Cited by 173Memory Processes and InfluencesMemory and Neural MechanismsCognitive Functions and Memory

Cortical reinstatement mediates the relationship between content-specific encoding activity and subsequent recollection decisions

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Gordon, Alan M., Rissman, Jesse, Kiani, Roozbeh, Wagner, Anthony D.·2014·Cerebral Cortex

Abstract

Episodic recollection entails the conscious remembrance of event details associated with previously encountered stimuli. Recollection depends on both the establishment of cortical representations of event features during stimulus encoding and the cortical reinstatement of these representations at retrieval. Here, we used multivoxel pattern analyses of functional magnetic resonance imaging data to examine how cortical and hippocampal activity at encoding and retrieval drive recollective memory decisions. During encoding, words were associated with face or scene source contexts. At retrieval, subjects were cued to recollect the source associate of each presented word. Neurally derived estimates of encoding strength and pattern reinstatement in occipitotemporal cortex were computed for each encoding and retrieval trial, respectively. Analyses demonstrated that (1) cortical encoding strength predicted subsequent memory accuracy and reaction time, (2) encoding strength predicted encoding-phase hippocampal activity, and (3) encoding strength and retrieval-phase hippocampal activity predicted the magnitude of cortical reinstatement. Path analyses further indicated that cortical reinstatement partially mediated both the effect of cortical encoding strength and the effect of retrieval-phase hippocampal activity on subsequent source memory performance. Taken together, these results indicate that memory-guided decisions are driven in part by a pathway leading from hippocampally linked cortical encoding of event attributes to hippocampally linked cortical reinstatement at retrieval.

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Authors
Gordon, A. M., Rissman, J., Kiani, R., & Wagner, A. D.
Affiliations
  • University of California, Los Angeles (US)
  • New York University (US)
  • Stanford University (US)
Corresponding author
Gordon, Alan M.
Venue
Cerebral Cortex
Published
2013-08-06
Volume
24
Issue
12
Pages
3350-3364
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2140270529
Cited by
173
References
111
Citations by year
2026: 10 · 2025: 18 · 2024: 13 · 2023: 11 · 2022: 16 · 2021: 15 · 2020: 9 · 2019: 15 · 2018: 15 · 2017: 11 · 2016: 16 · 2015: 16 · 2014: 8
FWCI
7.31
Type
journal article
Language
en
Open access
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health (5r01mh080309-04)
  • National Institute of Mental Health (R01-MH080309)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
episodic recollection, source memory, hippocampal activity, encoding strength, occipitotemporal cortex, memory retrieval
MeSH terms
Adolescent, Brain Mapping, Cerebral Cortex, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Oxygen, Psychomotor Performance, Mental Recall, Regression Analysis, Imagery, Psychotherapy, Young Adult

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