The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles.
Open accessAbstract
Gene expression profiles from the anterior cingulate cortex (ACC) of human, chimpanzee, gorilla, and macaque samples provide clues about genetic regulatory changes in human and other catarrhine primate brains. The ACC, a cerebral neocortical region, has human-specific histological features. Physiologically, an individual's ACC displays increased activity during that individual's performance of cognitive tasks. Of approximately 45,000 probe sets on microarray chips representing transcripts of all or most human genes, approximately 16,000 were commonly detected in human ACC samples and comparable numbers, 14,000-15,000, in gorilla and chimpanzee ACC samples. Phylogenetic results obtained from gene expression profiles contradict the traditional expectation that the non-human African apes (i.e., chimpanzee and gorilla) should be more like each other than either should be like humans. Instead, the chimpanzee ACC profiles are more like the human than like the gorilla; these profiles demonstrate that chimpanzees are the sister group of humans. Moreover, for those unambiguous expression changes mapping to important biological processes and molecular functions that statistically are significantly represented in the data, the chimpanzee clade shows at least as much apparent regulatory evolution as does the human clade. Among important changes in the ancestry of both humans and chimpanzees, but to a greater extent in humans, are the up-regulated expression profiles of aerobic energy metabolism genes and neuronal function-related genes, suggesting that increased neuronal activity required increased supplies of energy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This scenario reconciles human brain metabolism with comparative genetic analyses that show that genes related to cell metabolism are among those that exhibit the larger changes in human evolution [9], [10], with evidence of evolutionary pressure for high rates of aerobic energy consumption [52].”
From Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution (2011) · cites this paper as [10]
In the citing paper
“recent microarray studies have shown that genes involved in neuronal signaling and energy production are up-regulated in the human neocortex compared with chimpanzees and other great apes (4, 5).”
From Evolution of increased glia–neuron ratios in the human frontal cortex (2006) · cites this paper as [4]
In the citing paper
“Comparative microarray experiments have also revealed up-regulation of genes in the human neocortex related to energy metabolism (4, 5).”
From Evolution of increased glia–neuron ratios in the human frontal cortex (2006) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Does Rejection Hurt? An fMRI Study of Social Exclusion
Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003) · Science · doi:10.1126/science.1089134 · Cited by 3,849
MacDonald, A. W., Cohen, J. D., Stenger, V. A., & Carter, C. S. (2000) · Science · doi:10.1126/science.288.5472.1835 · Cited by 3,666
Whiten, A., Goodall, J., McGrew, W. C., Nishida, T., Reynolds, V., Sugiyama, Y., Tutin, C. E. G., Wrangham, R. W., & Boesch, C. (1999) · Nature · doi:10.1038/21415 · Cited by 2,448
Pardo, J. V., Pardo, P. J., Janer, K. W., & Raichle, M. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.256 · Cited by 1,495
Life and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344
Self-citationCytochrome oxidase: an endogenous metabolic marker for neuronal activity
Wong-Riley, M. T. T. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90165-3 · Cited by 1,238
Parsing executive processes: Strategic vs. evaluative functions of the anterior cingulate cortex
Carter, C. S., Macdonald, A. M., Botvinick, M., Ross, L. L., Stenger, V. A., Noll, D. C., & Cohen, J. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1944 · Cited by 954
Allman, J. M., Hakeem, A. Y., Erwin, J. M., Nimchinsky, E. A., & Hof, P. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03476.x · Cited by 922
Self-citationRefSeq and LocusLink: NCBI gene-centered resources
Pruitt, K. D. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.1.137 · Cited by 884
Research works printed but not linked: 2
- Goodall, J. [v. L.] (1968) Anim. Behav. Monogr. 1, 165-311.
- Yamakoshi, G. & Myowa-Yamakoshi, M. (2003) Primates 45, 25-32.14566573
Cited by
Sorted by citations
A Cellular Perspective on Brain Energy Metabolism and Functional Imaging
Magistretti, P. J., & Allaman, I. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.035 · Cited by 1,285
The evolution of gene expression levels in mammalian organs
Brawand, D., Soumillon, M., Necsulea, A., Julien, P., Csárdi, G., Harrigan, P., Weier, M., Liechti, A., Aximu-Petri, A., Kircher, M., et al. (2011) · Nature · doi:10.1038/nature10532 · Cited by 1,248
Brain metabolism in health, aging, and neurodegeneration
Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695810 · Cited by 752
Herculano-Houzel, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201895109 · Cited by 726
Conservation and evolution of gene coexpression networks in human and chimpanzee brains
Oldham, M. C., Horvath, S., & Geschwind, D. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605938103 · Cited by 566
Evolution of the Human Nervous System Function, Structure, and Development
Sousa, A. M. M., Meyer, K. A., Santpere, G., Gulden, F. O., & Sestan, N. (2017) · Cell · doi:10.1016/j.cell.2017.06.036 · Cited by 517
Use and misuse of the gene ontology annotations
Rhee, S. Y., Wood, V., Dolinski, K. J., & Drăghici, S. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2363 · Cited by 506
Dosage compensation of the active X chromosome in mammals
Nguyen, D. K., & Distèche, C. M. (2005) · Nature Genetics · doi:10.1038/ng1705 · Cited by 501
Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
Dorus, S., Vallender, E. J., Evans, P. D., Anderson, J. R., Gilbert, S. L., Mahowald, M. A., Wyckoff, G. J., Malcom, C. M., & Lahn, B. T. (2004) · Cell · doi:10.1016/j.cell.2004.11.040 · Cited by 429
A natural history of the human mind: tracing evolutionary changes in brain and cognition
Sherwood, C. C., Subiaul, F., & Zawidzki, T. W. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00868.x · Cited by 377
Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells
Izadpanah, R., Kaushal, D., Kriedt, C. L., Tsien, F., Patel, B. G., Dufour, J., & Bunnell, B. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5272 · Cited by 358
The eloquent ape: genes, brains and the evolution of language
Fisher, S. E., & Marcus, G. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1747 · Cited by 354
Evolution of primate gene expression
Khaitovich, P., Enard, W., Lachmann, M., & Pääbo, S. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1940 · Cited by 341
Comparing the human and chimpanzee genomes: Searching for needles in a haystackPreprint
Varki, A. P., & Altheide, T. K. (2005) · Genome Research · doi:10.1101/gr.3737405 · Cited by 339
Herculano-Houzel, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017514 · Cited by 343
Evolution of increased glia–neuron ratios in the human frontal cortex
Sherwood, C. C., Stimpson, C. D., Raghanti, M. A., Wildman, D. E., Uddin, M., Grossman, L. I., Goodman, M., Redmond, J. C., Bonar, C. J., Erwin, J. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605843103 · Cited by 342
Self-citationLenroot, R. K., Schmitt, J. E., Ordaz, S. J., Wallace, G. L., Neale, M. C., Lerch, J. P., Kendler, K. S., Evans, A. C., & Giedd, J. N. (2009) · Human Brain Mapping · doi:10.1002/hbm.20494 · Cited by 320
Regional Patterns of Gene Expression in Human and Chimpanzee BrainsPreprint
Khaitovich, P., Muetzel, B., She, X., Lachmann, M., Hellmann, I., Dietzsch, J., Steigele, S., Do, H.-H., Weiß, G., Enard, W., et al. (2004) · Genome Research · doi:10.1101/gr.2538704 · Cited by 310
Human-Specific Transcriptional Networks in the Brain
Konopka, G., Friedrich, T., Davis‐Turak, J., Winden, K. D., Oldham, M. C., Gao, F., Chen, L., Wang, G.-Z., Luo, R., Preuss, T. M., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.034 · Cited by 268
Molecular and cellular reorganization of neural circuits in the human lineage
Sousa, A. M. M., Zhu, Y., Raghanti, M. A., Kitchen, R. R., Onorati, M., Tebbenkamp, A. T. N., Stutz, B., Meyer, K. A., Li, M., Kawasawa, Y. I., et al. (2017) · Science · doi:10.1126/science.aan3456 · Cited by 253
Self-citationHuman brain evolution: transcripts, metabolites and their regulators
Somel, M., Liu, X., & Khaitovich, P. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3372 · Cited by 246
MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates
Somel, M., Liu, X., Tang, L., Yan, Z., Hu, H., Guo, S., Jiang, X., Zhang, X., Xu, G., Xie, G., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001214 · Cited by 232
The evolutionary history of the hominin hand since the last common ancestor of Pan and Homo
Tocheri, M. W., Orr, C. M., Jacofsky, M. C., & Marzke, M. W. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00865.x · Cited by 240
A comparison of the Thlaspi caerulescens and Thlaspi arvense shoot transcriptomes
Hammond, J. P., Bowen, H. C., White, P. J., Mills, V., Pyke, K. A., Baker, A. J. M., Whiting, S. N., May, S. T., & Broadley, M. R. (2006) · New Phytologist · doi:10.1111/j.1469-8137.2006.01662.x · Cited by 223
Human brain evolution: insights from microarrays
Preuss, T. M., Cáceres, M., Oldham, M. C., & Geschwind, D. H. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1469 · Cited by 215
Molecular insights into human brain evolution
Hill, R. S., & Walsh, C. A. (2005) · Nature · doi:10.1038/nature04103 · Cited by 208
Placing confidence limits on the molecular age of the human–chimpanzee divergence
Kumar, S., Filipski, A., Swarna, V., Walker, A., & Hedges, S. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509585102 · Cited by 206
Understanding Human Cognitive Uniqueness
Laland, K. N., & Seed, A. M. (2021) · Annual Review of Psychology · doi:10.1146/annurev-psych-062220-051256 · Cited by 211
Accelerated evolution of the electron transport chain in anthropoid primates
Grossman, L. I., Wildman, D. E., Schmidt, T. R., & Goodman, M. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.09.002 · Cited by 186
Self-citationCurcumin induces apoptosis via inhibition of PI3′-kinase/AKT pathway in Acute T cell Leukemias
Hussain, A. R., Al-Rasheed, M. M., Manogaran, P. S., Al‐Hussein, K. A., Platanias, L. C., Al-Kuraya, K. S., & Shahab Uddin, M. S. (2006) · APOPTOSIS · doi:10.1007/s10495-006-3392-3 · Cited by 184
Evaluating the role of natural selection in the evolution of gene regulation
Fay, J. C., & Wittkopp, P. J. (2007) · Heredity · doi:10.1038/sj.hdy.6801000 · Cited by 179
Genetic links between brain development and brain evolution
Gilbert, S. L., Dobyns, W. B., & Lahn, B. T. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1634 · Cited by 174
Aging and Gene Expression in the Primate Brain
Fraser, H. B., Khaitovich, P., Plotkin, J. B., Pääbo, S., & Eisen, M. B. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030274 · Cited by 172
Brain Plasticity and Human Evolution
Sherwood, C. C., & Gómez-Robles, A. (2017) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-102215-100009 · Cited by 170
Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates
Paz-Yaacov, N., Levanon, E. Y., Nevo, E., Kinar, Y., Harmelin, A., Jacob‐Hirsch, J., Amariglio, N., Eisenberg, E., & Rechavi, G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006183107 · Cited by 169
Human uniqueness: genome interactions with environment, behaviour and culture
Varki, A. P., Geschwind, D. H., & Eichler, E. E. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2428 · Cited by 172
Nowick, K., Gernat, T., Almaas, E., & Stubbs, L. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911376106 · Cited by 161
Liu, S., Lin, L., Jiang, P., Wang, D., & Xing, Y. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq817 · Cited by 146
Bianchi, S., Stimpson, C. D., Bauernfeind, A. L., Schapiro, S. J., Baze, W. B., McArthur, M. J., Bronson, E., Hopkins, W. D., Semendeferi, K., Jacobs, B., et al. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs239 · Cited by 144
Self-citationThe Talking Neanderthals: What Do Fossils, Genetics, and Archeology Say?
Johansson, S. (2013) · Biolinguistics · doi:10.5964/bioling.8955 · Cited by 136
DNA methylation: Insights into human evolution
Hernando-Herraez, I., Garcia-Perez, R., Sharp, A. J., & Marques-Bonet, T. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005661 · Cited by 128
Cell Cycle Activation and Aneuploid Neurons in Alzheimer's Disease
Arendt, T. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8262-0 · Cited by 138
A volumetric comparison of the insular cortex and its subregions in primates
Bauernfeind, A. L., de Sousa, A. A., Avasthi, T., Dobson, S. D., Raghanti, M. A., Lewandowski, A. H., Zilles, K., Semendeferi, K., Allman, J. M., Craig, A. D. (., et al. (2013) · Journal of Human Evolution · doi:10.1016/j.jhevol.2012.12.003 · Cited by 134
Self-citationAneuploidy: From a Physiological Mechanism of Variance to Down Syndrome
Dierssen, M., Hérault, Y., & Estivill, X. (2009) · Physiological Reviews · doi:10.1152/physrev.00032.2007 · Cited by 143
Human neoteny revisited: The case of synaptic plasticity
Bufill, E., Agustí, J., & Blesa, R. (2011) · American Journal of Human Biology · doi:10.1002/ajhb.21225 · Cited by 130
Brain Metabolic Alterations in Alzheimer’s Disease
Ardanaz, C. G., Ramírez, M. J., & Solas, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073785 · Cited by 135
Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
Shahab Uddin, M. S., Bu, R., Ahmed, M., Abubaker, J. A., Al‐Dayel, F., Bavi, P. P., & Al-Kuraya, K. S. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-74 · Cited by 125
Selection and Adaptation in the Human Genome
Fu, W., & Akey, J. M. (2013) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-091212-153509 · Cited by 129
Neuropil distribution in the cerebral cortex differs between humans and chimpanzees
Spocter, M. A., Hopkins, W. D., Barks, S. K., Bianchi, S., Hehmeyer, A. E., Anderson, S. M., Stimpson, C. D., Fobbs, A. J., Hof, P. R., & Sherwood, C. C. (2012) · Journal of Comparative Neurology · doi:10.1002/cne.23074 · Cited by 113
Self-citationHuman brain evolution writ large and small
Sherwood, C. C., Bauernfeind, A. L., Bianchi, S., Raghanti, M. A., & Hof, P. R. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-53860-4.00011-8 · Cited by 113
Self-citationMetabolic changes in schizophrenia and human brain evolution
Khaitovich, P., Lockstone, H. E., Wayland, M. T., Tsang, T. M., Jayatilaka, S. D., Guo, A. J., Zhou, J., Somel, M., Harris, L. W., Holmes, E. C., et al. (2008) · Genome biology · doi:10.1186/gb-2008-9-8-r124 · Cited by 115
Kehrer‐Sawatzki, H., & Cooper, D. N. (2006) · Human Mutation · doi:10.1002/humu.20420 · Cited by 112
Human brain evolution: From gene discovery to phenotype discovery
Preuss, T. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201894109 · Cited by 114
Conservation of Regional Gene Expression in Mouse and Human Brain
Strand, A. D., Aragaki, A. K., Baquet, Z. C., Hodges, A., Cunningham, P., Holmans, P., Jones, K. R., Jones, L., Kooperberg, C. L., & Olson, J. M. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030059 · Cited by 106
Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance
Bauernfeind, A. L., Barks, S. K., Duka, T., Grossman, L. I., Hof, P. R., & Sherwood, C. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0662-z · Cited by 105
Self-citationSchenker, N., Buxhoeveden, D., Blackmon, W., Amunts, K., Zilles, K., & Semendeferi, K. (2008) · The Journal of comparative neurology · doi:10.1002/cne.21792 · Cited by 100
Both Noncoding and Protein-Coding RNAs Contribute to Gene Expression Evolution in the Primate Brain
Babbitt, C. C., Fedrigo, O. D., Pfefferle, A. D., Boyle, A. P., Horvath, J. E., Furey, T. S., & Wray, G. A. (2010) · Genome Biology and Evolution · doi:10.1093/gbe/evq002 · Cited by 106
Metabolic drift in the aging brain
Ivanišević, J., Stauch, K. L., Petrascheck, M., Benton, H. P., Epstein, A. A., Fang, M., Gorantla, S., Tran, M., Hoang, L. T., Kurczy, M. E., et al. (2016) · Aging · doi:10.18632/aging.100961 · Cited by 103
Parsimony and Bayesian phylogenetics
Goloboff, P. A., & Pol, D. (2006) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199297306.003.0008 · Cited by 103
Genetic basis of human brain evolution
Vallender, E. J., Mekel-Bobrov, N., & Lahn, B. T. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.08.010 · Cited by 102
Rapid metabolic evolution in human prefrontal cortex
Fu, X., Giavalisco, P., Liu, X., Catchpole, G., Fu, N., Ning, Z., Guo, S., Zheng, Y., Somel, M., Pääbo, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019164108 · Cited by 101
Moving primate genomics beyond the chimpanzee genome
Goodman, M., Grossman, L. I., & Wildman, D. E. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.06.012 · Cited by 97
Self-citationReconstructing phylogenies and phenotypes: a molecular view of human evolution
Bradley, B. J. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2007.00840.x · Cited by 93
Hammond, J. P., Broadley, M. R., Craigon, D. J., Higgins, J. A., Emmerson, Z. F., Townsend, H. J., White, P. J., & May, S. T. (2005) · Plant Methods · doi:10.1186/1746-4811-1-10 · Cited by 89
The significance of the subplate for evolution and developmental plasticity of the human brain
Judáš, M., Sedmak, G., & Kostović, I. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00423 · Cited by 86
Stress-induced changes in primate prefrontal profiles of gene expression
Karssen, A. M., Her, S., Li, J. Z., Patel, P. D., Meng, F., Bunney, W. E., Jones, E. G., Watson, S. J., Akil, H., Myers, R., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002095 · Cited by 86
Raghanti, M. A., Stimpson, C. D., Marcinkiewicz, J. L., Erwin, J. M., Hof, P. R., & Sherwood, C. C. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm089 · Cited by 81
Self-citationHominini-specific regulation of CBLN2 increases prefrontal spinogenesis
Shibata, M., Pattabiraman, K., Muchnik, S. K., Kaur, N., Morozov, Y. M., Cheng, X., Waxman, S. G., & Šestan, N. (2021) · Nature · doi:10.1038/s41586-021-03952-y · Cited by 79
Sikela, J. M. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020080 · Cited by 72
The beginning of the end for chimpanzee experiments?
Knight, A. (2008) · Philosophy Ethics and Humanities in Medicine · doi:10.1186/1747-5341-3-16 · Cited by 67
Sequencing Primate Genomes: What Have We Learned?
Marquès‐Bonet, T., Ryder, O. A., & Eichler, E. E. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164420 · Cited by 65
Whole-Genome Positive Selection and Habitat-Driven Evolution in a Shallow and a Deep-Sea Urchin
Oliver, T. A., Garfield, D. A., Manier, M. K., Haygood, R., Wray, G. A., & Palumbi, S. R. (2010) · Genome Biology and Evolution · doi:10.1093/gbe/evq063 · Cited by 62
Bacolla, A., Collins, J., Gold, B., Chuzhanova, N. A., Yi, M., Stephens, R. M., Stefanov, S. A., Olsh, A., Jakupciak, J. P., Dean, M. C., et al. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl354 · Cited by 62
Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution
Mendizabal, I., Shi, L., Keller, T. E., Konopka, G., Preuss, T. M., Hsieh, T., Hu, E., Zhang, Z., Su, B., & Yi, S. V. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw176 · Cited by 64
Genomic signatures of diet-related shifts during human origins
Babbitt, C. C., Warner, L., Fedrigo, O. D., Wall, C. E., & Wray, G. A. (2010) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2010.2433 · Cited by 61
Invariant Synapse Density and Neuronal Connectivity Scaling in Primate Neocortical Evolution
Sherwood, C. C., Miller, S. B., Karl, M. T., Stimpson, C. D., Phillips, K. A., Jacobs, B., Hof, P. R., Raghanti, M. A., & Smaers, J. B. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa149 · Cited by 60
Self-citationDid brain-specific genes evolve faster in humans than in chimpanzees?
SHI, P., Bakewell, M. A., & ZHANG, J. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.09.001 · Cited by 58
Inactivation status of PCDH11X: sexual dimorphisms in gene expression levels in brain
Lopes, A. M., Ross, N., Close, J. P., Dagnall, A., Amorim, A., & Crow, T. J. (2006) · Human Genetics · doi:10.1007/s00439-006-0134-0 · Cited by 53
Distinct genomic signatures of adaptation in pre- and postnatal environments during human evolution
Uddin, M., Goodman, M., Erez, O., Romero, R. J., Liu, G., Islam, M., Opazo, J. C., Sherwood, C. C., Grossman, L. I., & Wildman, D. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712400105 · Cited by 52
Self-citationStructural divergence between the human and chimpanzee genomes
Kehrer‐Sawatzki, H., & Cooper, D. N. (2006) · Human Genetics · doi:10.1007/s00439-006-0270-6 · Cited by 54
Sherwood, C. C., Raghanti, M. A., Stimpson, C. D., Spocter, M. A., Uddin, M., Boddy, A. M., Wildman, D. E., Bonar, C. J., Lewandowski, A. H., Phillips, K. A., et al. (2009) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2009.1831 · Cited by 52
Self-citationWood, B. A., & Baker, J. L. (2011) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-102209-144653 · Cited by 47
Transcriptomic insights into human brain evolution: acceleration, neutrality, heterochrony
Somel, M., Rohlfs, R. V., & Liu, X. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.09.001 · Cited by 49
Molecular evolution of the cytochrome c oxidase subunit 5 A gene in primates
Uddin, M., Opazo, J. C., Wildman, D. E., Sherwood, C. C., Hof, P. R., Goodman, M., & Grossman, L. I. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-8 · Cited by 46
Self-citationLong versus short oligonucleotide microarrays for the study of gene expression in nonhuman primates
Walker, S. J., Wang, Y., Grant, K. A., Chan, F., & Hellmann, G. M. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.09.007 · Cited by 46
Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees
Bauernfeind, A. L., Soderblom, E. J., Turner, M. E., Moseley, M. A., Ely, J. J., Hof, P. R., Sherwood, C. C., Wray, G. A., & Babbitt, C. C. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv132 · Cited by 44
Self-citationGoidts, V., Szamalek, J. M., de Jong, P. J., Cooper, D. N., Chuzhanova, N. A., Hameister, H., & Kehrer‐Sawatzki, H. (2005) · Genome Research · doi:10.1101/gr.3732505 · Cited by 44
Verendeev, A., & Sherwood, C. C. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.02.003 · Cited by 43
Absolute brain size: Did we throw the baby out with the bathwater?
Marino, L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606337103 · Cited by 41
Wang, Z., Lewis, M. G., Nau, M. E., Arnold, A., & Vahey, M. (2004) · BMC Bioinformatics · doi:10.1186/1471-2105-5-165 · Cited by 41
Stone tool production and utilization by bonobo-chimpanzees ( Pan paniscus )
Roffman, I., Savage‐Rumbaugh, S., Rubert‐Pugh, E., Avraham, R., & Nevo, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212855109 · Cited by 40
Alzheimer's disease: an evolutionary approach.
Bufill, E., Blesa, R., & Augustí, J. (2013) · PubMed · doi:10.4436/jass.91001 · Cited by 43
Takaji, M., Komatsu, Y., Watakabe, A., Hashikawa, T., & Yamamori, T. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp062 · Cited by 39
Functional evidence for differences in sperm competition in humans and chimpanzees
Anderson, M., Chapman, S. J., Videan, E. N., Evans, E., Fritz, J., Stoinski, T. S., Dixson, A. F., & Gagneux, P. (2007) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20674 · Cited by 38
The Hominin Fossil Record and the Emergence of the Modern Human Central Nervous System
de Sousa, A. A., & Wood, B. A. (2007) · Elsevier eBooks · doi:10.1016/b0-12-370878-8/00018-5 · Cited by 37
The Evolution of Neuron Types and Cortical Histology in Apes and Humans
Sherwood, C. C., & Hof, P. R. (2007) · Evolution of Nervous Systems · doi:10.1016/b0-12-370878-8/00022-7 · Cited by 37
Self-citationRedox lipidomics to better understand brain aging and function
Pamplona, R., Borrás, C., Jové, M., Pradas, I., Ferrer, I., & Viña, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.03.016 · Cited by 39
Muntané, G., Horvath, J. E., Hof, P. R., Ely, J. J., Hopkins, W. D., Raghanti, M. A., Lewandowski, A. H., Wray, G. A., & Sherwood, C. C. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht354 · Cited by 36
Self-citationThe evolutionary origin and population history of the grauer gorilla
Tocheri, M. W., Dommain, R., McFarlin, S. C., Burnett, S. E., Case, D. T., Orr, C. M., Roach, N. T., Villmoare, B. A., Eriksen, A. B., Kalthoff, D. C., et al. (2016) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22900 · Cited by 36
Mitochondrial dysfunction in schizophrenia: an evolutionary perspective
Gonçalves, V. F., Andreazza, A. C., & Kennedy, J. L. (2014) · Human Genetics · doi:10.1007/s00439-014-1491-8 · Cited by 35
Metadata
- Authors
- Uddin, M., Wildman, D. E., Liu, G., Xu, W., Johnson, R. M., Hof, P. R., Kapatos, G., Grossman, L. I., & Goodman, M.
- Affiliations
- Wayne State University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-02-19
- Volume
- 101
- Issue
- 9
- Pages
- 2957-2962
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC365727
- OpenAlex
- W2044621597
- Cited by
- 238
- References
- 47
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 7 · 2013: 14 · 2012: 13
- FWCI
- 37.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0118696, 0318375)
- Wayne State University
- National Institutes of Health
- University of California, Davis
- National Institute of General Medical Sciences (GM 65580, R24GM065580)
- California National Primate Research Center
- Topics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Keywords
- chimpanzees, human, sister group relationships, anterior cingulate cortex, gene expression profiles, brain evolution, catarrhine primates, gorillas, macaque, regulatory evolution
- MeSH terms
- Animals, Base Sequence, Brain, Pan troglodytes, Chromosome Mapping, Humans, Phylogeny, Primates, Hominidae, Genome, Human, Genome, Evolution, Molecular, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
