336
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni904
OpenAlex: W2097811455
Cited by: 7,745
References: 26
Citations by year: 2026: 168 · 2025: 199 · 2024: 237 · 2023: 230 · 2022: 306 · 2021: 323 · 2020: 326 · 2019: 318 · 2018: 287 · 2017: 307 · 2016: 296 · 2015: 303 · 2014: 351 · 2013: 392 · 2012: 414
FWCI: 106.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: Foxp3, regulatory T cells, CD4+CD25+ T cells, Treg development, autoimmunity, scurfy mice, Treg suppressive function, transcription factors
MeSH terms: Animals, DNA-Binding Proteins, Female, Receptors, Interleukin-2, CD4-Positive T-Lymphocytes, Down-Regulation, Gene Targeting, Mice, Forkhead Transcription Factors

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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