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A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity
Open accessAbstract
BACKGROUND: The effects of a carbohydrate-restricted diet on weight loss and risk factors for atherosclerosis have been incompletely assessed. METHODS: We randomly assigned 132 severely obese subjects (including 77 blacks and 23 women) with a mean body-mass index of 43 and a high prevalence of diabetes (39 percent) or the metabolic syndrome (43 percent) to a carbohydrate-restricted (low-carbohydrate) diet or a calorie- and fat-restricted (low-fat) diet. RESULTS: Seventy-nine subjects completed the six-month study. An analysis including all subjects, with the last observation carried forward for those who dropped out, showed that subjects on the low-carbohydrate diet lost more weight than those on the low-fat diet (mean [+/-SD], -5.8+/-8.6 kg vs. -1.9+/-4.2 kg; P=0.002) and had greater decreases in triglyceride levels (mean, -20+/-43 percent vs. -4+/-31 percent; P=0.001), irrespective of the use or nonuse of hypoglycemic or lipid-lowering medications. Insulin sensitivity, measured only in subjects without diabetes, also improved more among subjects on the low-carbohydrate diet (6+/-9 percent vs. -3+/-8 percent, P=0.01). The amount of weight lost (P<0.001) and assignment to the low-carbohydrate diet (P=0.01) were independent predictors of improvement in triglyceride levels and insulin sensitivity. CONCLUSIONS: Severely obese subjects with a high prevalence of diabetes or the metabolic syndrome lost more weight during six months on a carbohydrate-restricted diet than on a calorie- and fat-restricted diet, with a relative improvement in insulin sensitivity and triglyceride levels, even after adjustment for the amount of weight lost. This finding should be interpreted with caution, given the small magnitude of overall and between-group differences in weight loss in these markedly obese subjects and the short duration of the study. Future studies evaluating long-term cardiovascular outcomes are needed before a carbohydrate-restricted diet can be endorsed.
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“We did not confirm previous findings that low-carbohydrate or high-protein diets caused increased weight loss at 6 months3–12 and that the advantage of these diets usually eroded by 12 months, with weight loss that was nearly or fully equivalent to that with low-fat diets6,11,18 or other diets.12”
From Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates (2009) · cites this paper as [7]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Nevertheless, low-carbohydrate, high-fat diets may lead to spontaneous reduction in calorie reduction and increased weight loss, especially over the short term50–52.”
From Maintenance of Lost Weight and Long-Term Management of Obesity (2018) · cites this paper as [52]
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“Several trials showed that low-carbohydrate, high-protein diets resulted in more weight loss over the course of 3 to 6 months than conventional high-carbohydrate, low-fat diets,4–12 but other studies did not show this effect.13–17”
From Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates (2009) · cites this paper as [7]
In the citing paper
“Significant reductions in fat mass including truncal fat, which is a marker for visceral obesity, have been demonstrated in many studies [9,11,26,29].”
From The case for low carbohydrate diets in diabetes management (2005) · cites this paper as [11]
In the citing paper
“It is interesting that despite advocating ad libitum fat and protein intake, a LoCHO diet may be hypocaloric either by design or by spontaneous reduction of intake [8-12].”
From The case for low carbohydrate diets in diabetes management (2005) · cites this paper as [11]
In the citing paper
“There are several other reports indicating metabolic advantage in low carbohydrate diets over short term (3–6 months) [8,10,11,26-28].”
From The case for low carbohydrate diets in diabetes management (2005) · cites this paper as [11]
In the citing paper
“Conversely, LoCHO diets have been consistently demonstrated to lower triglycerides and increase HDL [8-11,26-28].”
From The case for low carbohydrate diets in diabetes management (2005) · cites this paper as [11]
In the citing paper
“LoCHO diets have been reported to reduce fat mass including truncal fat over long term in many studies [11,21,26,29].”
From The case for low carbohydrate diets in diabetes management (2005) · cites this paper as [11]
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Cites
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6661 · Cited by 3,931
Rubins, H. B., Robins, S. J., Collins, D., Fye, C. L., Anderson, J. W., Elam, M. B., Faas, F. H., Linares, E., Schaefer, E. J., Schectman, G., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908053410604 · Cited by 3,439
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,366
Basic and Clinical Biostatistics,
(2002) · Survey of Ophthalmology · doi:10.1016/s0039-6257(02)00360-0 · Cited by 1,818
(1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00690.x · Cited by 758
Relationship Between Insulin Resistance and an Endogenous Nitric Oxide Synthase Inhibitor
Stuehlinger, M. (2002) · JAMA · doi:10.1001/jama.287.11.1420 · Cited by 578
St. Jeor, S. T., Howard, B. V., Prewitt, T. E., Bovee, V., Bazzarre, T., Eckel, R. H., & for the AHA Nutrition Committee (2001) · Circulation · doi:10.1161/hc4001.096152 · Cited by 292
Research works printed but not linked: 2
- Westman EC, 1999, J Clin Outcomes Manage, 6, 36
- 10.1210/jc.85.7.2402 · DOI · Paper page
Cited by
Sorted by citations
Barlow, S. E., & and the Expert Committee (2007) · Pediatrics · doi:10.1542/peds.2007-2329c · Cited by 4,497
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162
Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates
Sacks, F. M., Bray, G. A., Carey, V. J., Smith, S. R., Ryan, D. H., Anton, S. D., McManus, K., Champagne, C. M., Bishop, L. M., Laranjo, N., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804748 · Cited by 1,966
Dansinger, M. L., Gleason, J. A., Griffith, J. L., Selker, H. P., & Schaefer, E. J. (2005) · JAMA · doi:10.1001/jama.293.1.43 · Cited by 1,726
“1 mo 501 (308-686)† 198 (154-317)‡ 184 (134-237)† 82 (18-324)† .”
Mente, A., de Koning, L., Shannon, H. S., & Anand, S. S. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.38 · Cited by 1,267
Grundy, S. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-5839-6_1 · Cited by 1,227
Nordmann, A. J., Nordmann, A., Briel, M., Keller, U., Yancy, W. S., Brehm, B. J., & Bucher, H. C. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.3.285 · Cited by 973
Yancy, W. S., Olsen, M. K., Guyton, J. R., Bakst, R. P., & Westman, E. C. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-10-200405180-00006 · Cited by 946
“The low-carbohydrate diet has not been studied extensively in patients with chronic illness, and certain patients may require close medical supervision when following this diet (8).”
BackgroundKlein, S., Burke, L. E., Bray, G. A., Blair, S., Allison, D. B., Pi-Sunyer, X., Hong, Y., & Eckel, R. H. (2004) · Circulation · doi:10.1161/01.cir.0000145546.97738.1e · Cited by 934
Maintenance of Lost Weight and Long-Term Management of Obesity
Hall, K. D., & Kahan, S. (2018) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.08.012 · Cited by 876
Recommendations for Treatment of Child and Adolescent Overweight and Obesity
Spear, B. A., Barlow, S. E., Ervin, C., Ludwig, D. S., Saelens, B. E., Schetzina, K. E., & Taveras, E. M. (2007) · PEDIATRICS · doi:10.1542/peds.2007-2329f · Cited by 872
Ajala, O., English, P., & Pinkney, J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.042457 · Cited by 821
“Except for 3 studies (8, 35, 37), all other studies reported the method of random assignment, 10 studies reported the method of allocation concealment, and 6 studies were analyzed on an intention-to-treat basis (7, 32, 34, 36, 39, 40).”
BackgroundMethodResultInfluentialThe Effects of High Protein Diets on Thermogenesis, Satiety and Weight Loss: A Critical Review
Halton, T. L., & Hu, F. B. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719381 · Cited by 822
“A recent JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION 381 study by Samaha [59] compared a low carbohydrate, high protein Atkins diet (22% protein) to a low fat diet (16”
BackgroundInfluentialStern, L., Iqbal, N., Seshadri, P., Chicano, K. L., Daily, D. A., McGrory, J., Williams, M., Gracely, E. J., & Samaha, F. F. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-10-200405180-00007 · Cited by 831
“We recently reported that persons with severe obesity lost more weight and had greater improvements in triglyceride levels, insulin sensitivity, and glycemic control after 6 months of a low-carbohydrate diet as compared with a conventional weight loss diet based on calorie and fat restriction (5).”
BackgroundMethodSelf-citationMcKeown, N. M., Meigs, J. B., Liu, S., Saltzman, E., Wilson, P. W. F., & Jacques, P. F. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.538 · Cited by 786
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome
Lim, J. S., Mietus-Snyder, M., Valente, A., Schwarz, J.-M., & Lustig, R. H. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.41 · Cited by 771
“Furthermore, long-term voluntary consumption of an increased percentage of fat, as is seen in the Atkins diet, did not result in increased caloric intake, and did not increase the risk of obesity or NAFLD”
BackgroundLipids and Lipoproteins in Patients With Type 2 Diabetes
Krauss, R. M. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1496 · Cited by 764
Scientific Opinion on Dietary Reference Values for protein
EFSA Panel on Dietetic Products, N. A. A. (. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2557 · Cited by 739
“However, these studies are difficult to interpret with respect to whether the effects observed are due to an increase in dietary protein intake or to the concomitant modification of carbohydrate and/or fat intakes, and whether any observed effect of an increase in dietary protein intake would be sustainable (Brehm et…”
BackgroundComparison of Weight Loss Among Named Diet Programs in Overweight and Obese Adults: A Meta-analysis
Johnston, B. C., Kanters, S., Bandayrel, K., Wu, P., Naji, F., Siemieniuk, R. A., Ball, G. D. C., Busse, J. W., Thorlund, K., Guyatt, G., et al. (2014) · JAMA · doi:10.1001/jama.2014.10397 · Cited by 704
Defining high-fat-diet rat models: Metabolic and molecular effects of different fat types
Buettner, R., Parhofer, K. G., Woenckhaus, M., Wrede, C. E., Kunz-Schughart, L. A., Schölmerich, J., & Bollheimer, L. C. (2006) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01909 · Cited by 704
“glucose metabolism, as recently described (Samaha et al. 2003).”
MethodWeigle, D. S., Breen, P. A., Matthys, C. C., Callahan, H. S., Meeuws, K. E., Burden, V. R., & Purnell, J. Q. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.41 · Cited by 774
Behavioral treatment of obesity
Butryn, M. L., Webb, V., & Wadden, T. A. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.08.006 · Cited by 636
Stem, L., Iqbal, N., Seshadri, P., & Chicano, K. L. (2004) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.07.103 · Cited by 629
Self-citationUnderstanding and Addressing the Epidemic of Obesity: An Energy Balance Perspective
Hill, J. O. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0032 · Cited by 610
Lifestyle Modification for Obesity
Wadden, T. A., Webb, V. L., Moran, C. H., & Bailer, B. A. (2012) · Circulation · doi:10.1161/circulationaha.111.039453 · Cited by 613
Goodpaster, B. H., DeLany, J. P., Otto, A. D., Kuller, L., Vockley, J., South-Paul, J. E., Thomas, S. B., Brown, J., McTigue, K., Hames, K. C., et al. (2010) · JAMA · doi:10.1001/jama.2010.1505 · Cited by 558
Effects of exercise and diet on chronic disease
Roberts, C. K., & Barnard, R. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00852.2004 · Cited by 556
“Although many diets have been studied, for example the National Cholesterol Education Program (NCEP) Step I diet (414, 420) and high-fat, low-carbohydrate diets (110, 341), they have documented that benefits are modest.”
Boden, G., Sargrad, K., Homko, C., Mozzoli, M., & Stein, T. P. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-6-200503150-00006 · Cited by 542
“So far, however, patients with type 2 diabetes have been included in only 1 such study (25 of the 64 participants in that study had type 2 diabetes) (5).”
BackgroundThe obese adipose tissue microenvironment in cancer development and progression
Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542
Klein, S., Sheard, N. F., Pi-Sunyer, X., Daly, A., Wylie-Rosett, J., Kulkarni, K., & Clark, N. G. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.2067 · Cited by 540
“In addition, glycemic control was better with low-carbohydrate than lowfat diet therapy in subjects who had type 2 diabetes (65,67).”
BackgroundObesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association
Bays, H. E., Toth, P. P., Kris-Etherton, P. M., Abate, N., Aronne, L. J., Brown, W. V., Gonzalez-Campoy, J. M., Jones, S. R., Kumar, R., La Forge, R., et al. (2013) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2013.04.001 · Cited by 521
Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus
Mann, J. I., Leeuw, I. D., Hermansen, K., Karamanos, B. G., Karlström, B., Katsilambros, N. L., Riccardi, G., Rivellese, A. A., Rizkalla, S. W., Slama, G., et al. (2004) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/s0939-4753(04)80028-0 · Cited by 524
Foster, G. D., Wyatt, H. R., Hill, J. O., Makris, A. P., Rosenbaum, D. L., Brill, C., Stein, R. I., Mohammed, B. S., Miller, B., Rader, D. J., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-3-201008030-00005 · Cited by 520
“Sex, n (%) Male 49 (32) 50 (33) Female 105 (68) 103 (67) Race (non-Hispanic or Latino), n (%) White 111 (72) 106 (69) Black 33 (21) 35 (23) Asian 2 (1) 0 (0) American Indian or Alaska Native 1 ( 1) 0 (0) 1 race 1 ( 1) 1 ( 1) Race (Hispanic or Latino), n (%) American Indian or Alaska Native 0 (0) 3 (2) Black 0 (0) 1 (…”
CPAP, Weight Loss, or Both for Obstructive Sleep Apnea
Chirinos, J. A., Gurubhagavatula, I., Teff, K., Rader, D. J., Wadden, T. A., Townsend, R., Foster, G. D., Maislin, G., Saif, H., Broderick, P., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1306187 · Cited by 523
Efficacy of Lifestyle Modification for Long‐Term Weight Control
Wadden, T. A., Butryn, M. L., & Byrne, K. J. (2004) · Obesity Research · doi:10.1038/oby.2004.282 · Cited by 511
Westman, E. C., Yancy, W. S., Mavropoulos, J. C., Marquart, M., & McDuffie, J. R. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-36 · Cited by 475
Stiegler, P., & Cunliffe, A. (2006) · Sports Medicine · doi:10.2165/00007256-200636030-00005 · Cited by 474
“Although weight reduction following rious effects on blood pressure,[74] total cholesterol, physical activity is mainly brought about by the triglycerides[29,30,58,74,75] and bone turnover[30,57] have energy expended during the exercise bout, additionbeen reported.”
BackgroundKrieger, J. W., Sitren, H. S., Daniels, M. J., & Langkamp-Henken, B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.260 · Cited by 466
Johnstone, A. M., Horgan, G. W., Murison, S. D., Bremner, D. M., & Lobley, G. E. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.44 · Cited by 440
“There is growing evidence that weight loss, at least in the short term, is significantly greater in obese persons following lowcarbohydrate diets than in those following low-fat diets (8, 12, 13).”
Goldenberg, J. Z., Day, A., Brinkworth, G. D., Sato, J., Yamada, S., Jönsson, T., Beardsley, J., Johnson, J. A., Thabane, L., & Johnston, B. C. (2021) · BMJ · doi:10.1136/bmj.m4743 · Cited by 428
Speiser, P., RUDOLF, M. C. J., Anhalt, H., Camacho‐Hübner, C., Chiarelli, F., Eliakim, A., Freemark, M., Grüters, A., Hershkovitz, E., Iughetti, L., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1389 · Cited by 579
A high-fat, ketogenic diet induces a unique metabolic state in mice
Kennedy, A. R., Pissios, P., Otu, H., Xue, B., Asakura, K., Furukawa, N., Marino, F. E., Liu, F.-F., Kahn, B. B., Libermann, T. A., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00717.2006 · Cited by 420
“Although a small number of human studies have found such diets to be more effective in short-term weight loss and without adverse effects on glucose, insulin, lipids, or blood pressure (7, 14, 42, 49, 51), reports on metabolic effects remain inconclusive (8, 38).”
BackgroundHoward, B. V., Manson, J. E., Stefanick, M. L., Beresford, S. A., Frank, G., Jones, B., Rodabough, R. J., Snetselaar, L., Thomson, C., Tinker, L., et al. (2006) · JAMA · doi:10.1001/jama.295.1.39 · Cited by 426
Model of nonalcoholic steatohepatitis
Lieber, C. S., Leo, M. A., Mak, K. M., Xu, Y., Cao, Q., Ren, C., Ponomarenko, A. N., & DeCarli, L. M. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.3.502 · Cited by 425
Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss?
Astrup, A. V., Larsen, T. M., & Harper, A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16986-9 · Cited by 429
Lifestyle modification for the management of obesity
Wadden, T. A., Butryn, M. L., & Wilson, C. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.051 · Cited by 406
Hession, M., Rolland, C., Kulkarni, U., Wise, A., & Broom, J. I. (2008) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00518.x · Cited by 408
“…LF – women: 1200–1500 kcal d-1; men: 1500–1800 kcal d-1 Gardner et al., 2007 (16) VLC/HP vs. LF/HC 20 g increased to 50 g gradually LF – kcal restricted Samaha et al., 2003 (17) LC/HP vs. LF/HC 30 g LF – reduced by 500 kcal d-1 Seshadri et al., 2004 (18) LC/HP vs. LF/HC 30 g LF – reduced…”
Consensus statement : Childhood obesity
Speiser, P., RUDOLF, M. C. J., Anhalt, H., Camacho‐Hübner, C., Chiarelli, F., Freemark, M., Grüters, A., Hershkovitz, E., Krude, H., Latzer, Y., et al. (2005) · Cited by 394
Low-carbohydrate nutrition and metabolism
Westman, E. C., Feinman, R. D., Mavropoulos, J. C., Vernon, M. C., Volek, J. S., Wortman, J. A., Yancy, W. S., & Phinney, S. D. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.276 · Cited by 390
“Samaha et al, 2003 (52) 6 mo 132 51 33 16 1576 1.”
Dietary Proteins in the Regulation of Food Intake and Body Weight in Humans
Anderson, G. H., & Moore, S. E. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.974s · Cited by 381
Tobias, D. K., Chen, M., Manson, J. E., Ludwig, D. S., Willett, W., & Hu, F. B. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00367-8 · Cited by 373
Obesity energetics: body weight regulation and the effects of diet composition
Hall, K. D., & Guo, J. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.052 · Cited by 367
Similarity of the dog and human gut microbiomes in gene content and response to diet
Coelho, L. P., Kultima, J. R., Costea, P. I., Fournier, C., Pan, Y., Czarnecki-Maulden, G. L., Hayward, M. R., Forslund, S. K., Schmidt, T., Descombes, P., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0450-3 · Cited by 380
“In humans, low-carbohydrate diets have been similarly effective at reducing weight, at least over the short term [24, 25], with evidence that they increase satiety compared to low-calorie diets [26].”
BackgroundKetone bodies: from enemy to friend and guardian angel
Kolb, H., Kempf, K., Röhling, M., Lenzen-Schulte, M., Schloot, N. C., & Martin, S. (2021) · BMC Medicine · doi:10.1186/s12916-021-02185-0 · Cited by 389
Behavioral Treatment of Obesity
Wadden, T. A., Crerand, C. E., & Brock, J. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.09.008 · Cited by 351
Risk Factors for the Metabolic Syndrome
Carnethon, M. R., Loria, C. M., Hill, J. O., Sidney, S. S., Savage, P. J., & Liu, K. (2004) · Diabetes Care · doi:10.2337/diacare.27.11.2707 · Cited by 343
Effects of Low-Carbohydrate and Low-Fat Diets: A Randomized Trial
Bazzano, L. A., Hu, T., Reynolds, K., Yao, L., Bunol, C., Liu, Y., Chen, C.-S., Klag, M. J., Whelton, P. K., & He, J. (2014) · Annals of Internal Medicine · doi:10.7326/m14-0180 · Cited by 346
The role of diet in the prevention of type 2 diabetes
Salas‐Salvadó, J., Martínez‐González, M. Á., Bulló, M., & Ros, E. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.03.009 · Cited by 357
PRIMARY PREVENTION OF DIABETES: What Can Be Done and How Much Can Be Prevented?
Schulze, M. B., & Hu, F. B. (2004) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.26.021304.144532 · Cited by 340
Layman, D. K., Evans, E., Baum, J. I., Seyler, J., Erickson, D. J., & Boileau, R. A. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.8.1903 · Cited by 330
“4 g/(kg d) result in increased weight loss (6–8,12), increased loss of body fat (7,8,10), attenuated loss of fat-free mass (FFM)(4) (6,8,10,13,14), improved glycemic control (6,10–12), improved blood lipid profiles (10,12,16,17), and enhanced satiety (15).”
BackgroundEffect of low-calorie versus low-carbohydrate ketogenic diet in type 2 diabetes
Hussain, T. A., Mathew, T. C., Dashti, A. A., Asfar, S., Al-Zaid, N., & Dashti, H. M. (2012) · Nutrition · doi:10.1016/j.nut.2012.01.016 · Cited by 329
“Furthermore, other investigators have reported that antidiabetic medications were decreased in some participants of the dietary program [19,21,22].”
BackgroundSeparate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia
Krauss, R. M., Blanche, P. J., Rawlings, R. S., Fernstrom, H. S., & Williams, P. T. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.5.1025 · Cited by 321
Snow, V. T., Barry, P. P., Fitterman, N., Qaseem, A., & Weiss, K. B. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-7-200504050-00011 · Cited by 325
Das, S. K., Gilhooly, C. H., Golden, J. K., Pittas, A. G., Fuss, P. J., Cheatham, R. A., Tyler, S., Tsay, M., McCrory, M. A., Lichtenstein, A. H., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1023 · Cited by 314
Santos, F. L., Esteves, S. S., da Costa Pereira, A., Yancy Jr, W. S., & Nunes, J. P. L. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01021.x · Cited by 318
Austin, G. L., Ogden, L. G., & Hill, J. O. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.000141 · Cited by 317
I Diretriz Brasileira de Diagnóstico e Tratamento da Síndrome Metabólica
de Carvalho, M. H. C., Mancini, M. C., de Melo, M. E., Bahia, L., Negrão, C. E., de Matos, L. D. N. J., Sanjuliani, A. F., Kohlmann, O., Oliveira, J. E. P. D., Lerário, A. C., et al. (2005) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2005000700001 · Cited by 305
Caprio, M., Infante, M., Moriconi, E., Armani, A., Fabbri, A., Mantovani, G., Mariani, S., Lubrano, C., Poggiogalle, E., Migliaccio, S., et al. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01061-2 · Cited by 283
Lindström, J., Peltonen, M., Eriksson, J. G., Louheranta, A., Fogelholm, M., Uusitupa, M., & Tuomilehto, J. (2006) · Diabetologia · doi:10.1007/s00125-006-0198-3 · Cited by 293
Effects of a Low–Glycemic Load vs Low-Fat Diet in Obese Young Adults: A Randomized Trial
Ebbeling, C. B., Leidig, M. M., Feldman, H. A., Lovesky, M. M., & Ludwig, D. S. (2007) · JAMA · doi:10.1001/jama.297.19.2092 · Cited by 284
Higuchi, N., Kato, M., Shundo, Y., Tajiri, H., Tanaka, M., Yamashita, N., Kohjima, M., Kotoh, K., Nakamuta, M., Takayanagi, R., et al. (2008) · Hepatology Research · doi:10.1111/j.1872-034x.2008.00382.x · Cited by 290
Brinkworth, G. D., Noakes, M., Buckley, J. D., Keogh, J. B., & Clifton, P. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27326 · Cited by 284
Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome
Wang, H. H., Lee, D. K., Liu, M., Portincasa, P., & Wang, D. Q. ‐. (2020) · Pediatric Gastroenterology Hepatology & Nutrition · doi:10.5223/pghn.2020.23.3.189 · Cited by 309
“Clinical studies found that high daily carbohydrate intake is associated with increased plasma total cholesterol, LDL-cholesterol, and triglyceride concentrations, and reduced HDL-cholesterol levels [292,293,308-310].”
McAuley, K. A., Hopkins, C. M., Smith, K. J., McLay, R. T., Williams, S. M., Taylor, R. W., & Mann, J. I. (2005) · Diabetologia · doi:10.1007/s00125-004-1603-4 · Cited by 275
Klein, S., Sheard, N. F., Pi‐Sunyer, X., Daly, A. E., Wylie‐Rosett, J., Kulkarni, K. D., & Clark, N. G. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.257 · Cited by 274
Sainsbury, E., Kizirian, N. V., Partridge, S. R., Gill, T., Colagiuri, S., & Gibson, A. A. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.02.026 · Cited by 268
A low-carbohydrate, ketogenic diet to treat type 2 diabetes
Yancy, W. S., Foy, M. E., Chalecki, A. M., Vernon, M. C., & Westman, E. C. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-34 · Cited by 270
“A few studies have shown that in non-diabetic individuals, low-carbohydrate diets were more effective than higher carbohydrate diets at improving fasting serum glucose [13,14] and insulin [6,14-16], and at improving insulin sensitivity as measured by the homeostasis model [6].”
InfluentialAccurso, A., Bernstein, R. K., Dahlqvist, A., Draznin, B., Feinman, R. D., Fine, E. J., Gleed, A., Jacobs, D. B., Larson, G., Lustig, R. H., et al. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-9 · Cited by 263
“[27] are often cited as examples where low carbohydrate diets are more effective at 6 months but no better than low-fat diets at 1 year.”
BackgroundEfficacy of the Atkins diet as therapy for intractable epilepsy
Kossoff, E. H., Krauss, G. L., McGrogan, J. R., & Freeman, J. M. (2003) · Neurology · doi:10.1212/01.wnl.0000098889.35155.72 · Cited by 267
Saslow, L. R., Mason, A. E., Kim, S., Goldman, V., Ploutz-Snyder, R., Bayandorian, H., Daubenmier, J., Hecht, F. M., & Moskowitz, J. T. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.5806 · Cited by 265
“In previous trials of very low-carbohydrate diet programs in adults with type 2 diabetes that were at least 3 months or longer [7,38,43-58], researchers followed participants for a mean of 12 months.”
Schmidt, M., Pfetzer, N., Schwab, M., Strauss, I., & Kämmerer, U. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-54 · Cited by 271
“Nowadays, the Atkins diet is very popular and although it’s longterm effect on weight loss is discussed controversially [23] undoubtedly it has a positive effect on the triglyceride and insulin levels [24,25] and no adverse side effects.”
BackgroundRandomized Clinical Trials of Weight Loss Maintenance: A Review
Turk, M. W., Yang, K., Hravnak, M., Sereika, S. M., Ewing, L. J., & Burke, L. E. (2009) · Journal of Cardiovascular Nursing · doi:10.1097/01.jcn.0000317471.58048.32 · Cited by 258
Carbohydrate intake and obesity
van Dam, R. M., & Seidell, J. C. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602939 · Cited by 261
“Table 2 shows the characteristics and results of five 12-month weight loss trials that randomized participants to very-low carbohydrate ‘Atkins’ type diets or low-fat diets (Foster et al., 2003; Samaha et al., 2003; Stern et al., 2004; Dansinger et al., 2005; McAuley et al., 2005, 2006; Gardner et al., 2007).”
BackgroundInfluentialKetosis and appetite-mediating nutrients and hormones after weight loss
Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A. D., & Proietto, J. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.90 · Cited by 269
Expert panel report: Guidelines (2013) for the management of overweight and obesity in adults
(2014) · Obesity · doi:10.1002/oby.20660 · Cited by 257
Davis, N. J., Tomuta, N., Schechter, C., Isasi, C. R., Segal-Isaacson, C. J., Stein, D., Zonszein, J., & Wylie-Rosett, J. (2009) · Diabetes Care · doi:10.2337/dc08-2108 · Cited by 256
“Similar to prior studies, we observed a more rapid weight loss after initiation of a low-carbohydrate diet and equivalent weight loss after 1 year (2,3).”
ResultStamets, K., Taylor, D. S., Kunselman, A., Demers, L. M., Pelkman, C. L., & Legro, R. S. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.08.023 · Cited by 252
Lagiou, P., Sandin, S., Lof, M., Trichopoulos, D., Adami, H.-O., & Weiderpass, E. (2012) · BMJ · doi:10.1136/bmj.e4026 · Cited by 254
Naude, C. E., Schoonees, A., Senekal, M., Young, T., Garner, P., & Volmink, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100652 · Cited by 252
Low‐carbohydrate diets: nutritional and physiological aspects
Adam‐Perrot, A., Clifton, P. M., & Brouns, F. J. P. H. (2006) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00222.x · Cited by 253
“obesity reviews 7 , 49–58 consumption of low-CHO, high-fat diets, especially in diabetic subjects (6,12).”
BackgroundThe relation of saturated fatty acids with low-grade inflammation and cardiovascular disease
Ruiz-Núñez, B., Dijck-Brouwer, J., & Muskiet, F. A. J. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.12.007 · Cited by 249
South Asian diets and insulin resistance
Misra, A., Khurana, L., Isharwal, S., & Bhardwaj, S. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508073649 · Cited by 247
“(47) showed that severely obese subjects with a high prevalence of T2DM and the metabolic syndrome lost more weight and had greater improvements in the plasma TAG level and insulin sensitivity on a low-carbohydrate diet than those on a low-fat diet.”
BackgroundNutritional ketosis for weight management and reversal of metabolic syndrome
Gershuni, V. M., Yan, S. L., & Medici, V. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0235-0 · Cited by 239
Wycherley, T. P., Noakes, M., Clifton, P. M., Cleanthous, X., Keogh, J. B., & Brinkworth, G. D. (2010) · Diabetes Care · doi:10.2337/dc09-1974 · Cited by 240
“The substitution of some dietary carbohydrate for protein in a low fat (<30% total energy) diet may improve body composition and CVD risk factors including insulin sensitivity, glycemic control and blood lipids in overweight/obese populations, including T2D(2-5).”
BackgroundThe Potential Health Benefits of the Ketogenic Diet: A Narrative Review
Dowis, K., & Banga, S. (2021) · Nutrients · doi:10.3390/nu13051654 · Cited by 253
“[61] also found that patients lost significantly more weight on a 30 g/carbohydrate per day diet for six months compared to a LFD.”
MethodNoto, H., Goto, A., Tsujimoto, T., & Noda, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055030 · Cited by 240
Heymsfield, S. B., Harp, J. B., Reitman, M. L., Beetsch, J. W., Schoeller, D. A., Erondu, N., & Pietrobelli, A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.346 · Cited by 229
“Samaha et al (11) provided subjects weighing an average of 131.”
BackgroundInfluentialVolek, J. S., & Feinman, R. D. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-31 · Cited by 223
“It is notable that Samaha et al studied a population in which 39 % had diabetes and 43% had MetS [46].”
MethodTherapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease
Yurista, S. R., Chong, C., Badimón, J. J., Kelly, D. P., de Boer, R. A., & Westenbrink, B. D. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.12.065 · Cited by 230
The Association of Nephrolithiasis With Hypertension and Obesity: A Review
Obligado, S. H., & Goldfarb, D. S. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2007.62 · Cited by 219
Metadata
- Authors
- Samaha, F. F., Iqbal, N., Seshadri, P., Chicano, K. L., Daily, D. A., McGrory, J., Williams, T., Williams, M., Gracely, E. J., & Stern, L.
- Affiliations
- Veterans Health Administration (US)
- University of Pennsylvania (US)
- Drexel University (US)
- ORCID
- Gracely, Edward J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-05-22
- Volume
- 348
- Issue
- 21
- Pages
- 2074-2081
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2154184102
- Semantic Scholar
- b42feb4332c5988f5d769f116b2b96ffdfc37bd4
- Cited by
- 1,267
- References
- 20
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 26 · 2023: 24 · 2022: 39 · 2021: 38 · 2020: 58 · 2019: 33 · 2018: 36 · 2017: 36 · 2016: 43 · 2015: 28 · 2014: 37 · 2013: 46 · 2012: 62
- FWCI
- 70.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- low-carbohydrate diet, low-fat diet, morbid obesity, weight loss, triglycerides, insulin sensitivity, diabetes mellitus, metabolic syndrome, atherosclerosis risk factors, dietary intervention
- MeSH terms
- Arteriosclerosis, Blood Glucose, Diabetes Mellitus, Diet, Reducing, Dietary Carbohydrates, Female, Humans, Insulin Resistance, Lipids, Male, Middle Aged, Obesity, Risk Factors, Triglycerides, Weight Loss, Body Mass Index, Diet, Fat-Restricted, Metabolic Syndrome
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