The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata
Open accessAbstract
In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent and usually associated with pathological events. Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability. This organism has recently become the second most prevalent yeast pathogen in humans. Although the gene sequences were well conserved among different strains, their chromosome structures differed drastically. The most frequent events reshaping chromosomes were translocations of chromosomal arms. However, also larger segmental duplications were frequent and occasionally we observed novel chromosomes. Apparently, this yeast can generate a new chromosome by duplication of chromosome segments carrying a centromere and subsequently adding novel telomeric ends. We show that the observed genome plasticity is connected with antifungal drug resistance and it is likely an advantage in the human body, where environmental conditions fluctuate a lot.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Previous studies found that C. glabrata can undergo genomic re-arrangements as an adaptive survival mechanism (Shin et al., 2007; Muller et al., 2009; Poláková et al., 2009).”
From Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations (2019) · cites this paper as Poláková et al., 2009
In the citing paper
“According to Poláková et al. [90], the genetic instability results in segmental duplications, chromosomal rearrangements, and extra chromosomes occurring in C. glabrata at high frequency.”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [90]
In the citing paper
“Duplicated segments of ChrFL encode a transporter of the ATP-binding cassette family (CAGL0F01419g) that is very similar to S. cerevisiae AUS1.”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [90]
In the citing paper
“Aneuploidy gain of small chromosome segment on the left arm of chromosome F that encodes ABC transporter AUS1 and PDH1 is also observed in C. glabrata-resistant isolates [90].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [90]
In the citing paper
“The small chromosome F encodes an ortholog of S. cerevisiae ABC transporter PDR5 (CAGL0F02717g) known in C. glabrata as PDH1.”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [90]
In the citing paper
“Several genes on chromosomes (ChrEL and ChrFL) potentially mediate interactions between C. glabrata and the susceptible host.”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [90]
In the citing paper
“For the haploid yeast C. glabrata, genome rearrangements underlying azole resistance include chromosomal translocations, segmental duplications, and occasionally, the formation of de novo minichromosomes70.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [70]
In the citing paper
“Since genome plasticity has been connected with antifungal drug resistance in C. glabrata (Shin et al., 2007; Polakova et al., 2009)”
From Genetic Drivers of Multidrug Resistance in Candida glabrata (2016) · cites this paper as Polakova et al., 2009
In the citing paper
“the most frequent genome rearrangements identified were translocations of chromosomal arms and inter-chromosomal duplications, but formation of novel chromosomes was also reported (Muller et al., 2009; Polakova et al., 2009).”
From Genetic Drivers of Multidrug Resistance in Candida glabrata (2016) · cites this paper as Polakova et al., 2009
In the citing paper
“Karyotyping using pulsed-field gel electrophoresis (PFGE), which separates whole chromosomes, revealed that C. glabrata genome organization varies significantly among different isolates (Muller et al., 2009; Polakova et al., 2009).”
From Genetic Drivers of Multidrug Resistance in Candida glabrata (2016) · cites this paper as Polakova et al., 2009
In the citing paper
“Indeed, while the genome of a reference C. glabrata laboratory strain (CBS138) has been sequenced, we were not able to use that strain's genomic sequence as a template for assembling the sequences of other strains, e.g., various clinical isolates, due to the high karyotypic variability among strains (Muller et al., 2009; Polakova et al., 2009; Bader et al., 2012; Figure 1B).”
From Genetic Drivers of Multidrug Resistance in Candida glabrata (2016) · cites this paper as Polakova et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou, N., & Nei, M. (1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,959
Thompson, J. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.24.4876 · Cited by 38,685
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
Tamura, K., Dudley, J. T., Nei, M., & Kumar, S. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm092 · Cited by 28,734
Prospects for inferring very large phylogenies by using the neighbor-joining method
Tamura, K., Nei, M., & Kumar, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404206101 · Cited by 5,588
The Significance of Responses of the Genome to Challenge
McClintock, B. (1984) · Science · doi:10.1126/science.15739260 · Cited by 2,638
Dujon, B., Sherman, D., Fischer, G., Durrens, P., Casaregola, S., Lafontaine, I., de Montigny, J., Marck, C., Neuvéglise, C., Talla, E., et al. (2004) · Nature · doi:10.1038/nature02579 · Cited by 1,623
Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast
Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A. (2007) · Science · doi:10.1126/science.1142210 · Cited by 935
Phylogenetic test of the molecular clock and linearized trees.
Takezaki, N., Rzhetsky, A., & Nei, M. (1995) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040259 · Cited by 826
Potential Role of Phospholipases in Virulence and Fungal Pathogenesis
Ghannoum, M. A. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.1.122-143.2000 · Cited by 823
Aneuploidy and Isochromosome Formation in Drug-Resistant Candida albicans
Selmecki, A., Forche, A., & Berman, J. (2006) · Science · doi:10.1126/science.1128242 · Cited by 733
Research works printed but not linked: 2
- CE Gauwerky, CM Croce, Chromosomal translocations in leukemia. Semin Cancer Biol 4, 333–340 (1993).
- 10.1128/CMR.13.1.122 · DOI
Cited by
Sorted by citations
Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801
Mechanisms of Antifungal Drug Resistance
Cowen, L. E., Sanglard, D., Howard, S. J., Rogers, P. D., & Perlin, D. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019752 · Cited by 647
Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
Pavelka, N., Rancati, G., Zhu, J., Bradford, W. D., Saraf, A., Florens, L., Sanderson, B. W., Hattem, G. L., & Li, R. (2010) · Nature · doi:10.1038/nature09529 · Cited by 577
Fluconazole resistance in Candida species: a current perspective
Berkow, E., & Lockhart, S. (2017) · Infection and Drug Resistance · doi:10.2147/idr.s118892 · Cited by 542
Sionov, E., Lee, H., Chang, Y. C., & Kwon-Chung, K. J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000848 · Cited by 479
Candidiasis and Mechanisms of Antifungal Resistance
Bhattacharya, S., Sae-Tia, S., & Fries, B. C. (2020) · Antibiotics · doi:10.3390/antibiotics9060312 · Cited by 474
Chromosomal duplication is a transient evolutionary solution to stress
Yona, A. H., Manor, Y. S., Herbst, R. H., Romano, G. H., Mitchell, A., Kupiec, M., Pilpel, Y., & Dahan, O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211150109 · Cited by 376
Selmecki, A. M., Dulmage, K., Cowen, L. E., Anderson, J. B., & Berman, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000705 · Cited by 319
Regulation of multidrug resistance in pathogenic fungi
Morschhäuser, J. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.08.002 · Cited by 300
Molecular mechanisms governing antifungal drug resistance
Lee, Y., Robbins, N., & Cowen, L. E. (2023) · npj Antimicrobials and Resistance · doi:10.1038/s44259-023-00007-2 · Cited by 304
Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol productionPreprint
Argueso, J. L., Carazzolle, M. F., Mieczkowski, P. A., Duarte, F. M., Netto, O. V. C., Missawa, S. K., Galzerani, F., Costa, G. G., Vidal, R. O., Noronha, M. F., et al. (2009) · Genome Research · doi:10.1101/gr.091777.109 · Cited by 289
Sanglard, D., Coste, A., & Ferrari, S. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00578.x · Cited by 285
Genomic Plasticity of the Human Fungal Pathogen Candida albicans
Selmecki, A., Forche, A., & Berman, J. (2010) · Eukaryotic Cell · doi:10.1128/ec.00060-10 · Cited by 247
Polyploidy in fungi: evolution after whole-genome duplication
Albertin, W., & Marullo, P. (2012) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2012.0434 · Cited by 248
Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata
Singh-Babak, S. D., Babak, T., Diezmann, S., Hill, J. A., Xie, J. L., Chen, Y.-L., Poutanen, S. M., Rennie, R. P., Heitman, J., & Cowen, L. E. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002718 · Cited by 205
“glabrata undergoes chromosomal translocations and variation in gene copy number [28,29], mechanisms that also contribute to C.”
BackgroundFungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata
Healey, K. R., & Perlin, D. S. (2018) · Journal of Fungi · doi:10.3390/jof4030105 · Cited by 194
Islam, T., Danishuddin, M., Tamanna, N. T., Matin, M. N., Barai, H. R., & Haque, M. A. (2024) · Plants · doi:10.3390/plants13192737 · Cited by 221
Update on Antifungal Drug Resistance
Perlin, D. S., Shor, E., & Zhao, Y. (2015) · Current Clinical Microbiology Reports · doi:10.1007/s40588-015-0015-1 · Cited by 181
Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
Hassan, Y., Chew, S. Y., & Than, L. T. L. (2021) · Journal of Fungi · doi:10.3390/jof7080667 · Cited by 170
Schulze, J., & Sonnenborn, U. (2009) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2009.0837 · Cited by 176
Sterkers, Y., Lachaud, L., Crobu, L., Bastien, P., & Pagès, M. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01534.x · Cited by 160
Roetzer, A., Gabaldón, T., & Schüller, C. (2011) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.02102.x · Cited by 154
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
Todd, R. T., & Selmecki, A. (2020) · eLife · doi:10.7554/elife.58349 · Cited by 138
Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania
Mannaert, A., Downing, T., Imamura, H., & Dujardin, J. (2012) · Trends in Parasitology · doi:10.1016/j.pt.2012.06.003 · Cited by 150
Mechanisms of Chromosome Number Evolution in Yeast
Gordon, J., Byrne, K. P., & Wolfe, K. H. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002190 · Cited by 140
Stukenbrock, E. H., Jørgensen, F. G., Zala, M., Hansen, T. T., McDonald, B. A., & Schierup, M. H. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001189 · Cited by 137
Resistance of Candida spp. to antifungal drugs in the ICU: where are we now?
Maubon, D., Garnaud, C., Calandra, T., Sanglard, D., & Cornet, M. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3404-7 · Cited by 141
Sex or no sex: Evolutionary adaptation occurs regardless
Seidl, M. F., & Thomma, B. P. H. J. (2014) · BioEssays · doi:10.1002/bies.201300155 · Cited by 131
Dynamic Large-Scale Chromosomal Rearrangements Fuel Rapid Adaptation in Yeast Populations
Chang, S., Lai, H.-Y., Tung, S., & Leu, J. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003232 · Cited by 131
Clade-specific chromosomal rearrangements and loss of subtelomeric adhesins in Candida auris
Muñoz, J. F., Welsh, R. M., Shea, T., Batra, D., Gade, L., Howard, D., Rowe, L. A., Meis, J. F., Litvintseva, A. P., & Cuomo, C. A. (2021) · Genetics · doi:10.1093/genetics/iyab029 · Cited by 125
Aneuploidy in yeast: Segregation error or adaptation mechanism?
Gilchrist, C., & Stelkens, R. (2019) · Yeast · doi:10.1002/yea.3427 · Cited by 104
Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer
Pavelka, N., Rancati, G. I., & Li, R. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.06.003 · Cited by 110
Timmermans, B., De Las Peñas, A., Castaño, I., & Van Dijck, P. (2018) · Journal of Fungi · doi:10.3390/jof4020060 · Cited by 109
Forche, A., Cromie, G., Gerstein, A. C., Solis, N. V., Pisithkul, T., Srifa, W., Jeffery, E., Abbey, D., Filler, S. G., Dudley, A. M., et al. (2018) · Genetics · doi:10.1534/genetics.118.301019 · Cited by 94
The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects
Sunshine, A. B., Payen, C., Ong, G. T., Liachko, I., Tan, K. M., & Dunham, M. J. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002155 · Cited by 96
Genetic Drivers of Multidrug Resistance in Candida glabrata
Healey, K. R., Jimenez Ortigosa, C., Shor, E., & Perlin, D. S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01995 · Cited by 93
Minning, T. A., Weatherly, D. B., Flibotte, S., & Tarleton, R. L. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-139 · Cited by 95
Hidden killers: persistence of opportunistic fungal pathogens in the human host
d’Enfert, C. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.05.008 · Cited by 90
Extraordinary Genome Instability and Widespread Chromosome Rearrangements During Vegetative Growth
Möller, M., Habig, M., Freitag, M., & Stukenbrock, E. H. (2018) · Genetics · doi:10.1534/genetics.118.301050 · Cited by 88
Ben-Ami, R., Zimmerman, O., Finn, T., Amit, S., Novikov, A., Wertheimer, N., Lurie-Weinberger, M., & Berman, J. (2016) · mBio · doi:10.1128/mbio.00655-16 · Cited by 88
Azole Resistance in Candida glabrata
Whaley, S. G., & Rogers, P. D. (2016) · Current Infectious Disease Reports · doi:10.1007/s11908-016-0554-5 · Cited by 85
Aneuploidy underlies a multicellular phenotypic switch
Tan, Z., Hays, M., Cromie, G. A., Jeffery, E. W., Scott, A. C., Ahyong, V., Sirr, A., Skupin, A., & Dudley, A. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301047110 · Cited by 85
Complex Nature of the Genome in a Wine Spoilage Yeast, Dekkera bruxellensis
Hellborg, L., & Piškur, J. (2009) · Eukaryotic Cell · doi:10.1128/ec.00115-09 · Cited by 86
Fitness Trade-Offs Associated with the Evolution of Resistance to Antifungal Drug Combinations
Hill, J. A., O’Meara, T. R., & Cowen, L. E. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.009 · Cited by 80
Aneuploidy and Drug Resistance in Pathogenic Fungi
Kwon-Chung, K. J., & Chang, Y. C. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1003022 · Cited by 76
Telomeric gene deletion and intrachromosomal amplification in antimony‐resistant L eishmania
Mukherjee, A., Boisvert, S., do Monte‐Neto, R. L., Coelho, A. C., Raymond, F., Mukhopadhyay, R., Corbeil, J., & Ouellette, M. (2013) · Molecular Microbiology · doi:10.1111/mmi.12178 · Cited by 77
Pyruvate production inCandida glabrata: manipulation and optimization of physiological function
Li, S., Chen, X., Liu, L., & Chen, J. (2013) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2013.811636 · Cited by 76
Hu, G., Wang, J., Choi, J., Jung, W. H., Liu, I., Litvintseva, A. P., Bicanic, T. A., Aurora, R., Mitchell, T. G., Perfect, J. R., et al. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-526 · Cited by 77
The Dynamic Fungal Genome: Polyploidy, Aneuploidy and Copy Number Variation in Response to Stress
Vande Zande, P., Zhou, X., & Selmecki, A. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041320-112443 · Cited by 70
Dancing genomes: fungal nuclear positioning
Gladfelter, A. S., & Berman, J. G. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2249 · Cited by 75
Evolution of antifungal resistance in the environment
van Rhijn, N., & Rhodes, J. L. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02055-y · Cited by 83
Coping with Stress and the Emergence of Multidrug Resistance in Fungi
Shor, E., & Perlin, D. S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004668 · Cited by 73
Arastehfar, A. A., Daneshnia, F., Najafzadeh, M. J., Hagen, F., Mahmoudi, S., Salehi, M., Zarrinfar, H., Namvar, Z., Zareshahrabadi, Z., Khodavaisy, S., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00206 · Cited by 70
Genetic Diversity and Genomic Plasticity ofCryptococcus neoformansAD Hybrid Strains
Li, W., Averette, A. F., Desnos‐Ollivier, M., Ni, M., Dromer, F., & Heitman, J. (2012) · G3 Genes Genomes Genetics · doi:10.1534/g3.111.001255 · Cited by 71
A Double-Edged Sword: Aneuploidy is a Prevalent Strategy in Fungal Adaptation
Tsai, H.-J., & Nelliat, A. (2019) · Genes · doi:10.3390/genes10100787 · Cited by 60
Zhou, N., Bottagisi, S., Katz, M., Schacherer, J., Friedrich, A., Gojkovic, Z., Swamy, K. B. S., Knecht, W., Compagno, C., & Piškur, J. (2017) · FEMS Yeast Research · doi:10.1093/femsyr/fox060 · Cited by 67
Ormerod, K. L., Morrow, C. A., Chow, E. W. L., Lee, I. R., Arras, S. D. M., Schirra, H. J., Cox, G. M., Fries, B. C., & Fraser, J. A. (2013) · G3 Genes Genomes Genetics · doi:10.1534/g3.113.005660 · Cited by 66
Tipping the balance both ways: drug resistance and virulence in Candida glabrata
Vale-Silva, L. A., & Sanglard, D. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov025 · Cited by 71
Clade- and species-specific features of genome evolution in the Saccharomycetaceae
Wolfe, K. H., Armisén, D., Proux‐Wéra, E., hÉigeartaigh, S. Ó., Azam, H., Gordon, J., & Byrne, K. P. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov035 · Cited by 64
Medically Important Fungi Respond to Azole Drugs: An Update
Zavřel, M., & White, T. C. (2015) · Future Microbiology · doi:10.2217/fmb.15.47 · Cited by 64
Brunke, S., Seider, K., Fischer, D., Jacobsen, I. D., Kasper, L., Jablonowski, N., Wartenberg, A., Bader, O., Angoulvant, A., Schaller, M., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004478 · Cited by 62
Orta‐Zavalza, E., Guerrero‐Serrano, G., Gutiérrez‐Escobedo, G., Cañas‐Villamar, I., Juárez‐Cepeda, J., Castaño, I., & De Las Peñas, A. (2013) · Molecular Microbiology · doi:10.1111/mmi.12247 · Cited by 61
Semighini, C. P., Averette, A. F., Perfect, J. R., & Heitman, J. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002364 · Cited by 61
Rapid and extensive karyotype diversification in haploid clinical Candida auris isolates
Bravo Ruiz, G., Ross, Z. K., Holmes, E., Schelenz, S., Gow, N. A. R., & Lorenz, A. (2019) · Current Genetics · doi:10.1007/s00294-019-00976-w · Cited by 60
Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans
Yang, F., Gritsenko, V., Slor Futterman, Y., Gao, L., Zhen, C., Lu, H., Jiang, Y.-Y., & Berman, J. (2021) · mBio · doi:10.1128/mbio.02272-21 · Cited by 59
Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata
Tscherner, M., Schwarzmüller, T., & Kuchler, K. (2011) · Pharmaceuticals · doi:10.3390/ph4010169 · Cited by 60
Improved ATP supply enhances acid tolerance of Candida glabrata during pyruvic acid production
Zhou, J., Liu, L., & Chen, J. (2010) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2010.04865.x · Cited by 57
Healey, K. R., Nagasaki, Y., Zimmerman, M. D., Kordalewska, M., Park, S., Zhao, Y., & Perlin, D. S. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01412-17 · Cited by 58
Carreté, L., Ksiezopolska, E., Gómez-Molero, E., Angoulvant, A., Bader, O., Fairhead, C., & Gabaldón, T. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00112 · Cited by 58
Genome structure and dynamics of the yeast pathogen Candida glabrata
Ahmad, K. M., Kokošar, J., Guo, X., Gu, Z., Ishchuk, O. P., & Piškur, J. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12145 · Cited by 57
Gale, A. N., Sakhawala, R. M., Levitan, A., Sharan, R., Berman, J., Timp, W., & Cunningham, K. W. (2020) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.120.401595 · Cited by 56
Taming the tiger by the tail: modulation of DNA damage responses by telomeres
Lydall, D. A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.176 · Cited by 57
The effect of antifungal resistance development on the virulence of Candida species
Bohner, F., Papp, C., & Gácser, A. (2022) · FEMS Yeast Research · doi:10.1093/femsyr/foac019 · Cited by 72
Antifungal drug resistance in Candida: a special emphasis on amphotericin B
Ahmady, L., Gothwal, M., Mukkoli, M. M., & Bari, V. K. (2024) · Apmis · doi:10.1111/apm.13389 · Cited by 61
Salazar, S. B., Simões, R., Pedro, N. A., Pinheiro, M. J. F., Carvalho, M. F. N. N., & Mira, N. P. (2020) · Journal of Fungi · doi:10.3390/jof6010023 · Cited by 58
Fungal resistance to echinocandins and the MDR phenomenon in Candida glabrata
Healey, K., & Perlin, D. S. (2018) · doi:10.20944/preprints201808.0306.v1 · Cited by 194
Vale-Silva, L. A., Moeckli, B., Torelli, R., Posteraro, B., Sanguinetti, M., & Sanglard, D. (2016) · mSphere · doi:10.1128/msphere.00065-15 · Cited by 51
Yeast: a simple model system to study complex phenomena of aneuploidy
Mulla, W. A., Zhu, J., & Li, R. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12048 · Cited by 55
Gene Duplication and Environmental Adaptation within Yeast Populations
Ames, R. M., Rash, B. M., Hentges, K. E., Robertson, D. L., Delneri, D., & Lovell, S. C. (2010) · Genome Biology and Evolution · doi:10.1093/gbe/evq043 · Cited by 47
Halliwell, S., Smith, M. C. A., Muston, P., Holland, S. L., & Avery, S. V. (2011) · Eukaryotic Cell · doi:10.1128/ec.05232-11 · Cited by 46
Genomic insights into the evolution of industrial yeast speciesBrettanomyces bruxellensis
Curtin, C. D., & Pretorius, I. S. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12198 · Cited by 47
Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!
Cavalheiro, M., Pais, P., Galocha, M., & Teixeira, M. C. (2018) · Genes · doi:10.3390/genes9070332 · Cited by 44
Potocki, L., Depciuch, J., Kuna, E., Worek, M., Lewińska, A., & Wnuk, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040988 · Cited by 43
Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors
Donovan, P., Cato, K., Legaie, R., Jayalath, R., Olsson, G., Hall, B. I., Olson, S., Boros, S., Reynolds, B. A., & Harding, A. S. (2014) · Molecular BioSystems · doi:10.1039/c3mb70484j · Cited by 40
Bader, O., Schwarz, A., Kraneveld, E. A., Tangwattanchuleeporn, M., Schmidt, P., Jacobsen, M. D., Gross, U., De Groot, P. W. J., & Weig, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052218 · Cited by 39
Candida glabrata: A powerhouse of resistance
Duggan, S., & Usher, J. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011651 · Cited by 37
Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata
Kachouri‐Lafond, R., Dujon, B., Gilson, É., Westhof, É., Fairhead, C., & Teixeira, M. T. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.034 · Cited by 38
Functional Analysis of Sirtuin Genes in Multiple Plasmodium falciparum Strains
Merrick, C. J., Jiang, R. H. Y., Skillman, K. M., Samarakoon, U., Moore, R. M., Dzikowski, R., Ferdig, M. T., & Duraisingh, M. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118865 · Cited by 38
Ni, Q., Wang, C., Tian, Y., Dong, D., Jiang, C., Mao, E., & Peng, Y. (2018) · Mycoses · doi:10.1111/myc.12756 · Cited by 37
Constitutive aneuploidy and genomic instability in the single‐celled eukaryote Giardia intestinalis
Tůmová, P., Uzlíková, M., Jurczyk, T., & Nohýnková, E. (2016) · MicrobiologyOpen · doi:10.1002/mbo3.351 · Cited by 36
Narayanan, A., Kumar, P., Chauhan, A., Kumar, M., Yadav, K., Banerjee, A., Sharma, R. D., Rudramurthy, S. M., Chakrabarti, A., Sanyal, K., et al. (2022) · mBio · doi:10.1128/mbio.03052-22 · Cited by 35
Candida glabrata’s Genome Plasticity Confers a Unique Pattern of Expressed Cell Wall Proteins
López-Fuentes, E., Gutiérrez-Escobedo, G., Timmermans, B., Van Dijck, P., De Las Peñas, A., & Castaño, I. (2018) · Journal of Fungi · doi:10.3390/jof4020067 · Cited by 35
Unravelling genomic diversity ofZygosaccharomyces rouxiicomplex with a link to its life cycle
Solieri, L., Dakal, T. C., Croce, M. A., & Giudici, P. (2012) · FEMS Yeast Research · doi:10.1111/1567-1364.12027 · Cited by 34
Link between Aneuploidy and Chromosome Instability
Nicholson, J. M., & Cimini, D. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2014.11.002 · Cited by 32
Comparative study on synteny between yeasts and vertebrates
Drillon, G., & Fischer, G. (2011) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2011.05.011 · Cited by 31
Mitochondrial DNA Heteroplasmy in Candida glabrata after Mitochondrial Transformation
Zhou, J., Liu, L., & Chen, J. (2010) · Eukaryotic Cell · doi:10.1128/ec.00349-09 · Cited by 36
Large-Scale Chromosomal Changes and Associated Fitness Consequences in Pathogenic Fungi
Forche, A. (2014) · Current Fungal Infection Reports · doi:10.1007/s12281-014-0181-2 · Cited by 33
Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi
Ridenour, J. B., Möller, M., & Freitag, M. (2020) · Genes · doi:10.3390/genes11060638 · Cited by 30
Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens
Schikora-Tamarit, M. À., & Gabaldón, T. (2022) · Biochemical Society Transactions · doi:10.1042/bst20211123 · Cited by 30
Thierry, A., Dujon, B., & Richard, G. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0216-y · Cited by 29
Metadata
- Authors
- Poláková, S., Blume, C., Zárate, J. Á., Mentel, M., Jørck-Ramberg, D., Stenderup, J., & Piškur, J.
- Affiliations
- Lund University (SE)
- Technical University of Denmark (DK)
- Regionshospitalet Herning (DK)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-02-24
- Volume
- 106
- Issue
- 8
- Pages
- 2688-2693
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2637908
- OpenAlex
- W2105649156
- Cited by
- 206
- References
- 35
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 12 · 2023: 10 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 9 · 2018: 13 · 2017: 8 · 2016: 7 · 2015: 13 · 2014: 15 · 2013: 14 · 2012: 15
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Candida glabrata, chromosomal translocation, segmental duplication, genome plasticity, antifungal resistance, virulence, telomeres, centromere, haploid yeast, asexual reproduction, fungal pathogens
- MeSH terms
- Antifungal Agents, Base Sequence, Phylogeny, Virulence, Blotting, Southern, Chromosomes, Fungal, Polymerase Chain Reaction, Electrophoresis, Gel, Pulsed-Field, DNA Primers, Candida glabrata
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
