Cortical reinstatement mediates the relationship between content-specific encoding activity and subsequent recollection decisions
Open accessAbstract
Episodic recollection entails the conscious remembrance of event details associated with previously encountered stimuli. Recollection depends on both the establishment of cortical representations of event features during stimulus encoding and the cortical reinstatement of these representations at retrieval. Here, we used multivoxel pattern analyses of functional magnetic resonance imaging data to examine how cortical and hippocampal activity at encoding and retrieval drive recollective memory decisions. During encoding, words were associated with face or scene source contexts. At retrieval, subjects were cued to recollect the source associate of each presented word. Neurally derived estimates of encoding strength and pattern reinstatement in occipitotemporal cortex were computed for each encoding and retrieval trial, respectively. Analyses demonstrated that (1) cortical encoding strength predicted subsequent memory accuracy and reaction time, (2) encoding strength predicted encoding-phase hippocampal activity, and (3) encoding strength and retrieval-phase hippocampal activity predicted the magnitude of cortical reinstatement. Path analyses further indicated that cortical reinstatement partially mediated both the effect of cortical encoding strength and the effect of retrieval-phase hippocampal activity on subsequent source memory performance. Taken together, these results indicate that memory-guided decisions are driven in part by a pathway leading from hippocampally linked cortical encoding of event attributes to hippocampally linked cortical reinstatement at retrieval.
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How Do Expectations Shape Perception?
de Lange, F. P., Heilbron, M., & Kok, P. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.06.002 · Cited by 975 · see citing works
Dimsdale-Zucker, H. R., Ritchey, M., Ekstrom, A. D., Yonelinas, A. P., & Ranganath, C. (2018) · Nature Communications · doi:10.1038/s41467-017-02752-1 · Cited by 205 · see citing works
Reinstatement of associative memories in early visual cortex is signaled by the hippocampus
Bosch, S. E., Jehee, J. F. M., Fernández, G., & Doeller, C. F. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0805-14.2014 · Cited by 157 · see citing works
Wing, E. A., Ritchey, M., & Cabeza, R. (2015) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00740 · Cited by 174 · see citing works
Brain mechanisms underlying the subjective experience of remembering
Simons, J. S., Ritchey, M., & Fernyhough, C. (2022) · Annual Review of Psychology · doi:10.1146/annurev-psych-030221-025439 · Cited by 70 · see citing works
Stress Impairs Episodic Retrieval by Disrupting Hippocampal and Cortical Mechanisms of Remembering
Gagnon, S. A., Waskom, M. L., Brown, T. I., & Wagner, A. D. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy162 · Cited by 69 · see citing works
Self-citation
- Authors
- Gordon, A. M., Rissman, J., Kiani, R., & Wagner, A. D.
- Affiliations
- University of California, Los Angeles (US)
- New York University (US)
- Stanford University (US)
- Corresponding author
- Gordon, Alan M.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-08-06
- Volume
- 24
- Issue
- 12
- Pages
- 3350-3364
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC4296124
- OpenAlex
- W2140270529
- Cited by
- 173
- References
- 111
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 13 · 2023: 11 · 2022: 16 · 2021: 15 · 2020: 9 · 2019: 15 · 2018: 15 · 2017: 11 · 2016: 16 · 2015: 16 · 2014: 8
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (5r01mh080309-04)
- National Institute of Mental Health (R01-MH080309)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- episodic recollection, source memory, hippocampal activity, encoding strength, occipitotemporal cortex, memory retrieval
- MeSH terms
- Adolescent, Brain Mapping, Cerebral Cortex, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Oxygen, Psychomotor Performance, Mental Recall, Regression Analysis, Imagery, Psychotherapy, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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