Dynamic reconfiguration of structural and functional connectivity across core neurocognitive brain networks with development
Open accessAbstract
Brain structural and functional development, throughout childhood and into adulthood, underlies the maturation of increasingly sophisticated cognitive abilities. High-level attentional and cognitive control processes rely on the integrity of, and dynamic interactions between, core neurocognitive networks. The right fronto-insular cortex (rFIC) is a critical component of a salience network (SN) that mediates interactions between large-scale brain networks involved in externally oriented attention [central executive network (CEN)] and internally oriented cognition [default mode network (DMN)]. How these systems reconfigure and mature with development is a critical question for cognitive neuroscience, with implications for neurodevelopmental pathologies affecting brain connectivity. Using functional and effective connectivity measures applied to fMRI data, we examine interactions within and between the SN, CEN, and DMN. We find that functional coupling between key network nodes is stronger in adults than in children, as are causal links emanating from the rFIC. Specifically, the causal influence of the rFIC on nodes of the SN and CEN was significantly greater in adults compared with children. Notably, these results were entirely replicated on an independent dataset of matched children and adults. Developmental changes in functional and effective connectivity were related to structural connectivity along these links. Diffusion tensor imaging tractography revealed increased structural integrity in adults compared with children along both within- and between-network pathways associated with the rFIC. These results suggest that structural and functional maturation of rFIC pathways is a critical component of the process by which human brain networks mature during development to support complex, flexible cognitive processes in adulthood.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The central executive network is anchored in the dorsolateral prefrontal cortex and posterior parietal cortices and is associated with executive functioning.
“The CEN, anchored in the dorsolateral prefrontal cortex (dlPFC) and posterior parietal cortices (PPC), is associated with executive functioning [36–42].”
Effective connectivity work demonstrates greater causal outflow from the right anterior insula to the lateral frontoparietal network in adults compared with children.
“Effective connectivity work demonstrates greater causal outflow from the rAI to the L-FPN in adults compared with children (54).”
From Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder (2021) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
Self-citationHow do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 1× · see citing works
“The rFIC is situated at the interface of the cognitive, homeostatic, and affective systems of the brain, providing a link between stimulus-driven processing and regions involved in monitoring the internal milieu (Craig, 2009).”
BackgroundSaliency, switching, attention and control: a network model of insula function
Menon, V., & Uddin, L. Q. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0262-0 · Cited by 5,592 · see citing works
Self-citationThe basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,653 · see citing works
Numerical Recipes in C: The Art of Scientific Computing.
Birchenhall, C. R., Press, W. H., Teukolsky, S. A., Vetterling, W. T., & Flannery, B. P. (1994) · The Economic Journal · doi:10.2307/2234664 · Cited by 4,355 · see citing works
Consistent resting-state networks across healthy subjects
Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601417103 · Cited by 4,326 · see citing works
Basser, P. J., & Pierpaoli, C. (1996) · Journal of Magnetic Resonance, Series B · doi:10.1006/jmrb.1996.0086 · Cited by 4,306 · see citing works
Mapping the structural core of human cerebral cortex
Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., & Sporns, O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060159 · Cited by 4,173 · see citing works
Greicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308627101 · Cited by 3,684 · see citing works
Self-citationThree-dimensional tracking of axonal projections in the brain by magnetic resonance imaging
Mori, S., Crain, B. J., Chacko, V. P., & van Zijl, P. C. M. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199902)45:2 · Cited by 3,479 · see citing works
Predicting human resting-state functional connectivity from structural connectivity
Honey, C. J., Sporns, O., Cammoun, L., Gigandet, X., Thiran, J. P., Meuli, R., & Hagmann, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811168106 · Cited by 3,307 · see citing works
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072 · see citing works
Sridharan, D., Levitin, D. J., & Menon, V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800005105 · Cited by 2,892 · see citing works
Self-citationDistinct brain networks for adaptive and stable task control in humans
Dosenbach, N. U. F., Fair, D. A., Miezin, F. M., Cohen, A. L., Wenger, K. K., Dosenbach, R. A. T., Fox, M. D., Snyder, A. Z., Vincent, J. L., Raichle, M. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704320104 · Cited by 2,632 · see citing works
Large-scale brain networks in cognition: emerging methods and principles
Bressler, S. L., & Menon, V. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.04.004 · Cited by 2,348 · see citing works
Self-citationNetwork modelling methods for FMRI
Smith, S. M., Miller, K. L., Salimi-Khorshidi, G., Webster, M., Beckmann, C. F., Nichols, T. E., Ramsey, J. D., & Woolrich, M. W. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.063 · Cited by 1,878 · see citing works
Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging
Lenroot, R. K., & Giedd, J. N. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.06.001 · Cited by 1,863 · see citing works
Tracking neuronal fiber pathways in the living human brain
Conturo, T. E., Lori, N. F., Cull, T. S., Akbudak, E., Snyder, A. Z., Shimony, J. S., McKinstry, R. C., Burton, H., & Raichle, M. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10422 · Cited by 1,774 · see citing works
Reproducibility of quantitative tractography methods applied to cerebral white matter
Wakana, S., Caprihan, A., Panzenboeck, M. M., Fallon, J. H., Perry, M., Gollub, R. L., Hua, K., Zhang, J., Jiang, H., Dubey, P., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.049 · Cited by 1,686 · see citing works
Network structure of cerebral cortex shapes functional connectivity on multiple time scales
Honey, C. J., Kötter, R., Breakspear, M. J., & Sporns, O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701519104 · Cited by 1,683 · see citing works
Functional brain networks develop from a local to distributed organization
Fair, D. A., Cohen, A. L., Power, J. D., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Schlaggar, B. L., & Petersen, S. E. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000381 · Cited by 1,530 · see citing works
Basser, P. J. (1995) · NMR in Biomedicine · doi:10.1002/nbm.1940080707 · Cited by 1,526 · see citing works
Autism spectrum disorders: developmental disconnection syndromes
Geschwind, D. H., & Levitt, P. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.009 · Cited by 1,411 · see citing works
Neurophysiological Architecture of Functional Magnetic Resonance Images of Human Brain
Salvador, R. M., John Suckling, A., Coleman, M. R., Pickard, J. D., Menon, D. K., & Bullmore, E. T. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi016 · Cited by 1,334 · see citing works
The maturing architecture of the brain's default network
Fair, D. A., Cohen, A. L., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Barch, D. M., Raichle, M. E., Petersen, S. E., & Schlaggar, B. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800376105 · Cited by 1,314 · see citing works
Development of distinct control networks through segregation and integration
Fair, D. A., Dosenbach, N. U. F., Church, J. A., Cohen, A. L., Brahmbhatt, S., Miezin, F. M., Barch, D. M., Raichle, M. E., Petersen, S. E., & Schlaggar, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705843104 · Cited by 1,244 · see citing works
fMRI resting state networks define distinct modes of long-distance interactions in the human brain
De Luca, M., Beckmann, C. F., De Stefano, N., Matthews, P. M., & Smith, S. M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.035 · Cited by 1,241 · see citing works
Lateral prefrontal cortex: architectonic and functional organization
Petrides, M. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1631 · Cited by 1,212 · see citing works
Schmahmann, J. D., Pandya, D. N., Wang, R., Dai, G., D'Arceuil, H. E., de Crespigny, A. J., & Wedeen, V. J. (2007) · Brain · doi:10.1093/brain/awl359 · Cited by 1,067 · see citing works
Mapping directed influence over the brain using Granger causality and fMRI
Roebroeck, A. F., Formisano, E., & Goebel, R. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.11.017 · Cited by 1,024 · see citing works
Disrupted small-world networks in schizophrenia
Liu, Y., Liang, M., Zhou, Y., Yong He, A., Hao, Y., Song, M., Yu, C., Liu, H., Liu, Z., & Jiang, T. (2008) · Brain · doi:10.1093/brain/awn018 · Cited by 1,020 · see citing works
van den Heuvel, M. P., Mandl, R. C. W., Kahn, R. S., & Hulshoff Pol, H. E. (2009) · Human Brain Mapping · doi:10.1002/hbm.20737 · Cited by 987 · see citing works
Barnea-Goraly, N., Menon, V., Eckert, M., Tamm, L., Bammer, R., Karchemskiy, A., Dant, C. C., & Reiss, A. L. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi062 · Cited by 848 · see citing works
Self-citationStructural MRI of pediatric brain development: what have we learned and where are we going?
Giedd, J. N., & Rapoport, J. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.040 · Cited by 836 · see citing works
Twenty‐five pitfalls in the analysis of diffusion MRI data
Jones, D. K., & Cercignani, M. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1543 · Cited by 827 · see citing works
Development of large-scale functional brain networks in children
Supekar, K., Musen, M., & Menon, V. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000157 · Cited by 807 · see citing works
Self-citationJones, D. K. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20033 · Cited by 776 · see citing works
A MATLAB toolbox for Granger causal connectivity analysis
Seth, A. K. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.11.020 · Cited by 746 · see citing works
White matter maturation reshapes structural connectivity in the late developing human brain
Hagmann, P., Sporns, O., Madan, N., Cammoun, L., Pienaar, R., Wedeen, V. J., Meuli, R., Thiran, J.-P., & Grant, P. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009073107 · Cited by 700 · see citing works
Goebel, R., Roebroeck, A. F., Kim, D., & Formisano, E. (2003) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2003.08.026 · Cited by 687 · see citing works
Developmental neurobiology of cognitive control and motivational systems.
Somerville, L. H., & Casey, B. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.01.006 · Cited by 634 · see citing works
Conjoint activity of anterior insular and anterior cingulate cortex: awareness and response
Medford, N., & Critchley, H. D. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0265-x · Cited by 627 · see citing works
Levy, B. J., & Wagner, A. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05958.x · Cited by 625 · see citing works
Spatial transformations of diffusion tensor magnetic resonance images
Alexander, D. C., Pierpaoli, C., Basser, P. J., & Gee, J. C. (2001) · IEEE Transactions on Medical Imaging · doi:10.1109/42.963816 · Cited by 610 · see citing works
Spiral‐in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts
Glover, G. H., & Law, C. S. W. (2001) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1222 · Cited by 600 · see citing works
Development of Anterior Cingulate Functional Connectivity from Late Childhood to Early Adulthood
Kelly, A. M. C., Di Martino, A., Uddin, L. Q., Shehzad, Z., Gee, D. G., Reiss, P. T., Margulies, D. S., Castellanos, F. X., & Milham, M. P. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn117 · Cited by 572 · see citing works
Self-citationSupekar, K., Uddin, L. Q., Prater, K. E., Amin, H., Greicius, M. D., & Menon, V. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.009 · Cited by 524 · see citing works
Self-citationSelf‐navigated spiral fMRI: Interleaved versus single‐shot
Glover, G. H., & Lai, S. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390305 · Cited by 476 · see citing works
Uddin, L. Q., Supekar, K., Amin, H., Rykhlevskaia, E. I., Nguyen, D. A., Greicius, M. D., & Menon, V. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq011 · Cited by 449 · see citing works
Self-citationCausal Modelling and Brain Connectivity in Functional Magnetic Resonance Imaging
Friston, K. J. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000033 · Cited by 444 · see citing works
Growth of white matter in the adolescent brain: Myelin or axon?
Paus, T. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.002 · Cited by 424 · see citing works
The anterior insula in autism: Under-connected and under-examined
Uddin, L. Q., & Menon, V. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.002 · Cited by 424 · see citing works
Self-citationSun, F. T., Miller, L. M., & D’Esposito, M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.056 · Cited by 406 · see citing works
van den Heuvel, M., Mandl, R., Luigjes, J., & Hulshoff Pol, H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2964-08.2008 · Cited by 349 · see citing works
Uddin, L. Q. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00021 · Cited by 343 · see citing works
Self-citationDiffusion tensor imaging using single‐shot SENSE‐EPI
Bammer, R., Auer, M., Keeling, S. L., Augustin, M., Stables, L. A., PROKESCH, R. W., Stollberger, R., Moseley, M. E., & Fazekas, F. (2002) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10184 · Cited by 279 · see citing works
Ebisch, S. J. H., D, V. G. M., Willems, R. M., Mantini, D., Groen, W. B., Romani, G. L., Buitelaar, J. K., & Harold Bekkering, A. (2010) · Human Brain Mapping · doi:10.1002/hbm.21085 · Cited by 278 · see citing works
Changes in the interaction of resting-state neural networks from adolescence to adulthood
Stevens, M. C., Pearlson, G. D., & Calhoun, V. D. (2009) · Human Brain Mapping · doi:10.1002/hbm.20673 · Cited by 256 · see citing works
Roebroeck, A. F., Formisano, E., & Goebel, R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.036 · Cited by 238 · see citing works
Frontal parietal control network regulates the anti‐correlated default and dorsal attention networks
Gao, W., & Lin, W. (2011) · Human Brain Mapping · doi:10.1002/hbm.21204 · Cited by 216 · see citing works
Di Martino, A., Shehzad, Z., Kelly, C., Roy, A. K., Gee, D. G., Uddin, L. Q., Gotimer, K., Klein, D. F., Castellanos, F. X., & Milham, M. P. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121894 · Cited by 213 · see citing works
Self-citationResidual functional connectivity in the split-brain revealed with resting-state functional MRI
Uddin, L. Q., Mooshagian, E., Zaidel, E., Scheres, A., Margulies, D. S., Kelly, A. M. C., Shehzad, Z., Adelstein, J. S., Castellanos, F. X., Biswal, B. B., et al. (2008) · NeuroReport · doi:10.1097/wnr.0b013e3282fb8203 · Cited by 170 · see citing works
Self-citationCASCIO, C. J., GERIG, G., & PIVEN, J. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000246064.93200.e8 · Cited by 167 · see citing works
White matter atlases based on diffusion tensor imaging
Mori, S., Oishi, K., & Faria, A. V. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32832d954b · Cited by 166 · see citing works
Distributed and causal influence of frontal operculum in task control
Higo, T., Mars, R. B., Boorman, E. D., Buch, E. R., & Rushworth, M. F. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013361108 · Cited by 164 · see citing works
Deshpande, G., Santhanam, P., & Hu, X. P. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.024 · Cited by 163 · see citing works
Pajevic, S., Aldroubi, A., & Basser, P. J. (2002) · Journal of Magnetic Resonance · doi:10.1006/jmre.2001.2452 · Cited by 148 · see citing works
Resting-state networks in awake five- to eight-year old children
de Bie, H. M. A., Boersma, M., Adriaanse, S., Veltman, D. J., Wink, A. M., Roosendaal, S. D., Barkhof, F., Stam, C. J., Oostrom, K. J., Delemarre‐van de Waal, H. A., et al. (2012) · Human Brain Mapping · doi:10.1002/hbm.21280 · Cited by 143 · see citing works
Multivariate dynamical systems models for estimating causal interactions in fMRI
Ryali, S., Supekar, K., Chen, T., & Menon, V. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.052 · Cited by 110 · see citing works
Self-citationSchippers, M. B., Renken, R. J., & Keysers, C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.008 · Cited by 105 · see citing works
Measuringin VivoMyelination of Human White Matter Fiber Tracts with Magnetization Transfer MR
Rademacher, J., Engelbrecht, V., Bürgel, U., Freund, H., & Zilles, K. (1999) · NeuroImage · doi:10.1006/nimg.1998.0416 · Cited by 94 · see citing works
Neural correlates of the development of cognitive control
Bunge, S. A., & Crone, E. A. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511757402.005 · Cited by 73 · see citing works
Strength of default mode resting‐state connectivity relates to white matter integrity in children
Gordon, E. M., Lee, P. S., Maisog, J. M., Foss‐Feig, J. H., Billington, M. E., VanMeter, J. W., & Vaidya, C. J. (2010) · Developmental Science · doi:10.1111/j.1467-7687.2010.01020.x · Cited by 62 · see citing works
Network Analysis: Applications for the Developing Brain
Chu, C. J., Kramer, M., Bianchi, M. T., Caviness, V. S., & Cash, S. S. (2011) · Journal of Child Neurology · doi:10.1177/0883073810385345 · Cited by 26 · see citing works
Basser (2000) · doi:10.1002/1522-2594(200010)44:4
Flagged first, then by citations
Cited by
Sorted by citations
Network hubs in the human brain
van den Heuvel, M. P., & Sporns, O. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.09.012 · Cited by 2,123 · see citing works
Salience processing and insular cortical function and dysfunction
Uddin, L. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3857 · Cited by 2,083 · see citing works
Self-citationStructure and Function of the Human Insula
Uddin, L. Q., Nomi, J. S., Hébert-Seropian, B., Ghaziri, J., & Boucher, O. (2017) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000377 · Cited by 1,262 · see citing works
Self-citationDemystifying cognitive flexibility: Implications for clinical and developmental neuroscience
Dajani, D. R., & Uddin, L. Q. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.07.003 · Cited by 1,046 · see citing works
Self-citationGoulden, N., Khusnulina, A., Davis, N. J., Bracewell, R. M., Bokde, A. L., McNulty, J. P., & Mullins, P. G. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.05.052 · Cited by 810 · see citing works
Spreng, R. N., Sepulcre, J., Turner, G. R., Stevens, W. D., & Schacter, D. L. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00281 · Cited by 668 · see citing works
Salience Network–Based Classification and Prediction of Symptom Severity in Children With Autism
Uddin, L. Q., Supekar, K., Lynch, C. J., Khouzam, A., Phillips, J., Feinstein, C., Ryali, S., & Menon, V. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.104 · Cited by 621 · see citing works
Self-citationSalience network integrity predicts default mode network function after traumatic brain injury
Bonnelle, V., Ham, T. E., Leech, R., Kinnunen, K. M., Mehta, M. A., Greenwood, R. J., & Sharp, D. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113455109 · Cited by 606 · see citing works
Menon, V. (2015) · Brain Mapping · doi:10.1016/b978-0-12-397025-1.00052-x · Cited by 625 · see citing works
Self-citationTopological organization of the human brain functional connectome across the lifespan
Cao, M., Wang, J.-H., Dai, Z.-J., Cao, X.-Y., Jiang, L.-L., Fan, F.-M., Song, X.-W., Xia, M.-R., Shu, N., Dong, Q., et al. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2013.11.004 · Cited by 440 · see citing works
Grayson, D. S., & Fair, D. A. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.079 · Cited by 411 · see citing works
“These trends pointed to coherent changes that involved a dampening of non-specific local spread of activity and strengthening of long-range links, thereby facilitating cognitive development (Bunge and Wright, 2007; Fair et al., 2009; Uddin, 2011; Uddin et al., 2011).”
BackgroundAtzil, S., Gao, W., Fradkin, I., & Barrett, L. F. (2018) · Nature Human Behaviour · doi:10.1038/s41562-018-0384-6 · Cited by 415 · see citing works
Manoliu, A., Meng, C., Brandl, F., Doll, A., Tahmasian, M., Scherr, M., Schwerthöffer, D., Zimmer, C., Förstl, H., Bäuml, J., et al. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00930 · Cited by 382 · see citing works
Task-Based Core-Periphery Organization of Human Brain Dynamics
Bassett, D. S., Wymbs, N. F., Rombach, M. P., Porter, M. A., Mucha, P. J., & Grafton, S. T. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003171 · Cited by 356 · see citing works
Connolly, C. G., Wu, J., Ho, T. C., Hoeft, F., Wolkowitz, O., Eisendrath, S., Frank, G., Hendren, R., Max, J. E., Paulus, M. P., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.036 · Cited by 356 · see citing works
The contribution of network organization and integration to the development of cognitive control
Marek, S., Hwang, K., Foran, W., Hallquist, M. N., & Luna, B. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002328 · Cited by 337 · see citing works
Revisiting the role of the insula in addiction
Droutman, V., Read, S. J., & Bechara, A. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.05.005 · Cited by 317 · see citing works
Developmental changes in large-scale network connectivity in autism
Nomi, J. S., & Uddin, L. Q. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.02.024 · Cited by 274 · see citing works
Self-citationBeyond the Tripartite Cognition–Emotion–Interoception Model of the Human Insular Cortex
Uddin, L. Q., Kinnison, J., Pessoa, L., & Anderson, M. L. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00462 · Cited by 275 · see citing works
Self-citationThe implications of brain connectivity in the neuropsychology of autism
Maximo, J. O., Cadena, E. J., & Kana, R. K. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9250-0 · Cited by 259 · see citing works
Functional alignment with anatomical networks is associated with cognitive flexibility
Medaglia, J. D., Huang, W., Karuza, E. A., Kelkar, A., Thompson-Schill, S. L., Ribeiro, A., & Bassett, D. S. (2017) · Nature Human Behaviour · doi:10.1038/s41562-017-0260-9 · Cited by 223 · see citing works
Vértes, P. E., & Bullmore, E. T. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12365 · Cited by 197 · see citing works
Developmental changes in brain network hub connectivity in late adolescence
Baker, S. T. E., Lubman, D. I., Yucel, M., Allen, N. B., Whittle, S., Fulcher, B. D., Zalesky, A., & Fornito, A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5043-14.2015 · Cited by 168 · see citing works
Structural and functional rich club organization of the brain in children and adults
Grayson, D. S., Ray, S., Carpenter, S., Iyer, S., Dias, T. G. C., Stevens, C., Nigg, J. T., & Fair, D. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088297 · Cited by 187 · see citing works
Disruption of anterior insula modulation of large-scale brain networks in schizophrenia
Moran, L. V., Tagamets, M. A., Sampath, H., O’Donnell, A., Stein, E. A., Kochunov, P., & Hong, L. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.029 · Cited by 181 · see citing works
Adolescent Neurodevelopment and Vulnerability to Psychosis
Patel, P. K., Leathem, L. D., Currin, D. L., & Karlsgodt, K. H. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.028 · Cited by 152 · see citing works
Large-scale brain network dynamics supporting adolescent cognitive control
Dwyer, D. B., Harrison, B. J., Yücel, M., Whittle, S., Zalesky, A., Pantelis, C., Allen, N. B., & Fornito, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1634-14.2014 · Cited by 143 · see citing works
Manoliu, A., Riedl, V., Doll, A., Bäuml, J. G., Mühlau, M., Schwerthöffer, D., Scherr, M., Zimmer, C., Förstl, H., Bäuml, J., et al. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00216 · Cited by 128 · see citing works
Kaunhoven, R. J., & Dorjee, D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.007 · Cited by 130 · see citing works
Adolescent nicotine induces persisting changes in development of neural connectivity.
Smith, R. F., McDonald, C. G., Bergstrom, H. C., Ehlinger, D. G., & Brielmaier, J. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.019 · Cited by 120 · see citing works
Uddin, L. Q. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.010 · Cited by 116 · see citing works
Self-citationPredicting individual brain maturity using dynamic functional connectivity
Qin, J., Chen, S.-G., Hu, D., Zeng, L.-L., Fan, Y.-M., Chen, X.-P., & Shen, H. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00418 · Cited by 117 · see citing works
Cottam, W. J., Iwabuchi, S. J., Drabek, M. M., Reckziegel, D., & Auer, D. P. (2018) · Pain · doi:10.1097/j.pain.0000000000001209 · Cited by 110 · see citing works
Associations between white matter microstructure and infants' working memory
Short, S. J., Elison, J. T., Goldman, B. D., Styner, M., Gu, H., Connelly, M., Maltbie, E., Woolson, S., Lin, W., Gerig, G., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.021 · Cited by 105 · see citing works
Insula response and connectivity during social and non-social attention in children with autism
Odriozola, P., Uddin, L. Q., Lynch, C. J., Kochalka, J., Chen, T., & Menon, V. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv126 · Cited by 95 · see citing works
Self-citationAmygdala subnuclei resting-state functional connectivity sex and estrogen differences
Engman, J., Linnman, C., Van Dijk, K. R. A., & Milad, M. R. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.012 · Cited by 89 · see citing works
Peters, S., Jolles, D. J., Duijvenvoorde, A. C. K. V., Crone, E. A., & Peper, J. S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.01.004 · Cited by 88 · see citing works
Rocchetti, M., Radua, J., Paloyelis, Y., Xenaki, L., Frascarelli, M., Caverzasi, E., Politi, P., & Fusar‐Poli, P. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12185 · Cited by 83 · see citing works
Neurostructural abnormalities in pediatric anxiety disorders
Strawn, J. R., Hamm, L., Fitzgerald, D. A., Fitzgerald, K. D., Monk, C. S., & Phan, K. L. (2015) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2015.03.004 · Cited by 81 · see citing works
Richmond, S., Johnson, K. A., Seal, M. L., Allen, N. B., & Whittle, S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.024 · Cited by 70 · see citing works
Resting-state time-varying analysis reveals aberrant variations of functional connectivity in autism
Yao, Z., Hu, B., Xie, Y., Zheng, F., Liu, G., Chen, X., & Zheng, W. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00463 · Cited by 74 · see citing works
Wang, Z., Xia, M., Dai, Z., Liang, X., Song, H., He, Y., & Li, K. (2015) · Brain Structure and Function · doi:10.1007/s00429-013-0681-9 · Cited by 73 · see citing works
Immordino-Yang, M. H., Yang, X.-F., & Damasio, H. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00728 · Cited by 67 · see citing works
Choi, J., Jeong, B., Lee, S. W., & Go, H.-J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083516 · Cited by 58 · see citing works
Chien, H., Lin, H., Lai, M., Gau, S. S., & Tseng, W. I. (2015) · Autism Research · doi:10.1002/aur.1457 · Cited by 54 · see citing works
Morphological brain measures of cortico‐limbic inhibition related to resilience
Gupta, A., Love, A., Kilpatrick, L. A., Labus, J. S., Bhatt, R., Chang, L., Tillisch, K., Naliboff, B., & Mayer, E. A. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24007 · Cited by 54 · see citing works
Tomiyama, H., Nakao, T., Murayama, K., Nemoto, K., Ikari, K., Yamada, S., Kuwano, M., Hasuzawa, S., Togao, O., Hiwatashi, A., et al. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.102004 · Cited by 47 · see citing works
Jao Keehn, R. J., Pueschel, E. B., Gao, Y., Jahedi, A., Alemu, K., Carper, R., Fishman, I., & Müller, R.-A. (2021) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2020.02.007 · Cited by 34 · see citing works
Salience network dynamics underlying successful resistance of temptation
Steimke, R., Nomi, J. S., Calhoun, V. D., Stelzel, C., Paschke, L. M., Gaschler, R., Goschke, T., Walter, H., & Uddin, L. Q. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx123 · Cited by 30 · see citing works
Self-citationHoffmann, E., Brück, C., Kreifelts, B., Ethofer, T., & Wildgruber, D. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1544-3 · Cited by 30 · see citing works
Dajani, D. R., Odriozola, P., Winters, M., Voorhies, W., Marcano, S., Baez, A., Gates, K. M., Dick, A. S., & Uddin, L. Q. (2020) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01536 · Cited by 27 · see citing works
Self-citationYu, Q., Zhang, Z., Ludyga, S., Erickson, K. I., Cheval, B., Hou, M., Pindus, D. M., Hillman, C. H., Kramer, A. F., Falck, R. S., et al. (2025) · Advanced Science · doi:10.1002/advs.202406631 · Cited by 27 · see citing works
Creative thinking and brain network development in schoolchildren
Duval, P. E., Fornari, E., Décaillet, M., Ledoux, J., Beaty, R. E., & Denervaud, S. (2023) · Developmental Science · doi:10.1111/desc.13389 · Cited by 15 · see citing works
Perez, T. M., Glue, P., Adhia, D. B., Navid, M. S., Zeng, J., Dillingham, P., Smith, M., Niazi, I. K., Young, C. K., & De Ridder, D. (2022) · Trials · doi:10.1186/s13063-022-06863-z · Cited by 8 · see citing works
- Authors
- Uddin, L. Q., Supekar, K. S., Ryali, S., & Menon, V.
- Affiliations
- Stanford Medicine (US)
- Stanford University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-12-14
- Volume
- 31
- Issue
- 50
- Pages
- 18578-18589
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3641286
- OpenAlex
- W2025832022
- Cited by
- 520
- References
- 77
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 40 · 2023: 26 · 2022: 38 · 2021: 38 · 2020: 40 · 2019: 47 · 2018: 41 · 2017: 33 · 2016: 43 · 2015: 45 · 2014: 32 · 2013: 30 · 2012: 19
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Science Foundation (0449927, HD059205, MH084164)
- National Institutes of Health
- National Institute of Mental Health (MH084164, K01MH092288, R01MH084164)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD057610, HD047520, HD057610, HD059205, R01HD047520, R01HD059205)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- brain development, structural connectivity, functional connectivity, effective connectivity, salience network, frontoparietal network, default mode network, large-scale brain networks, causal influence, structural integrity, diffusion tensor tractography, cognitive control, attention
- MeSH terms
- Brain, Brain Mapping, Child, Cognition, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Young Adult, Diffusion Tensor Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review