Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research

Diet, muscle glycogen and physical performance.

Bergström, J., Hermansen, L., Hultman, E., & Saltin, B. (1967) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1967.tb03720.x · Cited by 1,740

Selective glycogen depletion pattern in human muscle fibres after exercise of varying intensity and at varying pedalling rates

Gollnick, P. D., Piehl, K., & Saltin, B. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010639 · Cited by 643

Muscle Glycogen Synthesis after Exercise : an Enhancing Factor localized to the Muscle Cells in Man

BERGSTRÖM, J., & HULTMAN, E. (1966) · Nature · doi:10.1038/210309a0 · Cited by 473

A Study of the Glycogen Metabolism during Exercise in Man

Bergström, J., & Hultman, E. (1967) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516709090629 · Cited by 426

Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans

Stephens, F. B., Wall, B. T., Marimuthu, K., Shannon, C. E., Constantin‐Teodosiu, D., Macdonald, I. A., & Greenhaff, P. L. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.255364 · Cited by 75

Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals

Chee, C., Shannon, C. E., Burns, A., Selby, A. L., Wilkinson, D., Smith, K., Greenhaff, P. L., & Stephens, F. B. (2016) · Diabetes · doi:10.2337/db15-1383 · Cited by 74

Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates

TROMMELEN, J., HOLWERDA, A. M., KOUW, I. W. K., LANGER, H., HALSON, S. L., ROLLO, I., VERDIJK, L. B., & VAN LOON, L. J. C. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001045 · Cited by 69

The muscle protein synthetic response to the ingestion of a plant-derived protein blend does not differ from an equivalent amount of milk protein in healthy, young males

Pinckaers, P. J., Kouw, I. W., Gorissen, S. H., Houben, L. H., Senden, J. M., Wodzig, W. K., de Groot, L. C., Verdijk, L. B., Snijders, T., & van Loon, L. J. (2022) · The Journal of Nutrition · doi:10.1093/jn/nxac222 · Cited by 70

Increased Expression of H19/MiR-675 Is Associated with a Low Fat-Free Mass Index in Patients with COPD

Lewis, A., Lee, J. Y., Donaldson, A. V., Natanek, S. A., Vaidyanathan, S., Man, W. D. ‐., Hopkinson, N. S., Sayer, A. A., Patel, H. P., Cooper, C., et al. (2016) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12078 · Cited by 68

Gender Differences in Lipoprotein Lipase Activity after Acute Exercise

Perreault, L., Lavely, J. M., Kittelson, J. M., & Horton, T. J. (2004) · Obesity Research · doi:10.1038/oby.2004.31 · Cited by 64

Creatine Loading Does not Preserve Muscle Mass or Strength during Leg Immobilization in Healthy, Young Males: A Randomized Controlled Trial

Backx, E. M. P., Hangelbroek, R., Snijders, T., Verscheijden, M.-L., Verdijk, L. B., de Groot, L. C. P. G. M., & van Loon, L. J. C. (2017) · Sports Medicine · doi:10.1007/s40279-016-0670-2 · Cited by 61

Sodium nitrate ingestion increases skeletal muscle nitrate content in humans

Nyakayiru, J., Kouw, I. W. K., Cermak, N. M., Senden, J. M., van Loon, L. J. C., & Verdijk, L. B. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01036.2016 · Cited by 60

Human vastus lateralis and soleus muscles display divergent cellular contractile properties

Luden, N., Minchev, K., Hayes, E., Louis, E., Trappe, T., & Trappe, S. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90564.2008 · Cited by 55

Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24 h of recovery following prolonged exhaustive exercise in humans

Roberts, P. A., Fox, J., Peirce, N., Jones, S. W., Casey, A., & Greenhaff, P. L. (2016) · Amino Acids · doi:10.1007/s00726-016-2252-x · Cited by 59

Effect of Short-Term Thyroxine Administration on Energy Metabolism and Mitochondrial Efficiency in Humans

Johannsen, D. L., Galgani, J. E., Johannsen, N. M., Zhang, Z., Covington, J. D., & Ravussin, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040837 · Cited by 57

High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men

Woodhead, J. S. T., D’Souza, R. F., Hedges, C. P., Wan, J., Berridge, M. V., Cameron-Smith, D., Cohen, P., Hickey, A. J. R., Mitchell, C. J., & Merry, T. L. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00032.2020 · Cited by 57

No superior adaptations to carbohydrate periodization in elite endurance athletes

GEJL, K. D., THAMS, L. B., HANSEN, M., ROKKEDAL-LAUSCH, T., PLOMGAARD, P., NYBO, L., LARSEN, F. J., CARDINALE, D. A., JENSEN, K., HOLMBERG, H.-C., et al. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001377 · Cited by 57

PGC-1β is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family

Mortensen, O. H., Plomgaard, P., Fischer, C. P., Hansen, A. K., Pilegaard, H., & Pedersen, B. K. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00575.2007 · Cited by 56

Impact of exercise training status on the fiber type-specific abundance of proteins regulating intramuscular lipid metabolism

Shaw, C. S., Swinton, C., Morales-Scholz, M. G., McRae, N., Erftemeyer, T., Aldous, A., Murphy, R. M., & Howlett, K. F. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00797.2019 · Cited by 56

Protein Supplementation Augments Muscle Fiber Hypertrophy but Does Not Modulate Satellite Cell Content During Prolonged Resistance-Type Exercise Training in Frail Elderly

Dirks, M. L., Tieland, M., Verdijk, L. B., Losen, M., Nilwik, R., Mensink, M., de Groot, L. C. P. G. M., & van Loon, L. J. C. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.02.006 · Cited by 56

Effects of 7 wk of endurance training on human skeletal muscle metabolism during submaximal exercise

LeBlanc, P. J., Howarth, K. R., Gibala, M. J., & Heigenhauser, G. J. F. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00517.2004 · Cited by 56

Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training

Dethlefsen, M. M., Halling, J. F., Møller, H. D., Plomgaard, P., Regenberg, B., Ringholm, S., & Pilegaard, H. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.07.011 · Cited by 54

Impact of protein coingestion on muscle protein synthesis during continuous endurance type exercise

Beelen, M., Zorenc, A., Pennings, B., Senden, J. M., Kuipers, H., & van Loon, L. J. C. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2010 · Cited by 54

Short inter-set rest blunts resistance exercise-induced increases in myofibrillar protein synthesis and intracellular signalling in young males

McKendry, J., Pérez‐López, A., McLeod, M., Luo, D., Dent, J. R., Smeuninx, B., Yu, J., Taylor, A. E., Philp, A., & Breen, L. (2016) · Experimental Physiology · doi:10.1113/ep085647 · Cited by 54

Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men

Kirmse, M., Oertzen-Hagemann, V., de Marées, M., Bloch, W., & Platen, P. (2019) · Nutrients · doi:10.3390/nu11051154 · Cited by 53

Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: a randomized trial

Gorissen, S. H., Horstman, A. M., Franssen, R., Kouw, I. W., Wall, B. T., Burd, N. A., de Groot, L. C., & van Loon, L. J. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.129924 · Cited by 53

Short-term muscle disuse atrophy is not associated with increased intramuscular lipid deposition or a decline in the maximal activity of key mitochondrial enzymes in young and older males

Wall, B. T., Dirks, M. L., Snijders, T., Stephens, F. B., Senden, J. M. G., Verscheijden, M.-L., & van Loon, L. J. C. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.11.019 · Cited by 52

Six Weeks of Low-Load Blood Flow Restricted and High-Load Resistance Exercise Training Produce Similar Increases in Cumulative Myofibrillar Protein Synthesis and Ribosomal Biogenesis in Healthy Males

Sieljacks, P., Wang, J., Groennebaek, T., Rindom, E., Jakobsgaard, J. E., Herskind, J., Gravholt, A., Møller, A. B., Musci, R. V., de Paoli, F. V., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00649 · Cited by 50

Effect of l-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians

Novakova, K., Kummer, O., Bouitbir, J., Stoffel, S. D., Hoerler-Koerner, U., Bodmer, M., Roberts, P., Urwyler, A., Ehrsam, R., & Krähenbühl, S. (2016) · European Journal of Nutrition · doi:10.1007/s00394-015-0838-9 · Cited by 51

Effect of endurance training on muscle tca cycle metabolism during exercise in humans

Howarth, K. R., LeBlanc, P. J., Heigenhauser, G. J. F., & Gibala, M. J. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01344.2003 · Cited by 50

Early rehabilitation in critical care (eRiCC): functional electrical stimulation with cycling protocol for a randomised controlled trial

Parry, S. M., Berney, S., Koopman, R., Bryant, A., El-Ansary, D., Puthucheary, Z., Hart, N., Warrillow, S., & Denehy, L. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-001891 · Cited by 50

EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS

Sparks, L. M., Redman, L. M., Conley, K. E., Harper, M.-E., Yi, F., Hodges, A., Eroshkin, A., Costford, S. R., Gabriel, M. E., Shook, C., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3211 · Cited by 45

Extremely low-volume, high-intensity interval training improves exercise capacity and increases mitochondrial protein content in human skeletal muscle

K. Ma, J., D. Scribbans, T., A. Edgett, B., Colin Boyd, J., A. Simpson, C., P. Little, J., & J. Gurd, B. (2013) · Open Journal of Molecular and Integrative Physiology · doi:10.4236/ojmip.2013.34027 · Cited by 47

Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men

Hamer, H. M., Wall, B. T., Kiskini, A., de Lange, A., Groen, B. B. L., Bakker, J. A., Gijsen, A. P., Verdijk, L. B., & van Loon, L. J. C. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-15 · Cited by 44

Methodology for studying Relative Energy Deficiency in Sport (REDs): a narrative review by a subgroup of the International Olympic Committee (IOC) consensus on REDs

Ackerman, K. E., Rogers, M. A., Heikura, I. A., Burke, L. M., Stellingwerff, T., Hackney, A. C., Verhagen, E., Schley, S., Saville, G. H., Mountjoy, M., et al. (2023) · British Journal of Sports Medicine · doi:10.1136/bjsports-2023-107359 · Cited by 43

Epigenetic programming of adipose-derived stem cells in low birthweight individuals

Broholm, C., Olsson, A. H., Perfilyev, A., Hansen, N. S., Schrölkamp, M., Strasko, K. S., Scheele, C., Ribel-Madsen, R., Mortensen, B., Jørgensen, S. W., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4099-9 · Cited by 43

Tumor necrosis factor-α impairs adiponectin signalling, mitochondrial biogenesis, and myogenesis in primary human myotubes cultures

Sente, T., Van Berendoncks, A. M., Fransen, E., Vrints, C. J., & Hoymans, V. Y. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00831.2015 · Cited by 41

Impact of caffeine and protein on postexercise muscle glycogen synthesis

BEELEN, M., VAN KRANENBURG, J., SENDEN, J. M., KUIPERS, H., & VAN LOON, L. J. C. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31823a40ef · Cited by 39

Continuous endurance-type exercise training does not modulate satellite cell content in obese type 2 diabetes patients.

Snijders, T., Verdijk, L. B., Hansen, D., Dendale, P., & van Loon, L. J. C. (2011) · Muscle & Nerve · doi:10.1002/mus.21891 · Cited by 37

The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?

Sparks, L. M., Goodpaster, B. H., & Bergman, B. C. (2021) · Diabetes · doi:10.2337/dbi19-0006 · Cited by 35

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity

Sparks, L. M., Gemmink, A., Phielix, E., Bosma, M., Schaart, G., Moonen-Kornips, E., Jörgensen, J. A., Nascimento, E. B. M., Hesselink, M. K. C., Schrauwen, P., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-3885-8 · Cited by 34

The Single Nucleotide Polymorphism Gly482Ser in the PGC-1α Gene Impairs Exercise-Induced Slow-Twitch Muscle Fibre Transformation in Humans

Steinbacher, P., Feichtinger, R. G., Kedenko, L., Kedenko, I., Reinhardt, S., Schönauer, A.-L., Leitner, I., Sänger, A. M., Stoiber, W., Kofler, B., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0123881 · Cited by 33

Fructose Coingestion Does Not Accelerate Postexercise Muscle Glycogen Repletion

TROMMELEN, J., BEELEN, M., PINCKAERS, P. J. M., SENDEN, J. M., CERMAK, N. M., & VAN LOON, L. J. C. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000829 · Cited by 33

NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults

Connell, N., Grevendonk, L., Fealy, C., Moonen-Kornips, E., Bruls, Y., Schrauwen-Hinderling, V., de Vogel, J., Hageman, R., Geurts, J., Zapata-Perez, R., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab193 · Cited by 33

Impact of blood flow‐restricted bodyweight exercise on skeletal muscle adaptations

Jakobsgaard, J. E., Christiansen, M., Sieljacks, P., Wang, J., Groennebaek, T., de Paoli, F., & Vissing, K. (2018) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12509 · Cited by 33

Effects of Creatine and Carbohydrate Loading on Cycling Time Trial Performance

TOMCIK, K. A., CAMERA, D. M., BONE, J. L., ROSS, M. L., JEACOCKE, N. A., TACHTSIS, B., SENDEN, J., VAN LOON, L. J. C., HAWLEY, J. A., & BURKE, L. M. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001401 · Cited by 33

MuRF-1 and Atrogin-1 Protein Expression and Quadriceps Fiber Size and Muscle Mass in Stable Patients with COPD

Natanek, S. A., Riddoch-Contreras, J., Marsh, G. S., Hopkinson, N. S., Moxham, J., Man, W. D.-C., Kemp, P. R., & Polkey, M. I. (2013) · COPD: Journal of Chronic Obstructive Pulmonary Disease · doi:10.3109/15412555.2013.781577 · Cited by 32

Reduced HDAC2 in Skeletal Muscle of COPD Patients

To, M., Swallow, E. B., Akashi, K., Haruki, K., Natanek, S. A., Polkey, M. I., Ito, K., & Barnes, P. J. (2017) · Respiratory Research · doi:10.1186/s12931-017-0588-8 · Cited by 31

Increasing skeletal muscle carnitine content in older individuals increases whole-body fat oxidation during moderate-intensity exercise

Chee, C., Shannon, C. E., Burns, A., Selby, A. L., Wilkinson, D., Smith, K., Greenhaff, P. L., & Stephens, F. B. (2021) · Aging Cell · doi:10.1111/acel.13303 · Cited by 29

Vegetarians have a reduced skeletal muscle carnitine transport capacity

Stephens, F. B., Marimuthu, K., Cheng, Y., Patel, N., Constantin, D., Simpson, E. J., & Greenhaff, P. L. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.012047 · Cited by 28

A Complete Workflow for High Throughput Human Single Skeletal Muscle Fiber Proteomics

(2023) · doi:10.1021/jasms.3c00072 · Cited by 28

24-Week β-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy males

Saunders, B., Franchi, M., de Oliveira, L. F., da Eira Silva, V., da Silva, R. P., de Salles Painelli, V., Costa, L. A. R., Sale, C., Harris, R. C., Roschel, H., et al. (2020) · European Journal of Nutrition · doi:10.1007/s00394-018-1881-0 · Cited by 23

Neuromuscular electrical stimulation prior to presleep protein feeding stimulates the use of protein-derived amino acids for overnight muscle protein synthesis

Dirks, M. L., Groen, B. B. L., Franssen, R., van Kranenburg, J., & van Loon, L. J. C. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00331.2016 · Cited by 22

Glucose ingestion during endurance training in men attenuates expression of myokine receptor

Akerstrom, T. C. A., Krogh‐Madsen, R., Petersen, A. M. W., & Pedersen, B. K. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.048983 · Cited by 21

Differing physiological effects of epinephrine in type 1 diabetes and nondiabetic humans

Guy, D. A., Sandoval, D., Richardson, M. A., Tate, D., Flakoll, P. J., & Davis, S. N. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00310.2004 · Cited by 21

Males and females exhibit similar muscle glycogen recovery with varied recovery food sources

Flynn, S., Rosales, A., Hailes, W., & Ruby, B. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04352-2 · Cited by 17

Effects of Oral Resveratrol Supplementation on Glycogen Replenishment and Mitochondria Biogenesis in Exercised Human Skeletal Muscle

Huang, C.-C., Liu, C.-C., Tsao, J.-P., Hsu, C.-L., & Cheng, I.-S. (2020) · Nutrients · doi:10.3390/nu12123721 · Cited by 16

Immobilization leads to alterations in intracellular phosphagen and creatine transporter content in human skeletal muscle

Luo, D., Edwards, S., Smeuninx, B., McKendry, J., Nishimura, Y., Perkins, M., Philp, A., Joanisse, S., & Breen, L. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00072.2020 · Cited by 11

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake

Kjærgaard, J., Lindqvist, C. B., Quesada, J. P., Jessen, S., Schlabs, F., Ehrlich, A. M., Yonamine, C. Y., García-Ureña, M., Schmalbruch, J. H., Small, L., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102163 · Cited by 11

Untitled work

Ochel (2001) · doi:10.1379/1466-1268(2001)006<0105:gtpoac>2.0.co;2