Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

Shepherd, J., Cobbe, S. M., Ford, I., Isles, C. G., Lorimer, A. R., Macfarlane, P. W., McKillop, J. H., & Packard, C. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511163332001 · Cited by 7,449

The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

Sacks, F. M., Pfeffer, M. A., Moye, L. A., Rouleau, J. L., Rutherford, J. D., Cole, T. G., Brown, L., Warnica, J. W., Arnold, J. M. O., Wun, C.-C., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351401 · Cited by 7,439

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction: Results of the Survival and Ventricular Enlargement Trial

Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911

A Receptor-Mediated Pathway for Cholesterol Homeostasis

Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703

Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men

Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504

Apoptosis in the Failing Human Heart

Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673

Probucol and Multivitamins in the Prevention of Restenosis after Coronary Angioplasty

Tardif, J.-C., Côté, G., Lespérance, J., Bourassa, M., Lambert, J., Doucet, S., Bilodeau, L., Nattel, S., & de Guise, P. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708073370601 · Cited by 565

Atherosclerosis--an inflammatory disease

Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725

C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women

Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850

Multi-Ethnic Study of Atherosclerosis: Objectives and Design

Bild, D. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf113 · Cited by 3,942

Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study

Lloyd-Jones, D. M., Wang, T. J., Leip, E. P., Larson, M. G., Levy, D., Vasan, R. S., D’Agostino, R. B., Massaro, J. M., Beiser, A., Wolf, P. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000140263.20897.42 · Cited by 2,041

Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality: The Framingham Heart Study

Wang, T. J., Larson, M. G., Levy, D., Vasan, R. S., Leip, E. P., Wolf, P. A., D’Agostino, R. B., Murabito, J. M., Kannel, W. B., & Benjamin, E. J. (2003) · Circulation · doi:10.1161/01.cir.0000072767.89944.6e · Cited by 1,970

The clinical implications of endothelial dysfunction

Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749

Epidemiology of Heart Failure

Roger, V. L. (2013) · Circulation Research · doi:10.1161/circresaha.113.300268 · Cited by 1,728

Rhythm control versus rate control for atrial fibrillation and heart failure

Roy, D., Talajic, M., Nattel, S., Wyse, D. G., Dorian, P., Lee, K. L., Bourassa, M. G., Arnold, J. M. O., Buxton, A. E., Camm, A. J., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708789 · Cited by 1,585

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

Ridker, P. M., Rifai, N., Clearfield, M., Downs, J. R., Weis, S. E., Miles, J. S., & Gotto, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442601 · Cited by 1,557

Prevalence of Conventional Risk Factors in Patients With Coronary Heart Disease

Khot, U. N. (2003) · JAMA · doi:10.1001/jama.290.7.898 · Cited by 1,494

Inflammation as a Cardiovascular Risk Factor

Willerson, J. T., & Ridker, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000129535.04194.38 · Cited by 1,304

Molecular inflammation: Underpinnings of aging and age-related diseases

Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203

Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease: Depression, Inflammation, and Clustering of Metabolic Risk Markers

Danese, A., Moffitt, T. E., Harrington, H., Milne, B. J., Polanczyk, G., Pariante, C. M., Poulton, R., & Caspi, A. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.214 · Cited by 1,165

Association of Atrial Fibrillation and Obstructive Sleep Apnea

Gami, A. S., Pressman, G., Caples, S. M., Kanagala, R., Gard, J. J., Davison, D. E., Malouf, J. F., Ammash, N. M., Friedman, P. A., & Somers, V. K. (2004) · Circulation · doi:10.1161/01.cir.0000136587.68725.8e · Cited by 1,148

Macrophage death and defective inflammation resolution in atherosclerosis

Tabas, I. (2010) · Nature Reviews Immunology · doi:10.1038/nri2675 · Cited by 1,120

Obstructive Sleep Apnea, Obesity, and the Risk of Incident Atrial Fibrillation

Gami, A. S., Hodge, D. O., Herges, R. M., Olson, E. J., Nykodym, J., Kara, T., & Somers, V. K. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.060 · Cited by 1,104

Recent insights into the cellular biology of atherosclerosis

Tabas, I., García-Cardeña, G., & Owens, G. K. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412052 · Cited by 1,016

Inflammatory Markers and Onset of Cardiovascular Events: Results From the Health ABC Study

Cesari, M., Penninx, B. W. J. H., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., Rubin, S. M., Ding, J., Simonsick, E. M., Harris, T. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000097109.90783.fc · Cited by 978

Obstructive Sleep Apnea and the Recurrence of Atrial Fibrillation

Kanagala, R., Murali, N. S., Friedman, P. A., Ammash, N. M., Gersh, B. J., Ballman, K. V., M. Shamsuzzaman, A. S., & Somers, V. K. (2003) · Circulation · doi:10.1161/01.cir.0000068337.25994.21 · Cited by 983

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A., Hoofnagle, A. N., Cheung, M. C., Byun, J., Vuletic, S., Kassim, S., Singh, P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26206 · Cited by 942

Effect of Weight Reduction and Cardiometabolic Risk Factor Management on Symptom Burden and Severity in Patients With Atrial Fibrillation: A Randomized Clinical Trial

Abed, H. S., Wittert, G. A., Leong, D. P., Shirazi, M. G., Bahrami, B., Middeldorp, M. E., Lorimer, M. F., Lau, D. H., Antic, N. A., Brooks, A. G., et al. (2013) · JAMA · doi:10.1001/jama.2013.280521 · Cited by 776

Epidemiology and natural history of atrial fibrillation: clinical implications

Chugh, S. S., Blackshear, J. L., Shen, W.-K., Hammill, S. C., & Gersh, B. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01107-4 · Cited by 768

The pathophysiology of heart failure with preserved ejection fraction

Borlaug, B. A. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.83 · Cited by 726

The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis

Tabas, I. (2010) · Circulation Research · doi:10.1161/circresaha.110.224766 · Cited by 480

Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress

Seimon, T. A., Nadolski, M. J., Liao, X., Magallon, J., Nguyen, M., Feric, N. T., Koschinsky, M. L., Harkewicz, R., Witztum, J. L., Tsimikas, S., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.010 · Cited by 457

Innate immunity and inflammation in ageing: a key for understanding age-related diseases

Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., & Caruso, C. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-8 · Cited by 453

Mortality Trends in Patients Diagnosed With First Atrial Fibrillation

Miyasaka, Y., Barnes, M. E., Bailey, K. R., Cha, S. S., Gersh, B. J., Seward, J. B., & Tsang, T. S. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.062 · Cited by 411

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe −/− Mice

Thorp, E., Cui, D., Schrijvers, D. M., Kuriakose, G., & Tabas, I. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.167197 · Cited by 357

Diabetes in heart failure: prevalence and impact on outcome in the population

From, A. M., Leibson, C. L., Bursi, F., Redfield, M. M., Weston, S. A., Jacobsen, S. J., Rodeheffer, R. J., & Roger, V. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.05.024 · Cited by 295

Atrial fibrillation in the Malmö diet and cancer study: a study of occurrence, risk factors and diagnostic validity

Smith, J. G., Platonov, P. G., Hedblad, B., Engström, G., & Melander, O. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-009-9404-1 · Cited by 275

Postprandial recruitment of neutrophils may contribute to endothelial dysfunction

van Oostrom, A. J. H. H. M., Sijmonsma, T. P., Verseyden, C., Jansen, E. H. J. M., de Koning, E. J. P., Rabelink, T. J., & Castro Cabezas, M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200419-jlr200 · Cited by 249

Stromal cell-derived factor-1α is cardioprotective after myocardial infarction

Saxena, A., Fish, J. E., White, M. D., Yu, S., Smyth, J. W. P., Shaw, R. M., DiMaio, J. M., & Srivastava, D. (2008) · Circulation · doi:10.1161/circulationaha.107.694992 · Cited by 237

Effects of Antibiotic Therapy on Outcomes of Patients With Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials

Andraws, R., Berger, J. S., & Brown, D. L. (2005) · JAMA · doi:10.1001/jama.293.21.2641 · Cited by 235

Influence of Obesity on Outcomes in Atrial Fibrillation: Yet Another Obesity Paradox

Badheka, A. O., Rathod, A., Kizilbash, M. A., Garg, N., Mohamad, T., Afonso, L., & Jacob, S. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.11.026 · Cited by 219

Electrocardiogram abnormalities among men with stress-related psychiatric disorders: Implications for coronary heart disease and clinical research

Boscarino, J. A., & Chang, J. (1999) · Annals of Behavioral Medicine · doi:10.1007/bf02884839 · Cited by 216

Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration

Bargehr, J., Ong, L. P., Colzani, M., Davaapil, H., Hofsteen, P., Bhandari, S., Gambardella, L., Le Novère, N., Iyer, D., Sampaziotis, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0197-9 · Cited by 195

Incidence and mortality risk of congestive heart failure in atrial fibrillation patients: a community-based study over two decades

Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W., Seward, J. B., Iwasaka, T., & Tsang, T. S. M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi694 · Cited by 192

Bullying victimization in childhood predicts inflammation and obesity at mid-life: a five-decade birth cohort study

Takizawa, R., Danese, A., Maughan, B., & Arseneault, L. (2015) · Psychological Medicine · doi:10.1017/s0033291715000653 · Cited by 134

Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: data from a community-based cohort

Miyasaka, Y., Barnes, M. E., Petersen, R. C., Cha, S. S., Bailey, K. R., Gersh, B. J., Casaclang-Verzosa, G., Abhayaratna, W. P., Seward, J. B., Iwasaka, T., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm012 · Cited by 133

A Multimethod Quality Improvement Intervention To Improve Preventive Cardiovascular Care: A Cluster Randomized Trial

Ornstein, S., Jenkins, R. G., Nietert, P. J., Feifer, C., Roylance, L. F., Nemeth, L., Corley, S., Dickerson, L., Bradford, W. D., & Litvin, C. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-7-200410050-00008 · Cited by 125

Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts

Patel, V., Adya, R., Chen, J., Ramanjaneya, M., Bari, M. F., Bhudia, S. K., Hillhouse, E. W., Tan, B. K., & Randeva, H. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087102 · Cited by 124

Atrioventricular Nodal Ablation in Atrial Fibrillation: A Meta-Analysis and Systematic Review

Chatterjee, N. A., Upadhyay, G. A., Ellenbogen, K. A., McAlister, F. A., Choudhry, N. K., & Singh, J. P. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.111.967810 · Cited by 109

Postprandial inflammation and endothelial dysfuction

Alipour, A., Elte, J. W. F., van Zaanen, H. C. T., Rietveld, A. P., & Cabezas, M. C. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350466 · Cited by 108

Plasma Fibrinogen as a Predictor of Total and Cause-Specific Mortality in Elderly Japanese-American Men

Yano, K., Grove, J. S., Chen, R., Rodriguez, B. L., Curb, J. D., & Tracy, R. P. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.21.6.1065 · Cited by 76

Global inflammation predicts cardiovascular risk in women: A report from the Women's Ischemia Syndrome Evaluation (WISE) study

Kip, K. E., Marroquin, O. C., Shaw, L. J., Arant, C. B., Wessel, T. R., Olson, M. B., Johnson, B. D., Mulukutla, S., Sopko, G., Merz, C. N. B., et al. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.02.002 · Cited by 74

Antioxidant activity and lipid-lowering effect of essential oils extracted from Ocimum sanctum L. leaves in rats fed with a high cholesterol diet

Suanarunsawat, T., Devakul Na Ayutthaya, W., Songsak, T., Thirawarapan, S., & Poungshompoo, S. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.09-52 · Cited by 75

Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy

Chen, K., Yuan, R., Zhang, Y., Geng, S., & Li, L. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004078 · Cited by 44

Is cardiac resynchronization therapy an antiarrhythmic therapy for atrial fibrillation? A systematic review and meta-analysis

Hess, P. L., Jackson, K. P., Hasselblad, V., & Al-Khatib, S. M. (2013) · Current Cardiology Reports · doi:10.1007/s11886-012-0330-6 · Cited by 38

Silent atrial fibrillation: Definition, clarification, and unanswered issues

Kennedy, H. L. (2015) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12307 · Cited by 32

Inflammation as a risk factor for myocardial infarction

Tanaka, T., & Ozaki, K. (2006) · Journal of Human Genetics · doi:10.1007/s10038-006-0411-8 · Cited by 33

LRP5/canonical Wnt signalling and healing of ischemic myocardium

Borrell-Pages, M., Vilahur, G., Romero, J. C., Casaní, L., Bejar, M. T., & Badimon, L. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0585-y · Cited by 31