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Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.
Open accessAbstract
A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones. CSIF can inhibit the production of IL-2, IL-3, lymphotoxin (LT)/TNF, IFN-gamma, and granulocyte-macrophage CSF (GM-CSF) by Th1 cells responding to antigen and APC, but Th2 cytokine synthesis is not significantly affected. Transforming growth factor beta (TGF-beta) also inhibits IFN-gamma production, although less effectively than CSIF, whereas IL-2 and IL-4 partially antagonize the activity of CSIF. CSIF inhibition of cytokine synthesis is not complete, since early cytokine synthesis (before 8 h) is not significantly affected, whereas later synthesis is strongly inhibited. In the presence of CSIF, IFN-gamma mRNA levels are reduced slightly at 8, and strongly at 12 h after stimulation. Inhibition of cytokine expression by CSIF is not due to a general reduction in Th1 cell viability, since actin mRNA levels were not reduced, and proliferation of antigen-stimulated cells in response to IL-2, was unaffected. Biochemical characterization, mAbs, and recombinant or purified cytokines showed that CSIF is distinct from IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IFN-gamma, GM-CSF, TGF-beta, TNF, LT, and P40. The potential role of CSIF in crossregulation of Th1 and Th2 responses is discussed.
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Cites
Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells
Stevens, T. L., Bossie, A., Sanders, V. M., Fernandez-Botran, R., Coffman, R. L., Mosmann, T. R., & Vitetta, E. S. (1988) · Nature · doi:10.1038/334255a0 · Cited by 933
Self-citation
Cited by
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134
Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Self-citationThe Central Role of CD4+ T Cells in the Antitumor Immune Response
Hung, K., Hayashi, R., Lafond-Walker, A., Lowenstein, C., Pardoll, D., & Levitsky, H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2357 · Cited by 1,345
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
Rousset, F., Garcia, E., Defrance, T., Péronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W., & Banchereau, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1890 · Cited by 1,238
Powrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90045-0 · Cited by 1,146
Interleukin‐10: new perspectives on an old cytokine
Mosser, D. M., & Zhang, X. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00706.x · Cited by 1,077
Sabat, R., Grütz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K., & Geginat, J. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.09.002 · Cited by 977
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
Trinchieri, G. (1998) · Advances in Immunology · doi:10.1016/s0065-2776(08)60387-9 · Cited by 760
Inflammation, Immunity, and Hypertensive End-Organ Damage
McMaster, W. G., Kirabo, A., Madhur, M. S., & Harrison, D. G. (2015) · Circulation Research · doi:10.1161/circresaha.116.303697 · Cited by 708
Experimental Autoimmune Encephalomyelitis Induction in Genetically B Cell–deficient Mice
Wolf, S. D., Dittel, B. N., Hardardottir, F., & Janeway, C. A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2271 · Cited by 699
Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.589 · Cited by 613
Maynard, C. L., Harrington, L. E., Janowski, K. M., Oliver, J. R., Zindl, C. L., Rudensky, A. Y., & Weaver, C. T. (2007) · Nature Immunology · doi:10.1038/ni1504 · Cited by 599
Modolell, M., Corraliza, I. M., Link, F., Soler, G., & Eichmann, K. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250436 · Cited by 554
Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10
Li, M. O., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.003 · Cited by 501
Cunha, F. Q., Mohcada, S., & Liew, F. Y. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91852-h · Cited by 383
Evolutionary divergence and functions of the human interleukin (IL) gene family
Brocker, C., Thompson, D., Matsumoto, A., Nebert, D. W., & Vasiliou, V. (2010) · Human Genomics · doi:10.1186/1479-7364-5-1-30 · Cited by 368
Heterogeneity of CD4+ memory T cells: Functional modules for tailored immunity
Sallusto, F., & Lanzavecchia, A. (2009) · European Journal of Immunology · doi:10.1002/eji.200939722 · Cited by 348
Oswald, I. P., Wynn, T. A., Sher, A., & James, S. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8676 · Cited by 353
Cai, Y., Liu, J., Wang, B., Sun, M., & Yang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.856376 · Cited by 351
IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity
Oft, M. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0214 · Cited by 322
A primer on cytokines: sources, receptors, effects, and inducers
Curfs, J. H., Meis, J. F., & Hoogkamp-Korstanje, J. A. (1997) · Clinical Microbiology Reviews · doi:10.1128/cmr.10.4.742 · Cited by 317
Villalta, S. A., Rinaldi, C., Deng, B., Liu, G., Fedor, B., & Tidball, J. G. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddq523 · Cited by 299
Current status of interleukin-10 and regulatory T-cells in cancer
Dennis, K. L., Blatner, N. R., Gounari, F., & Khazaie, K. (2013) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000006 · Cited by 289
Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy
Prete, G. D. (1992) · Allergy · doi:10.1111/j.1398-9995.1992.tb00662.x · Cited by 287
The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
Donnelly, R. P., Sheikh, F., Kotenko, S. V., & Dickensheets, H. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0204117 · Cited by 289
Inflammation induced loss of skeletal muscle
Londhe, P., & Guttridge, D. C. (2015) · Bone · doi:10.1016/j.bone.2015.03.015 · Cited by 276
Developmental and Functional Control of Natural Killer Cells by Cytokines
Wu, Y., Tian, Z., & Wei, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00930 · Cited by 269
IL-10 Gene Expression Is Controlled by the Transcription Factors Sp1 and Sp3
Tone, M., Powell, M. J., Tone, Y., Thompson, S. A. J., & Waldmann, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.286 · Cited by 250
Role of Stat3 in Lipopolysaccharide-Induced IL-10 Gene Expression
Benkhart, E. M., Siedlar, M., Wedel, A., Werner, T., & Ziegler-Heitbrock, H. W. L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1612 · Cited by 249
Breous, E., Somanathan, S., Vandenberghe, L. H., & Wilson, J. M. (2009) · Hepatology · doi:10.1002/hep.23043 · Cited by 237
Interleukin‐10 modulates susceptibility in experimental cerebral malaria
KOSSODO, S., MONSO, C., JUILLARD, P., VELU, T., GOLDMAN, M., & GRAU, G. E. (1997) · Immunology · doi:10.1046/j.1365-2567.1997.00290.x · Cited by 180
Opp, M. R., Smith, E. M., & Hughes, T. K. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00066-b · Cited by 145
Dual biological effects of the cytokines interleukin-10 and interferon-γ
Wilke, C. M., Wei, S., Wang, L., Kryczek, I., Kao, J., & Zou, W. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1104-5 · Cited by 138
Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity
Yano, H., Andrews, L. P., Workman, C. J., & Vignali, D. A. A. (2019) · Immunology · doi:10.1111/imm.13067 · Cited by 116
HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis
Porto, A. F., Neva, F. A., Bittencourt, H., Lisboa, W., Thompson, R., Alcântara, L., & Carvalho, E. M. (2001) · Parasite Immunology · doi:10.1046/j.1365-3024.2001.00407.x · Cited by 120
UVB exposure-induced systemic modulation of Th1- and Th2-mediated immune responses
Garssen, Vandebriel, Gruijl, D., Wolvers, Dijk, V., Fluitman, & Loveren, V. (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00801.x · Cited by 119
Shi, J., Li, J., Guan, H., Cai, W., Bai, X., Fang, X., Hu, X., Wang, Y., Wang, H., Zheng, Z., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098228 · Cited by 116
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Li, X., Liu, X., Tian, L., & Chen, Y. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-014-8465-4 · Cited by 104
Johansson, A. C. M., Hansson, A.-S., Nandakumar, K. S., Bäcklund, J., & Holmdahl, R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3505 · Cited by 96
Interleukin-10 responses from acute exercise in healthy subjects: A systematic review
Cabral‐Santos, C., de Lima Junior, E. A., Fernandes, I. M. D. C., Pinto, R. Z., Rosa‐Neto, J. C., Bishop, N. C., & Lira, F. S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27920 · Cited by 96
Im, E., Riegler, F. M., Pothoulakis, C., & Rhee, S. H. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00120.2012 · Cited by 79
IL‐10 Production by CD5 B Cells
O'GARRA, A., & HOWARD, M. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb24615.x · Cited by 74
Lee, S.-H., Heo, Y., & Kim, Y.-C. (2010) · Journal of Veterinary Science · doi:10.4142/jvs.2010.11.1.35 · Cited by 67
Viveros-Paredes, J. M., Puebla-Pérez, A. M., Gutiérrez-Coronado, O., Sandoval-Ramírez, L., & Villaseñor-García, M. M. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2005.11.011 · Cited by 62
Okamura, T., Yamamoto, K., & Fujio, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00340 · Cited by 41
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Metadata
- Authors
- Fiorentino, D. F., Bond, M. W., & Mosmann, T. R.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-12-01
- Volume
- 170
- Issue
- 6
- Pages
- 2081-2095
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2084990572
- Cited by
- 2,733
- References
- 1
- FWCI
- 26.72
- Type
- journal article
- Language
- en
- Open access
- green
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