Cited by 1,210

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Open access

Tobiume, Kei, Matsuzawa, Atsushi, Takahashi, Takumi, Nishitoh, Hideki, Morita, Kei‐ichi, Takeda, Kohsuke, Minowa, Osamu, Miyazono, Kohei, Noda, Tetsuo, Ichijo, Hidenori·2001·EMBO reports

DOI 10.1093/embo-reports/kve046

Open this paper in CoChat — free account

Abstract

Apoptosis signal‐regulating kinase (ASK) 1 is activated in response to various cytotoxic stresses including TNF, Fas and reactive oxygen species (ROS) such as H 2 O 2 , and activates c‐Jun NH 2 ‐terminal kinase (JNK) and p38. However, the roles of JNK and p38 signaling pathways during apoptosis have been controversial. Here we show that by deleting ASK1 in mice, TNF‐ and H 2 O 2 ‐induced sustained activations of JNK and p38 are lost in ASK1 −/− embryonic fibroblasts, and that ASK1 −/− cells are resistant to TNF‐ and H 2 O 2 ‐induced apoptosis. TNF‐ but not Fas‐induced apoptosis requires ROS‐dependent activation of ASK1–JNK/p38 pathways. Thus, ASK1 is selectively required for TNF‐ and oxidative stress‐induced sustained activations of JNK/p38 and apoptosis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/embo-reports/kve046

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells
Guo, Y.-L., Baysal, K., Kang, B., Yang, L.-J., & Williamson, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4027 · Cited by 249

Show all 2 references

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
Mehta, P. K., & Griendling, K. K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2006 · Cited by 1,924
Redox regulation of cell survival
Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781
Mitogen-activated protein kinases in apoptosis regulation
Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362
Understanding MAPK Signaling Pathways in Apoptosis
Yue, J., & López, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072346 · Cited by 1,245
Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?
Son, Y., Cheong, Y.-K., Kim, N.-H., Chung, H.-T., Kang, D. G., & Pae, H.-O. (2011) · Journal of Signal Transduction · doi:10.1155/2011/792639 · Cited by 1,219
The MAPK signalling pathways and colorectal cancer
Fang, J. Y., & Richardson, B. C. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70168-6 · Cited by 1,185
TNF and ROS crosstalk in inflammation
Blaser, H., Dostert, C., Mak, T. W., & Brenner, D. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.12.002 · Cited by 1,008
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
Jun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb2070 · Cited by 998
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883
Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
Junttila, M. R., Li, S., & Westermarck, J. (2008) · The FASEB Journal · doi:10.1096/fj.06-7859rev · Cited by 826
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., & Franzoso, G. (2001) · Nature · doi:10.1038/35104560 · Cited by 732
p38MAPK: stress responses from molecular mechanisms to therapeutics
Coulthard, L. R., White, D. E., Jones, D. L., McDermott, M. F., & Burchill, S. A. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.005 · Cited by 691
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., & Ichijo, H. (2005) · Nature Immunology · doi:10.1038/ni1200 · Cited by 667
Self-citation
JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species
Shen, H.-M., & Liu, Z.-G. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.056 · Cited by 629
ROS, stress‐activated kinases and stress signaling in cancer
Benhar, M., Engelberg, D., & Levitzki, A. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf094 · Cited by 600
The Two Faces of Reactive Oxygen Species in Cancer
Reczek, C. R., & Chandel, N. S. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-041916-065808 · Cited by 602
“…oxidation of TRX causes ASK1 dissociation and activation, thereby triggering the suppression of anti-apoptotic factors through the sustained activation of the downstream MAP kinase kinase (MKK)4/MKK7/JNK and MKK3/MKK6/p38 pathways (Ichijo et al. 1997, Saitoh et al. 1998, Tobiume et al. 2001).”
Background
Redox signaling and the MAP kinase pathways
Torres, M., & Forman, H. J. (2003) · BioFactors · doi:10.1002/biof.5520170128 · Cited by 580
ROS in Cancer: The Burning Question
Chio, I. I. C., & Tuveson, D. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.004 · Cited by 532
NF‐κB inhibits TNF‐induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
Sakon, S., Xue, X., Takekawa, M., Sasazuki, T., Okazaki, T., Kojima, Y., Piao, J., Yagita, H., Okumura, K., Doi, T., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg379 · Cited by 497
Oxidative Stress, Chronic Disease, and Muscle Wasting
Moylan, J. S., & Reid, M. B. (2007) · Muscle & Nerve · doi:10.1002/mus.20743 · Cited by 416
Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis
Han, S. J., Jung, S. Y., Wu, S.-P., Hawkins, S. M., Park, M. J., Kyo, S., Qin, J., Lydon, J. P., Tsai, S. Y., Tsai, M.-J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.034 · Cited by 380
TNF-α-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-XL
Kim, J. J., Lee, S. B., Park, J. K., & Yoo, Y. D. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2010.19 · Cited by 344
The ASK1-MAP Kinase Cascades in Mammalian Stress Response
Matsukawa, J. (2004) · Journal of Biochemistry · doi:10.1093/jb/mvh134 · Cited by 343
Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia
Bell, E. L., Klimova, T. A., Eisenbart, J., Schumacker, P. T., & Chandel, N. S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02265-06 · Cited by 237
Phosphorylation and Inactivation of Myeloid Cell Leukemia 1 by JNK in Response to Oxidative Stress
Inoshita, S., Takeda, K., Hatai, T., Terada, Y., Sano, M., Hata, J., Umezawa, A., & Ichijo, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207951200 · Cited by 233
Self-citation
The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal
Forman, H. J., Fukuto, J. M., Miller, T., Zhang, H., Rinna, A., & Levy, S. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.011 · Cited by 226
Ultraviolet radiation-induced apoptosis in keratinocytes: On the role of cytosolic factors
Assefa, Z., Van Laethem, A., Garmyn, M., & Agostinis, P. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.04.001 · Cited by 212
Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation
Chambers, J. W., & LoGrasso, P. V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.223602 · Cited by 194
Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress
Cheng, J.-Z., Sharma, R., Yang, Y., Singhal, S. S., Sharma, A., Saini, M. K., Singh, S. V., Zimniak, P., Awasthi, S., & Awasthi, Y. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106838200 · Cited by 185
Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response
Park, S. G., Kim, H. J., Min, Y. H., Choi, E.-C., Shin, Y. K., Park, B.-J., Lee, S. W., & Kim, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500226102 · Cited by 185
Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells
Yokoi, T., Fukuo, K., Yasuda, O., Hotta, M., Miyazaki, J., Takemura, Y., Kawamoto, H., Ichijo, H., & Ogihara, T. (2006) · Diabetes · doi:10.2337/db05-1607 · Cited by 169
Self-citation
Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth
Schöckel, L., Glasauer, A., Basit, F., Bitschar, K., Truong, H., Erdmann, G., Algire, C., Hägebarth, A., Willems, P. H., Kopitz, C., et al. (2015) · Cancer & Metabolism · doi:10.1186/s40170-015-0138-0 · Cited by 161
Lipopolysaccharide triggered TNF-α-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model
Kudo, H., Takahara, T., Yata, Y., Kawai, K., Zhang, W., & Sugiyama, T. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.02.032 · Cited by 152
BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
Heijink, A. M., Talens, F., Jae, L. T., van Gijn, S. E., Fehrmann, R. S. N., Brummelkamp, T. R., & van Vugt, M. A. T. M. (2019) · Nature Communications · doi:10.1038/s41467-018-07927-y · Cited by 140
p38α Mediates Cell Survival in Response to Oxidative Stress via Induction of Antioxidant Genes
Gutiérrez-Uzquiza, Á., Arechederra, M., Bragado, P., Aguirre-Ghiso, J. A., & Porras, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.323709 · Cited by 139
Zoledronate Sensitizes Endothelial Cells to Tumor Necrosis Factor-induced Programmed Cell Death
Bezzi, M., Hasmim, M., Bieler, G., Dormond, O., & Rüegg, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308114200 · Cited by 139
MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells
Roduit, R., & Schorderet, D. F. (2008) · Apoptosis · doi:10.1007/s10495-008-0179-8 · Cited by 110
Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury
Ben Mkaddem, S., Pedruzzi, E., Werts, C., Coant, N., Bens, M., Cluzeaud, F., Goujon, J. M., Ogier-Denis, E., & Vandewalle, A. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2010.26 · Cited by 90
Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase
Nakagawa, H., Hirata, Y., Takeda, K., Hayakawa, Y., Sato, T., Kinoshita, H., Sakamoto, K., Nakata, W., Hikiba, Y., Omata, M., et al. (2011) · Hepatology · doi:10.1002/hep.24357 · Cited by 86
Self-citation
BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling
Vin, H., Ojeda, S. S., Ching, G., Leung, M. L., Chitsazzadeh, V., Dwyer, D. W., Adelmann, C. H., Restrepo, M., Richards, K. N., Stewart, L. R., et al. (2013) · eLife · doi:10.7554/elife.00969 · Cited by 84
TNF‐induced death of adult human oligodendrocytes is mediated by c‐jun NH2‐terminal kinase‐3
Jurewicz, A., Matysiak, M., Tybor, K., & Selmaj, K. (2003) · Brain · doi:10.1093/brain/awg146 · Cited by 70
Peroxiredoxins in Regulation of MAPK Signalling Pathways; Sensors and Barriers to Signal Transduction
Latimer, H. R., & Veal, E. A. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2327 · Cited by 68
FIP200, a key signaling node to coordinately regulate various cellular processes
Gan, B., & Guan, J.-L. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.021 · Cited by 67
Nutraceutical Activation of Sirt1: A Review
DiNicolantonio, J. J., McCarty, M. F., & O'Keefe, J. H. (2022) · Open Heart · doi:10.1136/openhrt-2022-002171 · Cited by 65
Apelin-36 mediates neuroprotective effects by regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson’s disease model mice
Zhu, J., Gao, W., Shan, X., Wang, C., Wang, H., Shao, Z., Dou, S., Jiang, Y., Wang, C., & Cheng, B. (2020) · Brain Research · doi:10.1016/j.brainres.2019.146493 · Cited by 65
Reactive oxygen species are required for zoledronic acid-induced apoptosis in osteoclast precursors and mature osteoclast-like cells
Tai, T.-W., Chen, C.-Y., Su, F.-C., Tu, Y.-K., Tsai, T.-T., Lin, C.-F., & Jou, I.-M. (2017) · Scientific Reports · doi:10.1038/srep44245 · Cited by 51
Role of oxidative stress and JNK pathway in apoptotic death induced by potassium deprivation and staurosporine in cerebellar granule neurons
Ramiro-Cortés, Y., & Morán, J. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.05.015 · Cited by 33
ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming
Place, D. E., Samir, P., Karki, R., Briard, B., Vogel, P., & Kanneganti, T.-D. (2018) · The American Journal of Pathology · doi:10.1016/j.ajpath.2017.12.006 · Cited by 22
The Transcription Factor, α1ACT, Acts Through a MicroRNA Network to Regulate Neurogenesis and Cell Death During Neonatal Cerebellar Development
Wei, C., Benzow, K., Koob, M. D., Gomez, C. M., & Du, X. (2022) · The Cerebellum · doi:10.1007/s12311-022-01431-2 · Cited by 5

Authors: Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H.
Venue: EMBO reports
Publisher: Springer Science and Business Media LLC
Published: 2001-03
Volume: 2
Issue: 3
Pages: 222-228
ISSN: 1469-221X (ISSN-L)
1469-3178
DOI: 10.1093/embo-reports/kve046
OpenAlex: W2116938728
Cited by: 1,210
References: 2
FWCI: 17.80
Type: journal article
Language: en
Open access: bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources