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Specialized ribosomes: a new frontier in gene regulation and organismal biology

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Xue, Shifeng, Barna, Maria·2012·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm3359
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Abstract

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than intrinsic regulatory capacity in mRNA translation. However, emerging studies reveal that ribosome activity may be highly regulated. Heterogeneity in ribosome composition resulting from differential expression and post-translational modifications of ribosomal proteins, ribosomal RNA (rRNA) diversity and the activity of ribosome-associated factors may generate 'specialized ribosomes' that have a substantial impact on how the genomic template is translated into functional proteins. Moreover, constitutive components of the ribosome may also exert more specialized activities by virtue of their interactions with specific mRNA regulatory elements such as internal ribosome entry sites (IRESs) or upstream open reading frames (uORFs). Here we discuss the hypothesis that intrinsic regulation by the ribosome acts to selectively translate subsets of mRNAs harbouring unique cis-regulatory elements, thereby introducing an additional level of regulation in gene expression and the life of an organism.

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Cited by

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Metadata

Authors
Xue, S., & Barna, M.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2012-05-23
Volume
13
Issue
6
Pages
355-369
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm3359
OpenAlex
W2056032938
Cited by
703
References
9
FWCI
3.07
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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This page
CoChat. (2026). Citation check: Specialized ribosomes: a new frontier in gene regulation and organismal biology. https://app.cochat.ai/papers/10.1038/nrm3359
The paper
Xue, S., & Barna, M. (2012). Specialized ribosomes: a new frontier in gene regulation and organismal biology. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm3359

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.