A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978

Allergy and Allergic Diseases

Kay, A. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440106 · Cited by 1,368

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

Moussion, C., Ortega, N., & Girard, J.-P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003331 · Cited by 1,179

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo

Carriere, V., Roussel, L., Ortega, N., Lacorre, D.-A., Americh, L., Aguilar, L., Bouche, G., & Girard, J.-P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606854104 · Cited by 966

Mapping complex disease traits with global gene expression

Cookson, W., Liang, L., Abecasis, G., Moffatt, M., & Lathrop, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2537 · Cited by 849

Estimation of significance thresholds for genomewide association scans

Dudbridge, F., & Gusnanto, A. (2008) · Genetic Epidemiology · doi:10.1002/gepi.20297 · Cited by 703

Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease

Verlaan, D. J., Berlivet, S., Hunninghake, G. M., Madore, A.-M., Larivière, M., Moussette, S., Grundberg, E., Kwan, T., Ouimet, M., Ge, B., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.08.007 · Cited by 297

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Shi, J., Gao, W., & Shao, F. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.10.004 · Cited by 3,088

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Yazar, S., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00913-z · Cited by 2,607

The interleukin-1 family: back to the future

Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945

T follicular helper cell biology: a decade of discovery and diseases

Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591

Exposure to Environmental Microorganisms and Childhood Asthma

Ege, M. J., Mayer, M., Normand, A.-C., Genuneit, J., Cookson, W. O. C. M., Braun-Fahrländer, C., Heederik, D., Piarroux, R., & von Mutius, E. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1007302 · Cited by 1,529

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations

Martin, A. R., Gignoux, C. R., Walters, R. K., Wojcik, G. L., Neale, B. M., Gravel, S., Daly, M. J., Bustamante, C. D., & Kenny, E. E. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.03.004 · Cited by 1,391

After asthma: redefining airways diseases

Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)30879-6 · Cited by 1,073

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age

Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B. L. K., Skov, T., Paludan-Müller, G., Stokholm, J., Smith, B., & Krogfelt, K. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.060 · Cited by 786

The genetics of asthma and allergic disease: a 21st century perspective

Ober, C., & Yao, T. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01029.x · Cited by 698

New IBD genetics: common pathways with other diseases

Lees, C. W., Barrett, J. C., Parkes, M., & Satsangi, J. (2011) · Gut · doi:10.1136/gut.2009.199679 · Cited by 635

Interleukin-33 in tissue homeostasis, injury, and inflammation

Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638

International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557

Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Kasela, S., et al. (2018) · doi:10.1101/447367 · Cited by 2,607

IL-33–Responsive Lineage−CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs

Bartemes, K. R., Iijima, K., Kobayashi, T., Kephart, G. M., McKenzie, A. N., & Kita, H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102832 · Cited by 549

The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin

Weaver, C. T., Elson, C. O., Fouser, L. A., & Kolls, J. K. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130318 · Cited by 462

The biodiversity hypothesis and allergic disease: world allergy organization position statement

Haahtela, T., Holgate, S., Pawankar, R., Akdis, C. A., Benjaponpitak, S., Caraballo, L., Demain, J., Portnoy, J., & von Hertzen, L. (2013) · World Allergy Organization Journal · doi:10.1186/1939-4551-6-3 · Cited by 426

Enhanced innate type 2 immune response in peripheral blood from patients with asthma

Bartemes, K. R., Kephart, G. M., Fox, S. J., & Kita, H. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.06.024 · Cited by 390

Identification of IL6R and chromosome 11q13.5 as risk loci for asthma

Ferreira, M. A., Matheson, M. C., Duffy, D. L., Marks, G. B., Hui, J., Le Souëf, P., Danoy, P., Baltic, S., Nyholt, D. R., Jenkins, M., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60874-x · Cited by 381

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

Emdin, C. A., Khera, A. V., Natarajan, P., Klarin, D., Zekavat, S. M., Hsiao, A. J., & Kathiresan, S. (2017) · JAMA · doi:10.1001/jama.2016.21042 · Cited by 378

Genome-wide association study reveals two new risk loci for bipolar disorder

Mühleisen, T. W., Leber, M., Schulze, T. G., Strohmaier, J., Degenhardt, F., Treutlein, J., Mattheisen, M., Forstner, A. J., Schumacher, J., Breuer, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4339 · Cited by 346

The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines

Han, H., Roan, F., & Ziegler, S. F. (2017) · Immunological Reviews · doi:10.1111/imr.12546 · Cited by 285

IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma

Saglani, S., Lui, S., Ullmann, N., Campbell, G. A., Sherburn, R. T., Mathie, S. A., Denney, L., Bossley, C. J., Oates, T., Walker, S. A., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.012 · Cited by 258

Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

Emdin, C. A., Khera, A. V., Natarajan, P., Klarin, D., Won, H.-H., Peloso, G. M., Stitziel, N. O., Nomura, A., Zekavat, S. M., Bick, A. G., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.10.033 · Cited by 244

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Australian Asthma Genetics Consortium (AAGC), Bønnelykke, K., the EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Matheson, M. C., Pers, T. H., Granell, R., Strachan, D. P., Alves, A. C., Linneberg, A., Curtin, J. A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2694 · Cited by 244

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

Hinds, D. A., McMahon, G., Kiefer, A. K., Do, C. B., Eriksson, N., Evans, D. M., St Pourcain, B., Ring, S. M., Mountain, J. L., Francke, U., et al. (2013) · Nature Genetics · doi:10.1038/ng.2686 · Cited by 246

Epithelial barrier repair and prevention of allergy

Goleva, E., Berdyshev, E., & Leung, D. Y. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124608 · Cited by 251

A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order

Ramasamy, A., Curjuric, I., Coin, L. J., Kumar, A., McArdle, W. L., Imboden, M., Leynaert, B., Kogevinas, M., Schmid-Grendelmeier, P., Pekkanen, J., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.08.030 · Cited by 222

Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype

Ferreira, M. A. R., Matheson, M. C., Tang, C. S., Granell, R., Ang, W., Hui, J., Kiefer, A. K., Duffy, D. L., Baltic, S., Danoy, P., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.030 · Cited by 216

Impaired innate interferon induction in severe therapy resistant atopic asthmatic children

Edwards, M. R., Regamey, N., Vareille, M., Kieninger, E., Gupta, A., Shoemark, A., Saglani, S., Sykes, A., Macintyre, J., Davies, J., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2012.118 · Cited by 214

An epigenome-wide association study of total serum immunoglobulin E concentration

Liang, L., Willis-Owen, S. A. G., Laprise, C., Wong, K. C. C., Davies, G. A., Hudson, T. J., Binia, A., Hopkin, J. M., Yang, I. V., Grundberg, E., et al. (2015) · Nature · doi:10.1038/nature14125 · Cited by 213

Genetic risk factors for the development of allergic disease identified by genome‐wide association

Portelli, M. A., Hodge, E., & Sayers, I. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12327 · Cited by 206

Use of precision cut lung slices as a translational model for the study of lung biology

Liu, G., Betts, C., Cunoosamy, D. M., Åberg, P. M., Hornberg, J. J., Sivars, K. B., & Cohen, T. S. (2019) · Respiratory Research · doi:10.1186/s12931-019-1131-x · Cited by 206

DNA methylation in lung cells is associated with asthma endotypes and genetic risk

Nicodemus-Johnson, J., Myers, R. A., Sakabe, N. J., Sobreira, D. R., Hogarth, D. K., Naureckas, E. T., Sperling, A. I., Solway, J., White, S. R., Nobrega, M. A., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.90151 · Cited by 180

HpARI protein secreted by a helminth parasite suppresses interleukin-33

Osbourn, M., Soares, D. C., Vacca, F., Cohen, E. S., Scott, I. C., Gregory, W. F., Smyth, D. J., Toivakka, M., Kemter, A. M., le Bihan, T., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.015 · Cited by 178

Strategies targeting the IL-4/IL-13 axes in disease

May, R. D., & Fung, M. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.018 · Cited by 166

Timing of infant feeding in relation to childhood asthma and allergic diseases

Nwaru, B. I., Takkinen, H.-M., Niemelä, O., Kaila, M., Erkkola, M., Ahonen, S., Haapala, A.-M., Kenward, M. G., Pekkanen, J., Lahesmaa, R., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.10.028 · Cited by 151

Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)

Tamai, I. (2013) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.1816 · Cited by 141

Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses

Hristova, M., Habibovic, A., Veith, C., Janssen-Heininger, Y. M. W., Dixon, A. E., Geiszt, M., & van der Vliet, A. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.003 · Cited by 141

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

Schmiedel, B. J., Seumois, G., Samaniego-Castruita, D., Cayford, J., Schulten, V., Chavez, L., Ay, F., Sette, A., Peters, B., & Vijayanand, P. (2016) · Nature Communications · doi:10.1038/ncomms13426 · Cited by 127

Statistical Testing of Shared Genetic Control for Potentially Related Traits

Wallace, C. (2013) · Genetic Epidemiology · doi:10.1002/gepi.21765 · Cited by 115

Age-of-asthma onset as a determinant of different asthma phenotypes in adults: a systematic review and meta-analysis of the literature

Tan, D. J., Walters, E. H., Perret, J. L., Lodge, C. J., Lowe, A. J., Matheson, M. C., & Dharmage, S. C. (2015) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2015.1000311 · Cited by 112

Cytokine Responses to rhinovirus and development of asthma, allergic sensitization and respiratory infections during childhood

Custovic, A., Belgrave, D., Lin, L., Bakhsoliani, E., Telcian, A. G., Solari, R., Murray, C. S., Walton, R. P., Curtin, J., Edwards, M. R., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201708-1762oc · Cited by 95

Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project

Liu, S., Jørgensen, J. T., Ljungman, P., Pershagen, G., Bellander, T., Leander, K., Magnusson, P. K. E., Rizzuto, D., Hvidtfeldt, U. A., Raaschou-Nielsen, O., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.03099-2020 · Cited by 142

Global issues in allergy and immunology: Parasitic infections and allergy

Cruz, A. A., Cooper, P. J., Figueiredo, C. A., Alcantara-Neves, N. M., Rodrigues, L. C., & Barreto, M. L. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.005 · Cited by 82

Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

Karta, M. R., Broide, D. H., & Doherty, T. A. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0581-6 · Cited by 77

Genetics of allergy and allergic sensitization: common variants, rare mutations

Bønnelykke, K., Sparks, R., Waage, J., & Milner, J. D. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.08.002 · Cited by 73

Clinical and functional differences between early-onset and late-onset adult asthma: a population-based tasmanian longitudinal health study

Tan, D. J., Walters, E. H., Perret, J. L., Burgess, J. A., Johns, D. P., Lowe, A. J., Lodge, C. J., Hayati Rezvan, P., Simpson, J. A., Morrison, S., et al. (2016) · Thorax · doi:10.1136/thoraxjnl-2015-208183 · Cited by 69

Elevated Levels of Interleukin-33 in the Nasal Secretions of Patients with Allergic Rhinitis

Asaka, D., Yoshikawa, M., Nakayama, T., Yoshimura, T., Moriyama, H., & Otori, N. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000337764 · Cited by 59

Childhood Asthma Inception and Progression

Martinez, F. D. (2019) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2018.12.001 · Cited by 59

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

Scholtens, S., Postma, D. S., Moffatt, M. F., Panasevich, S., Granell, R., Henderson, A. J., Melén, E., Nyberg, F., Pershagen, G., Jarvis, D., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.08.049 · Cited by 51

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep

Cade, B. E., Chen, H., Stilp, A. M., Louie, T., Ancoli-Israel, S., Arens, R., Barfield, R., Below, J. E., Cai, J., Conomos, M. P., et al. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1007739 · Cited by 39

DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis

Sarnowski, C., Laprise, C., Malerba, G., Moffatt, M. F., Dizier, M.-H., Morin, A., Vincent, Q. B., Rohde, K., Esparza-Gordillo, J., Margaritte-Jeannin, P., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.12.1341 · Cited by 35

A Polymorphism Affecting MYB Binding within the Promoter of the PDCD4 Gene is Associated with Severe Asthma in Children

Binia, A., Van Stiphout, N., Liang, L., Michel, S., Bhavsar, P. K., Fan Chung, K., Brightling, C. E., Barnes, P. J., Kabesch, M., Bush, A., et al. (2013) · Human Mutation · doi:10.1002/humu.22340 · Cited by 24

Heterogeneity of obesity-asthma association disentangled by latent class analysis, the SAPALDIA cohort

Jeong, A., Imboden, M., Hansen, S., Zemp, E., Bridevaux, P.-O., Lovison, G., Schindler, C., & Probst-Hensch, N. (2017) · Respiratory Medicine · doi:10.1016/j.rmed.2017.02.014 · Cited by 23

Investigating highly replicated asthma genes as candidate genes for allergic rhinitis

Andiappan, A. K., Nilsson, D., Halldén, C., De Yun, W., Säll, T., Cardell, L. O., & Tim, C. F. (2013) · BMC Medical Genetics · doi:10.1186/1471-2350-14-51 · Cited by 20

Investigation of novel genes for lung function in children and their interaction with tobacco smoke exposure: a preliminary report

Panasevich, S., Melén, E., Hallberg, J., Bergström, A., Svartengren, M., Pershagen, G., & Nyberg, F. (2013) · Acta Paediatrica · doi:10.1111/apa.12204 · Cited by 15