The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles
Open accessAbstract
Despite significant evidence that opioids are involved in attachment by mediating social reward and motivation, the role of opioids in the formation of adult social attachments has not been explored. We used the socially monogamous prairie vole (Microtus ochrogaster) to explore the role of endogenous opioids in social bonding by examining partner preference formation in female prairie voles. We hypothesized that μ-opioid receptors (MORs) in the striatum have a critical role in partner preference formation. We therefore predicted that peripheral administration of an opioid receptor antagonist would inhibit partner preference formation, and more specifically, that μ-opioid selective receptor blockade within the striatum would inhibit partner preference formation. To test our hypotheses, we first administered the non-selective opioid antagonist naltrexone peripherally to females during an 18-h cohabitation with a male and later tested the female with a partner preference test (PPT). Females showed a dose schedule-dependent decrease in partner preference in the PPT, with females in the continuous dose group displaying stranger preferences. Next, we administered microinjections of the MOR selective antagonist D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) into either the nucleus accumbens shell (NAS) or the caudate-putamen (CP) immediately before a 24-h cohabitation with a male, and later tested the female with a PPT. Females receiving CTAP into the CP, but not the NAS, showed no preference in the PPT, indicating an inhibition of partner preference formation. We show here for the first time that MORs modulate partner preference formation in female prairie voles by acting in the CP.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In this species, a peripherally administered, non-selective opioid antagonist prevents pair bond formation between prairie voles, but also reduces mating (Burkett et al 2011).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Burkett et al 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
Balleine, B. W., & O'Doherty, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.131 · Cited by 1,775
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Self-citationThe neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · cited 2×
“Previous studies in female prairie voles have focused on the NAS as the striatal component of the pair bonding circuitry (Young and Wang, 2004).”
BackgroundSelf-citationIkemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
Reward representations and reward-related learning in the human brain: Insights from neuroimaging
O’Doherty, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.016 · Cited by 1,426
The Role of the Dorsal Striatum in Reward and Decision-Making: Figure 1.
Balleine, B. W., Delgado, M. R., & Hikosaka, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1554-07.2007 · Cited by 1,390
Greenway, F. L., Fujioka, K., Plodkowski, R. A., Mudaliar, S., Guttadauria, M., Erickson, J., Kim, D. D., & Dunayevich, E. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60888-4 · Cited by 1,036
The neural basis of romantic love
Bartels, A., & Zeki, S. (2000) · NeuroReport · doi:10.1097/00001756-200011270-00046 · Cited by 1,020
Reward Processing by the Opioid System in the Brain
Le Merrer, J., Becker, J. A. J., Befort, K., & Kieffer, B. L. (2009) · Physiological Reviews · doi:10.1152/physrev.00005.2009 · Cited by 1,013
Mansour, A., Khachaturian, H., Lewis, M. E. S., Akil, H., & Watson, S. J. (1988) · Pain · doi:10.1016/0304-3959(88)90103-0 · Cited by 973
Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love
Aron, A., Fisher, H., Mashek, D. J., Strong, G., Li, H., & Brown, L. L. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00838.2004 · Cited by 963
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · cited 1×
“The roles of oxytocin, vasopressin, dopamine, and CRF in social cognition have been explored using the partner preference test (PPT) as a laboratory proxy for pair bond formation (Lim et al, 2004, 2007; Curtis et al, 2006; Aragona and Wang, 2009; Ross and Young, 2009).”
MethodSelf-citationNeuroanatomical correlates of pleasant and unpleasant emotion
Lane, R. D., Reiman, E. M., Bradley, M. M., Lang, P. J., Ahern, G. L., Davidson, R. J., & Schwartz, G. E. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00070-5 · Cited by 830
A common neurobiology for pain and pleasure
Leknes, S., & Tracey, I. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2333 · Cited by 784 · cited 1×
“The opiate system has long been known to mediate the rewarding or positively reinforcing properties of unconditioned stimuli such as food, water, sex, and drugs of abuse (Turkish and Cooper, 1983; Agmo and Berenfeld, 1990; Self and Nestler, 1995; Yeomans and Gray, 1996; Fields, 2007; Leknes and Tracey, 2008).”
BackgroundExpectation of reward modulates cognitive signals in the basal ganglia
Kawagoe, R., Takikawa, Y., & Hikosaka, O. (1998) · Nature Neuroscience · doi:10.1038/1625 · Cited by 643
Variations in the Sensitivity of Instrumental Responding to Reinforcer Devaluation
Adams, C. D. (1982) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/14640748208400878 · Cited by 635
Liu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580 · cited 1×
“The NAS is an integral part of the pair bonding circuitry and is the site where oxytocin, CRF, and dopamine act to modulate partner preference formation (Young et al, 2005); the CP is an anatomically adjacent region of striatum that is involved in goal-directed behavior and habit formation (Balleine and O’Doherty, 201…”
BackgroundMoine, C. L., & Bloch, B. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903550308 · Cited by 576
Molecular Mechanisms of Drug Reinforcement and Addiction
Self, D. W., & Nestler, E. J. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.002335 · Cited by 571
Endogenous opioids and social behavior
Panksepp, J., Herman, B. H., Vilberg, T., Bishop, P., & DeEskinazi, F. G. (1980) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(80)90036-6 · Cited by 531
Insel, T. R., & Hulihan, T. J. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.782 · Cited by 528
Cellular Mechanisms of Social Attachment
Young, L. J., Lim, M. M., Gingrich, B., & Insel, T. R. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1691 · Cited by 523
Self-citationWilliams, J. R., Insel, T. R., Harbaugh, C. R., & Carter, C. S. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00579.x · Cited by 483
The biology of social attachments: opiates alleviate separation distress.
Panksepp, J., Herman, B., Conner, R., Bishop, P., & Scott, J. P. (1978) · PubMed · Cited by 473
Aragona, B. J., Liu, Y., Yu, Y. J., Curtis, J. T., Detwiler, J. M., Insel, T. R., & Wang, Z. (2006) · Nature Neuroscience · doi:10.1038/nn1613 · Cited by 473
Cloning and pharmacological characterization of a rat μ opioid receptor
Thompson, R. C., Mansour, A., Akil, H., & Watson, S. J. (1993) · Neuron · doi:10.1016/0896-6273(93)90120-g · Cited by 451
Deficit in Attachment Behavior in Mice Lacking the µ-Opioid Receptor Gene
Moles, A., Kieffer, B. L., & D'Amato, F. R. (2004) · Science · doi:10.1126/science.1095943 · Cited by 449
Peciña, S., & Berridge, K. C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02102-8 · Cited by 405
The neurobiology of pair bonding: Insights from a socially monogamous rodent
Young, K. A., Gobrogge, K. L., Liu, Y., & Wang, Z. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.006 · Cited by 389
Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior
Steiner, H., & Gerfen, C. R. (1998) · Experimental Brain Research · doi:10.1007/s002210050545 · Cited by 365
A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles
Aragona, B. J., Liu, Y., Curtis, J. T., Stephan, F. K., & Wang, Z. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03483.2003 · Cited by 351
Gingrich, B., Liu, Y., Cascio, C., Wang, Z., & Insel, T. R. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.173 · Cited by 339
An fMRI study of reward-related probability learning
Delgado, M. R., Miller, M. M., Inati, S., & Phelps, E. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.002 · Cited by 337
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 296
Self-citationPitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07392.2001 · Cited by 295
Self-citationOlazábal, D. E., & Young, L. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.017 · Cited by 289
Self-citationThe prairie vole: An emerging model organism for understanding the social brain
McGraw, L. A., & Young, L. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.006 · Cited by 276
Self-citationReinforcing properties of ejaculation in the male rat: Role of opioids and dopamine.
Ågmo, A., & Berenfeld, R. (1990) · Behavioral Neuroscience · doi:10.1037//0735-7044.104.1.177 · Cited by 236
Reinforcing properties of ejaculation in the male rat: Role of opioids and dopamine.
Ågmo, A., & Berenfeld, R. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.1.177 · Cited by 211
Sharif, N. A., & Hughes, J. W. (1989) · Peptides · doi:10.1016/0196-9781(89)90135-6 · Cited by 210
Autoradiographic tracing of nucleus accumbens efferents in the rat
Conrad, L. C. A., & Pfaff, D. W. (1976) · Brain Research · doi:10.1016/0006-8993(76)90060-3 · Cited by 200
Dickinson, A. (1994) · Animal Learning and Cognition · doi:10.1016/b978-0-08-057169-0.50009-7 · Cited by 200
Stefanacci, L., SUZUKI, W. A., & Amaral, D. G. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961125)375:4 · Cited by 192
Variation at the mu-opioid receptor gene ( OPRM1 ) influences attachment behavior in infant primates
Barr, C. S., Schwandt, M. L., Lindell, S. G., Higley, J. D., Maestripieri, D., Goldman, D., Suomi, S. J., & Heilig, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710225105 · Cited by 191
Pelton, J. T., Kazmierski, W. M., Gulya, K., Yamamura, H. I., & Hruby, V. J. (1986) · Journal of Medicinal Chemistry · doi:10.1021/jm00161a037 · Cited by 187
Averitt, D. L., Wang, X., & Murphy, A. Z. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4123-08.2008 · Cited by 177
Self-citationOpiates and play dominance in juvenile rats.
Panksepp, J., Jalowiec, J. E., DeEskinazi, F. G., & Bishop, P. (1985) · Behavioral Neuroscience · doi:10.1037//0735-7044.99.3.441 · Cited by 167
Opiates and play dominance in juvenile rats.
Panksepp, J., Jalowiec, J., DeEskinazi, F. G., & Bishop, P. (1985) · Behavioral Neuroscience · doi:10.1037/0735-7044.99.3.441 · Cited by 167
Understanding how opioids contribute to reward and analgesia
Fields, H. L. (2007) · Regional Anesthesia and Pain Medicine · doi:10.1097/00115550-200705000-00012 · Cited by 166
Anatomy and neurochemistry of the pair bond
Young, L. J., Murphy Young, A. Z., & Hammock, E. A. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20771 · Cited by 163
Self-citationCompartmental origins of striatal efferent projections in the cat
Jiménez-Castellanos, J., & Graybiel, A. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90080-8 · Cited by 155
Tang, X., McFarland, K., Cagle, S., & Kalivas, P. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0685-05.2005 · Cited by 148
Brain opioids and mother—infant social motivation
Panksepp, J., Nelson, E., & Siviy, S. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13264.x · Cited by 133
Selective effects of naltrexone on food pleasantness and intake
Yeomans, M. R., & Gray, R. W. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)80017-5 · Cited by 133
Spatial organization of patch and matrix compartments in the rat striatum
Desban, M., Kemel, M. L., Glowinski, J., & Gauchy, C. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90013-6 · Cited by 126
Dopamine regulation of social choice in a monogamous rodent species
Aragona, B. J. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.015.2009 · Cited by 119 · cited 1×
“The roles of oxytocin, vasopressin, dopamine, and CRF in social cognition have been explored using the partner preference test (PPT) as a laboratory proxy for pair bond formation (Lim et al, 2004, 2007; Curtis et al, 2006; Aragona and Wang, 2009; Ross and Young, 2009).”
MethodAhern, T. H., Hammock, E. A. D., & Young, L. J. (2011) · Developmental Psychobiology · doi:10.1002/dev.20498 · Cited by 113
Self-citationMartel, F. L., Nevison, C. M., Simpson, M. J. A., & Keverne, E. B. (1995) · Developmental Psychobiology · doi:10.1002/dev.420280202 · Cited by 111
The pharmacological treatment of opioid addiction—a clinical perspective
Lobmaier, P. P. K., Gossop, M., Waal, H., & Bramness, J. G. (2010) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-010-0793-6 · Cited by 111
CRF receptors in the nucleus accumbens modulate partner preference in prairie voles
Lim, M. M., Liu, Y., Ryabinin, A. E., Bai, Y., Wang, Z., & Young, L. J. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.01.006 · Cited by 99
Self-citationOmission Learning after Instrumental Pretraining
Dickinson, A. (2010) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/713932679 · Cited by 88
Naloxone fails to produce conditioned place aversion in μ-opioid receptor knock-out mice
Skoubis, P. D., Matthes, H. W. D., Walwyn, W. M., Kieffer, B. L., & Maidment, N. T. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00333-5 · Cited by 86
The Role of Vasopressin in the Genetic and Neural Regulation of Monogamy
Lim, M. M., Hammock, E. A. D., & Young, L. J. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01162.x · Cited by 84
Self-citationGiraudo, S. Q., Billington, C. J., & Levine, A. S. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01140-2 · Cited by 84
Characterization of the Murine μ Opioid Receptor Gene
Kaufman, D. L., Keith, D. E., Antón, B., Tian, J., Magendzo, K., Newman, D., Tran, T. H., Lee, D. S., Wen, C. H., Xia, Y.-R., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15877 · Cited by 83
Maternal behaviour in sheep and its neuroendocrine regulation
Keverne, B., & Kendrick, K. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13265.x · Cited by 82
Evaluation of two automated metrics for analyzing partner preference tests
Ahern, T. H., Modi, M. E., Burkett, J. P., & Young, L. J. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.06.010 · Cited by 82
Self-citationMacDonald, A. F., Billington, C. J., & Levine, A. S. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00271.2003 · Cited by 80
Abbruscato, T. J., Thomas, S. A., Hruby, V. J., & Davis, T. P. (1997) · PubMed · Cited by 77
Opioid receptor blockade reduces maternal affect and social grooming in rhesus monkeys
Martel, F. L., Nevison, C. M., Rayment, F. D., Simpson, M. J. A., & Keverne, E. B. (1993) · Psychoneuroendocrinology · doi:10.1016/0306-4530(93)90027-i · Cited by 75
Curtis, J. T., Liu, Y., Aragona, B. J., & Wang, Z. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.126 · Cited by 74
van Domburg, P. H., & ten Donkelaar, H. J. (1991) · PubMed · Cited by 72
Donaldson, Z. R., Spiegel, L., & Young, L. J. (2010) · Behavioral Neuroscience · doi:10.1037/a0018094 · Cited by 71
Self-citationThe Human Substantia Nigra and Ventral Tegmental Area
van Domburg, P. H. M. F., & ten Donkelaar, H. J. (1991) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-75846-1_4 · Cited by 69
Parker, L. A., & Rennie, M. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90373-n · Cited by 61
Fez1 is layer‐specifically expressed in the adult mouse neocortex
Inoue, K., Terashima, T., Nishikawa, T., & Takumi, T. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03763.x · Cited by 59
Self-citationBiological Contribution to Social Influences on Alcohol Drinking: Evidence from Animal Models
Anacker, A. M. J., & Ryabinin, A. E. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7020473 · Cited by 59
van Domburg, P. H. M. F., & ten Donkelaar, H. J. (1991) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-75846-1_1 · Cited by 54
Kendrick, K. M., & Keverne, E. B. (1989) · Brain Research · doi:10.1016/0006-8993(89)91462-5 · Cited by 49
Abbruscato, T. J., Thomas, S. A., Hruby, V. J., & Davis, T. P. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36405-5 · Cited by 45
Emerging drugs to treat alcoholism
Soyka, M., & Rösner, S. (2010) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2010.500811 · Cited by 42
The Nucleus Accumbens Core and Shell: Accumbal Compartments and Their Functional Attributes
Deutch, A. Y., Bourdelais, A. J., & Zahm, D. S. (2019) · CRC Press eBooks · doi:10.1201/9780429274411-2 · Cited by 42
Affiliative behavior in voles: Effects of morphine, naloxone, and cross-fostering
Shapiro, L. E., Meyer, M. E., & Dewsbury, D. A. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90357-0 · Cited by 37
Opioid receptor function in social attachment in young domestic fowl
Warnick, J. E., McCurdy, C. R., & Sufka, K. J. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.12.009 · Cited by 35
Comparative distribution of opiate agonists and antagonists by means of double isotope techniques
Fishman, J., Hahn, E. F., & Norton, B. I. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90333-1 · Cited by 16
Emerging therapies for fibromyalgia: an update
Ablin, J. N., & Buskila, D. (2010) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2010.491509 · Cited by 15
Bhargava, H. N., Rahmani, N. H., Villar, V. M., & Larsen, K. (2008) · Pharmacology · doi:10.1159/000139030 · Cited by 13
Fluid consumption in water-deprived rats after administration of naloxone or quaternary naloxone
Turkish, S., & Cooper, S. J. (1983) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(83)90078-7 · Cited by 6
Cited by
Sorted by citations
Oxytocin pathways and the evolution of human behavior
Carter, C. S. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115110 · Cited by 714
Oxytocin-dependent consolation behavior in rodents
Burkett, J. P., Andari, E., Johnson, Z. V., Curry, D. C., de Waal, F. B. M., & Young, L. J. (2016) · Science · doi:10.1126/science.aac4785 · Cited by 692
Self-citationThe neural mechanisms and circuitry of the pair bond
Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353
Self-citationDunbar, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.10.004 · Cited by 419
The role of the striatum in social behavior
Báez-Mendoza, R., & Schultz, W. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00233 · Cited by 312
Metadata
- Authors
- Burkett, J. P., Spiegel, L. L., Inoue, K., Murphy, A. Z., & Young, L. J.
- Affiliations
- Emory University (US)
- Georgia State University (US)
- Corresponding author
- Young, Larry J
- Venue
- Neuropsychopharmacology
- Published
- 2011-07-06
- Volume
- 36
- Issue
- 11
- Pages
- 2200-2210
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3176565
- OpenAlex
- W2140104467
- Cited by
- 133
- References
- 87
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 12 · 2016: 18 · 2015: 11 · 2014: 9 · 2013: 15 · 2012: 7
- FWCI
- 13.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P51OD011132)
- U.S. Public Health Service (077776)
- Yerkes National Primate Research Center, Emory University
- National Institute of Mental Health (MH-64692, K02MH064692)
- National Center for Research Resources (RR-0165, P51RR000165)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- mu-opioid receptor, Microtus ochrogaster, social attachment, mate preferences, dorsal striatum, caudate-putamen, nucleus accumbens shell, naltrexone, CTAP, opioid antagonists, social bonding, monogamy
- MeSH terms
- Age Factors, Animals, Corpus Striatum, Arvicolinae, Female, Male, Microinjections, Naltrexone, Pair Bond, Sexual Behavior, Animal, Social Behavior, Receptors, Opioid, mu, Opioid Peptides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
