The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
A functional genomic perspective on human well-being
Open accessAbstract
To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The CTRA can also be activated by modernday social, symbolic, anticipated, and imagined threats, however, leading to increased risk for several inflammation-related conditions, including depression”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Fredrickson et al., 2013
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“they can also be separated in that they seem to correlate with different neurobiological systems (Fredrickson et al., 2013).”
From Blended care in the treatment of subthreshold symptoms of depression and psychosis in emerging adults: A randomised controlled trial of Acceptance and Commitment Therapy in Daily-Life (ACT-DL) (2020) · cites this paper as Fredrickson et al., 2013
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Finally, a small study analyzed leukocyte basal gene expression profiles and reported distinct gene expression profiles for hedonic (positive affect) versus eudaimonic (striving, purpose) wellbeing (Fredrickson et al. 2013)”
From Genetics of Wellbeing and Its Components Satisfaction with Life, Happiness, and Quality of Life: A Review and Meta-analysis of Heritability Studies (2015) · cites this paper as Fredrickson et al. 2013
The cited source says what the claim attributes to it.
In the citing paper
“Additionally, a study that examined gene transcriptional profiles found that eudaimonic well-being (an overarching umbrella term that includes purpose) was associated with enhanced expression of antiviral response genes and reduced expression of proinflammatory genes (31).”
From Purpose in life and use of preventive health care services (2014) · cites this paper as [31]
In the citing paper
“Fredrickson and colleagues found that high levels of eudaimonic well-being were associated with significantly lower levels of CTRA-related gene expression (i.e., a more favorable, or less threatened, molecular profile) [54].”
From Human Social Genomics (2014) · cites this paper as [54]
In the citing paper
“In contrast, people who showed comparatively high levels of hedonic well-being relative to their level of eudaimonic well-being showed significantly elevated CTRA gene expression (above and beyond any effects of hedonistic behavioral factors such as smoking, alcohol consumption, or adiposity).”
From Human Social Genomics (2014) · cites this paper as [54]
In the citing paper
“the conserved transcriptional response to adversity (CTRA), and is characterized by increased proinflammatory and reduced antiviral skewing of the basal gene expression profile”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Fredrickson et al, 2013
In the citing paper
“which increases an individual's risk for both viral infection and inflammation-related disease”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Fredrickson et al, 2013
In the citing paper
“The impetus for this research was inspired by a wealth of research showing e that developing caring and compassion-focused motives for self and others has a range of benefits: on genetic expression [14, 31, 109], physiological processes [9, 68, 71, 73, 107, 108], psychological processes [63, 64, 66, 108], and social relationships [16, 18, 100].”
From The development of compassionate engagement and action scales for self and others (2017) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
Advances In Experimental Social Psychology
(2022) · Advances in experimental social psychology · doi:10.1016/s0065-2601(22)x0002-6 · Cited by 22,559
Happiness is everything, or is it? Explorations on the meaning of psychological well-being.
Ryff, C. D. (1989) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.57.6.1069 · Cited by 14,847
On Happiness and Human Potentials: A Review of Research on Hedonic and Eudaimonic Well-Being
Ryan, R. M., & Deci, E. L. (2001) · Annual Review of Psychology · doi:10.1146/annurev.psych.52.1.141 · Cited by 11,567
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
What good are positive emotions?
Fredrickson, B. L. (1998) · Review of General Psychology · doi:10.1037/1089-2680.2.3.300 · Cited by 6,066
Self-citationThe broaden–and–build theory of positive emotions
Fredrickson, B. L. (2004) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2004.1512 · Cited by 4,214
Self-citationOptimizing well-being: The empirical encounter of two traditions.
Keyes, C. L. M., Shmotkin, D., & Ryff, C. D. (2002) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.82.6.1007 · Cited by 3,322 · cited 2×
“As previously observed (6, 14, 27), hedonic and eudaimonic well-being were positively correlated (r = 0.”
BackgroundWaterman, A. S. (1993) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.64.4.678 · Cited by 3,220
Know thyself and become what you are: a eudaimonic approach to psychological well-being
Ryff, C. D., & Singer, B. H. (2008) · Journal of Happiness Studies · doi:10.1007/s10902-006-9019-0 · Cited by 3,149
Research works printed but not linked: 2
- LA King, JA Hicks, Positive affect and meaning in life: The intersection of hedonism and eudaimonia. The Human Quest for Meaning, ed PT Wong (Routledge, New York), pp. 125–142 (2012).
- MH Antoni, et al., Transcriptional modulation of human leukocytes by cognitive-behavioral stress management in women undergoing treatment for breast cancer. Biol Psychiatry 71, 366–372 (2012).
Cited by
Sorted by citations
Psychological Well-Being Revisited: Advances in the Science and Practice of Eudaimonia
Ryff, C. D. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000353263 · Cited by 2,976
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
“…social, symbolic, anticipated, and imagined threats, however, leading to increased risk for several inflammationrelated conditions, including depression (see Antoni et al., 2012; S. W. Cole et al., 2012; Fredrickson et al., 2013; Irwin & Cole, 2011; Powell et al., 2013; Slavich & Cole, 2013).”
BackgroundNature Contact and Human Health: A Research Agenda
Frumkin, H., Bratman, G. N., Breslow, S. J., Cochran, B., Kahn Jr, P. H., Lawler, J. J., Levin, P. S., Tandon, P. S., Varanasi, U., Wolf, K. L., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp1663 · Cited by 1,237
“…of brain activity including novel EEG methods (Aspinall et al. 2015; J Roe et al. 2013; Tilley et al. 2017) and functional brain imaging (Bratman et al. 2015b); genetic markers such as leukocyte basal gene expression profiles (Fredrickson et al. 2013); and telomere shortening (Woo et al. 2009).”
MethodA Meta-Analysis of Compassion-Based Interventions: Current State of Knowledge and Future Directions
Kirby, J. N., Tellegen, C. L., & Steindl, S. R. (2017) · Behavior Therapy · doi:10.1016/j.beth.2017.06.003 · Cited by 827
“…and positive associations of compassion for our physiological health, including influencing genetic expression in cross-sectional studies (e.g., Fredrickson et al., 2013), as well as in intervention studies (Klimecki, Leiberg, Ricard, & Singer, 2014), positive correlations found for mental…”
Garland, E. L., Farb, N. A., R. Goldin, P., & Fredrickson, B. L. (2015) · Psychological Inquiry · doi:10.1080/1047840x.2015.1064294 · Cited by 810
“Recent work has in fact linked a relative emphasis on eudaimonic or hedonic pursuits to a genomic profile that is potentially health generating (Fredrickson et al., 2015; Fredrickson et al., 2013).”
Self-citationSleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624
“(see also Irwin and Cole (2011); Antoni et al (2012); Fredrickson et al (2013)).”
BackgroundThe development of compassionate engagement and action scales for self and others
Gilbert, P., Catarino, F., Duarte, C., Matos, M., Kolts, R., Stubbs, J., Ceresatto, L., Duarte, J., Pinto-Gouveia, J., & Basran, J. (2017) · Journal of Compassionate Health Care · doi:10.1186/s40639-017-0033-3 · Cited by 527
“…wealth of research showing e that developing caring and compassion-focused motives for self and others has a range of benefits: on genetic expression [14, 31, 109], physiological processes [9, 68, 71, 73, 107, 108], psychological processes [63, 64, 66, 108], and social relationships [16, 18, 100].”
BackgroundDifferent types of well-being? A cross-cultural examination of hedonic and eudaimonic well-being
Disabato, D. J., Goodman, F. R., Kashdan, T. B., Short, J. L., & Jarden, A. (2016) · Psychological Assessment · doi:10.1037/pas0000209 · Cited by 583
“For example, Fredrickson et al. (2013) found that the unique variance among Hedonia and Eudaimonia may be genetically determined (although see Brown, MacDonald, Samanta, Friedman, & Coyne, 2014 for a critique of the methodology used).”
BackgroundPositive Psychology: A Personal History
Seligman, M. E. P. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095653 · Cited by 571
“People who prefer meaning (eudaimonia) to pleasure (hedonia) have a distinguishable genetic profile (Fredrickson et al. 2013).”
BackgroundCompassion interventions: The programmes, the evidence, and implications for research and practice
Kirby, J. N. (2017) · Psychology and Psychotherapy: Theory, Research and Practice · doi:10.1111/papt.12104 · Cited by 427
Cole, S. W. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004601 · Cited by 415
“, a more favorable, or less threatened, molecular profile) [54].”
BackgroundSelf-citationSubjective Well-Being: Measuring Happiness, Suffering, and Other Dimensions of Experience
Stone, A. A., & Mackie, C. (2013) · Cited by 343
Purpose in life and use of preventive health care services
Kim, E. S., Strecher, V. J., & Ryff, C. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414826111 · Cited by 332
“Additionally, a study that examined gene transcriptional profiles found that eudaimonic well-being (an overarching umbrella term that includes purpose) was associated with enhanced expression of antiviral response genes and reduced expression of proinflammatory genes (31).”
BackgroundChallenges and opportunities for grounding cognition.
Barsalou, L. W. (2020) · Journal of Cognition · doi:10.5334/joc.116 · Cited by 319
Cole, S. W., Capitanio, J. P., Chun, K., Arevalo, J. M. G., Ma, J., & Cacioppo, J. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514249112 · Cited by 310
“Year 5, 7, and 8 samples were assayed by Ref8 arrays (Gene Expression Omnibus Series GSE65213, GSE65298, and GSE65317), year 9–10 samples were assayed by HT-12 BeadArrays (GSE65341 and GSE65403), and CTRA gene expression was analyzed using mixed effect linear models (43) testing association between average expression…”
MethodSelf-citationEntrepreneurship and eudaimonic well-being: Five venues for new science
Ryff, C. D. (2018) · Journal of Business Venturing · doi:10.1016/j.jbusvent.2018.09.003 · Cited by 358
Bartels, M. (2015) · Behavior Genetics · doi:10.1007/s10519-015-9713-y · Cited by 293
“Finally, a small study analyzed leukocyte basal gene expression profiles and reported distinct gene expression profiles for hedonic (positive affect) versus eudaimonic (striving, purpose) wellbeing (Fredrickson et al. 2013), but replication is warranted, especially since distinguishing hedonic versus eudaimonic wellbe…”
BackgroundThe conserved transcriptional response to adversity
Cole, S. W. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.008 · Cited by 294
“It has sometimes been assumed that the CTRA is defined by the 53-gene contrast used in several high-visibility studies [33,34].”
BackgroundMethodSelf-citationIn pursuit of resilience: stress, epigenetics, and brain plasticity
McEwen, B. S. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13020 · Cited by 329
Activation of the reward system boosts innate and adaptive immunity
Ben-Shaanan, T. L., Azulay-Debby, H., Dubovik, T., Starosvetsky, E., Korin, B., Schiller, M., Green, N. L., Admon, Y., Hakim, F., Shen-Orr, S. S., et al. (2016) · Nature Medicine · doi:10.1038/nm.4133 · Cited by 272
Clinical characterization of allostatic overload
Fava, G. A., McEwen, B. S., Guidi, J., Gostoli, S., Offidani, E., & Sonino, N. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.028 · Cited by 265
Psychological Well-Being and Physical Health: Associations, Mechanisms, and Future Directions
Hernandez, R., Bassett, S. M., Boughton, S. W., Schuette, S. A., Shiu, E. W., & Moskowitz, J. T. (2018) · Emotion Review · doi:10.1177/1754073917697824 · Cited by 259
Eudaimonic and Hedonic Well-Being
Ryff, C. D., Boylan, J. M., & Kirsch, J. A. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197512531.003.0005 · Cited by 305
“…well- being predicted down- regulation of the conserved transcriptional response to adversity (CTRA; Cole, 2013), marked by higher expression of pro- inflammatory genes and lower expression of antibody synthesis genes across multiple studies (Cole et al., 2015; Fredrickson et al., 2013, 2015).”
BackgroundEudaimonic well-being, inequality, and health: Recent findings and future directions
Ryff, C. D. (2017) · International Review of Economics · doi:10.1007/s12232-017-0277-4 · Cited by 301
Gene expression in major depressive disorder
Jansen, R., Penninx, B. W. J. H., Madar, V, Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A., van der Wee, N., Smit, J. H., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.57 · Cited by 224
Association Between Life Purpose and Mortality Among US Adults Older Than 50 Years
Alimujiang, A., Wiensch, A., Bøss, J., Fleischer, N., Mondul, A., McLean, K., Mukherjee, B., & Pearce, C. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.4270 · Cited by 187
Understanding resilience: New approaches for preventing and treating PTSD
Horn, S. R. G.-V., Charney, D. S., & Feder, A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.002 · Cited by 240
“Recent studies have also identified differential expression of inflammatory response genes in relation to resilience (Fredrickson et al., 2013, Lee., 2015).”
BackgroundThe Evolution and Social Dynamics of Compassion
Gilbert, P. (2015) · Social and Personality Psychology Compass · doi:10.1111/spc3.12176 · Cited by 250
Psychological well‐being and the human conserved transcriptional response to adversity
Fredrickson, B. L., Grewen, K. M., Algoe, S. B., Firestine, A. M., Arevalo, J. M. G., Ma, J., & Cole, S. W. (2015) · PLOS ONE · doi:10.1371/journal.pone.0121839 · Cited by 205
“[11] reported an association between reduced CTRA gene expression and scores in one domain of an established summary measure of well-being known as the Mental Health Continuum—Short Form (MHC-SF, also known as the Short Flourishing Scale) [12–15].”
BackgroundMethodResultInfluentialSelf-citationLoneliness, eudaimonia, and the human conserved transcriptional response to adversity
Cole, S. W., Levine, M. E., Arevalo, J. M. G., Ma, J., Weir, D. R., & Crimmins, E. M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.07.001 · Cited by 238
“…anuscript loom so large in the psychobiological regulation of leukocyte gene transcription that they overwhelm any salutary effects of positive psychological conditions such as eudaimonic well-being (Fredrickson et al., 2015; Fredrickson et al., 2013; Friedman, 2012; Ryff, 2014; Ryff et al., 2004)?”
BackgroundMethodInfluentialSelf-citationSullivan, M. B., Erb, M., Schmalzl, L., Moonaz, S. H., Taylor, J. N., & Porges, S. W. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00067 · Cited by 251
“…gene expression changes in response to social adversity; reduction in perceived loneliness; decreased inflammation; improved immune regulation; mental flourishing; and decreased all-cause mortality independent of other variables (Keyes and Simoes, 2012; Fredrickson et al., 2013; Cole et al., 2015).”
BackgroundEnroth, S., Johansson, Å., Enroth, S. B., & Gyllensten, U. B. (2014) · Nature Communications · doi:10.1038/ncomms5684 · Cited by 178
“In data from leukocytes of 80 controls 22 , there was only a weak correlation between the expression levels of CD69 and CASP-3 ( R 2 ¼ 0.13), suggesting that the high correlation observed at the protein level is either because of post transcriptional regulation, for example, epigenetic regulation,…”
InfluentialThe Emerging Science of Virtue
Fowers, B. J., Carroll, J. S., Leonhardt, N. D., & Cokelet, B. (2020) · Perspectives on Psychological Science · doi:10.1177/1745691620924473 · Cited by 199
“In summary, there is a good deal of evidence supporting the relationships among many virtues and subjective assessments of HWB.”
BackgroundInfluentialMcEwen, B. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.029 · Cited by 179
“[70] Fredrickson BL, Grewen KM, Coffey KA, Algoe SB, Firestine AM, Arevalo JM, et al.”
BackgroundGarland, E. L., Hanley, A. W., Goldin, P. R., & Gross, J. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187727 · Cited by 163
Miller, G. E., Murphy, M. L. M., Cashman, R., Ma, R., Ma, J., Arevalo, J. M. G., Kobor, M. S., & Cole, S. W. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.016 · Cited by 166
“Transcriptional activity was analyzed with methods employed and validated in our previous research (Cole et al., 2003, 2005, 2011; Fredrickson et al., 2013; Miller et al., 2008).”
Self-citationIrwin, M. R., Olmstead, R., Breen, E. C., Witarama, T., Carrillo, C., Sadeghi, N., Arevalo, J. M. G., Ma, J., Nicassio, P. M., Ganz, P. A., et al. (2014) · JNCI Monographs · doi:10.1093/jncimonographs/lgu028 · Cited by 168
Self-citationThe impact of a brief gratitude intervention on subjective well-being, biology and sleep
Jackowska, M., Brown, J., Ronaldson, A., & Steptoe, A. (2015) · Journal of Health Psychology · doi:10.1177/1359105315572455 · Cited by 185
“SWB correlates with healthier biological profiles, suggesting that it may exert beneficial effects on health through optimising biological function (Fredrickson et al., 2013; Kok and Fredrickson, 2010; Pressman and Cohen, 2005).”
BackgroundThe Current and Future Role of Heart Rate Variability for Assessing and Training Compassion
Kirby, J. N., Doty, J. R., Petrocchi, N., & Gilbert, P. (2017) · Frontiers in Public Health · doi:10.3389/fpubh.2017.00040 · Cited by 152
“There is now considerable evidence that being the giver and recipient of caring behaviors, particularly compassion, has a range of health benefits (29, 30) and can affect genetic expression (31, 32).”
BackgroundChen, Y., Fang, L., Chen, S., Zhou, H., Fan, Y., Li, L., Li, J., Xu, J., Chen, Y., Ma, Y., et al. (2020) · BioMed Research International · doi:10.1155/2020/8456596 · Cited by 153
Understanding Resilience and Preventing and Treating PTSD
Horn, S. R. G.-V., & Feder, A. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000194 · Cited by 162
Phenoptosis: Programmed Death of an Organism
Skulachev, M. V., & Skulachev, V. P. (2018) · Wiley eBooks · doi:10.1002/9781119432463.ch13 · Cited by 145
Nelson, S. K., Fritz, M. M., Lyubomirsky, S., & Cole, S. W. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.03.025 · Cited by 153
“Research has begun to map the molecular pathways through which negative social and psychological processes can influence disease risk by altering the pattern of gene expression by the human genome (Cole, 2014; Slavich and Cole, 2013).”
BackgroundInfluentialSelf-citationCarroll, J. E., Cole, S. W., Seeman, T. E., Breen, E. C., Witarama, T., Arevalo, J. M. G., Ma, J., & Irwin, M. R. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.08.024 · Cited by 129
“…MCP-4, chemokine C-X-C motif ligand (CXCL)-1, CXCL-2, CXCL-3, granulocyte macrophage colony-stimulating factor (GMCSF), intracellular adhesion molecule (ICAM)-1) that promote disease (Effros, 2005; Campisi and d’Adda di Fagagna, 2007; Erusalimsky, 2009; Coppé et al., 2010; Freund et al., 2010).”
Self-citationAntoni, M. H., Moreno, P. I., & Penedo, F. J. (2023) · Annual Review of Psychology · doi:10.1146/annurev-psych-030122-124119 · Cited by 132
“To do so, they used the previously described CTRA gene expression composite (Fredrickson et al. 2013) at baseline, 6 months, and 12 months.”
BackgroundMethodPurposeful Engagement, Healthy Aging, and the Brain
Ryff, C. D., Heller, A. S., Schaefer, S. M., van Reekum, C. M., & Davidson, R. J. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0096-z · Cited by 141
Redefining neuroendocrinology: Epigenetics of brain-body communication over the life course
McEwen, B. S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.11.001 · Cited by 129
“…functional connectivity within the brain and benefit fluid intelligence as well as improving function in aging (Gard et al., 2014a; Gard et al., 2014b) and meaning and purpose in life also has benefits for overall health and cognitive function (Carlson et al., 2009; Fredrickson et al., 2013).”
Experienced discrimination and racial differences in leukocyte gene expression
Thames, A. D., Irwin, M. R., Breen, E. C., & Cole, S. W. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.016 · Cited by 125
“The profile of transcriptional/gene expression differences observed here is consistent with patterns previously observed in studies exploring the relationship between perceptions of the social environment and CTRA gene expression (Fredrickson et al. 2013; Miller et al. 2008, 2009, 2014; Powell et al. 2013).”
BackgroundResultSelf-citationPositive maternal mental health, parenting, and child development
Phua, D. Y., Kee, M. Z. L., & Meaney, M. J. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.028 · Cited by 124
The embodied mind: A review on functional genomic and neurological correlates of mind-body therapies
Muehsam, D. J., Lutgendorf, S. K., Mills, P. J., Rickhi, B., Chevalier, G., Bat, N., Chopra, D., & Gurfein, B. T. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.027 · Cited by 133
Bower, J. E., & Kuhlman, K. R. (2023) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-080621-045153 · Cited by 133
Zaninotto, P., Wardle, J., & Steptoe, A. (2016) · British medical journal · doi:10.1136/bmj.i6267 · Cited by 81
Kohrt, B. A., Worthman, C. M., Adhikari, R. P., Luitel, N. P., Arevalo, J. M. G., Ma, J., McCreath, H., Seeman, T. E., Crimmins, E. M., & Cole, S. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601301113 · Cited by 110
Self-citationAffective immunology: where emotions and the immune response converge
D’Acquisto, F. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.1/fdacquisto · Cited by 108
Schwaiger, M., Grinberg, M., Moser, D., Zang, J. C. S., Heinrichs, M., Hengstler, J. G., Rahnenführer, J., Cole, S. W., & Kumsta, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.57 · Cited by 107
Self-citationA daily diary study of relationships between feelings of gratitude and well-being
Nezlek, J. B., Newman, D. B., & Thrash, T. M. (2016) · The Journal of Positive Psychology · doi:10.1080/17439760.2016.1198923 · Cited by 110
Yehuda, R., Pratchett, L. C., Elmes, M. W., Lehrner, A. L., Daskalakis, N. P., Koch, E., Makotkine, I., Flory, J. D., & Bierer, L. M. (2014) · Interface Focus · doi:10.1098/rsfs.2014.0048 · Cited by 100
Insulin resistance, an unmasked culprit in depressive disorders: Promises for interventions
Watson, K. T., Nasca, C., Aasly, L., McEwen, B. S., & Rasgon, N. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.038 · Cited by 96
Antoni, M. H., Bouchard, L. C., Jacobs, J. M., Lechner, S. C., Jutagir, D. R., Gudenkauf, L. M., Carver, C. S., Lutgendorf, S., Cole, S. W., Lippman, M., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.012 · Cited by 89
Self-citationRelationship of eudaimonia and hedonia with work outcomes
Turban, D. B., & Yan, W. (2016) · Journal of Managerial Psychology · doi:10.1108/jmp-07-2015-0271 · Cited by 104
“…some evidence indicates they have a different pattern of relationships with the outcomes 1008 JMP 31,6 D ow nl oa de d by U ni ve rs ity o f M is so ur iC ol um bi a, D an ie l T ur ba n A t 0 7: 39 2 6 A ug us t 2 01 6 (P T ) (Fredrickson et al., 2013; Ryan et al., 2008; Waterman, 2007).”
Insulin resistance—a missing link no more
Rasgon, N., & McEwen, B. S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.162 · Cited by 91
Kristjansson, K. R., & Fowers, B. J. (2023) · doi:10.1093/oso/9780192871473.001.0001 · Cited by 94
Inflammation in multimorbidity and disability: An integrative review.
Friedman, E. M., & Shorey, C. (2019) · Health Psychology · doi:10.1037/hea0000749 · Cited by 119
“Recent evidence suggests that differences in psychological well-being are reflected in differential expression of genes related to inflammation and immune function (Fredrickson et al., 2013), and engaging in behaviors that promote some forms of well-being produce changes in the expression of these genes in ways that s…”
BackgroundKnight, J. M., Rizzo, J. D., Logan, B. R., Wang, T., Arevalo, J. M. G., Ma, J., & Cole, S. W. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1344 · Cited by 87
“Primary analyses tested an a priori–defined contrast score represent- ing the 53-gene CTRA profile of upregulated expression of 19 proinflammatory genes (IL1A, IL1B, IL6, IL8, TNF, PTGS1, PTGS2, FOS, FOSB, FOSL1, FOSL2, JUN, JUNB, JUND, NFKB1, NFKB2, REL, RELA, and RELB) and downregulated expression of 31 genes involv…”
BackgroundSelf-citationCole, S. W., Shanahan, M. J., Gaydosh, L. M., & Harris, K. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821367117 · Cited by 81
“Data analyses examined inflammatory and type I IFN gene regulation at three distinct levels of biological function: 1) expression of apriori-defined sets of inflammatory and type I IFN indicator genes (42); 2) activity of transcription factors involved in mediating inflammatory, type I IFN, SNS, and neuroendocrine res…”
BackgroundMethodInfluentialSelf-citationMarciano, L., Lin, J., Sato, T., Saboor, S., & Viswanath, K. (2024) · SSM - Mental Health · doi:10.1016/j.ssmmh.2024.100331 · Cited by 80
“Social Ties, Health and Wellbeing: A Literature Review and Model”,
Kemp, A. H., Arias, J. A., & Fisher, Z. (2017) · Neuroscience and Social Science · doi:10.1007/978-3-319-68421-5_17 · Cited by 79
Halamová, J., Kanovský, M., Gilbert, P., Troop, N. A., Zuroff, D. C., Hermanto, N., Petrocchi, N., Sommers‐Spijkerman, M., Kirby, J. N., Shahar, B., et al. (2018) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-018-9686-2 · Cited by 86
“Compassion training may impact physiological indicators of well-being and even impact processes such as telomere length – bits of chromosomes that are a biological indicator of aging (Fredrickson et al. 2013).”
BackgroundRyff, C. D. (2018) · Wiley eBooks · doi:10.1002/9781119362081.ch20 · Cited by 85
Matos, M., Albuquerque, I., Galhardo, A. B., Cunha, M. I. V. A., de Lima, M. P., Palmeira, L., Petrocchi, N., McEwan, K., Maratos, F. A., & Gilbert, P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263480 · Cited by 93
Boyle, C. C., Cole, S. W., Dutcher, J. M., Eisenberger, N. I., & Bower, J. E. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.01.024 · Cited by 75
Self-citationMatos, M., McEwan, K., Kanovský, M., Halamová, J., Steindl, S. R., Ferreira, N., Linharelhos, M., Rijo, D., Asano, K., Márquez, M. G., et al. (2022) · Mindfulness · doi:10.1007/s12671-021-01822-2 · Cited by 82
Seeman, T. E., Merkin, S. S., Goldwater, D. S., & Cole, S. W. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104468 · Cited by 74
Self-citationWork, meaning, and gene regulation: Findings from a Japanese information technology firm
Kitayama, S., Akutsu, S., Uchida, Y., & Cole, S. W. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.07.004 · Cited by 71
Self-citationdos Santos, R. M. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100103 · Cited by 74
“Positive psychological factors contribute to reduced CTRA activity (Fredrickson et al., 2013; Kitayama et al., 2016; Kohrt et al., 2016; Nelson-Coffey et al., 2017).”
Positive emotional well-being, health Behaviors, and inflammation measured by C-Reactive protein
Ironson, G., Banerjee, N., Fitch, C., & Krause, N. (2018) · Social Science & Medicine · doi:10.1016/j.socscimed.2017.06.020 · Cited by 78
van Aubel, E., Bakker, J. M., Batink, T., Michielse, S., Goossens, L., Lange, I., Schruers, K., Lieverse, R., Marcelis, M., van Amelsvoort, T., et al. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103592 · Cited by 57
Rashid, T., & Seligman, M. (2018) · doi:10.1093/med-psych/9780195325386.001.0001 · Cited by 77
A critical reanalysis of the relationship between genomics and well-being
Brown, N. J. L., MacDonald, D. A., Samanta, M. P., Friedman, H. L., & Coyne, J. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407057111 · Cited by 65
“(3) defined in terms of eudaimonic and hedonic well-being.”
BackgroundMethodInfluentialMitochondrial psychobiology: foundations and applications
Picard, M. A., Trumpff, C., & Burelle, Y. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.04.015 · Cited by 66
A genetic perspective on the relationship between eudaimonic –and hedonic well-being
Baselmans, B. M. L., & Bartels, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-32638-1 · Cited by 88
Wingo, A. P., & Gibson, G. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.09.016 · Cited by 59
Optimism and the conserved transcriptional response to adversity.
Uchida, Y., Kitayama, S., Akutsu, S., Park, J., & Cole, S. W. (2018) · Health Psychology · doi:10.1037/hea0000675 · Cited by 61
“…of association between z-score standardized optimism scores and an a priori-specified CTRA composite score computed over 53 indicator genes (Fredrickson et al., 2013), with 19 proinflammatory genes weighted 1 and 34 antiviral and antibody-related genes weighted 1 (to reflect their inverse…”
InfluentialSelf-citationMuehsam, D. J., & Ventura, C. (2014) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2014.008 · Cited by 71
Kumsta, R. (2019) · Psychology and Psychotherapy Theory Research and Practice · doi:10.1111/papt.12227 · Cited by 66
Emotion and biological health: the socio-cultural moderation
Kitayama, S., & Park, J. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.06.016 · Cited by 60
Biobehavioral Pathways and Cancer Progression: Insights for Improving Well-Being and Cancer Outcomes
Chang, A., Sloan, E. K., Antoni, M. H., Knight, J. M., Telles, R., & Lutgendorf, S. K. (2022) · Integrative Cancer Therapies · doi:10.1177/15347354221096081 · Cited by 61
Affiliative and prosocial motives and emotions in mental health
Gilbert, P. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/pgilbert · Cited by 64
McDade, T. W., M. Ross, K., L. Fried, R., Arevalo, J. M. G., Ma, J., Miller, G. E., & Cole, S. W. (2016) · Biodemography and Social Biology · doi:10.1080/19485565.2016.1185600 · Cited by 55
“Analyses used an a priori-defined contrast among differential gene expression estimates for 53 canonical CTRA indicator genes (Cole et al. 2015; Fredrickson et al. 2013, 2015; Vedhara et al. 2015), including 19 pro-inflammatory genes (IL1A, IL1B, IL6, IL8, TNF, PTGS1, PTGS2, FOS, FOSB, FOSL1,…”
InfluentialSelf-citationSubjective social status and inflammatory gene expression.
Murray, D. R., Haselton, M. G., Fales, M. R., & Cole, S. W. (2019) · Health Psychology · doi:10.1037/hea0000705 · Cited by 56
“…and differentially expressed genes were identified as those showing 1.5-fold difference in mean expression levels (as in previous research, e.g., Fredrickson et al., 2013) over the range from 2 SD to 2 SD relative to mean level of SSS in standard linear model analyses that additionally…”
InfluentialSelf-citationCalvo, V., D’Aquila, C., Rocco, D., & Carraro, E. (2022) · Current Psychology · doi:10.1007/s12144-020-00820-2 · Cited by 55
Perilla-Toro, L. E., & Gómez-Ortiz, V. (2017) · Journal of Work and Organizational Psychology · doi:10.1016/j.rpto.2017.02.005 · Cited by 55
“…salud es más sólida que la del bienestar afectivo e incluso los resultados de análisis genéticos revelan que la fisiología molecular correspondiente al bienestar hedónico resulta adversa, lo cual parece no registrarse en el nivel de afecto que experimentan las personas (Fredrickson et al., 2013).”
BackgroundNatural language indicators of differential gene regulation in the human immune system
Mehl, M. R., Raison, C. L., Pace, T. W. W., Arevalo, J. M. G., & Cole, S. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707373114 · Cited by 52
“the 50 available CTRA indicator transcripts (10, 27, 28) and a priori-specified”
BackgroundMethodInfluentialSelf-citationPositive Psychological Functioning and the Biology of Health
Kubzansky, L. D., Boehm, J. K., & Segerstrom, S. C. (2015) · Social and Personality Psychology Compass · doi:10.1111/spc3.12224 · Cited by 56
“Initial studies have suggested that PPF is associated with specific gene expression patterning that signals antiinf lammatory activity (Bhasin et al., 2013; Fredrickson et al., 2013).”
BackgroundLevin, N. J., Zebrack, B., & Cole, S. W. (2019) · Pediatric Blood & Cancer · doi:10.1002/pbc.27789 · Cited by 58
Self-citationBeyond Green Consumerism: Uncovering the Motivations of Green Citizenship
Harbo, S., Young, R. D., & Guckian, M. L. (2017) · Michigan Journal of Sustainability · doi:10.3998/mjs.12333712.0005.105 · Cited by 60
The Neuroscience of Resilience
Hunter, R. G., Gray, J. D., & McEwen, B. S. (2018) · Journal of the Society for Social Work and Research · doi:10.1086/697956 · Cited by 60
Happiness and meaning in life: Unique, differential, and indirect associations with mental health
Li, P. F. J., Wong, Y. J., & Chao, R. (2019) · Counselling Psychology Quarterly · doi:10.1080/09515070.2019.1604493 · Cited by 71
Knight, J. M., Rizzo, J. D., Hari, P., Pasquini, M. C., Giles, K. E., D’Souza, A., Logan, B. R., Hamadani, M., Chhabra, S., Dhakal, B., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000765 · Cited by 53
“Primary analyses tested for change in an a priori–defined composite score representing the CTRA profile of upregulated expression of proinflammatory genes (19 indicator transcripts positively weighted: IL1A, IL1B, IL6, IL8/CXCL8, TNF, PTGS1, PTGS2, FOS, FOSB, FOSL1, FOSL2, JUN, JUNB, JUND, NFKB1, NFKB2, REL, RELA, and…”
ResultSelf-citationHedonic and eudaimonic motives to pursue well-being in three samples of youth
Gentzler, A. L., DeLong, K. L., Palmer, C. A., & Huta, V. (2021) · Motivation and Emotion · doi:10.1007/s11031-021-09882-6 · Cited by 55
Metadata
- Authors
- Fredrickson, B. L., Grewen, K. M., Coffey, K. A., Algoe, S. B., Firestine, A. M., Arevalo, J. M. G., Ma, J., & Cole, S. W.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of California, Los Angeles (US)
- University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095; and
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-07-29
- Volume
- 110
- Issue
- 33
- Pages
- 13684-13689
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3746929
- OpenAlex
- W2155399165
- Cited by
- 512
- References
- 72
- Citations by year
- 2026: 17 · 2025: 32 · 2024: 16 · 2023: 36 · 2022: 37 · 2021: 36 · 2020: 47 · 2019: 38 · 2018: 76 · 2017: 48 · 2016: 59 · 2015: 34 · 2014: 28 · 2013: 7
- FWCI
- 63.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- National Institute on Aging (P30AG107265, P30AG017265)
- NIH Office of the Director (R01NR012899)
- National Cancer Institute (R01CA116778)
- National Institute of Nursing Research (R01NR012899)
- Common Fund
- Topics
- Social Sciences › Psychology › Social Psychology › Psychological Well-being and Life Satisfaction
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- psychological well-being, hedonic well-being, eudaimonic well-being, leukocyte gene expression, peripheral blood mononuclear cells, conserved transcriptional response to adversity, pro-inflammatory genes, type I interferon response, NF-κB signaling, AP-1 signaling, transcription factor activity, monocytes, plasmacytoid dendritic cells, B cells, depressive symptoms, stress response
- MeSH terms
- Adult, Antibodies, Happiness, Humans, Interferon Type I, Leukocytes, Mononuclear, Middle Aged, Models, Psychological, North Carolina, Quality of Life, Surveys and Questionnaires, Transcription Factors, Genome, Human, NF-kappa B, Transcription Factor AP-1, Computational Biology, Gene Regulatory Networks, Pleasure, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
