The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Duration of Humoral Immunity to Common Viral and Vaccine Antigens
Open accessAbstract
BACKGROUND: Maintenance of long-term antibody responses is critical for protective immunity against many pathogens. However, the duration of humoral immunity and the role played by memory B cells remain poorly defined. METHODS: We performed a longitudinal analysis of antibody titers specific for viral antigens (vaccinia, measles, mumps, rubella, varicella-zoster virus, and Epstein-Barr virus) and nonreplicating antigens (tetanus and diphtheria) in 45 subjects for a period of up to 26 years. In addition, we measured antigen-specific memory B cells by means of limiting-dilution analysis, and we compared memory B-cell frequencies to their corresponding serum antibody levels. RESULTS: Antiviral antibody responses were remarkably stable, with half-lives ranging from an estimated 50 years for varicella-zoster virus to more than 200 years for other viruses such as measles and mumps. Antibody responses against tetanus and diphtheria antigens waned more quickly, with estimated half-lives of 11 years and 19 years, respectively. B-cell memory was long-lived, but there was no significant correlation between peripheral memory B-cell numbers and antibody levels for five of the eight antigens tested. CONCLUSIONS: These studies provide quantitative analysis of serologic memory for multiple antigens in subjects followed longitudinally over the course of more than one decade. In cases in which multiple exposures or repeated vaccinations were common, memory B-cell numbers did not correlate with antibody titers. This finding suggests that peripheral memory B cells and antibody-secreting plasma cells may represent independently regulated cell populations and may play different roles in the maintenance of protective immunity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is likely that longer-term follow-up studies will reveal a further slowing of decay, with titres reaching a stable level analogous to humoral responses to other viral pathogens22,23.”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [23]
In the citing paper
“Previous work has found that antibodies and memory B cells correlate for some vaccines or antigens, but do not correlate for many others (34).”
From Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination (2021) · cites this paper as [34]
In the citing paper
“We focused on the RBD since it is the target of the majority of the more potent SARS-CoV-2 neutralizing antibodies discovered to date21–26.”
From mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants (2021) · cites this paper as [21]
In the citing paper
“Class 1 and 2 antibodies are among the most potent and also the most abundant antibodies7,8,21,22,25,39.”
From mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants (2021) · cites this paper as [21]
In the citing paper
“The vaccines elicit antibody responses against the RBD, the major target of neutralizing antibodies21–26, in a manner that resembles natural infection.”
From mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants (2021) · cites this paper as [21]
Citations
Cites
Adjusting for multiple testing—when and how?
Bender, R., & Lange, S. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00314-0 · Cited by 3,168
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
Edwards, J. C. W., Szczepański, L., Szechiński, J., Filipowicz-Sosnowska, A., Emery, P., Close, D. R., Stevens, R. M., & Shaw, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032534 · Cited by 2,623
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775
Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
Bernasconi, N. L., Traggiai, E., & Lanzavecchia, A. (2002) · Science · doi:10.1126/science.1076071 · Cited by 1,304
Humoral Immunity Due to Long-Lived Plasma Cells
Slifka, M. K., Antia, R., Whitmire, J. K., & Ahmed, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80541-5 · Cited by 1,249
Self-citationCompetence and competition: the challenge of becoming a long-lived plasma cell
Radbruch, A., Muehlinghaus, G., Luger, E., Inamine, A., Smith, K. G. C., Dörner, T., & Hiepe, F. (2006) · Nature reviews. Immunology · doi:10.1038/nri1886 · Cited by 1,033
Duration of antiviral immunity after smallpox vaccination
Hammarlund, E., Lewis, M. W., Hansen, S. G., Strelow, L. I., Nelson, J. A., Sexton, G. J., Hanifin, J. M., & Slifka, M. K. (2003) · Nature Medicine · doi:10.1038/nm917 · Cited by 946
Self-citationLifetime of plasma cells in the bone marrow
Manz, R. A., Thiel, A., & Radbruch, A. (1997) · Nature · doi:10.1038/40540 · Cited by 866
Cutting edge: long-term B cell memory in humans after smallpox vaccination
Crotty, S., Felgner, P., Davies, H., Glidewell, J., Villarreal, L., & Ahmed, R. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.4969 · Cited by 695
Measles Antibody: Reevaluation of Protective Titers
Chen, R. T., Markowitz, L. E., Albrecht, P. G., Stewart, J. A., MOFENSON, L. M., Preblud, S. R., & Orenstein, W. A. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/162.5.1036 · Cited by 606
Flagged first, then by citations
Research works printed but not linked: 3
- Bojlen K, 1955, Dan Med Bull, 2, 70
- Wolters KL, 1942, Zeitschrift fur Hyeitschrift, 124, 326
- Slifka MK. Mechanisms of antiviral immunity: studies on recombinant Listeria monocytogenes as a vaccine for inducing protective CTL memory and analysis of long-term antibody production after acute LCMV infection. Los Angeles: University of California, Los Angeles, 1996 (dissertation).
Cited by
Sorted by citations
Khoury, D. S., Cromer, D., Reynaldi, A., Schlub, T. E., Wheatley, A. K., Juno, J. A., Subbarao, K., Kent, S. J., Triccas, J. A., & Davenport, M. P. (2021) · Nature Medicine · doi:10.1038/s41591-021-01377-8 · Cited by 3,742
Vaccine Adjuvants: Putting Innate Immunity to Work
Coffman, R. L., Sher, A., & Seder, R. A. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.002 · Cited by 1,927
Seow, J., Graham, C., Merrick, B., Acors, S., Pickering, S., Steel, K. J. A., Hemmings, O., O’Byrne, A., Kouphou, N., Galao, R. P., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-00813-8 · Cited by 1,419
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
Wang, Z., Schmidt, F., Weisblum, Y., Muecksch, F., Barnes, C. O., Finkin, S., Schaefer-Babajew, D., Cipolla, M., Gaebler, C., Lieberman, J. A., et al. (2021) · Nature · doi:10.1038/s41586-021-03324-6 · Cited by 1,343
Expanding roles for CD4+ T cells in immunity to viruses
Swain, S. L., McKinstry, K. K., & Strutt, T. M. (2012) · Nature reviews. Immunology · doi:10.1038/nri3152 · Cited by 1,011
Vaccines: Correlates of Vaccine‐Induced Immunity
Plotkin, S. A. (2008) · Clinical Infectious Diseases · doi:10.1086/589862 · Cited by 829
A review of clinical trials of human papillomavirus prophylactic vaccines
Schiller, J. T., Castellsagué, X., & Garland, S. M. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.04.108 · Cited by 747
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659
Goel, R. R., Apostolidis, S. A., Painter, M. M., Mathew, D., Pattekar, A., Kuthuru, O., Gouma, S., Hicks, P., Meng, W., Rosenfeld, A. M., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abi6950 · Cited by 655
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19
Rodda, L. B., Netland, J., Shehata, L., Pruner, K. B., Morawski, P. A., Thouvenel, C. D., Takehara, K. K., Eggenberger, J., Hemann, E. A., Waterman, H. R., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.029 · Cited by 647
From Vaccines to Memory and Back
Sallusto, F., Lanzavecchia, A., Araki, K., & Ahmed, R. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.008 · Cited by 659
Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response
Pape, K. A., Taylor, J. J., Maul, R. W., Gearhart, P. J., & Jenkins, M. K. (2011) · Science · doi:10.1126/science.1201730 · Cited by 572
Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow
Halliley, J. L., Tipton, C. M., Liesveld, J. L., Rosenberg, A. F., Darce, J. R., Gregoretti, I. V., Popova, L., Kaminiski, D. A., Fucile, C., Albizua, I., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.016 · Cited by 545
Self-citationTang, F., Quan, Y., Xin, Z.-T., Wrammert, J., Ma, M.-J., Lv, H., Wang, T.-B., Yang, H., Richardus, J. H., Liu, W., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.0903490 · Cited by 496
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
Haynes, B. F., Kelsoe, G. H., Harrison, S. C., & Kepler, T. B. (2012) · Nature Biotechnology · doi:10.1038/nbt.2197 · Cited by 481
Broadly Neutralizing Antiviral Antibodies
Corti, D., & Lanzavecchia, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095916 · Cited by 469
Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens
Mina, M. J., Kula, T., Leng, Y., Li, M., de Vries, R. D., Knip, M., Siljander, H., Rewers, M., Choy, D. F., Wilson, M. S., et al. (2019) · Science · doi:10.1126/science.aay6485 · Cited by 466
Burbelo, P. D., Riedo, F. X., Morishima, C., Rawlings, S. A., Smith, D. M., Das, S., Strich, J. R., Chertow, D. S., Davey, R. T., & Cohen, J. I. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa273 · Cited by 471
Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors
Yu, X., Tsibane, T., McGraw, P. A., House, F. S., Keefer, C. J., Hicar, M. D., Tumpey, T. M., Pappas, C., Perrone, L. A., Martinez, O., et al. (2008) · Nature · doi:10.1038/nature07231 · Cited by 457
Cohen, K. W., Linderman, S. L., Moodie, Z., Czartoski, J., Lai, L., Mantus, G., Norwood, C., Nyhoff, L. E., Edara, V. V., Floyd, K., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100354 · Cited by 441
Long-lived autoreactive plasma cells drive persistent autoimmune inflammation
Hiepe, F., Dörner, T., Hauser, A. E., Hoyer, B. F., Mei, H. E., & Radbruch, A. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.1 · Cited by 390
Ellebedy, A. H., Jackson, K., Kissick, H. T., Nakaya, H. I., Davis, C. W., Roskin, K. M., McElroy, A. K., Oshansky, C. M., Elbein, R., Thomas, S., et al. (2016) · Nature Immunology · doi:10.1038/ni.3533 · Cited by 396
White, M. T., Verity, R., Griffin, J. T., Asante, K. P., Owusu‐Agyei, S., Greenwood, B. M., DRAKELEY, C. J., Gesase, S., Lusingu, J., Ansong, D., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00239-x · Cited by 383
Diversity in T Cell Memory: An Embarrassment of Riches
Jameson, S. C., & Masopust, D. (2009) · Immunity · doi:10.1016/j.immuni.2009.11.007 · Cited by 395
The Role of Antibodies in HIV Vaccines
Mascola, J. R., & Montefiori, D. C. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101256 · Cited by 382
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
Wheatley, A. K., Juno, J. A., Wang, J. J., Selva, K. J., Reynaldi, A., Tan, H.-X., Lee, W. S., Wragg, K. M., Kelly, H. G., Esterbauer, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21444-5 · Cited by 351
Mechanisms that determine plasma cell lifespan and the duration of humoral immunity
Amanna, I. J., & Slifka, M. K. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00912.x · Cited by 355
Self-citationMaturation and persistence of the anti-SARS-CoV-2 memory B cell response
Sokal, A., Chappert, P., Barba-Spaeth, G., Roeser, A., Fourati, S., Azzaoui, I., Vandenberghe, A., Fernandez, I., Meola, A., Bouvier-Alias, M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.050 · Cited by 340
SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact
Lipsitch, M., Krammer, F., Regev‐Yochay, G., Lustig, Y., & Balicer, R. D. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00662-4 · Cited by 345
Moss, W. J., & Griffin, D. E. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62352-5 · Cited by 337
Ripperger, T. J., Uhrlaub, J. L., Watanabe, M., Wong, R., Castaneda, Y., Pizzato, H. A., Thompson, M. R., Bradshaw, C. M., Weinkauf, C. C., Bime, C., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.004 · Cited by 338
Mcl-1 is essential for the survival of plasma cells
Peperzak, V., Vikstrom, I. B., Walker, J. A., Glaser, S. P., LePage, M., Coquery, C. M., Erickson, L. D., Fairfax, K. A., Mackay, F., Strasser, A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2527 · Cited by 334
Crompton, P. D., Moebius, J., Portugal, S., Waisberg, M., Hart, G. T., Garver, L. S., Miller, L. H., Barillas-Mury, C. V., & Pierce, S. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120220 · Cited by 341
Alexander, T., Thiel, A., Rosen, O., Massenkeil, G., Sattler, A., Köhler, S., Mei, H. E., Radtke, H., Gromnica‐Ihle, E., Burmester, G. R., et al. (2008) · Blood · doi:10.1182/blood-2008-07-168286 · Cited by 320
Lambert, N. D., Strebel, P. M., Orenstein, W. A., Icenogle, J. P., & Poland, G. A. (2015) · The Lancet · doi:10.1016/s0140-6736(14)60539-0 · Cited by 313
New insights into the role of antinuclear antibodies in systemic lupus erythematosus
Pisetsky, D. S., & Lipsky, P. E. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0480-7 · Cited by 315
Understanding and learning from the success of prophylactic human papillomavirus vaccines
Schiller, J. T., & Lowy, D. R. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2872 · Cited by 295
Habibi, M. S., Jóźwik, A., Makris, S., Dunning, J. W., Paras, A., DeVincenzo, J. P., de Haan, C. A. M., Wrammert, J., Openshaw, P., & Chiu, C. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201412-2256oc · Cited by 289
Memory B and memory plasma cells
Yoshida, T., Mei, H. E., Dörner, T., Hiepe, F., Radbruch, A., Fillatreau, S., & Hoyer, B. F. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00938.x · Cited by 301
Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells
Lam, W. Y., Becker, A. M., Kennerly, K., Wong, R., Curtis, J. D., Llufrio, E. M., McCommis, K. S., Fahrmann, J. F., Pizzato, H. A., Nunley, R. M., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.011 · Cited by 294
SARS-CoV-2 mRNA Vaccines: Immunological Mechanism and Beyond
Bettini, E., & Locci, M. (2021) · Vaccines · doi:10.3390/vaccines9020147 · Cited by 292
Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination
Palm, A.-K. E., & Henry, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01787 · Cited by 297
Bhoj, V. G., Arhontoulis, D. C., Wertheim, G. B. W., Capobianchi, J., Callahan, C. A., Ellebrecht, C. T., Obstfeld, A. E., Lacey, S. F., Melenhorst, J. J., Nazimuddin, F., et al. (2016) · Blood · doi:10.1182/blood-2016-01-694356 · Cited by 282
T follicular helper cells in space-time
Qi, H. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.94 · Cited by 281
Advances in Human B Cell Phenotypic Profiling
Kaminski, D. A., Wei, C., Yu, Q., Rosenberg, A. F., & Sanz, I. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00302 · Cited by 291
Human peripheral blood B‐cell compartments: A crossroad in B‐cell traffic
Pérez‐Andrés, M., Paiva, B., Nieto, W. G., Caraux, A., Schmitz, A., Almeida, J., Vogt, R. F., Marti, G. E., Rawstron, A. C., van Zelm, M. C., et al. (2010) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20547 · Cited by 269
Immunological memory to SARS‐CoV ‐2 infection and COVID ‐19 vaccines
Sette, A., & Crotty, S. (2022) · Immunological Reviews · doi:10.1111/imr.13089 · Cited by 270
Crawford, K. H. D., Dingens, A. S., Eguia, R., Wolf, C. R., Wilcox, N., Logue, J. K., Shuey, K., Casto, A. M., Fiala, B., Wrenn, S., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa618 · Cited by 265
Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection
Cromer, D., Juno, J. A., Khoury, D., Reynaldi, A., Wheatley, A. K., Kent, S. J., & Davenport, M. P. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00550-x · Cited by 265
Contributions of humoral and cellular immunity to vaccine-induced protection in humans
Amanna, I. J., & Slifka, M. K. (2011) · Virology · doi:10.1016/j.virol.2010.12.016 · Cited by 263
Self-citationBlood-borne human plasma cells in steady state are derived from mucosal immune responses
Mei, H. E., Yoshida, T., Sime, W., Hiepe, F., Thiele, K., Manz, R. A., Radbruch, A., & Dörner, T. (2008) · Blood · doi:10.1182/blood-2008-04-153544 · Cited by 259
Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination
Cho, A., Muecksch, F., Schaefer-Babajew, D. J., Wang, Z., Finkin, S., Gaebler, C., Ramos, V., Cipolla, M., Mendoza, P., Agudelo, M., et al. (2021) · Nature · doi:10.1038/s41586-021-04060-7 · Cited by 263
Wipasa, J., Suphavilai, C., Okell, L., Cook, J. A., Corran, P. H., Thaikla, K., Liewsaree, W., Riley, E. M., & Hafalla, J. C. R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000770 · Cited by 248
Mietzner, B., Tsuiji, M., Scheid, J. F., Velinzon, K., Tiller, T., Abraham, K., González, J., Pascual, V., Stichweh, D., Wardemann, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803644105 · Cited by 241
Lavinder, J. J., Wine, Y., Giesecke‐Thiel, C., Ippolito, G. C., Horton, A. P., Lungu, O. I., Hoi, K. H., DeKosky, B. J., Murrin, E. M., Wirth, M. M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317793111 · Cited by 247
Weiss, G. E., Traore, B., Kayentao, K., Ongoïba, A., Doumbo, S., Doumtabé, D., Koné, Y., Dia, S., Guindo, A., Traoré, A., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000912 · Cited by 237
Evolutionary biology of high-risk multiple myeloma
Pawlyn, C., & Morgan, G. J. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.63 · Cited by 242
Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors
Shroff, R. T., Chalasani, P., Wei, R., Pennington, D., Quirk, G., Schoenle, M. V., Peyton, K. L., Uhrlaub, J. L., Ripperger, T. J., Jergović, M., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01542-z · Cited by 237
Influence of Prior Influenza Vaccination on Antibody and B-Cell Responses
Sasaki, S., He, X.-S., Holmes, T. H., Dekker, C. L., Kemble, G. W., Arvin, A. M., & Greenberg, H. B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002975 · Cited by 234
A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow
Mei, H. E., Wirries, I., Frölich, D., Brisslert, M., Giesecke‐Thiel, C., Grün, J. R., Alexander, T., Schmidt, S., Luda, K. M., Kühl, A. A., et al. (2015) · Blood · doi:10.1182/blood-2014-02-555169 · Cited by 231
Neutralization of Virus Infectivity by Antibodies: Old Problems in New Perspectives
Klasse, P. J. (2014) · Advances in Biology · doi:10.1155/2014/157895 · Cited by 246
Inoue, T., & Kurosaki, T. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00897-3 · Cited by 245
Explanations for the high potency of HPV prophylactic vaccines
Schiller, J. T., & Lowy, D. R. (2018) · Vaccine · doi:10.1016/j.vaccine.2017.12.079 · Cited by 235
Frasca, D., Diaz, A., Romero, M., Garcia, D., & Blomberg, B. B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-011620-034148 · Cited by 232
Obeng-Adjei, N., Portugal, S., Tran, T. M., Yazew, T., Skinner, J., Li, S., Jain, A., Felgner, P. L., Doumbo, O. K., Kayentao, K., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.004 · Cited by 229
Safaeian, M., Porras, C., Pan, Y., Kreimer, A. R., Schiller, J. T., González, P., Lowy, D. R., Wacholder, S., SCHIFFMAN, M. H., Rodríguez, A. C., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0203 · Cited by 223
Clonal dissection of the human memory B‐cell repertoire following infection and vaccination
Pinna, D., Corti, D., Jarrossay, D., Sallusto, F., & Lanzavecchia, A. (2009) · European Journal of Immunology · doi:10.1002/eji.200839129 · Cited by 222
Evaluation of Durability of a Single Dose of the Bivalent HPV Vaccine: The CVT Trial
Kreimer, A. R., Sampson, J. N., Porras, C., Schiller, J. T., Kemp, T. J., Herrero, R., Wagner, S. A., Boland, J. F., Schussler, J. E., Lowy, D. R., et al. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa011 · Cited by 220
Wang, S., Liang, B., Wang, W., Li, L., Feng, N., Zhao, Y., Wang, T., Yan, F., Yang, S., & Xia, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01408-5 · Cited by 230
The human spleen is a major reservoir for long-lived vaccinia virus–specific memory B cells
Mamani‐Matsuda, M., Cosma, A., Weller, S., Faili, A., Staib, C., Garçon, L., Hermine, O., Beyne‐Rauzy, O., Fieschi, C., Pers, J., et al. (2008) · Blood · doi:10.1182/blood-2007-11-123844 · Cited by 229
A guide to adaptive immune memory
Lam, N., Lee, Y. S., & Färber, D. L. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01040-6 · Cited by 236
A method for identification of HIV gp140 binding memory B cells in human blood
Scheid, J. F., Mouquet, H., Feldhahn, N., Walker, B. D., Pereyra, F., Cutrell, E., Seaman, M. S., Mascola, J. R., Wyatt, R. T., Wardemann, H., et al. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.11.012 · Cited by 212
Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection
Zhang, A., Stacey, H. D., D’Agostino, M. R., Tugg, Y., Marzok, A., & Miller, M. S. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00813-1 · Cited by 225
Dengue: knowledge gaps, unmet needs, and research priorities
Katzelnick, L. C., Coloma, J., & Harris, E. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30473-x · Cited by 211
Plasma cell survival in the absence of B cell memory
Hammarlund, E., Thomas, A., Amanna, I. J., Holden, L. A., Slayden, O. D., Park, B., Gao, L., & Slifka, M. K. (2017) · Nature Communications · doi:10.1038/s41467-017-01901-w · Cited by 210
Self-citationHatano, H., Delwart, E., Norris, P. J., Lee, T., Dunn-Williams, J., Hunt, P. W., Hoh, R., Stramer, S. L., Linnen, J. M., McCune, J. M., et al. (2008) · Journal of Virology · doi:10.1128/jvi.01763-08 · Cited by 208
B cells as therapeutic targets in autoimmune neurological disorders
Dalakas, M. C. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0901 · Cited by 205
B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells
Mahévas, M., Patin, P., Huetz, F., Descatoire, M., Cagnard, N., Bôle‐Feysot, C., Gallou, S. L., Khellaf, M., Fain, O., Boutboul, D., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65689 · Cited by 200
Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies
Muellenbeck, M. F., Ueberheide, B. M., Amulic, B., Epp, A., Fenyö, D., Busse, C. E., Esen, M., Theisen, M., Mordmüller, B. G., & Wardemann, H. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121970 · Cited by 199
Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle
Lightman, S. M., Utley, A. T., & Lee, K. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00965 · Cited by 198
Challenges and strategies for developing efficacious and long-lasting malaria vaccines
Beeson, J. G., Kurtovic, L., Dobaño, C., Opi, D. H., Chan, J.-A., Feng, G., Good, M. F., Reiling, L., & Boyle, M. J. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau1458 · Cited by 195
Contributions of Antinucleoprotein IgG to Heterosubtypic Immunity against Influenza Virus
LaMere, M. W., Lam, H.-T., Moquin, A., Haynes, L., Lund, F. E., Randall, T. D., & Kaminski, D. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003057 · Cited by 202
Miller, M. S., Gardner, T. J., Krammer, F., Aguado, L. C., Tortorella, D., Basler, C. F., & Palese, P. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006637 · Cited by 190
Kernéis, S., Launay, O., Turbelin, C., Batteux, F., Hanslik, T., & Boëlle, P. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/cit937 · Cited by 190
Miho, E., Yermanos, A., Weber, C. R., Berger, C. T., Reddy, S. T., & Greiff, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00224 · Cited by 189
Levesque, M. C., Moody, M. A., Hwang, K.-K., Marshall, D. J., Whitesides, J. F., Amos, J. D., Gurley, T. C., Allgood, S. D., Haynes, B. B., Vandergrift, N., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000107 · Cited by 184
Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells
Rozanski, C. H., Arens, R., Carlson, L. M., Nair, J. R., Boise, L., Chanan-Khan, A. A., Schoenberger, S. P., & Lee, K. P. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110040 · Cited by 193
Memory B cells and plasma cells: The differentiative continuum of humoral immunity
Cancro, M. P., & Tomayko, M. M. (2021) · Immunological Reviews · doi:10.1111/imr.13016 · Cited by 189
Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production
Chen, Y., Zuiani, A., Fischinger, S., Mullur, J., Atyeo, C. G., Travers, M. E., Lelis, F., Pullen, K. M., Martin, H., Tong, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.051 · Cited by 182
Markowitz, L. E., & Schiller, J. T. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa621 · Cited by 195
Studies of the immune response in heparin-induced thrombocytopenia
Warkentin, T. E., Sheppard, J. I., Moore, J. C., Cook, R. J., & Kelton, J. G. (2009) · Blood · doi:10.1182/blood-2008-10-186064 · Cited by 177
The role of B cells and humoral immunity in Mycobacterium tuberculosis infection
Chan, J., Mehta, S., Bharrhan, S., Chen, Y., Achkar, J. M., Casadevall, A., & Flynn, J. L. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.10.005 · Cited by 183
B-cell-directed therapies for autoimmune disease
Dörner, T., Radbruch, A., & Burmester, G. R. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.141 · Cited by 176
Vaccines for preventing herpes zoster in older adults
Gagliardi, A. M., Andriolo, B. N., Torloni, M. R., & Soares, B. G. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008858.pub3 · Cited by 175
Adhikari, U. K., Tayebi, M., & Rahman, M. (2018) · Journal of Immunology Research · doi:10.1155/2018/6718083 · Cited by 174
Malaria prevention: from immunological concepts to effective vaccines and protective antibodies
Cockburn, I. A., & Seder, R. A. (2018) · Nature Immunology · doi:10.1038/s41590-018-0228-6 · Cited by 174
Pensieroso, S., Cagigi, A., Palma, P., Nilsson, A., Capponi, C., Freda, E., Bernardi, S., Thorstensson, R., Chiodi, F., & Rossi, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901702106 · Cited by 164
Zuiani, A., Dulberger, C. L., Silva, N. S. D., Marquette, M., Lu, Y.-J., Palowitch, G. M., Dokic, A., Sanchez-Velazquez, R., Schlatterer, K., Sarkar, S., et al. (2024) · Cell · doi:10.1016/j.cell.2024.01.017 · Cited by 166
Walsh, R. C., Brailey, P. A., Girnita, A. L., Alloway, R. R., Shields, A. R., Wall, G. E., Sadaka, B. H., Cardi, M. A., Tevar, A. D., Govil, A., et al. (2011) · Transplantation · doi:10.1097/tp.0b013e318218e901 · Cited by 161
Moris, P., der Most, R. G. V., Leroux‐Roels, I., Clément, F., Dramé, M., Hanon, E., Leroux-Roels, G. G., & Mechelen, M. V. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9490-6 · Cited by 159
Metadata
- Authors
- Amanna, I. J., Carlson, N. E., & Slifka, M. K.
- Affiliations
- Oregon Health & Science University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-11-08
- Volume
- 357
- Issue
- 19
- Pages
- 1903-1915
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2128666074
- Cited by
- 1,286
- References
- 38
- Citations by year
- 2026: 60 · 2025: 81 · 2024: 82 · 2023: 72 · 2022: 103 · 2021: 127 · 2020: 73 · 2019: 60 · 2018: 64 · 2017: 64 · 2016: 52 · 2015: 47 · 2014: 68 · 2013: 67 · 2012: 66
- FWCI
- 17.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG023664)
- National Center for Research Resources (RR000163, P51RR000163, M01RR000334, UL1RR024140, RR024140, RR 000334)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- humoral immunity, antibody half-life, memory B cells, long-term antibody persistence, vaccine antigens, measles, mumps, rubella, varicella-zoster virus, Epstein-Barr virus, tetanus toxoid, diphtheria toxoid, protective immunity
- MeSH terms
- Adult, Aging, Antibodies, Bacterial, Antibodies, Viral, Antibody Formation, Antigens, Bacterial, Antigens, Viral, B-Lymphocytes, Diphtheria, Female, Half-Life, Humans, Longitudinal Studies, Male, Middle Aged, Plasma Cells, Tetanus, Time Factors, Vaccines, Virus Diseases, Seroepidemiologic Studies, Lymphocyte Count
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review