Molecular motors and mechanisms of directional transport in neurons

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993 · cited 1×

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory

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Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

De Strooper, B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00205-8 · Cited by 965

Reelin Is a Ligand for Lipoprotein Receptors

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Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria

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Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

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A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain

Butz, S., Okamoto, M., & Südhof, T. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81736-5 · Cited by 548

Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration

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Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity.

Nishimura, T., Kato, K., Yamaguchi, T., Fukata, Y., Ohno, S., & Kaibuchi, K. (2004) · Nature Cell Biology · doi:10.1038/ncb1118 · Cited by 289

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Kinesin superfamily motor proteins and intracellular transport

Hirokawa, N., Noda, Y., Tanaka, Y., & Niwa, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2774 · Cited by 1,859

NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

Lau, C. G., & Zukin, R. S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2153 · Cited by 1,159

The cell biology of synaptic plasticity: AMPA receptor trafficking

Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978

Microtubule Acetylation Promotes Kinesin-1 Binding and Transport

Reed, N. A., Cai, D., Blasius, T. L., Jih, G. T., Meyhofer, E., Gaertig, J., & Verhey, K. J. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.014 · Cited by 919

Axon degeneration mechanisms: Commonality amid diversity

Coleman, M. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1788 · Cited by 819

The axonal transport of mitochondria

Hollenbeck, P. J., & Saxton, W. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02745 · Cited by 771

Animal models of Alzheimer's disease and frontotemporal dementia

Götz, J., & Ittner, L. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2420 · Cited by 676

Neuronal polarity: from extracellular signals to intracellular mechanisms.

Arimura, N., & Kaibuchi, K. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2056 · Cited by 655

Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity

Jaworski, J., Kapitein, L. C., Gouveia, S. M., Dortland, B. R., Wulf, P. S., Grigoriev, I., Camera, P., Spangler, S. A., Di Stefano, P., Demmers, J., et al. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.013 · Cited by 643

Coordinated protein sorting, targeting and distribution in polarized cells

Mellman, I., & Nelson, W. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2525 · Cited by 521

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

Kadavath, H., Hofele, R. V., Biernat, J., Kumar, S., Tepper, K., Urlaub, H., Mandelkow, E., & Zweckstetter, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504081112 · Cited by 524

Establishment of axon-dendrite polarity in developing neurons.

Barnes, A. P., & Polleux, F. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125536 · Cited by 523

Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms

Salinas, S., Proukakis, C., Crosby, A., & Warner, T. T. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70258-8 · Cited by 474

The axon initial segment and the maintenance of neuronal polarity

Rasband, M. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2852 · Cited by 442

ORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY

Kennedy, M. J., & Ehlers, M. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112808 · Cited by 346

Kinesin Motor Mechanics: Binding, Stepping, Tracking, Gating, and Limping

Block, S. M. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.100677 · Cited by 338

A selective filter for cytoplasmic transport at the axon initial segment

Song, A.-H., Wang, D., Chen, G., Li, Y., Luo, J., Duan, S., & Poo, M.-M. (2009) · Cell · doi:10.1016/j.cell.2009.01.016 · Cited by 322

Mixed microtubules steer dynein-driven cargo transport into dendrites

Kapitein, L. C., Schlager, M. A., Kuijpers, M., Wulf, P. S., van Spronsen, M., MacKintosh, F. C., & Hoogenraad, C. C. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.052 · Cited by 320

Induction of Autophagy in Axonal Dystrophy and Degeneration

Wang, Q. J., Ding, Y., Kohtz, S., Mizushima, N., Cristea, I. M., Rout, M. P., Chait, B. T., Zhong, Y., Heintz, N., & Yue, Z. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2261-06.2006 · Cited by 308

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

Jeganathan, S., Hascher, A., Chinnathambi, S., Biernat, J., Mandelkow, E.-M., & Mandelkow, E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805300200 · Cited by 278

Mitochondria on the move

Boldogh, I. R., & Pon, L. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.008 · Cited by 270

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

Dunn, S., Morrison, E. E., Liverpool, T. B., Molina-París, C., Cross, R. A., Alonso, M. C., & Peckham, M. (2008) · Journal of Cell Science · doi:10.1242/jcs.026492 · Cited by 242

Snapin-Regulated Late Endosomal Transport Is Critical for Efficient Autophagy-Lysosomal Function in Neurons

Cai, Q., Lu, L., Tian, J.-H., Zhu, Y.-B., Qiao, H., & Sheng, Z.-H. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.022 · Cited by 233

Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles

Encalada, S. E., Szpankowski, L., Xia, C.-H., & Goldstein, L. S. B. (2011) · Cell · doi:10.1016/j.cell.2011.01.021 · Cited by 206

Anterograde Transport of TrkB in Axons Is Mediated by Direct Interaction with Slp1 and Rab27

Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., Shimada, A., Ménager, C., Kawabata, S., Fujii, K., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.03.005 · Cited by 192

Control of neuronal polarity and plasticity – a renaissance for microtubules?

Hoogenraad, C. C., & Bradke, F. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.08.006 · Cited by 173

How kinesin waits between steps

Mori, T., Vale, R. D., & Tomishige, M. (2007) · Nature · doi:10.1038/nature06346 · Cited by 171

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis

Schlager, M. A., Kapitein, L. C., Grigoriev, I., Burzynski, G. M., Wulf, P. S., Keijzer, N., de Graaff, E., Fukuda, M., Shepherd, I. T., Akhmanova, A., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.51 · Cited by 165

Preferential binding of a kinesin-1 motor to GTP-tubulin–rich microtubules underlies polarized vesicle transport

Nakata, T., Niwa, S., Okada, Y., Perez, F., & Hirokawa, N. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201104034 · Cited by 156

Folding of the Tau Protein on Microtubules

Kadavath, H., Jaremko, M., Jaremko, Ł., Biernat, J., Mandelkow, E., & Zweckstetter, M. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201501714 · Cited by 153

Involvement of myosin Vb in glutamate receptor trafficking

Lisé, M.-F., Wong, T. P., Trinh, A., Hines, R. M., Liu, L., Kang, R., Hines, D. J., Lu, J., Goldenring, J. R., Wang, Y. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511725200 · Cited by 123

Functional coordination of alternative splicing in the mammalian central nervous system

Fagnani, M., Barash, Y., Ip, J. Y., Misquitta, C., Pan, Q., Saltzman, A. L., Shai, O., Lee, L., Rozenhek, A., Mohammad, N., et al. (2007) · Genome Biology · doi:10.1186/gb-2007-8-6-r108 · Cited by 120

Acetylated Microtubules Are Preferentially Bundled Leading to Enhanced Kinesin-1 Motility

Balabanian, L., Berger, C. L., & Hendricks, A. G. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2017.08.009 · Cited by 103

SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects

Lepagnol-Bestel, A.-M., Maussion, G., Boda, B., Cardona, A., Iwayama, Y., Delezoide, A.-L., Moalic, J.-M., Muller, D., Dean, B., Yoshikawa, T., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002120 · Cited by 93

A secretagogin locus of the mammalian hypothalamus controls stress hormone release

Romanov, R. A., Alpár, A., Zhang, M., Zeisel, A., Calas, A., Landry, M., Fuszard, M., Shirran, S. L., Schnell, R., Dobolyi, Á., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201488977 · Cited by 85

Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila

Reis, G. F., Yang, G., Szpankowski, L., Weaver, C., Shah, S. B., Robinson, J. T., Hays, T. S., Danuser, G., & Goldstein, L. S. B. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-11-0938 · Cited by 80

The advantage of channeling nucleotides for very processive functions

Zala, D., Schlattner, U., Desvignes, T., Bobe, J., Roux, A., Chavrier, P., & Boissan, M. (2017) · F1000Research · doi:10.12688/f1000research.11561.2 · Cited by 79

Role of MAP1B in axonal retrograde transport of mitochondria

Jiménez-Mateos, E.-M., González-Billault, C., Dawson, H. N., Vitek, M. P., & Avila, J. (2006) · Biochemical Journal · doi:10.1042/bj20060205 · Cited by 70

Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions

Toh, W. H., & Gleeson, P. A. (2016) · Biochemical Journal · doi:10.1042/bcj20160147 · Cited by 62

Axonopathy in Huntington's disease

Li, J.-Y., & Conforti, L. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2012.08.010 · Cited by 55

Molecular mechanisms of synaptogenesis

Qi, C., Luo, L.-D., Feng, I., & Ma, S. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.939793 · Cited by 54

Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle

Giovarelli, M., Zecchini, S., Martini, E., Garrè, M., Barozzi, S., Ripolone, M., Napoli, L., Coazzoli, M., Vantaggiato, C., Roux-Biejat, P., et al. (2020) · Cell Death & Differentiation · doi:10.1038/s41418-020-0510-7 · Cited by 41

The Pathophysiology of Axonal Transport in Alzheimer's Disease

Vicario-Orri, E., Opazo, C. M., & Muñoz, F. J. (2014) · Journal of Alzheimer’s Disease · doi:10.3233/jad-141080 · Cited by 41

Genetic disruption of tubulin acetyltransferase, αTAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/β-catenin signaling

Oh, S., You, E., Ko, P., Jeong, J., Keum, S., & Rhee, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.039 · Cited by 41

Tau; One Protein, So Many Diseases

Tabeshmehr, P., & Eftekharpour, E. (2023) · Biology · doi:10.3390/biology12020244 · Cited by 33

A multiscale approach reveals the molecular architecture of the autoinhibited kinesin KIF5A

Carrington, G., Fatima, U., Caramujo, I., Lewis, T., Casas-Mao, D., & Peckham, M. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.105713 · Cited by 26

Tau differentially regulates the transport of early endosomes and lysosomes

Balabanian, L., Lessard, D. V., Swaminathan, K., Yaninska, P., Sébastien, M., Wang, S., Stevens, P. W., Wiseman, P. W., Berger, C. L., & Hendricks, A. G. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-01-0018 · Cited by 26

Global and local mechanisms sustain axonal proteostasis of transmembrane proteins

Cornejo, V. H., Luarte, A., & Couve, A. (2017) · Traffic · doi:10.1111/tra.12472 · Cited by 19

Molecular organization and assembly of the postsynaptic density of excitatory brain synapses.

Kim, E., & Ko, J. (2006) · Results and Problems in Cell Differentiation · doi:10.1007/400_011 · Cited by 11

Protein trafficking and synaptic demand configure complex and dynamic synaptome architectures of individual neurons

Sorokina, O., Bulovaite, E., Sorokin, A., Grant, S. G. N., & Armstrong, J. D. (2026) · Scientific Reports · doi:10.1038/s41598-026-40513-7 · Cited by 2