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Bone Quality — The Material and Structural Basis of Bone Strength and Fragility

Seeman, Ego, Delmas, Pierre D.·2006·New England Journal of Medicine

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This review discusses advances in knowledge regarding the composition and structure of bone, the modeling and remodeling of bone, the formation of bone during growth and its reconstruction in adults, and how age-related abnormalities in these processes compromise the composition and structure of bone.

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Show all 6 references

An overview and management of osteoporosis
Sözen, T., Özışık, L., & Çalık Başaran, N. (2019) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2016.048 · Cited by 2,262
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Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778
Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Jorenby, D. E. (2006) · JAMA · doi:10.1001/jama.296.1.56 · Cited by 1,635
Targeting the tumour stroma to improve cancer therapy
Valkenburg, K. C., de Groot, A. E., & Pienta, K. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0007-1 · Cited by 1,084
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
Xie, H., Cui, Z., Wang, L., Xia, Z., Hu, Y., Xian, L., Li, C., Xie, L., Crane, J., Wan, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3668 · Cited by 951
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kobayashi, T., Kohno, K., Ito, M., Takeshita, S., & Ikeda, K. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.001 · Cited by 848
Osteoprotection by semaphorin 3A
Hayashi, M., Nakashima, T., Taniguchi, M., Kodama, T., Kumanogoh, A., & Takayanagi, H. (2012) · Nature · doi:10.1038/nature11000 · Cited by 606
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Osterhoff, G., Morgan, E. F., Shefelbine, S. J., Karim, L., McNamara, L. M., & Augat, P. (2016) · Injury · doi:10.1016/s0020-1383(16)47003-8 · Cited by 557
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Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
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Authors: Seeman, E., & Delmas, P. D.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2006-05-25
Volume: 354
Issue: 21
Pages: 2250-2261
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra053077
OpenAlex: W2113697838
Cited by: 2,080
References: 6
FWCI: 94.56
Type: journal article
Language: en
Open access: closed

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Bone Quality — The Material and Structural Basis of Bone Strength and Fragility

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