Caspase Functions in Cell Death and Disease

The plant immune system

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The Inflammasome

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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Apoptosis: controlled demolition at the cellular level

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Non-canonical inflammasome activation targets caspase-11

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

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Amyloid Precursor Protein Processing and Alzheimer's Disease

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Molecular mechanisms of caspase regulation during apoptosis

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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Immune Signaling by RIG-I-like Receptors

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

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Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

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The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

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Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

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Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

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Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

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Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

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Pro-inflammatory programmed cell death

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[Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children].

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

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An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

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Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

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Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

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Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis

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Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

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Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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An Induced Proximity Model for Caspase-8 Activation

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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

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Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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A Unified Model for Apical Caspase Activation

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The NLR Gene Family: A Standard Nomenclature

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MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

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Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

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Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

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Three-Dimensional Structure of the Apoptosome

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The Nalp3 inflammasome is essential for the development of silicosis

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IL-1 pathways in inflammation and human diseases

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FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

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Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

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Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

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Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

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Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

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Spectrum of clinical features in Muckle‐Wells syndrome and response to anakinra

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Chronic Infantile Neurological Cutaneous and Articular Syndrome Is Caused by Mutations in CIAS1, a Gene Highly Expressed in Polymorphonuclear Cells and Chondrocytes

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An inducible caspase 9 safety switch for T-cell therapy

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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

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A pilot study of IL-1 inhibition by anakinra in acute gout

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NALPs: a novel protein family involved in inflammation

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Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

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Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

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De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin‐associated autoinflammatory diseases

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Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

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Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

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The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

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Interleukin-1–Receptor Antagonist in the Muckle–Wells Syndrome

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Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

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