Cited by 520Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology Studies

Dynamic reconfiguration of structural and functional connectivity across core neurocognitive brain networks with development

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Uddin, Lucina Q., Supekar, Kaustubh S., Ryali, Srikanth, Menon, Vinod·2011·The Journal of Neuroscience

Abstract

Brain structural and functional development, throughout childhood and into adulthood, underlies the maturation of increasingly sophisticated cognitive abilities. High-level attentional and cognitive control processes rely on the integrity of, and dynamic interactions between, core neurocognitive networks. The right fronto-insular cortex (rFIC) is a critical component of a salience network (SN) that mediates interactions between large-scale brain networks involved in externally oriented attention [central executive network (CEN)] and internally oriented cognition [default mode network (DMN)]. How these systems reconfigure and mature with development is a critical question for cognitive neuroscience, with implications for neurodevelopmental pathologies affecting brain connectivity. Using functional and effective connectivity measures applied to fMRI data, we examine interactions within and between the SN, CEN, and DMN. We find that functional coupling between key network nodes is stronger in adults than in children, as are causal links emanating from the rFIC. Specifically, the causal influence of the rFIC on nodes of the SN and CEN was significantly greater in adults compared with children. Notably, these results were entirely replicated on an independent dataset of matched children and adults. Developmental changes in functional and effective connectivity were related to structural connectivity along these links. Diffusion tensor imaging tractography revealed increased structural integrity in adults compared with children along both within- and between-network pathways associated with the rFIC. These results suggest that structural and functional maturation of rFIC pathways is a critical component of the process by which human brain networks mature during development to support complex, flexible cognitive processes in adulthood.

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Crossref · 10.1523/jneurosci.4465-11.2011

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Authors
Uddin, L. Q., Supekar, K. S., Ryali, S., & Menon, V.
Affiliations
  • Stanford Medicine (US)
  • Stanford University (US)
Venue
The Journal of Neuroscience
Published
2011-12-14
Volume
31
Issue
50
Pages
18578-18589
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2025832022
Cited by
520
References
77
Citations by year
2026: 19 · 2025: 29 · 2024: 40 · 2023: 26 · 2022: 38 · 2021: 38 · 2020: 40 · 2019: 47 · 2018: 41 · 2017: 33 · 2016: 43 · 2015: 45 · 2014: 32 · 2013: 30 · 2012: 19
FWCI
13.15
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
Funders
  • National Science Foundation (0449927, HD059205, MH084164)
  • National Institutes of Health
  • National Institute of Mental Health (MH084164, K01MH092288, R01MH084164)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD057610, HD047520, HD057610, HD059205, R01HD047520, R01HD059205)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
brain development, structural connectivity, functional connectivity, effective connectivity, salience network, frontoparietal network, default mode network, large-scale brain networks, causal influence, structural integrity, diffusion tensor tractography, cognitive control, attention
MeSH terms
Brain, Brain Mapping, Child, Cognition, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Young Adult, Diffusion Tensor Imaging

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