Is there more to gaba than synaptic inhibition?

Excitatory actions of gaba during development: the nature of the nurture

Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448

Two genes encode distinct glutamate decarboxylases

Erlander, M. G., Tillakaratne, N. J. K., Feldblum, S., Patel, N., & Tobin, A. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90077-d · Cited by 1,213

Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study

Colonnier, M. (1968) · Brain Research · doi:10.1016/0006-8993(68)90234-5 · Cited by 946

Long-term potentiation and functional synapse induction in developing hippocampus

Durand, G. M., Kovalchuk, Y., & Konnerth, A. (1996) · Nature · doi:10.1038/381071a0 · Cited by 789

Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters

Yuste, R., & Katz, L. C. (1991) · Neuron · doi:10.1016/0896-6273(91)90243-s · Cited by 591

Ca2+ Oscillations Mediated by the Synergistic Excitatory Actions of GABAA and NMDA Receptors in the Neonatal Hippocampus

Leinekugel, X., Medina, I., Khalilov, I., Ben-Ari, Y., & Khazipov, R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80265-2 · Cited by 407

New evidence for neurotransmitter influences on brain development

Levitt, P., Harvey, J. A., Friedman, E., Simansky, K., & Murphy, E. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01028-4 · Cited by 362

GABA receptor antagonists modulate postmitotic cell migration in slice cultures of embryonic rat cortex

Behar, T. N. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.9.899 · Cited by 218

Excitatory actions of gaba during development: the nature of the nurture

Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448

Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081

GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations

Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304

The genetics of autism

Muhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207

Neurosteroids: endogenous regulators of the GABAA receptor

Belelli, D., & Lambert, J. J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1703 · Cited by 1,159

The origin and specification of cortical interneurons

Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980

Mechanisms underlying spontaneous patterned activity in developing neural circuits

Blankenship, A. G., & Feller, M. B. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2759 · Cited by 851

Origins of Cortical Interneuron Subtypes

Xu, Q., Cobos, I., De La Cruz, E., Rubenstein, J. L., & Anderson, S. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5667-03.2004 · Cited by 639

Cl− uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1

Yamada, J., Okabe, A., Toyoda, H., Kilb, W., Luhmann, H. J., & Fukuda, A. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.062471 · Cited by 572

Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex

Cruikshank, S. J., Lewis, T. J., & Connors, B. W. (2007) · Nature Neuroscience · doi:10.1038/nn1861 · Cited by 558

Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction

Goldberg, E. M., & Coulter, D. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3482 · Cited by 542

Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery

Tyzio, R., Cossart, R., Khalilov, I., Minlebaev, M., Hübner, C. A., Represa, A., Ben-Ari, Y., & Khazipov, R. (2006) · Science · doi:10.1126/science.1133212 · Cited by 485

Two developmental switches in GABAergic signalling: the K+–Cl− cotransporter KCC2 and carbonic anhydrase CAVII

Rivera, C., Voipio, J., & Kaila, K. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.077495 · Cited by 428

Prefrontal Cortex, Thalamus, and Cerebellar Volumes in Adolescents and Young Adults with Adolescent-Onset Alcohol Use Disorders and Comorbid Mental Disorders

Bellis, M. D., Narasimhan, A., Thatcher, D. L., Keshavan, M. S., Soloff, P., & Clark, D. B. (2005) · Alcoholism: Clinical and Experimental Research · doi:10.1097/01.alc.0000179368.87886.76 · Cited by 424

Excitatory GABA Action Is Essential for Morphological Maturation of Cortical Neurons In Vivo

Cancedda, L., Fiumelli, H., Chen, K., & Poo, M.-M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5169-06.2007 · Cited by 392

KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent Manner

Bortone, D., & Polleux, F. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.034 · Cited by 387

A shared vesicular carrier allows synaptic corelease of GABA and glycine

Wojcik, S. M., Katsurabayashi, S., Guillemin, I., Friauf, E., Rosenmund, C., Brose, N., & Rhee, J.-S. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.016 · Cited by 374

Activation of GABAA Receptors: Views from Outside the Synaptic Cleft

Glykys, J., & Mody, I. (2007) · Neuron · doi:10.1016/j.neuron.2007.11.002 · Cited by 358

Barrel cortex function

Feldmeyer, D., Brecht, M., Helmchen, F., Petersen, C. C. H., Poulet, J. F. A., Staiger, J. F., Luhmann, H. J., & Schwarz, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.11.002 · Cited by 354

Defining the role of GABA in cortical development

Wang, D. D., & Kriegstein, A. R. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.167635 · Cited by 336

GABA Regulates Excitatory Synapse Formation in the Neocortex via NMDA Receptor Activation

Wang, D. D., & Kriegstein, A. R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5599-07.2008 · Cited by 299

A Blueprint for the Spatiotemporal Origins of Mouse Hippocampal Interneuron Diversity

Tricoire, L., Pelkey, K. A., Erkkila, B. E., Jeffries, B. W., Yuan, X., & McBain, C. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-11.2011 · Cited by 292

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

Li, G., Bien-Ly, N., Andrews-Zwilling, Y., Xu, Q., Bernardo, A., Ring, K., Halabisky, B., Deng, C., Mahley, R. W., & Huang, Y. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.10.015 · Cited by 288

The Neurochemistry of Autism

Marotta, R., Risoleo, M. C., Messina, G., Parisi, L., Carotenuto, M., Vetri, L., & Roccella, M. (2020) · Brain Sciences · doi:10.3390/brainsci10030163 · Cited by 279

Early somatostatin interneuron connectivity mediates the maturation of deep layer cortical circuits

Tuncdemir, S. N., Wamsley, B., Stam, F. J., Osakada, F., Goulding, M., Callaway, E. M., Rudy, B., & Fishell, G. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.020 · Cited by 224

GABAergic Interneuron Lineages Selectively Sort into Specific Cortical Layers during Early Postnatal Development

Miyoshi, G., & Fishell, G. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq155 · Cited by 230

The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampus

Rao, M. S., Hattiangady, B., & Shetty, A. K. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00243.x · Cited by 241

Postnatal phenotype and localization of spinal cord V1 derived interneurons

Alvarez, F. J., Jonas, P. C., Sapir, T., Hartley, R., Berrocal, M. C., Geiman, E. J., Todd, A. J., & Goulding, M. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20711 · Cited by 243

Ion channels and signaling in the pituitary gland

Stojilkovic, S. S., Tabak, J., & Bertram, R. (2010) · Endocrine Reviews · doi:10.1210/er.2010-0005 · Cited by 229

Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain

Hörtnagl, H., Tasan, R. O., Wieselthaler, A., Kirchmair, E., Sieghart, W., & Sperk, G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.008 · Cited by 229

Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer’s Disease.

Sun, B., Halabisky, B., Zhou, Y., Palop, J. J., Yu, G., Mucke, L., & Gan, L. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.10.003 · Cited by 205

Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications

Nimgampalle, M., Chakravarthy, H., Sharma, S., Shree, S., Bhat, A. R., Pradeepkiran, J. A., & Devanathan, V. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101994 · Cited by 207

Depolarizing GABA Acts on Intrinsically Bursting Pyramidal Neurons to Drive Giant Depolarizing Potentials in the Immature Hippocampus

Sipilä, S. T., Huttu, K., Soltesz, I., Voipio, J., & Kaila, K. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0378-05.2005 · Cited by 190

Development of the GABAergic System from Birth to Adolescence

Kilb, W. (2012) · The Neuroscientist · doi:10.1177/1073858411422114 · Cited by 190

GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis

Purwana, I., Zheng, J., Li, X., Deurloo, M., Son, D. O., Zhang, Z., Liang, C., Shen, E., Tadkase, A., Feng, Z.-P., et al. (2014) · Diabetes · doi:10.2337/db14-0153 · Cited by 183

Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex

Daw, M. I., Ashby, M. C., & Isaac, J. T. R. (2007) · Nature Neuroscience · doi:10.1038/nn1866 · Cited by 174

Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression

Amar, D., Safer, H., & Shamir, R. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002955 · Cited by 169

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

Oliva, C. A., Vargas, J. Y., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00224 · Cited by 162

Long-range GABAergic inputs regulate neural stem cell quiescence and control adult hippocampal neurogenesis

Bao, H., Asrican, B., Li, W., Gu, B., Wen, Z., Lim, S.-A., Haniff, I., Ramakrishnan, C., Deisseroth, K., Philpot, B., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.10.003 · Cited by 151

Blocking Early GABA Depolarization with Bumetanide Results in Permanent Alterations in Cortical Circuits and Sensorimotor Gating Deficits

Wang, D. D., & Kriegstein, A. R. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq124 · Cited by 148

Posttraumatic GABAA-Mediated [Ca2+]i Increase Is Essential for the Induction of Brain-Derived Neurotrophic Factor-Dependent Survival of Mature Central Neurons

Shulga, A., Thomas-Crusells, J., Sigl, T., Blaesse, A., Mestres, P., Meyer, M., Yan, Q., Kaila, K., Saarma, M., Rivera, C., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5268-07.2008 · Cited by 137

Dopamine Receptor Activation Modulates GABA Neuron Migration from the Basal Forebrain to the Cerebral Cortex

Crandall, J. E., McCarthy, D. M., Araki, K. Y., Sims, J. R., Ren, J.-Q., & Bhide, P. G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5124-06.2007 · Cited by 134

Oxytocin modulation of neural circuits for social behavior

Marlin, B. J., & Froemke, R. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22452 · Cited by 130

Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders

Spooren, W., Lindemann, L., Ghosh, A., & Santarelli, L. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.09.004 · Cited by 119

Postnatal development of pre- and postsynaptic GABA markers at chandelier cell connections with pyramidal neurons in monkey prefrontal cortex

Cruz, D. A., Eggan, S. M., & Lewis, D. A. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10833 · Cited by 118

GABAergic system in the endocrine pancreas: a new target for diabetes treatment

Wang, Q., Prud'homme, G., & Wan, Y. (2015) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s50642 · Cited by 100

Chapter 2 Hypothalamic Neural Systems Controlling the Female Reproductive Life Cycle

(2009) · International Review of Cell and Molecular Biology · doi:10.1016/s1937-6448(08)02002-9 · Cited by 93

Effects of oxytocin on GABA signalling in the foetal brain during delivery

KHAZIPOV, R., TYZIO, R., & BENARI, Y. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00421-4 · Cited by 77

Development of Thalamocortical Connections between the Mediodorsal Thalamus and the Prefrontal Cortex and Its Implication in Cognition

Ferguson, B. R., & Gao, W.-J. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.01027 · Cited by 75

Developmental synaptic plasticity at the thalamocortical input to barrel cortex: Mechanisms and roles

Daw, M. I., Scott, H. L., & Isaac, J. T. R. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.001 · Cited by 70

Delayed maturation of fast-spiking interneurons is rectified by activation of the TrkB receptor in the mouse model of fragile X syndrome.

Nomura, T., Musial, T. F., Marshall, J. J., Zhu, Y., Remmers, C. L., Xu, J., Nicholson, D. A., & Contractor, A. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2893-16.2017 · Cited by 64

GABA Actions in Hippocampal Area CA3 During Postnatal Development: Differential Shift From Depolarizing to Hyperpolarizing in Somatic and Dendritic Compartments

Romo-Parra, H., Treviño, M., Heinemann, U., & Gutiérrez, R. (2008) · Journal of Neurophysiology · doi:10.1152/jn.01074.2007 · Cited by 52

Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex

Peyre, E., Silva, C. G., & Nguyen, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00129 · Cited by 51

Gamma-aminobutyric acid acts as a specific virulence regulator in Pseudomonas aeruginosa

Dagorn, A., Hillion, M., Chapalain, A., Lesouhaitier, O., Duclairoir Poc, C., Vieillard, J., Chevalier, S., Taupin, L., Le Derf, F., & Feuilloley, M. G. J. (2013) · Microbiology · doi:10.1099/mic.0.061267-0 · Cited by 51

GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons

Maddox, F. N., Valeyev, A. Y., Poth, K., Holohean, A. M., Wood, P. M., Davidoff, R. A., Hackman, J. C., & Luetje, C. W. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.01.001 · Cited by 43

Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development

Jansen, E. E., Struys, E., Jakobs, C., Hager, E., Snead, O. C., & Gibson, K. M. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-112 · Cited by 41

A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise

Methi, A., Islam, M. R., Kaurani, L., Sakib, M. S., Krüger, D. M., Pena, T., Burkhardt, S., Liebetanz, D., & Fischer, A. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03869-9 · Cited by 33

Developing new pharmacotherapies for autism

Ecker, C., Spooren, W., & Murphy, D. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12113 · Cited by 31

Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord

Shimizu-Okabe, C., Kobayashi, S., Kim, J., Kosaka, Y., Sunagawa, M., Okabe, A., & Takayama, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020834 · Cited by 22