The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
Open accessAbstract
New granule cells are born throughout life in the dentate gyrus of the hippocampal formation. Given the fundamental role of the hippocampus in processes underlying certain forms of learning and memory, it has been speculated that newborn granule cells contribute to cognition. However, previous strategies aiming to causally link newborn neurons with hippocampal function used ablation strategies that were not exclusive to the hippocampus or that were associated with substantial side effects, such as inflammation. We here used a lentiviral approach to specifically block neurogenesis in the dentate gyrus of adult male rats by inhibiting WNT signaling, which is critically involved in the generation of newborn neurons, using a dominant-negative WNT (dnWNT). We found a level-dependent effect of adult neurogenesis on the long-term retention of spatial memory in the water maze task, as rats with substantially reduced levels of newborn neurons showed less preference for the target zone in probe trials >2 wk after acquisition compared with control rats. Furthermore, animals with strongly reduced levels of neurogenesis were impaired in a hippocampus-dependent object recognition task. Social transmission of food preference, a behavioral test that also depends on hippocampal function, was not affected by knockdown of neurogenesis. Here we identified a role for newborn neurons in distinct aspects of hippocampal function that will set the ground to further elucidate, using experimental and computational strategies, the mechanism by which newborn neurons contribute to behavior.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, the newborn cells of dentate gyrus are critical for OPP memory (Jessberger et al., 2009).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Jessberger et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Self-citationMechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Self-citationFunctional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Self-citationInflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078
Self-citationNeurogenesis in the adult is involved in the formation of trace memories
Shors, T. J., Miesegaes, G. R., Beylin, A. V., Zhao, M., Rydel, T. A., & Gould, E. (2001) · Nature · doi:10.1038/35066584 · Cited by 2,014
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,891
Wnt signalling regulates adult hippocampal neurogenesis
Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,544
Self-citationMilestones of neuronal development in the adult hippocampus
Kempermann, G., Jessberger, S., Steiner, B., & Kronenberg, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.013 · Cited by 1,460
Self-citationEnhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292
Recognition memory and the medial temporal lobe: a new perspective
Squire, L. R., Wixted, J. T., & Clark, R. E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2154 · Cited by 1,059
Self-citationRoles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054
Saxe, M. D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607207103 · Cited by 1,020
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 1,019
Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M., & Gage, F. H. (2002) · Development · doi:10.1242/dev.00203 · Cited by 1,003
Self-citationSpatial memory, recognition memory, and the hippocampus
Broadbent, N. J., Squire, L. R., & Clark, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406344101 · Cited by 985
Self-citationProduction and purification of lentiviral vectors
Tiscórnia, G., Singer, O., & Verma, I. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.37 · Cited by 974
Moser, E., Moser, M. ‐., & Andersen, P. N. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03916.1993 · Cited by 953
Spatial learning with a minislab in the dorsal hippocampus.
Moser, M., Moser, E. I., Forrest, E., Andersen, P. N., & Morris, R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9697 · Cited by 944
A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927
Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W. (2007) · Nature Neuroscience · doi:10.1038/nn1847 · Cited by 875
A role for adult neurogenesis in spatial long-term memory
Snyder, J. S., Hong, N. S., McDonald, R. J., & Wojtowicz, J. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.009 · Cited by 854
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y., & Gould, E. (2002) · Hippocampus · doi:10.1002/hipo.10103 · Cited by 853
Suh, H., Consiglio, A., Ray, J., Sawai, T., D’Amour, K. A., & Gage, F. H. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.09.002 · Cited by 851
Self-citationImpaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740
Self-citationPotential role for adult neurogenesis in the encoding of time in new memories
Aimone, J. B., Wiles, J., & Gage, F. H. (2006) · Nature Neuroscience · doi:10.1038/nn1707 · Cited by 661
Self-citationDissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1
Gilbert, P. E., Kesner, R. P., & Lee, I. (2001) · Hippocampus · doi:10.1002/hipo.1077 · Cited by 641
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
Tashiro, A., Sandler, V. M., Toni, N., Zhao, C., & Gage, F. H. (2006) · Nature · doi:10.1038/nature05028 · Cited by 640
Self-citationSpatial Relational Memory Requires Hippocampal Adult Neurogenesis
Dupret, D., Revest, J., Koehl, M., Ichas, F., Giorgi, F. D., Costet, P., Abrous, D. N., & Piazza, P. V. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001959 · Cited by 631
Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic Mice
Bush, T. G., Savidge, T., Freeman, T. C., Cox, H. J., Campbell, E. A., Mucke, L., Johnson, M. H., & Sofroniew, M. V. (1998) · Cell · doi:10.1016/s0092-8674(00)81571-8 · Cited by 608
Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry
Brun, V. H., Otnæss, M. K., Molden, S., Steffenach, H.-A., Witter, M. P., Moser, M.-B., & Moser, E. I. (2002) · Science · doi:10.1126/science.1071089 · Cited by 606
Inhibition of neurogenesis interferes with hippocampus‐dependent memory function
Winocur, G., Wojtowicz, J. M., Sekeres, M. J., Snyder, J. S., & Wang, S. Z. (2006) · Hippocampus · doi:10.1002/hipo.20163 · Cited by 601
Bruel‐Jungerman, E., Laroche, S., & Rampon, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03875.x · Cited by 530
A role for adult TLX-positive neural stem cells in learning and behaviour
Zhang, C., Zou, Y., He, W., Gage, F. H., & Evans, R. M. (2008) · Nature · doi:10.1038/nature06562 · Cited by 523
Self-citationTransgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
Nakashiba, T., Young, J. Z., McHugh, T. J., Buhl, D. L., & Tonegawa, S. (2008) · Science · doi:10.1126/science.1151120 · Cited by 492
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
Meshi, D., Drew, M. R., Saxe, M., Ansorge, M. S., David, D. J. P., Santarelli, L., Malapani, C., Moore, H. M., & Hen, R. (2006) · Nature Neuroscience · doi:10.1038/nn1696 · Cited by 458
Heterogenous properties of dentate granule neurons in the adult rat
Wang, S. Z., Scott, B. W., & Wojtowicz, J. M. (2000) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(20000205)42:2 · Cited by 421
Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus
Laplagne, D. A., Esposito, M. S., Piatti, V. C., Morgenstern, N. A., Zhao, C., van Praag, H., Gage, F. H., & Schinder, A. F. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040409 · Cited by 373
Self-citationThe neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?
Kempermann, G. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.002 · Cited by 372
Anterograde and retrograde amnesia in rats with dorsal hippocampal or dorsomedial thalamic lesions
Winocur, G. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90012-4 · Cited by 352
Adult‐born hippocampal neurons mature into activity‐dependent responsiveness
Jessberger, S., & Kempermann, G. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.02986.x · Cited by 326
Self-citationActivity-dependent synaptic Wnt release regulates hippocampal long term potentiation
Chen, J., Park, C. S., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511920200 · Cited by 298
Bunsey, M. D., & Eichenbaum, H. (1995) · Hippocampus · doi:10.1002/hipo.450050606 · Cited by 268
A computational principle for hippocampal learning and neurogenesis
Becker, S. (2005) · Hippocampus · doi:10.1002/hipo.20095 · Cited by 255
Paradoxical influence of hippocampal neurogenesis on working memory
Saxe, M., Malleret, G., Vronskaya, S., Mendez‐David, I., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., & Hen, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611718104 · Cited by 244
Lifelong corticosterone level determines age-related decline in neurogenesis and memory
Montaron, M., Drapeau, E., Dupret, D., Kitchener, P., Aurousseau, C., Moal, M. L., Piazza, P. V., & Abrous, D. N. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.02.014 · Cited by 213
Clark, R. E., Broadbent, N., Zola, S. M., & Squire, L. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04663.2002 · Cited by 196
Self-citationXavier, G. F., Oliveira-Filho, F. J. B., & Santos, A. M. G. (1999) · Hippocampus · doi:10.1002/(sici)1098-1063(1999)9:6 · Cited by 182
The rodent hippocampus and spatial memory: from synapses to systems
Martin, S. J., & Clark, R. E. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6336-3 · Cited by 165
Self-citationThe effects of running and of inhibiting adult neurogenesis on learning and memory in rats.
Wojtowicz, J. M., Askew, M. L., & Winocur, G. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06128.x · Cited by 158 · cited 2×
“For example, classical conditioning of context fear has been reported to be impaired after blocking neurogenesis (Saxe et al. 2006; Winocur et al. 2006; Imayoshi et al. 2008; Wojtowicz et al. 2008 ), whereas contextual fear conditioning has also been reported to be intact after blocking hippocampal neurogenesis (Dupre…”
BackgroundDynamics of Hippocampal and Cortical Activation during Consolidation of a Nonspatial Memory
Ross, R. S., & Eichenbaum, H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0659-06.2006 · Cited by 156
Bast, T., da Silva, B. M., & Morris, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0698-05.2005 · Cited by 154
HIV-Based Vectors: Preparation and Use
Follenzi, A., & Naldini, L. (2003) · Humana Press eBooks · doi:10.1385/1-59259-141-8:259 · Cited by 141
A Hypothesis About the Role of Adult Neurogenesis in Hippocampal Function
Schinder, A. F., & Gage, F. H. (2004) · Physiology · doi:10.1152/physiol.00012.2004 · Cited by 112
Self-citationNadel, L., & Bohbot, V. D. (2001) · Hippocampus · doi:10.1002/1098-1063(2001)11:1 · Cited by 92
A failure to find socially mediated taste aversion learning in Norway rats (R. norvegicus).
Galef, B. G., Wigmore, S. W., & Kennett, D. J. (1983) · Journal of comparative psychology · doi:10.1037/0735-7036.97.4.358 · Cited by 91
Spooner, R. I., Thomson, A. C., Hall, J., Morris, R., & Salter, S. H. (1994) · Learning & Memory · doi:10.1101/lm.1.3.203 · Cited by 89
Implicit and explicit memory for novel visual objects in older and younger adults.
Schacter, D. L., Cooper, L. A., & Valdiserri, M. (1992) · Psychology and Aging · doi:10.1037//0882-7974.7.2.299 · Cited by 84
Alvarez, P., Lipton, P. A., Melrose, R. J., & Eichenbaum, H. (2001) · Learning & Memory · doi:10.1101/lm.38201 · Cited by 81
Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus
Dupret, D., Montaron, M., Drapeau, E., Aurousseau, C., Moal, M. L., Piazza, P., & Abrous, D. N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04262.x · Cited by 73
Scali, C., Giovannini, M. G., Prosperi, C., Bartolini, L., & Pepeu, G. (1997) · Pharmacological Research · doi:10.1006/phrs.1997.0252 · Cited by 58
Implicit and explicit memory for novel visual objects in older and younger adults.
Schacter, D. L., Cooper, L. A., & Valdiserri, M. (1992) · Psychology and Aging · doi:10.1037/0882-7974.7.2.299 · Cited by 49
Beaumont, V., Thompson, S. A., Choudhry, F., Nuthall, H. N., Glantschnig, H., Lipfert, L., David, G. R., Swain, C. J., McAllister, G., & Muñoz-Sanjuán, I. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.03.004 · Cited by 42
Memory Consolidation and NMDA Receptors: Discrepancy Between Genetic and Pharmacological Approaches
Day, M., & Morris, R. (2001) · Science · doi:10.1126/science.293.5531.755a · Cited by 31
Flagged first, then by citations
Cited by
Sorted by citations
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120
Self-citationA Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642
Self-citationThe role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719
Self-citationThe effects of aging in the hippocampus and cognitive decline
Bettio, L. E. B., Rajendran, L., & Gil‐Mohapel, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.030 · Cited by 700
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis
Kuwabara, T., Hsieh, J., Muotri, A., Yeo, G., Warashina, M., Lie, D. C., Moore, L., Nakashima, K., Asashima, M., & Gage, F. H. (2009) · Nature Neuroscience · doi:10.1038/nn.2360 · Cited by 648
Self-citation
Metadata
- Authors
- Jessberger, S., Clark, R. E., Broadbent, N. J., Clemenson, G. D., Consiglio, A., Lie, D. C., Squire, L. R., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- University of California San Diego (US)
- ORCID
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-01-29
- Volume
- 16
- Issue
- 2
- Pages
- 147-154
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC2661246
- OpenAlex
- W2148727841
- Cited by
- 654
- References
- 66
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 20 · 2023: 29 · 2022: 28 · 2021: 30 · 2020: 46 · 2019: 28 · 2018: 30 · 2017: 44 · 2016: 48 · 2015: 42 · 2014: 53 · 2013: 60 · 2012: 46
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by-nc)
- Site cant be reached (submittedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by-nc)
- Funders
- National Science Foundation
- U.S. Department of Veterans Affairs
- James S. McDonnell Foundation
- National Alliance for Research on Schizophrenia and Depression
- National Institute on Aging (P50AG005131, P50-AG05131)
- National Institute of Mental Health (P50 AG05131, AG05131, R01MH024600)
- National Institute of Neurological Disorders and Stroke (R01NS050217, NS050217)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, dentate gyrus, hippocampus, spatial memory, object recognition memory, Wnt signaling, lentiviral knockdown, social transmission of food preference, water maze
- MeSH terms
- Animals, Food Preferences, Form Perception, Genetic Vectors, Male, Memory, Neurons, Psychomotor Performance, Social Environment, Space Perception, Stereotaxic Techniques, Lentivirus, Rats, Sprague-Dawley, Maze Learning, Dentate Gyrus, Recognition, Psychology, Animals, Genetically Modified, Wnt Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
