The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
Open accessAbstract
Summary: Parallel heatmaps with carefully designed annotation graphics are powerful for efficient visualization of patterns and relationships among high dimensional genomic data. Here we present the ComplexHeatmap package that provides rich functionalities for customizing heatmaps, arranging multiple parallel heatmaps and including user-defined annotation graphics. We demonstrate the power of ComplexHeatmap to easily reveal patterns and correlations among multiple sources of information with four real-world datasets. Availability and Implementation: The ComplexHeatmap package and documentation are freely available from the Bioconductor project: http://www.bioconductor.org/packages/devel/bioc/html/ComplexHeatmap.html. Contact: m.schlesner@dkfz.de Supplementary information: Supplementary data are available at Bioinformatics online.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Comprehensive molecular profiling of lung adenocarcinoma
The Cancer Genome Atlas Research Network (2014) · Nature · doi:10.1038/nature13385 · Cited by 5,732
Buettner, F., Natarajan, K. N., Casale, F. P., Proserpio, V., Scialdone, A., Theis, F. J., Teichmann, S. A., Marioni, J. C., & Stegle, O. (2015) · Nature Biotechnology · doi:10.1038/nbt.3102 · Cited by 1,136
Research works printed but not linked: 3
- Galili, 2015, dendextend: an R package for visualizing, adjusting, and comparing trees of hierarchical clustering, Bioinformatics, 31, 3718, 10.1093/bioinformatics/btv428 · DOI
- Gao, 2013, Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal, Sci. Signal, 6, pl1, 10.1126/scisignal.2004088 · DOI · Paper page
- Sturm, 2012, Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma, Cancer Cell, 22, 425, 10.1016/j.ccr.2012.08.024 · DOI · Paper page
Cited by
Items 101–200 of 202
Baranasic, D., Hörtenhuber, M., Balwierz, P. J., Zehnder, T., Mukarram, A. K., Nepal, C., Várnai, C., Hadzhiev, Y., Jimenez-Gonzalez, A., Li, N., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01089-w · Cited by 101
Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
Alraies, Z., Rivera, C. A., Delgado, M.-G., Sanséau, D., Maurin, M., Amadio, R., Maria Piperno, G., Dunsmore, G., Yatim, A., Lacerda Mariano, L., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01856-3 · Cited by 106
Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility
Meijer, M., Agirre, E., Kabbe, M., van Tuijn, C. A., Heskol, A., Zheng, C., Mendanha Falcão, A., Bartosovic, M., Kirby, L., Calini, D., et al. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.034 · Cited by 98
Béziat, V., Rapaport, F., Hu, J., Titeux, M., Bonnet des Claustres, M., Bourgey, M., Griffin, H., Bandet, É., Ma, C. S., Sherkat, R., et al. (2021) · Cell · doi:10.1016/j.cell.2021.06.004 · Cited by 95
Guo, X., Nie, H., Zhang, W., Li, J., Ge, J., Xie, B., Hu, W., Zhu, Y., Zhong, N., Zhang, X., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.01.001 · Cited by 100
Clonal tracing with somatic epimutations reveals dynamics of blood ageing
Scherer, M., Singh, I., Braun, M. M., Szu-Tu, C., Sanchez Sanchez, P., Lindenhofer, D., Jakobsen, N. A., Körber, V., Kardorff, M., Nitsch, L., et al. (2025) · Nature · doi:10.1038/s41586-025-09041-8 · Cited by 89
Anderson, A. G., Rogers, B. B., Loupe, J. M., Rodriguez-Nunez, I., Roberts, S. C., White, L. M., Brazell, J. N., Bunney, W. E., Bunney, B. G., Watson, S. J., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100263 · Cited by 82
Bishehsari, F., Engen, P. A., Voigt, R. M., Swanson, G., Shaikh, M., Wilber, S., Naqib, A., Green, S. J., Shetuni, B., Forsyth, C. B., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.10.011 · Cited by 76
“The software package Linear Discriminant Analysis Effect Size was used to identify biologically meaningful features differentiating groups, and ComplexHeatmaps in the R environment was used to depict differential feature abundances between groups.(71,72)”
MethodEndothelial sensing of AHR ligands regulates intestinal homeostasis
Wiggins, B. G., Wang, Y.-F., Burke, A., Grunberg, N., Vlachaki Walker, J. M., Dore, M., Chahrour, C., Pennycook, B. R., Sanchez-Garrido, J., Vernia, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06508-4 · Cited by 89
The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function
Oberbeck, N., Pham, V. C., Webster, J. D., Reja, R., Huang, C. S., Zhang, Y., Roose-Girma, M., Warming, S., Li, Q., Birnberg, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1615-3 · Cited by 86
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
Kimura, K., Subramanian, A., Yin, Z., Khalilnezhad, A., Wu, Y., He, D., Dixon, K. O., Chitta, U. K., Ding, X., Adhikari, N., et al. (2025) · Nature · doi:10.1038/s41586-025-08852-z · Cited by 85
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation
Sun, T., Annunziato, S., Bergling, S., Sheng, C., Orsini, V., Forcella, P., Pikiolek, M., Kancherla, V., Holwerda, S., Imanci, D., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.05.013 · Cited by 84
Revolutionizing finance: The synergy of fintech, digital adoption, and innovation
Rizvi, S. K. A., Rahat, B., Naqvi, B., & Umar, M. (2024) · Technological Forecasting and Social Change · doi:10.1016/j.techfore.2023.123112 · Cited by 83
A cross-species proteomic map reveals neoteny of human synapse development
Wang, L., Pang, K., Zhou, L., Cebrián-Silla, A., González-Granero, S., Wang, S., Bi, Q., White, M. L., Ho, B., Li, J., et al. (2023) · Nature · doi:10.1038/s41586-023-06542-2 · Cited by 82
Greve, H. J., Dunbar, A. L., Lombo, C. G., Ahmed, C., Thang, M., Messenger, E. J., Mumaw, C. L., Johnson, J. A., Kodavanti, U. P., Oblak, A. L., et al. (2023) · Brain · doi:10.1093/brain/awac113 · Cited by 82
A cross-species proteomic map reveals neoteny of human synapse development
Wang, L., Pang, K., Zhou, L., Cebrián-Silla, A., González-Granero, S., Wang, S., Bi, Q., White, M. L., Ho, B., Li, J., et al. (2022) · doi:10.1101/2022.10.24.513541 · Cited by 82
Filipello, F., You, S.-F., Mirfakhar, F. S., Mahali, S., Bollman, B., Acquarone, M., Korvatska, O., Marsh, J. A., Sivaraman, A., Martinez, R., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02568-y · Cited by 81
Natural proteome diversity links aneuploidy tolerance to protein turnover
Muenzner, J., Trébulle, P., Agostini, F., Zauber, H., Messner, C. B., Steger, M., Kilian, C., Lau, K., Barthel, N., Lehmann, A., et al. (2024) · Nature · doi:10.1038/s41586-024-07442-9 · Cited by 81
Kasikova, L., Hensler, M., Truxova, I., Skapa, P., Laco, J., Belicova, L., Praznovec, I., Vosahlikova, S., Halaska, M. J., Brtnicky, T., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0781-z · Cited by 79
Deciphering the decline of metabolic elasticity in aging and obesity
Zhou, Q., Yu, L., Cook, J. R., Qiang, L., & Sun, L. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.08.001 · Cited by 80
Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
Richter, M. L., Deligiannis, I. K., Yin, K., Danese, A., Lleshi, E., Coupland, P., Vallejos, C. A., Matchett, K. P., Henderson, N. C., Colome-Tatche, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24543-5 · Cited by 75
Araujo, H. A., Pechuan-Jorge, X., Zhou, T., Do, M. T., Hu, X., Rojas Alvarez, F. R., Salvatierra, M. E., Ibarguen, H. P., Lee, R., Raghulan, R., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0421 · Cited by 70
Koopen, A. M., Almeida, E. L., Attaye, I., Witjes, J. J., Rampanelli, E., Majait, S., Kemper, M., Levels, J. H. M., Schimmel, A. W. M., Herrema, H., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.662159 · Cited by 64
Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes
Ignatenko, O., Malinen, S., Rybas, S., Vihinen, H., Nikkanen, J., Kononov, A., Jokitalo, E. S., Ince-Dunn, G., & Suomalainen, A. (2023) · Journal of Cell Biology · doi:10.1083/jcb.202203019 · Cited by 63
Li, M., Lin, A., Luo, P., Shen, W., Xiao, D., Gou, L., Zhang, J., & Guo, L. (2020) · Aging · doi:10.18632/aging.102683 · Cited by 62
Yi, R., Lin, A., Cao, M., Xu, A., Luo, P., & Zhang, J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00933 · Cited by 60
Thatikonda, V., Lyu, H., Jurado, S., Kostyrko, K., Bristow, C. A., Albrecht, C., Alpar, D., Arnhof, H., Bergner, O., Bosch, K., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00800-6 · Cited by 76
Pełka-Wysiecka, J., Kaczmarczyk, M., Bąba-Kubiś, A., Liśkiewicz, P., Wroński, M., Skonieczna-Żydecka, K., Marlicz, W., Misiak, B., Starzyńska, T., Kucharska-Mazur, J., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101605 · Cited by 59
“2)) [41] and ComplexHeatmap [42], and custom-made scripts.”
InfluentialWalker, J. M., Kazempour Dehkordi, S., Fracassi, A., Vanschoiack, A., Pavenko, A., Taglialatela, G., Woltjer, R., Richardson, T. E., Zare, H., & Orr, M. E. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01324-9 · Cited by 59
Higa, K. C., Goodspeed, A., Chavez, J. S., De Dominici, M., Danis, E., Zaberezhnyy, V., Rabe, J. L., Tenen, D. G., Pietras, E. M., & DeGregori, J. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20200560 · Cited by 57
Chen, Y., Wang, T., Liang, F., Han, J., Lou, Z., Yu, Y., Li, J., Zhan, T., Gu, Y., Dong, L., et al. (2024) · Theranostics · doi:10.7150/thno.94482 · Cited by 60
“The heatmap was visualized by the R package Circlize (version 0.4.15) [33] and Complex Heatmap (version 2.14.0) [34, 35].”
MethodInfluentialMartínez, B. A., Shrotri, S., Kingsmore, K. M., Bachali, P., Grammer, A. C., & Lipsky, P. E. (2022) · Science Advances · doi:10.1126/sciadv.abn4776 · Cited by 56
Ou, Y., Belzer, C., Smidt, H., & de Weerth, C. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2038853 · Cited by 54
“The relative abundances of the top 15 predominant genera in infancy and childhood were displayed in heatmaps by the ComplexHeatmap package.(97) Phylogenetic alpha diversity was computed by using the picante GUT MICROBES e2038853-15”
MethodJoshi, M., Kim, J., D’Alessandro, A., Monk, E., Bruce, K., Elajaili, H., Nozik-Grayck, E., Goodspeed, A., Costello, J. C., & Schlaepfer, I. R. (2020) · Cancers · doi:10.3390/cancers12113431 · Cited by 54
Rocafort, M., Bowen, J. K., Hassing, B., Cox, M. P., McGreal, B., de la Rosa, S., Plummer, K. M., Bradshaw, R. E., & Mesarich, C. H. (2022) · BMC Biology · doi:10.1186/s12915-022-01442-9 · Cited by 52
N-glycosylation as a eukaryotic protective mechanism against protein aggregation
Duran-Romaña, R., Houben, B., De Vleeschouwer, M., Louros, N., Wilson, M. P., Matthijs, G., Schymkowitz, J., & Rousseau, F. (2024) · Science Advances · doi:10.1126/sciadv.adk8173 · Cited by 52
Fuentealba, M., Rouch, L., Guyonnet, S., Lemaitre, J.-M., de Souto Barreto, P., Vellas, B., Andrieu, S., & Furman, D. (2025) · Nature Aging · doi:10.1038/s43587-025-00883-5 · Cited by 51
Zhang, W., Roy Burman, S. S., Chen, J., Donovan, K. A., Cao, Y., Shu, C., Zhang, B., Zeng, Z., Gu, S., Zhang, Y., et al. (2022) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2022.11.008 · Cited by 51
The M1/M2 spectrum and plasticity of malignant pleural effusion-macrophage in advanced lung cancer
Wu, M.-F., Lin, C.-A., Yuan, T.-H., Yeh, H.-Y., Su, S.-F., Guo, C.-L., Chang, G.-C., Li, K.-C., Ho, C.-C., & Chen, H.-W. (2021) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-020-02781-8 · Cited by 48
Yoon, S.-B., Hong, H., Lim, H.-J., Choi, J. H., Choi, Y. P., Seo, S. W., Lee, H. W., Chae, C. H., Park, W.-K., Kim, H. Y., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.001 · Cited by 44
Kelley, D. P., Venable, K., Destouni, A., Billac, G., Ebenezer, P., Stadler, K., Nichols, C., Barker, S., & Francis, J. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00660 · Cited by 42
Hsu, M.-J., Karkossa, I., Schäfer, I., Christ, M., Kühne, H., Schubert, K., Rolle-Kampczyk, U. E., Kalkhof, S., Nickel, S., Seibel, P., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8090350 · Cited by 43
Global analysis of protein turnover dynamics in single cells
Sabatier, P., Lechner, M., Guzmán, U. H., Beusch, C. M., Zeng, X., Wang, L., Izaguirre, F., Seth, A., Gritsenko, O., Rodin, S., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.002 · Cited by 41
Yi, R., Hong, S., Zhang, Y., Lin, A., Ying, H., Zou, W., Wang, Q., Wei, T., Cheng, Q., Zhu, W., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.757137 · Cited by 37
“The ComplexHeatmap R package (Gu et al., 2016) was used to visualize the mutation and clinical landscape of the ICI-cohort and the TCGA-BLCA cohort.”
MethodJammihal, T., Saliby, R. M., Labaki, C., Soulati, H., Gallegos, J., Peris, A., McCurry, D., Yu, C., Shah, V., Poduval, D., et al. (2025) · Nature Cancer · doi:10.1038/s43018-024-00896-w · Cited by 38
Lee, J., Villarreal, O. D., Chen, X., Zandee, S., Young, Y. K., Torok, C., Lamarche-Vane, N., Prat, A., Rivest, S., Gosselin, D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108560 · Cited by 38
Koch, A., Yukioka, S., Tanaka, S., Yeung, L. W. Y., Kärrman, A., & Wang, T. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130179 · Cited by 40
scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cells
Bianchi, A., Scherer, M., Zaurin, R., Quililan, K., Velten, L., & Beekman, R. (2022) · Genome Biology · doi:10.1186/s13059-022-02796-7 · Cited by 36
Genomic analysis of biomarkers related to the prognosis of acute myeloid leukemia
Li, G., Gao, Y., Li, K., Lin, A., & Jiang, Z. (2020) · Oncology Letters · doi:10.3892/ol.2020.11700 · Cited by 35
A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation
Valverde, J. M., Dubra, G., Phillips, M., Haider, A., Elena-Real, C., Fournet, A., Alghoul, E., Chahar, D., Andrés-Sanchez, N., Paloni, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42049-0 · Cited by 33
AAV vectors trigger DNA damage responses and STING-dependent inflammation in human CNS cells
Costa-Verdera, H., Meneghini, V., Fitzpatrick, Z., Alezz, M. A., Fabyanic, E., Huang, X., Dzhashiashvili, Y., Ahiya, A., Mangiameli, E., Valeri, E., et al. (2024) · doi:10.21203/rs.3.rs-4171795/v1 · Cited by 32
Costa-Verdera, H., Meneghini, V., Fitzpatrick, Z., Abou Alezz, M., Fabyanic, E., Huang, X., Dzhashiashvili, Y., Ahiya, A., Mangiameli, E., Valeri, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58778-3 · Cited by 32
Bashour, H., Smorodina, E., Pariset, M., Zhong, J., Akbar, R., Chernigovskaya, M., Lê Quý, K., Snapkow, I., Rawat, P., Krawczyk, K., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06561-3 · Cited by 32
Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion
Becker, H. J., Ishida, R., Wilkinson, A. C., Kimura, T., Lee, M. S. J., Coban, C., Ota, Y., Tanaka, Y., Roskamp, M., Sano, T., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.06.002 · Cited by 32
Mitra, A., Andrews, M. C., Roh, W., De Macedo, M. P., Hudgens, C. W., Carapeto, F., Singh, S., Reuben, A., Wang, F., Mao, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15538-9 · Cited by 27
Design principles of cell-state-specific enhancers in hematopoiesis
Frömel, R., Rühle, J., Bernal Martinez, A., Szu-Tu, C., Pacheco Pastor, F., Martinez-Corral, R., & Velten, L. (2025) · Cell · doi:10.1016/j.cell.2025.04.017 · Cited by 29
Broos, J. Y., Loonstra, F. C., de Ruiter, L. R. J., Gouda, M., Fung, W. H., Schoonheim, M. M., Heijink, M., Strijbis, E. M. M., Teunissen, C., Killestein, J., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207459 · Cited by 29
The AhR‐SRC axis as a therapeutic vulnerability in BRAFi‐resistant melanoma
Paris, A., Tardif, N., Baietti, F. M., Berra, C., Leclair, H. M., Leucci, E., Galibert, M., & Corre, S. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202215677 · Cited by 26
Plattner, C., Lamberti, G., Blattmann, P., Kirchmair, A., Rieder, D., Loncova, Z., Sturm, G., Scheidl, S., Ijsselsteijn, M., Fotakis, G., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108399 · Cited by 27
Graham, C., Seow, J., Huettner, I., Khan, H., Kouphou, N., Acors, S., Winstone, H., Pickering, S., Galao, R. P., Lista, M. J., et al. (2021) · doi:10.1101/2021.02.03.429355 · Cited by 27
Fu, T.-L., Li, G.-R., Li, D.-H., He, R.-Y., Liu, B.-H., Xiong, R., Xu, C.-Z., Lu, Z.-L., Song, C.-K., Qiu, H.-L., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01202-7 · Cited by 27
Bhandary, R., & Ghosh, B. K. (2025) · Journal of Risk and Financial Management · doi:10.3390/jrfm18010023 · Cited by 27
Rastogi, M., Bartolucci, M., Nanni, M., Aloisio, M., Vozzi, D., Petretto, A., Contestabile, A., & Cancedda, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.05.002 · Cited by 26
Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis
Araujo David, B., Atif, J., Vargas e Silva Castanheira, F., Yasmin, T., Guillot, A., Ait Ahmed, Y., Peiseler, M., Hommes, J. W., Salm, L., Brundler, M.-A., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adq9704 · Cited by 25
Ahmed, H. A., Elsohaby, I., Elamin, A. M., El-Ghafar, A. E. A., Elsaid, G. A., Elbarbary, M., Mohsen, R. A., El Feky, T. M., & El Bayomi, R. M. (2023) · BMC Microbiology · doi:10.1186/s12866-023-02948-0 · Cited by 25
Serquiña, A. K. P., Tagawa, T., Oh, D., Mahesh, G., & Ziegelbauer, J. M. (2021) · mBio · doi:10.1128/mbio.02907-21 · Cited by 24
Dijkstra, J. J., Neikes, H. K., Rezaeifard, S., Ma, X., Voest, E. E., Tauriello, D. V. F., & Vermeulen, M. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00551 · Cited by 23
Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
Boehm, V., Wallmeroth, D., Wulf, P. O., Popp, O., Teixeira Alves, L. G., Reinecke, L., Riedel, M., Wyler, E., Franitza, M., Becker, K., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.08.015 · Cited by 23
Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor
Smith, G. A., Padmanabhan, A., Lau, B. H., Pampana, A., Li, L., Lee, C. Y., Pelonero, A., Nishino, T., Sadagopan, N., Xia, V. Q., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj8670 · Cited by 23
LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer
Murray, C. W., Brady, J. J., Han, M., Cai, H., Tsai, M. K., Pierce, S. E., Cheng, R., Demeter, J., Feldser, D. M., Jackson, P. K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28619-8 · Cited by 22
CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts
Huang, L., Wang, J., Fang, B., Meric-Bernstam, F., Roth, J. A., & Ha, M. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-16933-6 · Cited by 21
ProteoMixture: A cell type deconvolution tool for bulk tissue proteomic data
Teng, P.-N., Schaaf, J. P., Abulez, T., Hood, B. L., Wilson, K. N., Litzi, T. J., Mitchell, D., Conrads, K. A., Hunt, A. L., Olowu, V., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109198 · Cited by 21
Salamandane, A., Leech, J., Almeida, R., Silva, C., Crispie, F., Cotter, P. D., Malfeito-Ferreira, M., & Brito, L. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114556 · Cited by 20
Lhx2 specifically expressed in HSCs promotes liver regeneration and inhibits liver fibrosis
Tao, J., Wu, Z., Liang, Y., Wang, J., Tang, M., Huang, S., Jiang, F., Zhou, G., Guo, L., Yuan, S., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001201 · Cited by 19
Szadai, L., Velasquez, E., Szeitz, B., Almeida, N. P. D., Domont, G., Betancourt, L. H., Gil, J., Marko-Varga, M., Oskolas, H., Jánosi, Á. J., et al. (2021) · Cancers · doi:10.3390/cancers13236105 · Cited by 18
Cancer-Associated Fibroblast Proteins as Potential Targets against Colorectal Cancers
Shah, R., Johnson, K. A., Lippert, A. E. L., Kraus, S. G., Emmerich, P. B., Pasch, C. A., Zhang, W., Matkowskyj, K. A., LeBeau, A. M., & Deming, D. A. (2024) · Cancers · doi:10.3390/cancers16183158 · Cited by 18
Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design
Shao, Y., Wang, S., Gichuki, B. M., Stares, M. D., Rozday, T. J., Kumar, N., Browne, H. P., Dawson, N. J. R., Njunge, J. M., Tigoi, C., et al. (2026) · Cell · doi:10.1016/j.cell.2026.01.007 · Cited by 17
Lim, B., Kamal, A., Gomez Ramos, B., Adrian Segarra, J. M., Ibarra, I. L., Dignas, L., Kindinger, T., Volz, K., Rahbari, M., Rahbari, N., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02081-w · Cited by 17
Slota, J. A., Medina, S. J., Frost, K. L., & Booth, S. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.918811 · Cited by 16
Salgado, R. C., Fonseca, D. L. M., Marques, A. H. C., da Silva Napoleao, S. M., França, T. T., Akashi, K. T., de Souza Prado, C. A., Baiocchi, G. C., Plaça, D. R., Jansen-Marques, G., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-99838-0 · Cited by 14
Ang, D. A., Carter, J.-M., Deka, K., Tan, J. H. L., Zhou, J., Chen, Q., Chng, W. J., Harmston, N., & Li, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-46728-4 · Cited by 13
Epigenetic phase variation in the gut microbiome enhances bacterial adaptation
Ni, M., Junker, K., Liu, Y., Fan, Y., Li, Y., Qiao, W., Zhang, X.-S., Ksiezarek, M., Mead, E. A., Tourancheau, A., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.04.019 · Cited by 13
Zok, A., Matecka, M., Zapala, J., Izycki, D., & Baum, E. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043770 · Cited by 13
“For this purpose, the “Complexheatmap” package was used [33].”
MethodProteomic analysis of hepatic effects of phenobarbital in mice with humanized liver
Sprenger, H., Rasinger, J. D., Hammer, H., Naboulsi, W., Zabinsky, E., Planatscher, H., Schwarz, M., Poetz, O., & Braeuning, A. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03338-7 · Cited by 12
Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment
Snabel, R. R., Cofiño-Fabrés, C., Baltissen, M., Schwach, V., Passier, R., & Veenstra, G. J. C. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102422 · Cited by 10
Fluctuating selection on bacterial iron regulation in the mammalian gut
Barreto, H. C., Abreu, B., & Gordo, I. (2022) · Current Biology · doi:10.1016/j.cub.2022.06.017 · Cited by 10
Kananen, K., Veseli, I., Quiles Pérez, C. J., Miller, S. E., Eren, A. M., & Bradley, P. H. (2024) · Bioinformatics Advances · doi:10.1093/bioadv/vbaf039 · Cited by 10
Foamy microglia link oxylipins to disease progression in multiple sclerosis
van der Vliet, D., Di, X., Shamorkina, T. M., Coulon-Bainier, C., Pavlovic, A., van der Vliet, I. A. C. M., Zeng, Y., Macnair, W., van Egmond, N., Chen, J. Q. A., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02302-3 · Cited by 9
Das, S., Guha, P., Nath, M., Das, S., Sen, S., Sahu, J., Kopanska, M., Dutta, S., Jamal, Q. M. S., Kesari, K. K., et al. (2022) · Genes · doi:10.3390/genes13101721 · Cited by 9
Dang, X., Hanson, B. A., Orban, Z. S., Jimenez, M., Suchy, S., & Koralnik, I. J. (2024) · PLOS ONE · doi:10.1371/journal.pone.0299891 · Cited by 9
Multi-omics analysis identifies glioblastoma dependency on H3K9me3 methyltransferase activity
Xie, Q., Du, Y., Ghosh, S., Rajendran, S., Cohen-Gadol, A. A., Baizabal, J.-M., Nephew, K. P., Han, L., & Shen, J. (2025) · NPJ Precision Oncology · doi:10.1038/s41698-025-00829-5 · Cited by 10
Hu, C., Yin, L., Chen, Z., Waldron, R. T., Lugea, A., Lin, Y., Zhai, X., Wen, L., Han, Y.-P., Pandol, S. J., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.11.031 · Cited by 8
Zhang, Z., Qiu, X., Zeng, X., Liu, X., Lu, J., Xu, C., Huang, J., Zhao, C., & Zhan, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-18650-2 · Cited by 6
TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration
Melzer, M. K., Schirge, S., Gout, J., Arnold, F., Srinivasan, D., Burtscher, I., Allgöwer, C., Mulaw, M., Zengerling, F., Günes, C., et al. (2023) · BMC Biology · doi:10.1186/s12915-023-01553-x · Cited by 5
“An initial exploratory analysis included principal component analysis (PCA), multidimensional scaling (MDS), sample distance, and expression heatmap plots, all annotated with variables used in the expression modelling (ggplot2 [85], 3.3.6, and Bioconductor ComplexHeatmap [86], 2.10.0), as well as volcano plots (Biocon…”
InfluentialGambichler, T., Rohrmoser, E. ‐., Horny, K., Sucker, A., Schadendorf, D., Skrygan, M., Susok, L., Stücker, M., & Becker, J. C. (2022) · Clinical and Experimental Dermatology · doi:10.1111/ced.14951 · Cited by 4
Cheng, C. C. Y., Cheung, M. F., Lee, A. Y., Wu, Q., Chow, S. H.-C., Ang, J. Y. J., Riquelme Medina, I., Lo, G., Wu, H., Yang, W., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09154-w · Cited by 3
Denzer, L., Muranyi, W., Herold, R., Stump-Guthier, C., Ishikawa, H., Sticht, C., Schroten, H., Schwerk, C., & Weichert, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041779 · Cited by 3
Cis-regulatory evolution of the recently expanded Ly49 gene family
Fan, C., Xing, X., Murphy, S. J. H., Poursine-Laurent, J., Schmidt, H., Parikh, B. A., Yoon, J., Choudhary, M. N. K., Saligrama, N., Piersma, S. J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48990-y · Cited by 3
Metadata
- Authors
- Gu, Z., Eils, R., & Schlesner, M.
- Venue
- Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-05-20
- Volume
- 32
- Issue
- 18
- Pages
- 2847-2849
- ISSN
- 1367-4803 (ISSN-L)
- 1367-4811
- OpenAlex
- W2406250479
- Cited by
- 10,034
- References
- 3
- FWCI
- 72.83
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.