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Psychosocial Modifiers of Immunocompetence in Medical Students
Abstract
This study addressed the effects of a naturally occurring stressor on components of the immune response. Blood was drawn twice from 75 first-year medical students, with a baseline sample taken one month before their final examinations and a stress sample drawn on the first day of final examinations. Median splits on scores from the Holmes--Rahe Social Readjustment Rating Scale and the UCLA Loneliness Scale produced a 2 X 2 X 2 repeated measures ANOVA when combined with the trials variable. Natural killer (NK) cell activity declined significantly from the first to the second sample. High scorers on stressful life events and loneliness had significantly lower levels of NK activity. Total plasma IgA increased significantly from the first to second sample, while plasma IgG and IgM, C-reactive protein, and salivary IgA did not change significantly.
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“Loneliness has been associated with impaired cellular immunity as reflected in lower natural killer (NK) cell activity and higher antibody titers to the Epstein Barr Virus and human herpes viruses [70, 80–82].”
From Loneliness matters: a theoretical and empirical review of consequences and mechanisms (2010) · cites this paper as [82]
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Metadata
- Authors
- Kiecolt-Glaser, J. K., Garner, W., Speicher, C., Penn, G. M., Holliday, J., & Glaser, R.
- Affiliations
- The Ohio State University (US)
- Venue
- Psychosomatic Medicine
- Published
- 1984-01
- Volume
- 46
- Issue
- 1
- Pages
- 7-14
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2025609684
- Cited by
- 782
- References
- 1
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 7 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 17 · 2016: 12 · 2015: 15 · 2014: 19 · 2013: 10 · 2012: 23
- FWCI
- 13.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- immunocompetence, psychosocial stress, medical students, final examinations, NK cell cytotoxicity, loneliness, life events, immunoglobulin A, salivary IgA, C-reactive protein, immune response
- MeSH terms
- Adult, C-Reactive Protein, Female, Humans, Immunity, Cellular, Immunocompetence, Immunoglobulins, Killer Cells, Natural, Leukocyte Count, Male, Stress, Psychological
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