Cited by 1,790Gut microbiota and healthOral microbiology and periodontitis researchBacterial biofilms and quorum sensing

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The keystone-pathogen hypothesis

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Hajishengallis, George, Darveau, Richard P., Curtis, Michael A.·2012·Nature Reviews Microbiology

DOI 10.1038/nrmicro2873PMC PMC3498498

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Abstract

Recent studies have highlighted the importance of the human microbiome in health and disease. However, for the most part the mechanisms by which the microbiome mediates disease, or protection from it, remain poorly understood. The keystone-pathogen hypothesis holds that certain low-abundance microbial pathogens can orchestrate inflammatory disease by remodelling a normally benign microbiota into a dysbiotic one. In this Opinion article, we critically assess the available literature that supports this hypothesis, which may provide a novel conceptual basis for the development of targeted diagnostics and treatments for complex dysbiotic diseases.

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Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
Self-citation
Keystone taxa as drivers of microbiome structure and functioning
Banerjee, S., Schlaeppi, K., & van der Heijden, M. G. A. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0024-1 · Cited by 3,148
The gut microbiota and host health: a new clinical frontier
Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., Quraishi, M. N., Kinross, J., Smidt, H., Tuohy, K. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309990 · Cited by 2,302
“The keystone-pathogen hypothesis 88 and the α -bug hypothesis both state that certain, low abundance microbiota members (such as enterotoxigenic B. fragilis ) possess unique virulence traits, which are pro-oncogenic and remodel the microbiome and in turn promote mucosal immune responses and colonic…”
Background
The Oral Microbiota: Dynamic Communities and Host Interactions
Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217
Self-citation
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256

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Authors: Hajishengallis, G., Darveau, R. P., & Curtis, M. A.
Affiliations: University of Pennsylvania (US)
University of Washington (US)
Queen Mary University of London (GB)
Corresponding author: Hajishengallis, George
ORCID: Hajishengallis, George
Darveau, Richard P.
Curtis, Michael A.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2012-09-03
Volume: 10
Issue: 10
Pages: 717-725
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro2873
PMC: PMC3498498
OpenAlex: W2043248182
Cited by: 1,790
References: 86
Citations by year: 2026: 163 · 2025: 149 · 2024: 146 · 2023: 172 · 2022: 146 · 2021: 199 · 2020: 167 · 2019: 125 · 2018: 116 · 2017: 101 · 2016: 100 · 2015: 77 · 2014: 63 · 2013: 58 · 2012: 4
FWCI: 5.89
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Medical Research Council (MR/J011118/1)
National Institute of Dental and Craniofacial Research (R01DE018292, DE-015254, R01DE015254, DE012768, DE021580, DE18274, DE021685, R01DE018274, DE018292, RC4DE021580, R01DE021685, R01DE012768)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: human microbiome, dysbiosis, commensal microbiota, inflammatory diseases, targeted therapeutics
MeSH terms: Bacteria, Colonic Neoplasms, Humans, Inflammation, Models, Biological, Periodontitis, Inflammatory Bowel Diseases, Host-Pathogen Interactions, Metagenome, Microbial Interactions

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