Cited by 1,000Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorDecision-Making and Behavioral Economics

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Optimal decision making and the anterior cingulate cortex

Kennerley, Steven W, Walton, Mark E, Behrens, Timothy E J, Buckley, Mark J, Rushworth, Matthew F S·2006·Nature Neuroscience

DOI 10.1038/nn1724

Open this paper in CoChat — free account

Abstract

Learning the value of options in an uncertain environment is central to optimal decision making. The anterior cingulate cortex (ACC) has been implicated in using reinforcement information to control behavior. Here we demonstrate that the ACC's critical role in reinforcement-guided behavior is neither in detecting nor in correcting errors, but in guiding voluntary choices based on the history of actions and outcomes. ACC lesions did not impair the performance of monkeys (Macaca mulatta) immediately after errors, but made them unable to sustain rewarded responses in a reinforcement-guided choice task and to integrate risk and payoff in a dynamic foraging task. These data suggest that the ACC is essential for learning the value of actions.

Integrity signals

Registry

Crossref · 10.1038/nn1724

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Conflict monitoring and cognitive control
Botvinick, M. M., Braver, T. S., Barch, D. M., Carter, C. S., & Cohen, J. D. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.624 · Cited by 7,351
An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472
The neural basis of human error processing: Reinforcement learning, dopamine, and the error-related negativity.
Holroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027
Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197
A neural system for error detection and compensation
Gehring, W. J., Goss, B., Coles, M. G. H., Meyer, D. E., & Donchin, E. (1993) · Psychological Science · doi:10.1111/j.1467-9280.1993.tb00586.x · Cited by 2,862
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574
Reinforcement learning
Barto, A. (1998) · IFAC Proceedings Volumes · doi:10.1016/s1474-6670(17)38315-5 · Cited by 2,172
Uncertainty, Neuromodulation, and Attention
Yu, A. J., & Dayan, P. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.026 · Cited by 1,774
Primate anterior cingulate cortex: Where motor control, drive and cognition interface
Paus, T. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077500 · Cited by 1,722
Neural correlates of decision variables in parietal cortex
Platt, M. L., & Glimcher, P. W. (1999) · Nature · doi:10.1038/22268 · Cited by 1,721

Flagged first, then by citations

Show all 52 references

Sorted by citations

Items 101–200 of 1,000

Neurons in anterior cingulate cortex multiplex information about reward and action
Hayden, B. Y., & Platt, M. L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4874-09.2010 · Cited by 236
The nexus between decision making and emotion regulation: A review of convergent neurocognitive substrates
Mitchell, D. G. V. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.030 · Cited by 234
The Neural Network Underlying Incentive-Based Learning: Implications for Interpreting Circuit Disruptions in Psychiatric Disorders
Haber, S. N., & Behrens, T. E. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.031 · Cited by 230
Self-citation
Oscillatory Activity and Phase–Amplitude Coupling in the Human Medial Frontal Cortex during Decision Making
Cohen, M. X., Elger, C. E., & Fell, J. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.21020 · Cited by 230
The auditory and non-auditory brain areas involved in tinnitus. An emergent property of multiple parallel overlapping subnetworks
Vanneste, S., & Ridder, D. D. (2012) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2012.00031 · Cited by 225
Variability in Nucleus Accumbens Activity Mediates Age-Related Suboptimal Financial Risk Taking
Samanez-Larkin, G. R., Kuhnen, C. M., Yoo, D. J., & Knutson, B. D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4902-09.2010 · Cited by 224
Separate Neural Mechanisms Underlie Choices and Strategic Preferences in Risky Decision Making
Venkatraman, V., Payne, J. W., Bettman, J. R., Luce, M. F., & Huettel, S. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.007 · Cited by 222
Genetic origins of social networks in rhesus macaques
Brent, L. J. N., Heilbronner, S. R., Horvath, J. E., Gonzalez-Martinez, J., Ruiz-Lambides, A., Robinson, A. G., Skene, J. H. P., & Platt, M. L. (2013) · Scientific Reports · doi:10.1038/srep01042 · Cited by 220
Neuronal Encoding of Subjective Value in Dorsal and Ventral Anterior Cingulate Cortex
Cai, X., & Padoa‐Schioppa, C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3864-11.2012 · Cited by 220
An information theory account of cognitive control
Fan, J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00680 · Cited by 214
Evaluating choices by single neurons in the frontal lobe: outcome value encoded across multiple decision variables
Kennerley, S. W., & Wallis, J. D. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06743.x · Cited by 211
Self-citation
Dissociated roles of the anterior cingulate cortex in reward and conflict processing as revealed by the feedback error-related negativity and N200
Baker, T. E., & Holroyd, C. B. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.01.010 · Cited by 211
Encoding of Marginal Utility across Time in the Human Brain
Pine, A., Seymour, B., Roiser, J. P., Bossaerts, P. L., Friston, K. J., Curran, H. V., & Dolan, R. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1126-09.2009 · Cited by 210
PERIL AND PLEASURE: AN RDOC-INSPIRED EXAMINATION OF THREAT RESPONSES AND REWARD PROCESSING IN ANXIETY AND DEPRESSION: Neighborhood Characteristics and Mental Health
Dillon, D. G., Rosso, I. M., Pechtel, P., Killgore, W. D. S., Rauch, S. L., & Pizzagalli, D. A. (2014) · Depression and Anxiety · doi:10.1002/da.22202 · Cited by 209
Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala
Murray, E. A., Wise, S. P., & Drevets, W. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.041 · Cited by 208
Surprise! Neural correlates of Pearce–Hall and Rescorla–Wagner coexist within the brain
Roesch, M. R., Esber, G. R., Li, J., Daw, N. D., & Schoenbaum, G. M. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07986.x · Cited by 208
Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression
Borsini, A., Wallis, A. S. J., Zunszain, P., Pariante, C. M., & Kempton, M. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00804-6 · Cited by 207
Neural structures underlying set-shifting: Roles of medial prefrontal cortex and anterior cingulate cortex
Bissonette, G. B., Powell, E. M., & Roesch, M. R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.037 · Cited by 207
Computational noise in reward-guided learning drives behavioral variability in volatile environments
Findling, C., Skvortsova, V., Dromnelle, R., Palminteri, S., & Wyart, V. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0518-9 · Cited by 205
Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task
Bush, G., Spencer, T. J., Holmes, J., Shin, L. M., Valera, E. M., Seidman, L. J., Makris, N., Surman, C., Aleardi, M., Mick, E., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.16 · Cited by 201
Neuronal Activity in Primate Dorsal Anterior Cingulate Cortex Signals Task Conflict and Predicts Adjustments in Pupil-Linked Arousal
Ebitz, R. B., & Platt, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.053 · Cited by 201
Frontal Oscillatory Dynamics Predict Feedback Learning and Action Adjustment
van de Vijver, I., Ridderinkhof, K. R., & Cohen, M. X. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00110 · Cited by 201
Posterior Cingulate Cortex Mediates Outcome-Contingent Allocation of Behavior
Hayden, B. Y., Nair, A. C., McCoy, A. N., & Platt, M. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.012 · Cited by 200
A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales
Fusi, S., Asaad, W. F., Miller, E. K., & Wang, X.-J. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.017 · Cited by 199
Hierarchical control over effortful behavior by rodent medial frontal cortex: A computational model.
Holroyd, C. B., & McClure, S. M. (2014) · Psychological Review · doi:10.1037/a0038339 · Cited by 199
A Potential Role of the Inferior Frontal Gyrus and Anterior Insula in Cognitive Control, Brain Rhythms, and Event-Related Potentials
Tops, M., & Boksem, M. A. S. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00330 · Cited by 198
Decision Making: The Neuroethological Turn
Pearson, J. M., Watson, K. K., & Platt, M. L. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.037 · Cited by 197
Double Dissociation of Stimulus-Value and Action-Value Learning in Humans with Orbitofrontal or Anterior Cingulate Cortex Damage
Camille, N., Tsuchida, A., & Fellows, L. K. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3164-11.2011 · Cited by 195
Computational Models of Performance Monitoring and Cognitive Control
Alexander, W. H., & Brown, J. W. (2010) · Topics in Cognitive Science · doi:10.1111/j.1756-8765.2010.01085.x · Cited by 193
Decision making and reward in frontal cortex: Complementary evidence from neurophysiological and neuropsychological studies.
Kennerley, S. W., & Walton, M. E. (2011) · Behavioral Neuroscience · doi:10.1037/a0023575 · Cited by 193
Self-citation
Hierarchical reasoning by neural circuits in the frontal cortex
Sarafyazd, M., & Jazayeri, M. (2019) · Science · doi:10.1126/science.aav8911 · Cited by 191
Adaptive decision making and value in the anterior cingulate cortex
Walton, M. E., Croxson, P. L., Behrens, T. E. J., Kennerley, S. W., & Rushworth, M. F. S. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.029 · Cited by 191
Self-citation
Neurons in Posterior Cingulate Cortex Signal Exploratory Decisions in a Dynamic Multioption Choice Task
Pearson, J. M., Hayden, B. Y., Raghavachari, S., & Platt, M. L. (2009) · Current Biology · doi:10.1016/j.cub.2009.07.048 · Cited by 191
Perceptual Learning and Decision-Making in Human Medial Frontal Cortex
Kahnt, T., Grueschow, M., Speck, O., & Haynes, J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.054 · Cited by 189
When is an error not a prediction error? An electrophysiological investigation
Holroyd, C. B., Krigolson, O. E., Baker, R., Lee, S., & Gibson, J. (2009) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.9.1.59 · Cited by 189
Motor, cognitive, and affective areas of the cerebral cortex influence the adrenal medulla
Dum, R. P., Levinthal, D. J., & Strick, P. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605044113 · Cited by 188
Beyond reversal: a critical role for human orbitofrontal cortex in flexible learning from probabilistic feedback
Tsuchida, A., Doll, B. B., & Fellows, L. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1958-10.2010 · Cited by 188
“…studies in humans and lesion work in monkeys, it has been suggested that this region is particularly important for choices in stochastic environments in which integration of outcome history is required for behavioral adjustment (Kennerley et al., 2006; Behrens et al., 2007; Jocham et al., 2009b).”
Background
Why humans deviate from rational choice
Hewig, J. S., Kretschmer, N., Trippe, R. H., Hecht, H., COLES, M. G. H., Holroyd, C. B., & Miltner, W. H. R. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2010.01081.x · Cited by 188
Dopamine and effort-based decision making
Kurniawan, I. T. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00081 · Cited by 188
The research domain criteria framework: The case for anterior cingulate cortex
Holroyd, C. B., & Umemoto, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.021 · Cited by 187
Real and Fictive Outcomes Are Processed Differently but Converge on a Common Adaptive Mechanism
Fischer, A. G., & Ullsperger, M. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.006 · Cited by 187
Heterogeneous reward signals in prefrontal cortex
Wallis, J. D., & Kennerley, S. W. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.02.009 · Cited by 186
Self-citation
Resolving response, decision, and strategic control: evidence for a functional topography in dorsomedial prefrontal cortex.
Venkatraman, V., Rosati, A. G., Taren, A. A., & Huettel, S. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2708-09.2009 · Cited by 186
Knowing When to Stop: The Brain Mechanisms of Chasing Losses
Campbell-Meiklejohn, D. K., Woolrich, M. W., Passingham, R. E., & Rogers, R. D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.014 · Cited by 186
Divided Representation of Concurrent Goals in the Human Frontal Lobes
Charron, S., & Koechlin, É. (2010) · Science · doi:10.1126/science.1183614 · Cited by 186
Neural Correlates of Forward Planning in a Spatial Decision Task in Humans
Simon, D. A., & Daw, N. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4647-10.2011 · Cited by 186
Life Span Differences in Electrophysiological Correlates of Monitoring Gains and Losses during Probabilistic Reinforcement Learning
Hämmerer, D., Li, S., Müller, V., & Lindenberger, U. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21475 · Cited by 186
Bayesian Prediction and Evaluation in the Anterior Cingulate Cortex
Ide, J. S., Shenoy, P., Yu, A. J., & Li, C.-S. R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2201-12.2013 · Cited by 185
Nicotine Dependence Is Characterized by Disordered Reward Processing in a Network Driving Motivation
Bühler, M., Vollstädt-Klein, S., Kobiella, A., Budde, H., Reed, L. J., Braus, D. F., Büchel, C., & Smolka, M. N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.029 · Cited by 185
The five factors of personality and regional cortical variability in the baltimore longitudinal study of aging
Kapogiannis, D., Sutin, A. R., Davatzikos, C. A., Costa, P. T., & Resnick, S. M. (2012) · Human Brain Mapping · doi:10.1002/hbm.22108 · Cited by 185
Dopamine DRD2 Polymorphism Alters Reversal Learning and Associated Neural Activity
Jocham, G., Klein, T. A., Neumann, J., von Cramon, D. Y., Reuter, M., & Ullsperger, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5195-08.2009 · Cited by 185
Prefrontal transcranial direct current stimulation alters activation and connectivity in cortical and subcortical reward systems: a tDCS-fMRI study
Weber, M. J., Messing, S. B., Rao, H., Detre, J. A., & Thompson‐Schill, S. L. (2014) · Human Brain Mapping · doi:10.1002/hbm.22429 · Cited by 183
Learning from feedback: The neural mechanisms of feedback processing facilitating better performance
Luft, C. D. B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.043 · Cited by 182
Functional Imaging of Decision Conflict
Pochon, J.-B., Riis, J., Sanfey, A. G., Nystrom, L. E., & Cohen, J. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4195-07.2008 · Cited by 179
Ventromedial Prefrontal and Anterior Cingulate Cortex Adopt Choice and Default Reference Frames during Sequential Multi-Alternative Choice
Boorman, E. D., Rushworth, M. F. S., & Behrens, T. E. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3022-12.2013 · Cited by 178
Self-citation
Effects of Amygdala Lesions on Reward-Value Coding in Orbital and Medial Prefrontal Cortex
Rudebeck, P. H., Mitz, A. R., Chacko, R. V., & Murray, E. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.036 · Cited by 178
Neuropharmacology of performance monitoring
Jocham, G., & Ullsperger, M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.011 · Cited by 177
Dorsal anterior cingulate cortex integrates reinforcement history to guide voluntary behavior
Holroyd, C. B., & COLES, M. G. H. (2007) · Cortex · doi:10.1016/j.cortex.2007.08.013 · Cited by 176
Stable representations of decision variables for flexible behavior
Bari, B. A., Grossman, C. D., Lubin, E. E., Rajagopalan, A. E., Cressy, J. I., & Cohen, J. Y. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.001 · Cited by 173
Separate Prefrontal-Subcortical Circuits Mediate Different Components of Risk-Based Decision Making
Onge, J. R. S., Stopper, C. M., Zahm, D. S., & Floresco, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5625-11.2012 · Cited by 172
The Anterior Cingulate Cortex Predicts Future States to Mediate Model-Based Action Selection
Akam, T., Rodrigues-Vaz, I., Marcelo, I., Zhang, X., Pereira, M., Oliveira, R. F., Dayan, P., & Costa, R. M. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.013 · Cited by 170
Re-evaluating the role of the orbitofrontal cortex in reward and reinforcement
Noonan, M. P., Kolling, N., Walton, M. E., & Rushworth, M. F. S. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08023.x · Cited by 169
Self-citation
Orbitofrontal contributions to value-based decision making: evidence from humans with frontal lobe damage
Fellows, L. K. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06229.x · Cited by 169
Selective Theta-Synchronization of Choice-Relevant Information Subserves Goal-Directed Behavior
Womelsdorf, T., Vinck, M. A., Leung, L.-W. S., & Everling, S. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00210 · Cited by 168
The Rostral Anterior Cingulate Cortex Modulates the Efficiency of Amygdala-Dependent Fear Learning
Bissière, S., Plachta, N., Hoyer, D., McAllister, K. H., Olpe, H.-R., Grace, A. A., & Cryan, J. F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.022 · Cited by 168
Risk prediction and aversion by anterior cingulate cortex
Brown, J. W., & Braver, T. S. (2007) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.7.4.266 · Cited by 166
Anterior cingulate is a source of valence-specific information about value and uncertainty
Monosov, I. E. (2017) · Nature Communications · doi:10.1038/s41467-017-00072-y · Cited by 163
The cingulate cortex and limbic systems for action, emotion, and memory
Rolls, E. T. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00002-9 · Cited by 161
Reward processing in anorexia nervosa
Keating, C., Tilbrook, A. J., Rossell, S. L., Enticott, P. G., & Fitzgerald, P. B. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.01.036 · Cited by 161
Where Does Value Come From?
Juechems, K., & Summerfield, C. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.07.012 · Cited by 160
Freezing revisited: coordinated autonomic and central optimization of threat coping
Roelofs, K., & Dayan, P. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00608-2 · Cited by 160
Orbitofrontal Cortex and Amygdala Contributions to Affect and Action in Primates
Murray, E. A., & Izquierdo, A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.021 · Cited by 160
Attention for Learning Signals in Anterior Cingulate Cortex
Bryden, D. W., Johnson, E. E., Tobia, S. C., Kashtelyan, V., & Roesch, M. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4715-11.2011 · Cited by 159
A brain network supporting social influences in human decision-making
Zhang, L., & Gläscher, J. P. (2020) · Science Advances · doi:10.1126/sciadv.abb4159 · Cited by 158
Neurons in the Rat Anterior Cingulate Cortex Dynamically Encode Cost–Benefit in a Spatial Decision-Making Task
Hillman, K. L., & Bilkey, D. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1273-10.2010 · Cited by 157
Rodent versions of the Iowa gambling task: opportunities and challenges for the understanding of decision-making
de Visser, L. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00109 · Cited by 157
Impaired decision‐making and impulse control in Internet gaming addicts: evidence from the comparison with recreational Internet game users
Wang, Y., Wu, L., Wang, L., Zhang, Y., Du, X., & Dong, G. (2016) · Addiction Biology · doi:10.1111/adb.12458 · Cited by 157
Neural Processing of Reward and Punishment in Young People at Increased Familial Risk of Depression
McCabe, C., Woffindale, C., Harmer, C. J., & Cowen, P. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.034 · Cited by 155
Cortico–Basal Ganglia Circuit Function in Psychiatric Disease
Gunaydin, L. A., & Kreitzer, A. C. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105355 · Cited by 155
Altered Brain Reward Circuits in Eating Disorders: Chicken or Egg?
Frank, G. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0396-x · Cited by 153
Distinct Roles of Three Frontal Cortical Areas in Reward-Guided Behavior
Noonan, M. P., Mars, R. B., & Rushworth, M. F. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6456-10.2011 · Cited by 151
Self-citation
The Sight of Others' Pain Modulates Motor Processing in Human Cingulate Cortex
Morrison, I., Peelen, M. V., & Downing, P. E. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl129 · Cited by 151
Functional dissociation of the frontoinsular and anterior cingulate cortices in empathy for pain
Gu, X., Liu, X., Guise, K. G., Naidich, T. P., Hof, P. R., & Fan, J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4844-09.2010 · Cited by 150
TOWARDS A GENERAL MODEL OF TEMPORAL DISCOUNTING
van den Bos, W., & McClure, S. M. (2013) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.6 · Cited by 149
Juvenile mice show greater flexibility in multiple choice reversal learning than adults
Johnson, C. V., & Wilbrecht, L. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.05.008 · Cited by 149
Amygdala and Orbitofrontal Cortex Lesions Differentially Influence Choices during Object Reversal Learning
Rudebeck, P. H., & Murray, E. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2272-08.2008 · Cited by 148
Should I stay or should I go? Conceptual underpinnings of goal-directed actions
Mirabella, G. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00206 · Cited by 148
Downregulation of the Posterior Medial Frontal Cortex Prevents Social Conformity
Klucharev, V. A., Munneke, M. A. M., Smidts, A., & Fernández, G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1869-11.2011 · Cited by 147
Social learning through prediction error in the brain
Joiner, J. A., Piva, M., Turrin, C., & Chang, S. W. C. (2017) · npj Science of Learning · doi:10.1038/s41539-017-0009-2 · Cited by 147
Predictive decision making driven by multiple time-linked reward representations in the anterior cingulate cortex
Wittmann, M. K., Kolling, N., Akaishi, R., Chau, B. K. H., Brown, J. W., Nelissen, N., & Rushworth, M. F. S. (2016) · Nature Communications · doi:10.1038/ncomms12327 · Cited by 146
Self-citation
Compulsivity reveals a novel dissociation between action and confidence
Vaghi, M. M., Luyckx, F., Sule, A., Fineberg, N. A., Robbins, T. W., & De Martino, B. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.006 · Cited by 145
Different Varieties of Uncertainty in Human Decision-Making
Bland, A. R., & Schaefer, A. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00085 · Cited by 145
Expectations, gains, and losses in the anterior cingulate cortex
Sallet, J., Quilodran, R., Rothé, M., Vezoli, J., Joseph, J., & Procyk, E. (2007) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.7.4.327 · Cited by 143
Single dose of a dopamine agonist impairs reinforcement learning in humans: Evidence from event‐related potentials and computational modeling of striatal‐cortical function
Santesso, D. L., Evins, A. E., Frank, M. J., Schetter, E. C., Bogdan, R., & Pizzagalli, D. A. (2008) · Human Brain Mapping · doi:10.1002/hbm.20642 · Cited by 143
Single-Neuron Mechanisms Underlying Cost-Benefit Analysis in Frontal Cortex
Hosokawa, T., Kennerley, S. W., Sloan, J., & Wallis, J. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2221-13.2013 · Cited by 141
Self-citation
Computational Models of Anterior Cingulate Cortex: At the Crossroads between Prediction and Effort
Vassena, E., Holroyd, C. B., & Alexander, W. H. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00316 · Cited by 140
Dopamine modulates neural networks involved in effort-based decision-making
Assadi, S. M., Yücel, M., & Pantelis, C. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.010 · Cited by 140
Neural correlates of a Go/NoGo task with alcohol stimuli in light and heavy young drinkers
Ames, S. L., Wong, S. W. H., Bechara, A., Cappelli, C., Dust, M., Grenard, J. L., & Stacy, A. W. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.039 · Cited by 140
The Importance of Failure: Feedback-Related Negativity Predicts Motor Learning Efficiency
van der Helden, J., Boksem, M. A. S., & Blom, J. H. G. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp224 · Cited by 140
Distinct contributions of frontal areas to emotion and social behaviour in the rat
Rudebeck, P. H., Walton, M. E., Millette, B. H. P., Shirley, E., Rushworth, M. F. S., & Bannerman, D. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05844.x · Cited by 139
Self-citation

Authors: Kennerley, S. W., Walton, M. E., Behrens, T. E. J., Buckley, M. J., & Rushworth, M. F. S.
Affiliations: University of Oxford (GB)
John Radcliffe Hospital (GB)
Corresponding author: Kennerley, Steven W
ORCID: Kennerley, Steven W
Walton, Mark E
Behrens, Timothy E J
Buckley, Mark J
Rushworth, Matthew F S
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2006-06-18
Volume: 9
Issue: 7
Pages: 940-947
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1724
OpenAlex: W2009639618
Cited by: 948
References: 52
Citations by year: 2026: 38 · 2025: 43 · 2024: 41 · 2023: 47 · 2022: 33 · 2021: 37 · 2020: 28 · 2019: 41 · 2018: 35 · 2017: 57 · 2016: 58 · 2015: 51 · 2014: 49 · 2013: 58 · 2012: 55
FWCI: 26.05
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Keywords: anterior cingulate cortex, optimal decision making, reinforcement learning, value learning, error correction, error detection, voluntary choice, foraging behavior, lesion studies, macaque
MeSH terms: Animals, Behavior, Animal, Conditioning, Operant, Decision Making, Gyrus Cinguli, Macaca mulatta, Male, Probability Learning, Psychomotor Performance, Reinforcement, Psychology, Reinforcement Schedule

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Optimal decision making and the anterior cingulate cortex

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks